David G. Hoel, Ph.D.

Dr. Hoel has more than 40 years of experience in the fields of epidemiology, statistics, and risk analysis. He is internationally known for his work in risk assessment and has served on and also chaired numerous committees for the WHO and the U.N. as well as the U.S. National Academy of Sciences, the NIH, the EPA and the FDA. For over 20 years, Dr. Hoel was at the National Institute of Environmental Health Sciences, where he directed the Division of Risk Assessment, which included the Laboratories of Biochemical and Molecular Toxicology, as well as the Branches of Epidemiology and Statistics. This Division focused on the development of quantitative methods of estimating human health risks from environmental and occupational exposures. In addition to working with asbestos and chemicals, he is especially active in the area of radiation risk assessment. He has also been involved with issues of adverse outcomes of pharmaceuticals.

Dr. Hoel has published more than 175 papers and chapters in the general area of statistics and risk assessment. He also has been active in studies conducted by the National Research Council of the National Academy. These studies have included reports on beryllium, depleted uranium, dioxin/agent orange, radiation effects in space travel, and radiation dose reconstruction from atomic testing. He has also testified to Congress on several occasions, most recently to the Senate on tricholoethylene and perchlorate. For the last 15 years, he has taught doctoral students as well as clinical fellows at the Medical University of South Carolina, where he is a Distinguished University Professor. The courses he has taught have been in the areas of advanced methods in epidemiology, cancer epidemiology, and risk assessment. His doctoral students have taken positions in industry, universities, and government.

McGreevy KM, Lipsitz SR, Linder JA, Rimm E, Hoel DG. Using median regression to obtain adjusted estimates of central tendency for skewed laboratory and epidemiologic data. J Clin Chem, in press.

Gebregziabher M, Hoel DG. Applications of the Poly-k statistical test to life-time cancer bioassay studies. J Hum Ecol Risk Assess, in press.

Wilson DA, Diel JH, Hoel DG. Lung fibrosis and lung cancer incidence in Beagle dogs that inhaled 238PuO2 or 239PuO2. Health Phys 2009; 96:493–503.

Little MP, Hoel DG, Molitor J, Boice Jr JD, Wakeford R, Muirhead CR. New models for evaluation of radiation-induced lifetime cancer risk and its uncertainty in the UNSCEAR report. Radiat Res 2008; 169:660-676.

Baker PJ, Hoel DG. Meta-analysis of standardized incidence and mortality rates of childhood leukemia in proximity to nuclear facilities. Eur J Cancer Care 2007; 16:355-363.

Reiss R, Anderson EL, Cross CE, Hidy G, Hoel D, McClellan R, Moolgavkar S. Evidence of health impacts of sulfate and nitrate containing particles in ambient air. Inhal Toxicol 2007; 19:419-449.

Adelman AS, Groves FD, O’Rourke K, Sinha D, Hulsey TC, Lawson AB, Wartenberg D, Hoel DG. Residential mobility and risk of childhood acute lymphoblastic leukemia: An ecological study. Br J Cancer 2007; 97:140-144.

Hoel DG. Ionizing radiation and cardiovascular disease. Ann NY Acad Sci 2006; 1076:309-317.

Baker GS, Nakamura T, Hoel DG. Comparison of two models of cancer risk estimation: A statistical analysis. Eur J Oncol 2006; 11:165-176.

Bronley-Delancey A, McMillan DC, McMillan JM, Jollow DJ, Mohr LC, Hoel DG. Application of cryopreserved human hepatocytes in trichloroethylene risk assessment: Relative disposition of chloral hydrate to its carcinogenic and non-carcinogenic metabolites. Environ Health Perspect 2006; 114:1237-1242.

McGreevy KM, Hoel B, Lipsitz SR, Hoel DG. Impact of nutrients on insulin-like growth factor-I, insulin-like growth factor binding protein-3 and their ratio in black and white males. Pub Health Nutr 2006; 10:97-105.

McGreevy KM, Lipsitz SR, Bissada NK, Hoel DG. Impact of race and baseline PSA on longitudinal PSA. Int J Cancer 2006; 118:1773-1776.

Priest ND, Hoel DG, Brooks PN. Relative toxicity of chronic irradiation by 45Ca ß- particles and 242Cm à- particles, with respect to the production of lung tumours in BA/Ca mice. Radiat Res 2006; 166:782-793.

Makie T, Adcock D, Lackland DT, Hoel DG. Pulmonary abnormalities associated with occupational exposures. Am J Indust Med 2005; 48:365-372.

McGreevy KM, Hoel B, Lipsitz SR, Bissada, NK, Hoel DG. Racial and anthropometric differences in insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) levels. Urology 2005; 66:587-592.

Starr TB, Goodman JI, Hoel DG. Uses of benchmark dose methodology in quantitative risk assessment. Regul Toxicol Pharmacol 2005; 42:1-2.

