Cara L. Frankenfeld, Ph.D.

Dr. Frankenfeld has more than 10 years experience in the design, conduct, and statistical analysis of epidemiologic studies. Her work has primarily focused in the areas of cancer and nutrition, but she has also published in other areas of epidemiology, including genetics, infectious disease, microbiological, and injury. She is also experienced in conducting critical reviews of the scientific literature. Since joining Exponent, she has provided epidemiologic evaluations and support in a variety of research areas, including benzene, sulfur dioxide, dioxins, asbestos, and electric and magnetic fields.

Prior to joining Exponent, Dr. Frankenfeld conducted research at the National Cancer Institute, the Fred Hutchinson Cancer Research Center, and the Harborview Injury Prevention Research Center. At NCI and FHCRC, she worked on and published from more than six research studies in the areas of bacteria-related associations with cancer biomarkers and nutritional epidemiology. As part of this work, she designed and managed research studies, developed research protocols and questionnaires, conducted laboratory work, analyzed small and large-scale studies, and wrote manuscripts. At HIPRC, she was responsible for statistical analysis of a case-control study examining risk factors for falls.

Lunn JC, Kuhnle G, Mai V, Frankenfeld C, Shuker DE, Glen RC, Goodman, JM, Pollock JR, Bingham SA. The effect of haem in red and processed meat on the endogenous formation of N-nitroso compounds in the upper gastrointestinal tract. Carcinogenesis 2007; 28:685-690.

Song KB, Atkinson C, Frankenfeld CL, Jokela T, Wähälä K, Thomas WK, Lampe JW. Prevalence of daidzein-metabolizing phenotypes differs between Caucasian and Korean-American women and girls. J Nutr 2006; 136:1347–1351.

Frankenfeld CL, McTiernan A, Thomas WK, LaCroix K, McVarish L, Weiss NS, Holt VL, Weiss NS, Holt VL, Schwartz SM, Lampe JW. Bone mineral density in postmenopausal women in relation to daidzein-metabolizing phenotypes. Maturitas 2006; 53:315–324.

Frankenfeld CL, Atkinson C, Thomas WK, Goode EL, Gonzalez A, Jokela T, Wähälä K, Schwartz SM, Li SS, Lampe JW. Concordance of daidzein-metabolizing phenotypes in 92 individuals measured one to three years apart. Brit J Nutr 2005; 94:873–876.

Atkinson C, Frankenfeld CL, Lampe JW. Gut bacterial metabolism of the soy isoflavone daidzein: exploring the relevance to human health. Exp Biol Med (Maywood) 2005; 230:155–170.

Phillips LE, Frankenfeld CL, Drangsholt M, Koepsell TD, van Belle G, Longstreth Jr WT. Intracranial meningioma and ionizing radiation in occupational and medical settings. Neurology 2005; 64:350–352.

Tencer AF, Koepsell TD, Wolf ME, Frankenfeld CL, Buchner DM, Kukull WA, LaCroix AZ, Larson EB, Tautvydas M. Biomechanical properties of shoes and risk of falls in older adults. J Am Geriatr Soc 2004; 52:1840–1846.

Frankenfeld CL, Atkinson C, Thomas WK, Goode EL, Gonzalez A, Jokela T, Wähälä K, Schwartz SM, Li SS, Lampe JW. Familial aggregation, segregation analysis and environmental correlates of daidzein-metabolizing phenotypes. Exp Biol Med (Maywood) 2004; 229:902–913.

Frankenfeld CL, Lampe JW, Shannon J, Gao DL, Ray RM, Prunty J, Kalhorn T, Wähälä K, Patterson R, Thomas DB. Frequency of soy food consumption and serum isoflavone concentrations among Chinese women in Shanghai. Public Health Nutr 2004; 7:765–772.

Koepsell TD, Wolf ME, Buchner WA, LaCroiz AZ, Tencer AF, Frankenfeld CL, Tautvydas M, Larson EB. Footwear style and risk of falls in older adults. J Am Geriatr Soc 2004; 52:1495–1501.

Frankenfeld CL, McTiernan A, Aiello EJ, Thomas WK, LaCroix K, Schramm J, Weiss NS, Schwartz SM, Holt VL, Lampe JW. Mammographic density in overweight, postmenopausal women in relation to daidzein-metabolizing phenotypes. Cancer Epidemiol Biomark Prev 2004; 13:1156–1162.

Frankenfeld CL, McTiernan A, Tworoger SS, Atkinson C, Thomas WK, Stanczyk F, Marcinova S, Weigle S, Weiss NS, Holt VL, Schwartz SM, Lampe JW. Serum hormone and sex hormone binding globulin concentrations and urinary hydroxylated estrogen metabolites in postmenopausal women in relation to daidzein-metabolizing phenotypes. J Steroid Biochem Mol Biol 2004; 88:399–408.

