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Implications of EPA's New Strategic Plan for Evaluating Toxic Chemicals: Pathway-Based Risk Assessment


April 29, 2009

On March 25th, the EPA released a strategic plan to incorporate advances in molecular biology and computational sciences into toxicity testing and risk assessment practices across the Agency. This ambitious plan proposes a landmark transformation in toxicity testing and risk assessment over the next ten years, to rely increasingly on knowledge of toxicity pathways. This rapidly evolving science studies the manner in which genes, proteins, and small molecules interact to form molecular pathways that maintain cell function, and how exposure to environmental agents can perturb these pathways and produce adverse effects. EPA has embraced new technologies and databases as a foundation for advances in safety assessment, as described in their strategic plan.

Exponent is on the forefront of these developments. For more information related to risk-based product evaluations, including implications for testing and risk assessment, as well as current applications, please click here.