Heath Jr, CW, Bond PD, Hoel DG, Meinhold CB. Residential radon exposure and lung cancer risk: Commentary on Cohen’s county-based study. Health Phys 2004; 87:647-655.

Baker GS, Hoel DG. Corrections in the atomic bomb data to examine low dose risk. Health Phys 2003; 85:709-720.

Nakamura T, Hoel DG. Comparing risks between radiation and dioxin exposure based on two-stage model. Environmetrics 2003; 14:203-211.

Carnes BA, Grahn D, Hoel D. Mortality of atomic bomb survivors predicted from laboratory animals. Radiat Res 2003; 160:159-167.

Creasman WT, Hoel DG, DiSaia PJ. WHI: Now that the dust has settled. A commentary. Am J Obstet Gynecol 2003; 189:621-626.

Nicholas J, Butler G, Davis S, Bryant E, Hoel D, Mohr L. Stable chromosome aberrations and ionizing radiation in airline pilots. Aviation Space Environ Med 2003; 74:953-956.

McGreevy KM, Baron LF, Hoel DG. Clinical breast examination practices among women undergoing screening mammography. Radiology 2002; 224:555-559.

Schubauer-Berigan MK, Baron L, Frey GD, Hoel DG. Breast dose variability in a biracial population undergoing screening mammography. Radiat Protect Dosimetry 2002; 98:417-424.

Schubauer-Berigan MK, Frey GD, Baron L, Hoel DG. Mammography dose in relation to body mass index, race, and menopausal status. Radiat Protect Dosimetry 2002; 98:425-432.

Nicholas JS, Butler GC, Lackland DT, Tessier GS, Mohr LC, Hoel DG. Health among commercial airline pilots. Aviation Space Environ Med 2001; 72:821-826.

Tessier GS, Lam C, Nakamura T, Hoel DG. Two-stage cancer models applied to gamma and neutron exposed mice. Eur J Oncol 2001; 6:297-301.

Radivoyevitch T, Hoel D. Biologically-based risk estimation for radiation-induced chronic myeloid leukemia. Radiat Environ Biophys 2000; 39:153-159.

Nicholas JS, Butler GC, Lackland DT, Hood WC, Hoel DG, Mohr LC. Flight deck magnetic fields in Commercial Aircraft. Am J Ind Med 2000; 38:548-554.

Radivoyevitch T, Hoel DG. Modeling the low-LET dose-response of BCR-ABL formation: Predicting stem cell numbers from A-bomb data. Math Biosci 1999; 162:85-101.

Dinse GE, Umbach DM, Sasco AJ, Hoel DG, Davis DL. Unexplained increase in cancer incidence in the United States from 1975 to 1994: Possible sentinel health indicators? Ann Rev Public Health 1999; 20.

Grosche B, Lackland D, Mohr L, Dunbar J, Nicholas J, Burkart W, Hoel D. Leukemia in the vicinity of two Tritium releasing nuclear facilities: A comparison of the Kruemmel Site, Germany, and the Savannah River Site, South Carolina, USA. J Radiol Protect 1999; 19:243-252.

Hoel DG, Li P. Threshold models in radiation carcinogenesis. Health Phys 1998; 75:241-250.

Nicholas JS, Lackland DT, Butler GC, Mohr LC, Dunbar JB, Kaune WT, Grosche B, Hoel DG. Cosmic radiation and magnetic field exposure to airline flight crews. Am J Indust Med 1998; 34:574-580.

Nicholas JS, Lackland DT, Dosemeci M, Mohr L, Dunbar JB, Grosche B, Hoel DG. Mortality among United States commercial pilots and navigators. J Occup Environ Med 1998; 40:980-985.

Nietert P, Sutherland SE, Silver RM, Pandey JP, Knapp R, Hoel DG, Dosemeci M. Is occupational organic solvent exposure a risk factor for scleroderma? Arthritis and Rheumatism 1998; 41:1111-1118.

Radivoyevitch T, Hoel DG, Chen AM, Sachs RK. Double-strand break misrejoining after X irradiation: Relating moderate to very high doses by a Markov model. Radiat Res 1998; 149:59-67.

Radivoyevitch T, Hoel DG, Hahnfeldt PJ, Rydberg B, Sachs RK. Recent pulsed fields gel electrophoresis data suggest two types of DSBs. Radiat Res 1998; 149:52-58.

Radivoyevitch T, Hoel DG, Hahnfeldt, Sachs RK. Size distribution of misrejoining DNA fragments in irradiation cells. Math Biosci 1998; 149:107-136.

Daniel DM, Lackland DT, Baron LF, Nixon DW, Garr DR, Gross AJ, O’Brien, Hoel DG. Comparison of white and african-american barriers to mammography: A need for a barrier-specific approach to care. Cancer Prevent Int 1995; 2:3-21.

