Javier C. Waksman, M.D., DABT, FACMT

Dr. Waksman is board certified in Internal Medicine and Toxicology by the American Board of Toxicology. He is a Fellow of the American College of Medical Toxicology and currently holds an academic appointment of Associate Professor of Medicine at the Division of Clinical Pharmacology and Toxicology and Division of General Internal Medicine at the University of Colorado Denver, and is a faculty member of the Rocky Mountain Poison and Drug Center in Denver, Colorado.

As a medical toxicologist, Dr. Waksman has comprehensive clinical expertise and experience in internal medicine and clinical pharmacology and toxicology, emphasizing drug safety identifying, evaluating and managing adverse drug effects, drug-drug interactions, and medical monitoring. Additionally he has extensive experience in assessing and managing adverse health effects associated with exposure to chemical substances and microbial organisms in the workplace, residence, and general environment, as well as exposure to heavy metals, and building-related symptoms.

His unique background in internal medicine and medical toxicology provides the appropriate tools for a clinically oriented causation analysis of exposure to adverse health effects. Dr. Waksman has been involved in the assessment of health impacts associated with exposure to chemical substances and heavy metals in the United States and Latin America and has served as an external medical toxicology advisor for the Pan American Health Organization in major poisoning incidents in Central America.

Dr. Waksman received his MD from Ben Gurion University in Israel. He completed residency training in Internal Medicine at Rabin Medical Center in Israel and subsequently completed fellowship training in Medical Toxicology at the Rocky Mountain Poison and Drug Center in Denver, Colorado.

Dr. Waksman has lectured in the field of toxicology at local and international professional meetings in the USA and Latin America. He has also participated in community risk communication meetings in Latin America, as well as the United States. Dr. Waksman is the author or co-author of several publications in books and peer-reviewed journals in the fields of pharmacology and medical toxicology.

A native of Argentina, Dr. Waksman is able to perform assessments in Spanish as well.

Waksman JC, Brody A. Contrast sensitivity in occupational and environmental neurotoxicology: What does it really mean? Arch Environ Occup Health, in press.

Bebarta VS, Waksman JC. Amitriptyline-induced Brugada pattern fails to respond to sodium bicarbonate. Clin Toxicol 2007, 45(2):186-188.

Bebarta VS, Phillips S, Eberhardt A, Calihan KJ, Waksman JC, Heard K. Incidence of brugada electrocardiographic pattern and outcomes of these patients after intentional tricyclic antidepressant ingestion. Am J Cardiol 2007; 100(4):656-660.

DeWitt CR, Heard K, Waksman JC. Insulin and C peptide levels in sulfonylurea-induced hypoglycemia: A systematic review. J Med Toxicol 2007; 3(1):107-118.

Greenberg MI, Waksman J, Curtis J. Silicosis: A review. Dis Mon 2007; 53(8):394-416.

Waksman JC, Brody A, Phillips SD. Nonselective nonsteroidal anti-inflammatory drugs (non-coxibs) and cardiovascular risk: Are they safe? Ann Pharmacotherapy 2007; 41:1163-1173.

Evangelista M, Piola JC, Waksman JC, Prada DB. Registry of (FP) in Santa Fe, Argentina from 1990–2005: The SERTOX experience. Clin Toxicol 2006; 44(5).

Piola JC, Prada DB, Waksman JC, Evangelista M. Increase mortality and morbidity of Tityus trivitattus envenomations in Argentina. Clin Toxicol 2006; 44(5).

Rogers JJ, Waksman JC. Normal LV function and BNP levels in a case of severe verapamil poisoning: Time to look at the role of vasodilatation as the cause of toxicity. J Tox Clin Tox 2005; 43(6).

Schaeffer TH, Waksman JC, Schaffer MS. Accidental overdose of verapamil in an infant from medical error. J Tox Clin Tox. 2005; 43(6).

