Janci Chunn Lindsay, Ph.D.

Dr. Lindsay has 16 years of scientific experience, with an emphasis on the study of pulmonary pathologies resulting from environmental, occupational, and chemotherapeutic exposures. Her expertise within Exponent centers on evaluating the complex dynamics of toxicity, such as toxicant pharmacology, exposure route, dose/response, host metabolism, and subsequent cellular effects as they relate to the contribution of specific substances to human disease.

Dr. Lindsay holds a doctorate in Biochemistry and Molecular Biology and has extensive experience in analyzing the molecular profile of pharmacologic responses as they pertain to the dose/response relationship, specifically in terms of analyzing and evaluating molecular markers of disease, or “Toxicogenomics.” Additionally, she brings her expertise in evaluating toxicant contributions to lung pathologies—such as asthma, reactive airway disease, chronic obstructive pulmonary disease (COPD), bronchiolitis obliterans, organizing pneumonitis, interstitial pneumonia, and pulmonary fibrosis—that may be claimed following chemical, drug, or particulate exposure.

Mi T, Abbasi S, Zhang H, Uray K, Chunn JL, Xia LW, Molina JG, Weisbrodt NW, Kellems RE, Blackburn MR, Xia Y. Excess adenosine in murine penile erectile tissue contributes to priapism via A_2B adenosine receptor signaling. J Clin Invest 2008; 118(4):1491–1501.

Chunn JL, Mohsenin A, Young HY, Lee CG, Elias JA, Kellems RE, Blackburn MR. Partially adenosine deaminase deficient mice develop pulmonary fibrosis in association with adenosine elevations. Am J Physiol Lung Cell Mol Physiol 2006; 290:579–587.

Willems L, Reichelt ME, Molina JG, Sun CX, Chunn JL, Ashton KJ, Schnermann J, Blackburn MR, Headrick JP. Effects of genetic deletion of adenosine deaminase and A1 receptors in normoxic and ischaemic hearts. Cardiovasc Res 2006; 1:71(1):79–87.

Sun CX, Zhong H, Molina JG, Belardinelli L, Zeng D, Mohsennin A, Chunn JL, Blackburn MR. Role of A2B Receptor signaling in adenosine-dependent pulmonary inflammation and injury. J Clin Invest 2006; 116(8):2173–2182.

Reichelt ME, Willems L, Molina JG, Sun CX, Chunn JC (Noble), Ashton KJ, Schnermann J, Blackburn MR, Headrick JP. Genetic deletion of the A1 adenosine receptor limits myocardial ischemic tolerance. Circ Res 2005; 18:96(3):363-367.

Chunn J, Molina JG, Mei T, Xia Y, Kellems R, Blackburn MR. Adenosine dependant pulmonary fibrosis in adenosine deaminase deficient mice. J Immunol 2005; 175:1937-1946.

Blackburn MR, Lee CG, Young HWJ, Chunn JL, Banerjee SK, Elias JA. Adenosine is an important mediator of IL-13 induced inflammation in the lung: Evidence for an IL-13-adenosine amplification pathway. J Clin Invest 2003; 112:332–343.

Chunn JL, Young WJ, Colasurdo GN, Banerjee SK, Blackburn MR. Adenosine-dependent airway inflammation and hyperresponsiveness in partially adenosine deaminase deficient mice. J Immunol 2001; 167:4676–4685.

Blackburn MR, Volmer JB, Chunn JL (Thrasher), Crosby JR, Lee JJ, Kellems RE. Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation and airway obstruction. J Exp Med 2000; 192:159-170.

Zhong H, Chunn JL, Volmer JB, Fozard JL Blackburn MR. Adenosine mediated mast cell degranulation in adenosine deaminase-deficient mice. J Pharmacol Exp Ther 2000; 298(2):433-440.

Blackburn MR, Wubah JA Chunn JL, Thompson LF, Knudsen TB. Transitory expression of the A2b adenosine receptor during implantation chamber development. Develop Dynam 1999; 216:127–136.

Skinner SM, Kieback DG, Chunn JL, Jones LA, Metzger DA, Malinak LR, Dunbar BS. Identification of a meiotically expressed carbohydrate antigen in ovarian carcinoma II. Association with proteins in tumors and peritoneal fluid. Anticancer Res 1997; 17:901-906.

Book Chapters

Dunbar BS, Chunn JL. Multimedia methods in molecular biology. In: Techniques in Electrophoresis. Roultledge (ed), Chapman and Hall, Inc., Hampshire, U.K., 1997.

Wagner M, Chunn JL. Allergy. In: The Encyclopedia of Epidemiology, 2007.

Chunn JL. Asthma. In: The Encyclopedia of Epidemiology, 2007.

Published Abstracts

Fernandez P, Trzaska S, Chunn JL, Blackburn MR, Cronstein BN, Chan ESL. Adenosine deaminase deficiency promotes dermal fibrosis. 8th International Symposium on Adenosine and Adenine Nucleotides. Universita Degli Studi Di Ferrara, Italy, 2006.

Chunn Noble JL, Molina TM, Yang X, Rodney KJ, Blackburn MR. Adenosine induced pulmonary fibrosis in adenosine deaminase-deficient mice. American Thoracic Society, San Diego, CA, 2005.

Chunn Noble JL, Molina JG, Blackburn, MR. Examining the role of adenosine in an experimental model of pulmonary fibrosis. International Purine Meeting, Chapel Hill, NC, 2004.

Chunn JL, Young HWJ, Blackburn MR. Examining the role of adenosine in bleomycin-induced lung fibrosis. American Thoracic Society Annual Meeting, Atlanta, GA, 2002.

Chunn JL, Young HWJ, Colasurdo GN, Blackburn MR. Chronic elevations in adenosine are associated with severe lung inflammation and fibrosis in partially adenosine deaminase deficient mice. American Thoracic Society Annual Meeting, San Francisco, CA, 2001.

Blackburn MR, Zhong H, Chunn JL, Volmer JB. Adenosine deaminase deficient mice as models of adenosine mediated lung inflammation. 96th American Thoracic Society Meeting, P209:D21, 2000.

Prasad SV, Chunn JL, Skinner SM, DeMayo F, Dunbar BS. Generation of mice transgenic for the human homologue of the rabbit 55kd zonae pellucida sperm receptor protein. Mol Biol Cell 7:481a; Annual Meeting for the Society for the Study of Reproduction, Davis, CA, 1996.

Chunn JL, Skinner SM, Dunbar BS. Biological reproduction characterization of secretory proteins of rabbit ovarian surface antigens. Annual Meeting for the Society for the Study of Reproduction, Davis, CA, 1995.

• Graduate Research Assistant, The University of Texas Medical School, UTHSC, Department of Biochemistry and Molecular Biology, 2000–2006
• Research Assistant II, The University of Texas Medical School, UTHSC, Department of Biochemistry and Molecular Biology, 1998–2000
• Research Assistant I, Baylor College of Medicine, The Children’s Nutrition Research Center, Department of Pediatrics, Houston Medical Center, 1998
• Research Technician III, Baylor College of Medicine, Department of Neonatology, Houston Medical Center, 1997–1998
• Research Technician II, Baylor College of Medicine, Cell Biology Department, 1993–1996
  

• American Thoracic Society (member)
• American Chemical Society (member)
• Society of Toxicology (member)