Gordis L, Berry DA, Chu SY, Fajardo LL, Hoel DG, Laufman LR, Rufenbarger CA, Scott, JR, Sullivan DC, Wasson JH, Westhoff CL, Zern RT. National Institutes of Health consensus development conference statement: Breast cancer screening for women ages 40-49. J Nat Cancer Inst 1997; 89(14):1015-1026.

Hoel DG. Ionizing radiation and cancer prevention. Environ Health Perspect 1995; 103(Suppl. 8):241-243.

Hoel DG, Portier CJ. Nonlinearity of carcinogenesis dose. Environ Health Perspect 1994; 102:109-113.

Davis DL, Dinse GE, Hoel DG. Decreasing cardiovascular disease and increasing cancer among whites in the United States from 1973 to 1987. JAMA 1994; 271:431-437.

Mori H, Nakamura T, Mine M, Kondo H, Okumura Y, Hoel DG. Early mortality of atomic bomb survivors based on house reconstruction survey. Int J Radiat Biol 1994; 65:267-275.

Hoel DG. Questions about radiation and risk estimates that remain after BEIR-V. Radiat Res 1993; 136:137-139.

Davis DL, Bradlow HL, Wolff M, Woodruff T, Hoel DG, Anton-Culver H. Medical hypothesis: Xeno-estrogens as preventable causes of breast cancer. Environ Health Perspect 1993; 101:372-377.

Fung VA, Huff JE, Weisburger EK, Hoel DG. Predictive strategies for selecting 379 NCI/NTP chemicals evaluated for carcinogenic potential: Scientific and public health impact. Fundam Appl Toxicol 1993; 20:413-436.

Hoel DG, Carter R, Ron E, Mabuchi K. The influence of death certificate errors on cancer mortality trends. J Nat Cancer Inst 1993; 85:1063-1068.

Portier C, Clark G, Edler L, Greenlee W, Hoel D, Tritscher A, Lucier G. Ligand/receptor binding for 2,3,7,8-TCDD: Implication for risk assessment. Fundam Appl Toxicol 1993; 20:48-56.

Davis DL, Hoel DG. Figuring out cancer. Int J Health Serv 1992; 22(3):447-453.

Dinse GE, Hoel DG. Exploring time trends in cancer incidence. Cancer Causes Control 1992; 3:409-417.

Huff J, Hoel DG. Perspective and overview of the concepts and value of hazard identification as the initial phase of risk assessment for cancer and human health. Scand J Work Environ Health 1992; 18(1):83-89.

Davis DL, Blair A, Hoel DG. Agricultural exposures and cancer trends in developed countries. Environ Health Perspect 1992; 100:39-44.

Hoel DG, Davis DL, Miller AB, Sondik EJ, Swerdlow AJ. Trends in cancer mortality in 15 industrial countries 1969-1986. J Nat Cancer Instit 1992; 84:313-320.

Piegorsch WW, Carr GJ, Portier CJ, Hoel DG. Concordance of carcinogenic response between rodent species: Potency dependence and potential underestimation. Risk Anal 1992; 12:115-121.

Shimizu Y, Kato H, Schull WJ, Hoel DG. Studies of the mortality of A-bomb survivors. Mortality, 1950-8: Part 3. Non-cancer mortality in the years 1950-85 based on the recently revised doses (DS86). Radiat Res 1992; 130:249-266.

deSerres FJ, Hoel DG. Collaborative study on the genetic toxicology of 2-amino-N6-hydroxadenine (AHA): An exercise in genetic risk assessment. Mutat Res 1991; 253:1-3.

Davis DL, Ahlbom A, Hoel DG, Percy C. Is brain cancer mortality increasing in industrial countries? Am J Indust Med 1991; 19:421-431.

Swenberg JA, Hoel DG, Magee PN. Mechanistic and statistical insight into the large carcinogenesis bioassays on DEN and DMN. Cancer Res 1991; 51:6409-6414.

Hoel DG. An overview of the probable consequences of prolonged inhibition of gastric acid secretion. Res Clinical Forums 1990; 12(1):169-176.

Hoel DG. Assumptions of the HERP index. Risk Anal 1990; 10:623-624.

Hoel DG, Dinse GE. Using mortality data to estimate radiation effects on breast cancer incidence. Environ Health Perspect 1990; 87:123-129.

Davis DL, Hoel DG, Fox J, Lopez A. International trends in cancer in France, West Germany, Italy, Japan, England and Wales, and the United States. Ann NY Acad Sci 1990; 609:5-48.

Davis DL, Hoel DG, Fox J, Lopez A. International trends in cancer mortality in France, West Germany, Italy, Japan, England and Wales, and the USA. Lancet 1990; 336:474-481.

Bailer AJ, Hoel DG. Benzene risk assessments: Review and update. Cell Biol Toxicol 1989; 5(3):287-295.

Bailer AJ, Hoel DG. Metabolite-based internal doses used in a risk assessment of benzene. Environ Health Perspect 1989; 82:177-184.