Bebarta VS, Phillips S, Eberhardt A, Callihan KJ, Heard K, Waksman J. Incidence and outcomes of patients with the Brugada pattern in a large case series of tricyclic overdoses. J Tox Clin Tox 2004; 42(5).

Bebarta VS, Waksman JC, Minick M. Brugada. Pattern after large amitriptyline overdose not responsive to sodium bicarbonate. J Tox Clin Tox 2004; 42(5).

Delgado JH, Waksman JC. Polymer fume fever-like syndrome due to hairspray inhalation. Vet Hum Toxicol 2004; 46(5):266-267.

Delgado JH, Caruso MJ, Waksman JC, Honigman B, Stillman D. Acute, transient urinary retention from combined ecstasy and methamphetamine use. J Emerg Med 2004; 26(2):173-175.

Dewitt C, Waksman JC. Pharmacology, pathophysiology and management of calcium channel blocker and beta-blocker toxicity. Toxicol Rev 2004; 23(4):223-238.

DeWitt C, Waksman J, Heard K. Insulin and C-peptide in sulfonylurea-induced hypoglycemia. J Tox Clin Tox 2004; 42(5).

Phillips SD, Waksman JC. Hepatorenal solvent toxicology. Clin Occup Environ Med 2004; 4(4):731-740.

Phillips SD, Palmer RB, Krieger GR, Waksman JC. The clinical relevance of vapor intrusion pathways. Clin Occup Environ Med 2004; 4 (3):423-443.

Reznikov LL, Waksman J, Azam T, Kim SH, Bufler P, Niwa T, Werman A, Zhang X, Pischetsrieder M, Shaldon S, Dinarello CA. Effect of advanced glycation end products on endotoxin-induced TNF-alpha, IL-1beta and IL-8 in human peripheral blood mononuclear cells. Clin Nephrol 2004; 61(5):324-336.

Waksman JC, Phillips SD. Biological markers of exposure to chlorinated solvents. Clin Occup Environ Med 2004; 4(3):413-421.

Burgees JL, Waksman JC, Fleming JE, Rowland HE, Conley SM. Effects of smoke exposure on sputum inflammatory cytokines. J Tox Clin Tox 2002; 40(5):651.

Erdman AE, Jolliff HA, Waksman JC, Earnest M, Dart RC. Empiric treatment with intravenous acyclovir: Is it safe? J Tox Clin Tox 2001; 39(5):506.

Erdman AE, Mallea MC, Jolliff HA, Waksman JC, Dart RC. Is the osmolar gap a reliable surrogate for ethylene glycol measurement? J Tox Clin Tox 2001; 39(5):480.

Jolliff HA, Megarbane B, Waksman JC, Dart RC. The value of serum bicarbonate and base deficit in the diagnosis of ethylene glycol toxicity: A systematic review. J Tox Clin Tox 2001; 39(3):245.

Waksman JC, Fantuzzi G, Bogdan GB, Dart RC, Dinarello C. Decreased serum interleukin-6 (IL-6) following acute acetaminophen (APAP) overdose is associated with hepatic injury. J Tox Clin Tox 2001; 39(5):486.

Waksman JC, Fantuzzi G, Bogdan GB, Dart RC, Dinarello C. Interleukin –18(IL-18) is involved in acetaminophen (APAP) induced hepatic injury in a Fas/Fas Ligand independent mechanism. J Tox Clin Tox 2001; 39(5):495.

Waksman J, Taylor RN, Bodor GS, Daly FFS, Dart RC. Acute myocardial infarction from amphetamine use. Mayo Clin Proc 2001; 76(3):323-326.

Daly FFS, Dart RC, Bogdan GM, Jolliff HA, Waksman JC. Repeated supratherapeutic dosing of acetaminophen (APAP): Can serum transaminase levels predict the risk of hepatotoxicity. J Tox Clin Tox 2000; 38(5):501.

