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Services Related to Endocrine Disruption

News

October 24, 2012


Endocrine disruptors are described as substances that may affect the production, release, transport, metabolism, binding, action, or elimination of hormones in the body. Still under debate are the interpretation of what actually constitutes endocrine disruption and whether a hormonal modulation in a constantly fluctuating system, or any dose of a weakly hormonally active substance, is potentially adverse. Exponent is well qualified to offer creative solutions to complex endocrine disruption problems. Our experience has been applied to a wide variety of molecules, including BPA, phthalates, pesticides, industrial (HPV) chemicals, and pesticide inert ingredient surfactants.

Exponent scientists have been recognized leaders in endocrine disruption mammalian and wildlife science and policy. Our consultants have served on National Academy of Science, International Life Science Institute (ILSI), or government advisory committees, including the Endocrine Disruption Screening and Testing Advisory Committee. Our expert scientists have been invited participants at workshops, conferences, and other scientific forums both in the U.S. and abroad. Our experience and accomplishments include conducting and evaluating significant endocrine studies.

Our endocrine disruption consultation includes the following services:

  • Mammalian and wildlife OSRI identification, evaluation, and strategy
  • Consortia organization and management
  • Identification of potential endocrine disruption issues
  • Development of EDSP Tier 1 and Tier 2 testing strategy
  • Preparation and submission of OSRI and Tier 1 data development plans
  • EDSP Tier 1 assay placement and monitoring
  • Submission of EDSP Tier 1 study results and dossiers to EPA
  • Representation to EPA, EU, and international regulatory authorities
  • EU REACH, Agrochemicals, and Biocides vulnerability and registration strategy
  • Critical assessment of published chemical-specific literature compared to GLP study data

Exponent and Crowell & Moring will be presenting a webinar on Endocrine Disrupting Chemicals on November 20th.  If you are interested in attending the webinar, .