Piegorsch WW, Hoel DG. Exploring relationships between mutagenic and carcinogenic potencies. Mutat Res 1988; 196:161-175.

Yanagawa T, Hoel DG, Brooks G. A conservative use of historical data for a trend test in proportions. J Japan Stat Soc 1989; 19(1):83-94.

Hoel DG, Haseman JK, Hogan MD, Huff JE, McConnell EE. The impact of toxicity on carcinogenicity studies: Implications for risk assessment. Carcinogenesis 1988; 9:2045-2052.

Pedersen LG, Darden TA, Deerfield DW, Anderson MW, Hoel DG. A theoretical study of the effect of methylation or ethylation at 06-guanine on the structure and energy of DNA double strands. Carcinogenesis 1988; 9:1553-1562.

Hoel DG. Cancer risk models for ionizing radiation. Environ Health Perspect 1987; 76:121-124.

Hoel DG. Radiation risk estimation models. Environ Health Perspect 1987; 75:105-107.

Portier CJ, Hoel DG. Issues concerning the estimation of the TD50. Risk Anal 1987; 7:437-447.

Weinberg CR, Brown KG, Hoel DG. Altitude, radiation, and mortality from cancer and heart disease. Radiat Res 1987; 112:381-390.

Brown KG, Hoel DG. Statistical modeling of animal bioassay data with variable dosing regimens: Example—vinyl chloride. Risk Anal 1986; 6:155-166.

Hoel DG, Yanagawa T. Incorporating historical controls in testing for a trend in proportions. J Am Stat Assoc 1986; 81:1095-1099.

Gold LS, Bernstein L, Kaldor J, Backman G, Hoel DG. An empirical comparison of methods used to estimate carcinogenic potency in long-term animal bioassays: Lifetable vs. summary incidence data. Fundam Appl Toxicol 1986; 6:263-269.

Portier CJ, Hedges JC, Hoel DG. Age-specific models of mortality and tumor onset for historical control animals in the National Toxicology Program’s carcinogenicity experiments. Cancer Res 1986; 46:4372-4378, 1986.

Hoel DG. Epidemiology and the inference of cancer mechanisms. Nat Cancer Inst Monogr 1985; 67:199-203.

Hoel DG, Jennrich RI. Life table analysis with small numbers of cases: An example—multiple myeloma in Hiroshima and Nagasaki. J Stat Comput Simul 1985; 20:311-322.

Yanagawa T, Hoel DG. Use of historical controls for animal experiments. Environ Health Perspect 1985; 63:217-224.

Bernstein L, Gold LS, Ames BN, Pike MC, Hoel DG. Some tautologous aspects of the comparison of carcinogenic potency in rats and mice. Fundam Appl Toxicol 1985; 5:79-86.

Bernstein L, Gold LS, Ames BN, Pike MC, Hoel DG. Toxicity and carcinogenic potency. Risk Anal 1985; 5:263-264.

Portier C, Hoel DG. Design of animal carcinogenicity studies for goodness-of-fit to multistage models. Fundam Appl Toxicol 1984; 4:949-959.

Portier C, Hoel DG. Type 1 error of trend tests in proportions and the design of cancer screens. Comm Stat A 1984; 13:1-16.

Poon AH, Hoel DG. Nonparametric estimation of the survival function when cause of death is uncertain. Biometrics 1984; 40:1151-1158.

Brown KG, Hoel DG. Modeling time-to-tumor data: Analysis of the ED01 Study. Fundam Appl Toxicol 1983; 3:458-469.

Brown KG, Hoel DG. Multistage prediction of cancer in serially dosed animals with application to the ED01 study. Fundam Appl Toxicol 1983; 3:470-477.

Portier C, Hoel DG. Low-dose rate extrapolation using the multistage model. Biometrics 1983; 39:897-906.

Portier C, Hoel DG. Optimal bioassay design under the Armitage-Doll multistage model. J Toxicol Environ Health 1983; 12:1-19.

Hoel DG, Kaplan N, Anderson MW. Implication of nonlinear kinetics on risk estimation in carcinogenesis. Science 1983; 219:1032-1037.

Hoel DG, Wakabayashi T, Pike MC. Secular trends in the distributions of the breast cancer risk factors—menarche, first birth, menopause, and weight—in Hiroshima and Nagasaki, Japan. Am J Epidemiol 1983; 118:78-89.

Pike MC, Krailo MD, Henderson BE, Casagrande JT, Hoel DG. ‘Hormonal’ risk factors, ‘breast tissue age’ and the age-incidence of breast cancer. Nature 1983; 303:767-770.

Hoel DG. Extrapolation of laboratory data to human health effects. Environ Sci Res 1982; 25:521-526.

Hoel DG. Statistical measures of risk. Drug Metab Rev 1982; 13:829-838.