Waksman JC, Heard K, Jolliff H, Daly FFS, Bogdan GM, Dart RC. Serotonin syndrome associated with the use of St. John’s wort (Hypericum perforatum) and Paroxetine. J Tox Clin Tox 2000; 38(5):492.

Waksman JC, Pitlik SD. Delayed synchronous outbreak of Plasmodium vivax malaria in four travelers. J Travel Med 1999; 6(2):142-143.

Wabitsch R, Margolis CZ, Malkin JE, Abu-Saad K, Waksman J. Evaluating the process of tailoring the global HIV/AIDS practice guidelines for use in developing countries. Int J Qual Health Care 1998; 10(2):147-154.

Kaplansky J, Shemi D, Waksman J, Potashnik G, Sod-Moriah UA. The effects of 1,2- dibromo-3-chloropropane (DBCP) on general toxicity and gonadotoxicity in rats. Andrologia 1991; 23(5):363-366.

Book Chapters

Waksman JC, Kulig K. Beta-blocker poisoning. In: Intensive Care Medicine, Sixth Edition. Irwin RS and Rippe JM (eds), Lippincott Williams & Wilkins, Philadelphia, PA, 2007.

Occupational related hematological problems. In: Occupational and Environmental Medicine Review, First Edition. Greenberg M, Hendrickson R, Lyons KM, Madsen J, Meier MJ, Morocco A, Phillips S, and Waksman J (eds), McGraw Hill Medical, 2006.

Occupational related hepatic problems. In: Occupational and Environmental Medicine Review, First Edition. Greenberg M, Hendrickson R, Lyons KM, Madsen J, Meier MJ, Morocco A, Phillips S, and Waksman J (eds), McGraw Hill Medical, 2006.

Occupational related renal problems. In: Occupational and Environmental Medicine Review, First Edition. Greenberg M, Hendrickson R, Lyons KM, Madsen J, Meier MJ, Morocco A, Phillips S, and Waksman J (eds), McGraw Hill Medical, 2006.

Waksman JC, Phillips SD. Antimony and nickel toxicity. pp. 845-850. In: Critical Care Toxicology. Diagnosis and Management of the Critically Poisoned Patient, First Edition. Brent J, Phillips SD, Wallace K (eds), Elsevier Mosby, Philadelphia, PA, 2005.

Waksman JC, Delgado JH. Immunosuppressants. pp. 1039-1047. In: Medical Toxicology, Third Edition. Dart RC (ed), Lippincott Williams & Wilkins, Philadelphia, PA, 2004.

Waksman JC, Kulig K. Beta-blocker poisoning. pp. 1411-1415. In: Intensive Care Medicine, Fifth Edition. Irwin RS and Rippe JM (eds), Lippincott Williams & Wilkins, Philadelphia, PA, 2003.

Platforms

Bebarta VS, Phillips S, Eberhardt A, Callihan KJ, Heard K, Waksman J. Incidence and outcomes of patients with the Brugada pattern in a large case series of tricyclic overdoses. North American Congress of Clinical Toxicology, Seattle, WA, 2004.

Burgees JL, Waksman JC, Fleming JE, Rowland HE, Conley SM. Effects of smoke exposure on sputum inflammatory cytokines. North American Congress of Clinical Toxicology, Palm Springs, CA, 2002.

Waksman JC, Fantuzzi G, Bogdan GB, Dart RC, Dinarello C. Interleukin –18(IL-18) is involved in acetaminophen (APAP) induced hepatic injury in a Fas/Fas ligand independent mechanism. North American Congress of Clinical Toxicology, Montreal, Canada, 2001.

Daly FFS, Dart RC, Bogdan GM, Jolliff HA, Waksman JC. Repeated supratherapeutic dosing of acetaminophen (APAP): Can serum transaminase levels predict the risk of hepatotoxicity. North American Congress of Clinical Toxicology, Tucson, AZ, 2000.

