October 8, 2008
Drs. Abby Li and Laura McIntosh of Exponent’s Health Sciences Center for Toxicology and Mechanistic Biology recently co-authored an article in Neurotoxicology, “Building a scientific framework for studying hormonal effects on behavior and on the development of the sexually dimorphic nervous system.”
With increasing concern that low-dose exposure to hormonally active chemicals disrupts sexual differentiation of the brain and peripheral nervous system, there is also drug development research on the therapeutic potential of hormone therapy on behaviors. These research goals have the common need to develop reliable animal models to study the effect of hormones on brain function and behaviors that are predictive of effects in humans.
Using examples from the bisphenol A neurobehavioral literature, Drs. Abby Li and Laura McIntosh, in particular, discuss some of the methodological issues that should be considered in designing developmental neurobehavioral animal studies so they can be useful for human health risk assessment.
Li AA, Baum MJ, McIntosh LJ, Day M, Liu F, Gray LE. Building a scientific framework for studying hormonal effects on behavior and on the development of the sexually dimorphic nervous system. Neurotoxicology 2008; 29:504–519.