Kato H, Brown CC, Hoel DG, Schull WJ. Studies of the mortality of A-Bomb survivors. Report 7. Mortality, 1950-1978: Part II. Mortality from causes other than cancer and mortality in early entrants. Radiat Res 1982; 91:243-264.

Hoel DG. Carcinogenic risk. Risk Anal 1981; l:63-64.

Hoel DG. Statistical issues in toxicology. Selected Papers, Society for Industrial & Applied Mathematics. Environmetrics 1981; 81:248-257.

Hogan MD, Hoel DG. Estimated cancer risk associated with occupational asbestos exposure. Risk Anal 1981; l:67-76.

Haseman JK, Hoel DG, Jennrich RI. Some practical problems arising from the use of the gamma multi-hit model for risk estimation. J Toxicol Environ Health1981; 8:379-386.

Hoel DG. Incorporation of background in dose-response models. Proc. Symposium on Extrapolation of Laboratory Toxicity Data to Man: Factors Influencing the Dose-Toxic Response Relationship, April 1979. Fed Proc 1980; 39:73-75.

Yanagimoto T, Hoel DG. Comparisons of models for estimation of safe doses using measures of the heaviness of tail of a distribution. Ann Inst Stat Math B 1980; 32:465-480.

Anderson MW, Hoel DG, Kaplan NL. A general scheme for the incorporation of pharmacokinetics in low dose risk estimation for chemical carcinogenesis: Example—vinyl chloride. Toxicol Appl Pharmacol 1980; 55:154-161.

Hoel DG. Animal experimentation and its relevance to man. Proc. US-Japan Conference on Biostatistics in the Study of Human Cancer, May 1978. Environ Health Perspect 1979; 32:25-30.

Hoel DG. Sequential methods in genetic risk assessment. Genetics 1979; 92: s195-s198.

Hoel DG. Statistical approaches to toxicological data. Proc. 5th Symposium on Statistics and the Environment, NAS. Environ Health Perspect 1979; 32:267-271.

Haseman JK, Hoel DG. Statistical design of toxicity assays: Role of genetic structure of test animal population. J Toxicol Environ Health 1979; 5:89-101.

Schoenfelder CA, Hoel DG. Properties of the Neyman-Scott carcinogenesis model at low dose rates. Math Biosci 1979; 45:227-246.

Hogan MD, Chi P, Hoel DG, Mitchell TJ. Association between chloroform levels in finished drinking water supplies and various site-specific cancer mortality rates. J Environ Pathol Toxicol 1979; 2:873-887.

Guess HA, Hoel DG. The effect of dose on cancer latency period. J Environ Toxicol 1977; 1:279-286.

Hoel DG, Weiss GH. Properties of noise emitted by vehicular queues. Transport Res 1977; 11:39-44.

Simon R, Hoel DG, Weiss GH. The use of covariate information in the sequential analysis of dichotomous response experiments. Comm Stat A 1977; 6:777-788.

Hoel DG. Statistical extrapolation methods for estimating risks from animal data. Ann NY Acad Sci 1976; 271:418-420.

Crump KS, Hoel DG, Langley CH, Peto R. Fundamental carcinogenic processes and their implications for low dose risk assessment. Cancer Res 1976; 36:2973-2979.

Hoel DG, Weiss GH, Simon R. Sequential tests for composite hypotheses with two binomial populations. Royal Stat Soc 1976; 38:302-308.

Chase GR, Hoel DG. Serial dilutions: Error effects and optimal designs. Biometrika 1975; 62:329-334.

Hoel DG, Weiss GH. A clinical trial design with a fixed maximum number of failures. Comm Stat 1975; 4:429-436.

Hoel DG, Gaylor DW, Kirschstein RL, Saffiotti U, Schneiderman MA. Estimation of risks of irreversible, delayed toxicity. J Toxicol Environ Health 1975; 1:133-151.

Hoel DG, Sobel M, Weiss GH. Comparisons of sampling methods for choosing the best binomial population with delayed observations. J Stat Comput Simul 1975; 3:299-313.

Simon R, Weiss GH, Hoel DG. Sequential analysis of binomial clinical trials. Biometrika 1975; 62:195-200.

Crump KS, Hoel DG. Mathematical models for estimating mutation rates in cell populations. Biometrika 1974; 61:237-252.

Haseman JK, Hoel DG. Tables of Gehan’s generalized Wilcoxon test with fixed point censoring. J Stat Comput Simul 1974; 3:117-135.

Beauchamp JJ, Hoel DG. Some investigations and simulation studies of canonical analysis. J Stat Comput Simul 1973; 2:197-209.

Hoel DG, Crump KS. Estimating the generation time distribution of an age-dependent branching process. Biometrics 1973; 30:125-135.

Patel KM, Hoel DG. A generalized Jonckheere K-sample test against ordered alternatives when observations are subject to arbitrary right censorship. Comm Stat 1973; 2:373-380.