Books Edited

Occupational related hepatic problems. In: Occupational and Environmental Medicine Review, First Edition. Greenberg M, Hendrickson R, Lyons KM, Madsen J, Meier MJ, Morocco A, Phillips S, Waksman J (eds), McGraw Hill Medical, 2006.

Invited Lectures

Waksman JC. Toxic alcohols. What did we learn? Pan American Health Organization, Washington, DC, October 2006.

Waksman JC. Chemical terrorism of water & food supplies. Chemical agents of opportunity for terrorism: The medical and psychological consequences of TICs (toxic industrial chemicals) and TIMs (toxic industrial materials). American College of Medical Toxicology/Agency for Toxic Substances and Disease Registry, Chula Vista, CA, September 2006.

Waksman JC. The psychological impact of mass chemical exposures. Chemical agents of opportunity for terrorism: The medical and psychological consequences of TICs (toxic industrial chemicals) and TIMs (toxic industrial materials). American College of Medical Toxicology/Agency for Toxic Substances and Disease Registry, Chula Vista, CA, September 2006.

Waksman JC. Introduction to exposure pathways, causation, and association. Environmental risk management designation. International Institute of Environmental Risk Management-Texas Tech University, Steamboat Springs, CO, March 2006.

Waksman JC. Introduction to toxicology. Environmental risk management designation. International Institute of Environmental Risk Management-Texas Tech University, Steamboat Springs, CO, March 2006.

Waksman JC. Envenomations. Family Medicine Department, Swedish Medical Center, Englewood, CO, January 24, 2006.

Waksman JC. Vapor intrusion and its health implication. International Institute of Environmental Risk Management-Texas Tech University, Steamboat Springs, CO, March 2006.

Waksman JC. Hydrogen sulfide: Acute and chronic toxicity. Campbell County Memorial Hospital, Gillette, WY, December 15, 2005.

Waksman JC. The Clinical neurotoxicology of chemical terrorism. Chemical agents of opportunity for terrorism: The medical and psychological consequences of TICs (toxic industrial chemicals) and TIMs (toxic industrial materials). National Center for Environmental Health/Agency for Toxic Substances and Disease Registry, Helena, MT, October, 2004, and National Center for Environmental Health/Agency for Toxic Substances and Disease Registry, Breckenridge, CO, September 2004.

Waksman JC. Mold in indoor environments: Exposures and health effects. Family Medicine Department, Swedish Medical Center, Denver, CO, August 2003.

Waksman JC. Cyanide toxicity and methhemoglobinemia. Rocky Mountain Poison & Drug Center, Denver, CO, July 17, 2003.

Waksman JC. Toxicology of analgesics. Rapid City Regional Hospital, Rapid City, SD, June 20, 2003.

Waksman JC. Toxicology of common drug overdose. Rapid City Regional Hospital, Rapid City, SD, June 19, 2003.

Waksman JC. Mold in indoor environments: Exposures and health effects. Family Medicine Department, Porter Hospital, Denver, CO, June 17, 2003.

Waksman JC. Toxicology of cardiotrophic drugs and cyanide, CO poisoning, and methemoglobinemia. Toxicology Fellows, Rocky Mountain Poison & Drug Center, Denver, CO, July 9, 2002.

Waksman JC. Toxicology of drugs of abuse and spider bites. EMT Department, Porter Hospital, Denver, CO, March 20, 2002.

Waksman JC. Toxicology of drugs of abuse. Family Medicine Department, Porter Hospital, Denver, CO, December 7, 2001.

Waksman JC. Arsenic poisoning. Toxicology Fellows, Rocky Mountain Poison & Drug Center, Denver, CO, October 30, 2001.

Waksman JC. Arsenic and lead poisoning. Pediatric Department, Denver Health Medical Center, Denver, CO, October 17, 2001.

Waksman JC. Pediatric toxicology. University of Colorado Family Medicine Residency, Denver, CO, August 8, 2001.