Frankenfeld CL, Patterson RE, Horner NK, Neuhouser ML, Skor HE, Kalhorn TF, Howald WN, Lampe JW. Validation of a soy food frequency questionnaire and evaluation of correlates of plasma isoflavone concentrations in postmenopausal women. Am J Clin Nutr 2003; 77:674–680.

Frankenfeld CL, Patterson RE, Kalhorn TF, Howald WN, Lampe JL. Validation of a soy food frequency questionnaire with plasma concentrations of isoflavones in U.S. adults. J Am Dietetic Assoc. 2002; 102:1407–1413.

Published Abstracts

Lampe JW, Nishino Y, Wu C, Li W, Ray RM, Lin M-G, Gao DL, Hu Y, Shannon J, Stahlsberg, H, Porter PL, Frankenfeld CL, Wähälä K, Thomas DB. Serum isoflavone concentrations and risk of fibrocystic breast conditions and breast cancer in Shanghai. Experimental Biology Annual Meeting, San Diego, CA, 2005.

Lampe JW, Frankenfeld CL, Atkinson C, Thomas WK, Gonzalez A, Jokela T, Wähälä K, Schwartz SM, Li SS. High concordance of daidzein-metabolizing phenotypes in 92 individuals measured one to three years apart. EU PHYTOHEALTH Research Platform Meeting, Lausanne, Switzerland, April 25–26, 2005.

Frankenfeld CL, Atkinson C, Thomas WK, Gonzalez A, Jokela T, Schwartz SM, Wähälä K, Li SS, Lampe JW. Familial aggregation of Daidzein-Metabolizing phenotypes. 5th International Symposium on the Role of Soy in Preventing and Treating Chronic Disease, The American Oil Chemists' Society, Orlando, FL, September 21–24, 2003 (poster).

Atkinson C, Frankenfeld CL, Thomas WK, Gonzalez A, Wähälä K, Jokela T, Schwartz SM, Li SS, Lampe JW. Equol-producer phenotyping in a free-living population in the United States. 5th International Symposium on the Role of Soy in Preventing and Treating Chronic Disease, The American Oil Chemists' Society, Orlando, FL, September 21–24, 2003 (poster).

Frankenfeld CL, McTiernan A, Schramm JK, Yasui Y, McVarish L, Ulrich CM, Thomas WK, Lampe JW. Influence of interindividual variability in colonic microfloral daidzein metabolism on postmenopausal bone mineral density. Experimental Biology Annual Meeting 2003, American Society for Nutritional Sciences Nutrition Epidemiology Research Interest Section Business Meeting, San Diego, CA, April 14, 2003 (poster).

Frankenfeld CL, McTiernan A, Aiello EJ, Schramm JK, Thomas WK, Lampe JW. Lower mammographic density in postmenopausal women with the capacity to produce equol from daidzein. American Association for Cancer Research, Washington, DC, 2003 (poster).

Lampe JW, Skor HE, Atkinson CA, and Frankenfeld CL. Intestinal bacterial conversion of the soy isoflavone Daidzein to Equol: Implications for Human Health. 4th International Symposium on the Role of Soy in Preventing and Treating Chronic Disease, The American Oil Chemists' Society, San Diego, CA, November 4–7, 2001 (poster).

Frankenfeld C, Taren D, van Ejik A, Nahlen B, Otieno J, Misore A, Shi YP, Steketee R. Presence of HIV infection negatively associated with infant growth in Kisumu, Kenya. Experimental Biology Annual Meeting, San Diego, CA, 2000 (poster).

Frankenfeld C, van Ejik A, Ayisi J, Shi YP, Otieno J, Taren D, Misore A, Steketee R, Nahlen B. HIV infection negatively associated with infant growth in Kisumu, Kenya. World AIDS Conference XIII, Durban, South Africa, July 13, 2000.

Books and Book Chapters

Frankenfeld C and Taren D. HIV and infant growth. In: Nutrition and AIDS, Second Edition. R. Watson (ed), CRC Press, Florida, September, 2000.

Invited Presentations

Frankenfeld C. Got bugs? Interindividual variability of intestinal bacteria and breast cancer risk factors. Breast Cancer Series Seminar, Seattle Cancer Care Alliance, October 10, 2003.

• Quantitative Research Analyst, CSR, Incorporated, 2006–2007
• Cancer Prevention Fellow, National Cancer Institute, 2004–2006
• Postdoctoral Research Associate, Fred Hutchinson Cancer Research Center, 2003–2004
• Predoctoral Research Assistant, Harborview Injury Prevention Research Center, 2001–2002
• Predoctoral Research Assistant, Fred Hutchinson Cancer Research Center, 2000–2003
  
  

• International Society for Environmental Epidemiology, 2007–present
• American Society for Microbiology, 2005–2006
• American Association for Cancer Research, 2002–2005
• American Society for Nutrition, 1999–2005