Patel KM, Hoel DG. A nonparametric test for interaction in factorial experiments. J Am Stat Assoc 1973; 68:615-620.

Hoel DG. An inverse stopping rule for play-the-winner sampling. J Am Stat Assoc 1972; 67:148-151.

Hoel DG. A representation of mortality data by competing risks. Biometrics 1972; 28:475-488.

Hoel DG, Walburg Jr. HE. Statistical analysis of survival experiments. J Nat Cancer Inst 1972; 49:361-372.

Hoel DG, Sobel M, Weiss GH. A two-stage procedure for choosing the better of two binomial populations. Biometrika 1972; 59:317-322.

Hook GER, Bend JR, Hoel DG, Fouts JR, Gram TE. Preparation of lung microsomes and a comparison of the distribution of enzymes between subcellular fractions of rabbit lung and liver. J Pharmocol Exper Therap 1972; 182:474-490.

Hoel DG. A method for the construction of sequential selection procedures. Ann Math Stat 1971; 42:630-642.

Hoel DG, Mitchell TJ. The simulation, fitting, and testing of a stochastic cellular proliferation model. Biometrics 1971; 27:191-199.

Hoel DG. A simple two-compartmental model applicable to enzyme regulation. J Biol Chem 1970; 245:5811-5812.

Hoel DG. On the monotonicity of the OC of an SPRT. Ann Math Stat 1970; 41:310-314.

Hoel DG. Some modifications and applications of Wald’s OC formula. Ann Inst Stat Math 1970; 22:65-75.

Crump KS, Hoel DG. Some applications of renewal theory on the whole line. J Appl Prob 1970; 7:734-746.

Gaver Jr. DP, Hoel DG. Comparison of certain small-sample Poisson probability estimates. Technometrics 1970; 12:835-850.

Kastenbaum MA, Hoel DG, Bowman KO. Sample size requirements: One-way analysis of variance. Biometrika 1970; 57:421-430.

Kastenbaum MA, Hoel DG, Bowman KO. Sample size requirements: Randomized block designs. Biometrika 1970; 57:573-577.

Hoel DG. Discussion of engineering analysis of experimental data by Robert P. Benedict. ASME Trans 1969; 91:130.

Hoel DG, Mazumdar M. A class of sequential tests for an exponential parameter. J Am Stat Assoc 1969; 64:1549-1559.

Hoel DG. Closed sequential tests of an exponential parameter. Biometrika 1968; 55:387-391.

Hoel DG. Sequential testing of sample size. Technometrics 1968; 10:331-341.

Hoel DG, Mazumdar M. An extension of Paulson’s selection procedure. Ann Math Stat 1968; 39:2067-2074.

Hoel DG. The number of k-simplices in the mth barycentric subdivision of an r-simplex. Am Math Monthly 1967; 74:819-820.

Books Edited

Hoel DG, Vouk VB, Butler GC, Pekall DB (eds). Methods for Estimating Risk of Chemical Injury: Human and Nonhuman Biota and Ecosystems, SCOPE /SGOMSEC 2. Proceedings of Workshop on Quantitative Estimation of Risk to Human Health from Chemicals, Rome, Italy, 1982.

Hoel DG, Merrill R, Perera F (eds). Banbury Report 19: Risk Quantitation and Regulatory Policy. Proceedings of the Banbury Conference on Risk Quantitation and Regulatory Policy. Cold Spring Harbor Laboratory, 1985.

Blot W, Hirayama T, Hoel DG. Statistical Methods in Cancer Epidemiology. Proceedings of a Conference of the U.S. Japan Cooperative Cancer Research Program, 1985.

Davis D, Hoel DG. Trends in Cancer Mortality in Industrial Countries. New York Academy of Sciences, 1990.

Yanagawa, Hoel DG. Biostatistics in Cancer Risk Assessment. Scientist, Inc., Tokyo, 1991.

De Serres FJ, Hoel DG. 2-Amino-N6-hydroxyadenine: A collaborative study on the genetic toxicology of 2-amino-N6-hydroxyadenine. Mutation Research, Vol. 253, 1991.

Mohr L, Nixon W, Hoel DG. International Case Studies in Risk Assessment and Management. The Medical University of South Carolina Press, 1998.

Regens J, Travis C, Hoel DG. Multimedia Modeling and Risk Assessment. The Medical University of South Carolina Press 1999.

Extrapolation of Radiation-Induced Cancer Risks from Nonhuman Experimental Systems To Human. National Council on Radiation Protection and Measurements, NCRP Report No. 150, 2005. (Chairman Members include Carnes B, Dedrick R, Fry RJM, Grahn D, Griffith W, Groer P, Preston RJ).

Book Chapters

Yanagawa T, Hoel DG. Incorporating geographic distribution into the expected number of deaths in a comparative study. pp. 25-32. In: Statistical Science and Data Analysis. Matsusita K et al. (eds), 1993.