Waksman JC. Withdrawal syndromes. Trauma and critical care nurses, Swedish Hospital, Denver, CO, July 23, 2001.

Waksman JC. Acute care toxicology. American Association of Critical-Care Nurses, Denver Chapter, Denver, CO, June 28, 2001.

Waksman JC. Pediatric toxicology. North Colorado Family Medicine, Greeley, CO, December 7, 2000.

Waksman JC. Toxicity of calcium channel blockers and beta blockers. Internal Medicine Department, Denver Health Medical Center, Denver, CO, September 29, 2000.

Waksman JC. Methemoglobinemia, cyanide and carbon monoxide poisoning. Emergency Medicine Department, Denver Health Medical Center, Denver, CO, March 15, 2000.

Waksman JC. Introduction to toxicology. Emergency Medicine Department, Denver Health Medical Center, Denver, CO, August 20, 1999.

Invited Lectures-International Forums/Meetings

Waksman JC. Exposure to chlorine and respiratory diseases, epidemiology, mechanism, and treatment. MEDICHEM-FeNaSTAC Congress on Occupational Health, Queretaro, Mexico, September 12-15, 2007; and II International Conference in Toxicology, Lima, Peru, October 11-14, 2007.

Waksman JC. Cyanide and the mining industry. MEDICHEM-FeNaSTAC Congress on Occupational Health, Queretaro, Mexico, September 12-15, 2007; and II International Conference in Toxicology, Lima, Peru, October 11-14, 2007.

Waksman JC. The practice of toxicology in Latin America. North American Conference in Clinical Toxicology, New Orleans, LA, October 2007.

Waksman JC. Use and abuse of biomarkers of mold exposure. North American Conference in Clinical Toxicology, New Orleans, LA, October 2007.

Waksman JC. Analgesics: Acetaminophen and salycilates: Toxicity and management. International Course in Toxicological Emergencies, Lima, Peru, July 4-7, 2007.

Waksman JC. Methamphetamines and designer drugs: Toxicity and management. International Course in Toxicological Emergencies, Lima, Peru, July 4-7, 2007.

Waksman JC. Toxic alcohols: Ethylene glycol, methanol, and diethylene glycol. International Course in Toxicological Emergencies, Lima, Peru, July 4-7, 2007.

Waksman JC. Tricyclic antidepressants and SSRIs: Toxicity and management. International Course in Toxicological Emergencies, Lima, Peru, July 4-7, 2007.

Waksman JC. Preparation and response to emergencies with hazardous materials and chemical terrorism. Argentinean Toxicological Association, Buenos Aires, Argentina, August 28-31, 2006.

Waksman JC. Introduction to the use of biological markers to evaluate exposure to chemical substances. XII Conference of the Latin American Toxicological Association and International Conference in Toxicology and Chemical Safety, Santiago, Chile, August 21-25, 2006.

Waksman JC. Emergency preparedness. XII Conference of the Latin American Toxicological Association and International Conference in Toxicology and Chemical Safety, Santiago, Chile, August 21-25, 2006.

Waksman JC. Introduction to risk assessment. XII Conference of the Latin American Toxicological Association and International Conference in Toxicology and Chemical Safety, Santiago, Chile, August 21-25, 2006.

Waksman JC. Chemical weapons as terrorist agents. VI Latin American Congress of Environmental Mutagenesis, Carcinogenesis and Teratogenesis and the XIV Argentinean Toxicology Congress, Mendoza, Argentina, October 31-November 4, 2005.

Waksman JC. Toxic chemical agents in your community. VI Latin American Congress of Environmental Mutagenesis, Carcinogenesis and Teratogenesis and the XIV Argentinean Toxicology Congress, Mendoza, Argentina, October 31-November 4, 2005.