Portier CJ, Hoel DG, Kaplan NL, Koop A. Biologically based models for risk assessment. In: Complex Mixtures and Cancer Risk. Vannio H, Sora M, McMichael AJ (eds), International Agency for Research on Cancer Scientific Publications, No. 104.Lyon, France, 1990.

Hoel DG. Statistical aspects of chemical mixtures. pp. 369-377. In: Methods for Assessing the Effects of Mixtures of Chemicals, SGOMSEC3. Vouk VB, Butler GC, Upton AC, Parke DV, Asher SC (eds), J. Wiley & Sons Limited, New York, NY, 1987.

Hoel DG, Landrigan PJ. Comprehensive evaluation of human data. pp. 121-129. In: Toxic Substances and Human Risk, Principles of Data Interpretation. Tardiff RG, Rodricks JV (eds), Plenum Press, New York, NY, 1987.

Kaplan N, Hoel DG, Portier CJ, Hogan MD. An evaluation of the safety factor approach in risk assessment. pp. 335-346. In: Developmental Toxicology: Mechanisms and Risk. Banbury Report 26, Pratt RM, McLachlan JA, Markert CL (eds), Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1987.

Hogan M, Hoel DG. Utilizing scientific data in assessing human cancer risk associated with chemical exposure. pp. 201-282. In: Report: Chemical Carcinogens: A Review of the Science and Its Associated Principles. U.S. Interagency Staff Group on Carcinogens, Environmental Health Perspectives, Volume 67, 1986.

Hoel DG. The incorporation of pharmacokinetics in low-dose risk estimation. pp. 205-214. In: Toxicological Risk Assessment, Volume I. Clayton D, Krewski D, Munro I (eds), CRC Press, Boca Raton, FL, 1985.

Hoel DG. Dose-response in radiation carcinogenesis: Animal studies. pp. 93-103. In: Epidemiology and Quantitation of Environmental Risk in Humans from Radiation and Other Agents: Potential and Limitations. Castellani A (ed), Plenum Press, London, 1985.

Hoel DG, Preston DL. Dose-response in radiation carcinogenesis: Human studies. pp. 105-122. In: Epidemiology and Quantitation of Environmental Risk in Humans from Radiation and Other Agents: Potential and Limitations. Castellani A (ed), Plenum Press, London, 1985.

Hoel DG. Mathematical dose-response models and their application to risk estimation. pp. 347-359. In: Methods for Estimating Risk of Chemical Injury: Human and Nonhuman Biota and Ecosystems, Scope 1985/SGOMSEC 2. Vouk VB, Butler GC, Hoel DG, Pekall DB (eds), J. Wiley and Sons, New York, NY, 1985.

Portier CJ, Hoel DG, Van Ryzin J. Statistical analysis of the carcinogenesis bioassay data relating to the risks from exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. pp. 99-119. In: Public Health Risks of the Dioxins. Lowrance WW (ed), Rockefeller University, New York, NY, 1984.

Hoel DG. Conditional two sample tests with historical controls. pp. 229-236. In: Contributions to Statistics: Essays in Honour of Norman L. Johnson. Sen PK (ed), North Holland Publishing Company, Amsterdam, 1983.

Hogan MD, Hoel DG. Extrapolation to man. pp. 711-731. In: Principles and Methods of Toxicology. Hayes AW (ed), Raven Press, New York, NY, 1982.

Hoel DG, Crump KS. Waterbourne carcinogens: A scientist’s view. pp. 173-195. In: The Scientific Basis of Health in Safety Regulations. Crandell R, Lave L (ed), The Brookings Institute, 1981.

Gaylor DW, Hoel DG. Statistical analysis of carcinogenesis data from chronic animal studies. pp. 97-111. In: Carcinogens in Industry and Environment. Sontag JM (ed), Marcel Dekker, New York, NY, 1981.

Yanagimoto T, Hoel DG. Measures of the heaviness of tail of estimation of safe doses. Pp 347-357. In: Recent Developments in Statistical Inference and Data Analysis. Matusita K (ed), North Holland Publishing Company, New York, NY, 1980.

Hoel DG. Low-dose and species-to-species extrapolation for chemically induced carcinogenesis. pp. 135-145. In: Banbury Report 1: Assessing Chemical Mutagens: The Risk to Humans. McElheny VK, Abrahamson S (eds), Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1979.

Hoel DG. Some problems in low dose extrapolation. pp. 1391-1396. In: Origins of Human Cancer, Volume 4, Book C. Hiatt HH, Watson JD, Winsten JA (eds), Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1977.

Hoel DG, Sobel M, Weiss GH. A survey of adaptive sampling for clinical trials. pp. 29-61. In: Perspectives in Biometrics. Elashoff RM (ed), Academic Press, New York, NY, 1975.

Hoel DG. Some statistical aspects of experiments for determining the teratogenic effects of chemicals. pp. 375-381. In: Statistical and Mathematical Aspects of Pollution Problems. Pratt J (ed), Marcel Dekker, Inc., New York, NY, 1974.

Chand N, Hoel DG. A comparison of models for determining safe levels of environmental agents. pp. 681-700. In: Reliability and Biometry. Proschan F, Serfling RJ (eds), SIAM, Philadelphia, PA, 1974.

Hoel DG, Weiss GH. A comparison of methods for choosing the better of two negative exponential lifetime distributions. pp. 619-636. In: Reliability and Biometry. Proschan F, Serfling RJ (eds), SIAM, Philadelphia, PA, 1974.

Published Presentations

Hoel DG. Multistage models of carcinogenesis and their implications for dose-response models and risk projections. pp. 123-126. Proceedings, International Conference on Radiation Effects and Protection, Mito, Japan, March 18-20, 1992.

Hoel DG. A balanced approach to risk assessment. pp. 305-311. Proceedings, Toxicology and Industrial Health, Volume 7. Tsuchiya K, Lee SD, Grant LD, Mehlman MA (eds), IXth UOEH International Symposium and First Pan Pacific Cooperative Symposium, Kitakyushu, Japan, 1991.

Ellett WH, Hoel DG, Cooper RD. BEIR V estimates of excess cancer mortality. pp. 309-314. Proceedings, Statistics of Human Exposure to Ionizing Radiation Workshop, Oxford, England, 1990, Radiation Protection Dosimetry, Volume 36, 1991.

Hoel DG. Extrapolation models of animal toxicity data to man. pp. 4-95 to 4-103. Proceedings, Environmental Risk Assessment: How New Regulations Will Affect the Utility Industry. Hoch RJ (ed), Electric Power Research Institute, Palo Alto, CA, 1981.

Hoel DG. Human risk assessment based on laboratory animal studies. pp. 22-24. Proceedings, Second Joint US/USSR Symposium on the Comprehensive Analysis of the Environment, U.S. Environmental Protection Agency, Washington, DC, 1975.

Hoel DG. Statistical models for estimating carcinogenic risks from animal data. pp. 285-291. Proceedings, 5th Annual Conference on Environmental Toxicology, AMRL-TR-74-125, Washington, DC, 1974.

Hoel DG, Sobel M. Comparisons of sequential procedures for selecting the best binomial population. Proceedings, Sixth Berkeley Symposium on Probability and Statistics 4:53-69, 1971.

• Professor and Chairman, Department of Biometry and Epidemiology and Associate Director for Epidemiology, Hollings Cancer Center, 1993–1997
• Director, Division of Biometry and Risk Assessment, National Institute of Environmental Health Sciences, 1981–1993
• Acting Director, National Institute of Environmental Health Sciences and also the National Toxicology Program, 1990–1991
• Associate Director, Radiation Effects Research Foundation, Japan, 1984–1986
• Visiting Scientist, Epidemiology Department, Radiation Effects Research Foundation, Japan, 1979–1980
• Acting Scientific Director, National Institute of Environmental Health Sciences, 1977–1979
• Chief, Biometry Branch, National Institute of Environmental Health Sciences, 1973–1981
• Mathematical Statistician, National Institute of Environmental Health Sciences, 1970–1973
• Adjunct Professor, Department of Biostatistics, University of North Carolina, Chapel Hill, 1970
• Statistician, Oak Ridge National Laboratory, 1968–1970
• Senior Mathematician, Westinghouse Research Laboratories, 1967–1968
  

Conducted an evaluation of laboratory and epidemiological studies since the publication of the National Academy of Sciences’ report on the Biological Effects of Ionizing Radiation (BEIR VII) has been completed. The project was developed and sponsored by the Electric Power Research Institute (EPRI). The report of the findings and conclusions has been peer reviewed and the report will be released this year.

Contributed to the Exponent project on evidence of health impacts of sulfate and nitrate containing particles in ambient air. Results were published in the literature.

Evaluated the primate studies of early developmental effects of methyl chloride for the American Forest Products Association (AFPA). Besides analysis, presentations were made to the EPA administration.

A reanalysis of the Harvard Railroad Workers Study of lung cancer and diesel exhaust was carried out for Health Effects Institute in Boston. This related to attempts by the US EPA and Cal EPA to develop exposure standards for diesel exhaust. A committee report was published by HEI.

Assessed the potential risks of prolonged inhibition of gastric acid inhibition for Glaxo Pharmaceuticals and attended Glaxo sponsored meetings in London and Florence with the proceedings published (Elder J (Ed.): Profound Gastric Acid Suppression: Long Term Safety Risk? Res Clinical Forums 1990; 12(1).

• American Statistical Association
• Biometric Society
• Society for Risk Analysis
• Collegium Ramazzini
• American Association for the Advancement of Science
• Radiation Research Society
• Health Phys Society
• Society for Epidemiological Research