Waksman JC. Occupational and toxicological perspectives of the use of organophosphate pesticides: Chronic effects in exposed population. VI Latin American Congress of Environmental Mutagenesis, Carcinogenesis and Teratogenesis and the XIV Argentinean Toxicology Congress, Mendoza, Argentina, October 31-November 4, 2005.

Waksman JC. Occupational aspects of benzene toxicity. SERTOX, Rosario, Argentina, October 28, 2005.

Waksman JC. Toxicity and new treatments for calcium channel and beta blockers poisoning. SERTOX, Rosario, Argentina, October 28, 2005.

Waksman JC. Anthrax as a bioterrorist weapon. First International Conference in Toxicology, Lima, Peru, July 26-29, 2005.

Waksman JC. An update in the treatment of acute poisoning. First International Conference in Toxicology, Lima, Peru, July 26-29, 2005.

Waksman JC. Lead poisoning in children. First International Conference in Toxicology, Lima, Peru, July 26-29, 2005.

Waksman JC. The toxicity of benzene. First International Conference in Toxicology, Lima, Peru, July 26-29, 2005.

Waksman JC. The toxicity of paracetamol. First International Conference in Toxicology, Lima, Peru, July 26-29, 2005.

Waksman JC. The immune system and inflammation in toxicological responses. ACMT Scientific Symposium: The Role of the Immune System in Toxicological Responses. North American Congress of Clinical Toxicology, Orlando, FL, 2005.

Waksman JC. The role of cytokines in toxic lung diseases. American Occupational Health Conference (American College of Occupational and Environmental Medicine), Toronto, Canada, October 13, 2003.

Waksman JC. Applying biological markers. American Occupational Health Conference (American College of Occupational and Environmental Medicine), Atlanta, GA, May 5, 2003.

Waksman JC. The mining industry and the environment: A feasible and possible coexistence. Argentinean College of Medicine, Patagonian Chapter, Argentina, February 13, 2003.

Waksman JC. The use of cyanide in the mining industry. Governmental Representatives, Chubut, Argentina, February 12, 2003.

Waksman JC. Toxicology of cardiotropic drugs. Specialists in Poison Information, North American Congress of Clinical Toxicology (American Academy of Clinical Toxicology), Palm Springs, CA, September 26, 2002.

Waksman JC. Toxicology of mercurial compounds. Peruvian Ministry of Health. Lima, Peru. June 6, 2002.

Waksman JC. Health effects of mercury poisoning. University of Cajamarca, Cajamarca, Peru, July 3, 2001; Peruvian Medical Association, Lima, Peru, July 5, 2001.

• American Academy of Clinical Toxicology
  – Member, Environmental and Occupational Committee, 1999–present
• American College of Medical Toxicology 
  – Fellow of the American College of Medical Toxicology, 2006–present 
  – Member, Educational Committee, 1999–present 
  – Member, Scientific Subcommittee, 1999–present
• Society of Toxicology 
  – Member, Carcinogenesis Specialty Section, 2003–present 
  – Member, Occupational and Public Health Specialty Section, 2003–present 
  – Member, Mountain West Chapter, 2003–2007 
  – Member, Immunotoxicology Specialty Section, 2005–2007
• National Hispanic Medical Association 
  – Member, National Advisory Committee, 2003–2005
• Denver Medical Society 
  – Member, 2003–present
• Colorado Medical Society 
  – Member, 2003–present
• Society for Occupational and Environmental Health 
  – Member, 2004–2008
• American College of Occupational And Environmental Medicine 
  – Member, Occupational & Clinical Toxicology Committee, 2005–present 
  – Member, Rocky Mountain Academy of Occupational & Environmental Medicine, 2005–present
• International Society of Indoor Air Quality and Climate 
  – Member, 2005–2008
• Peruvian Toxicology Association (Asociacion Peruana De Toxicologia) 
  – Honorary Member, 2005–present
• Argentinean Toxicology Association (Asociación Toxicológica Argentina) 
  – Member, 2006–present