Joseph E. Olberding, Ph.D.

Dr. Olberding's technical background is in computational and experimental biomechanics, with particular emphasis in the nonlinear elasticity, viscoelasticity, and anisotropy of biological tissue and their relation to tissue injury, growth, and remodeling. He has extensive research experience in these areas investigating biomechanical questions at multiple scales and in multiple modalities. This includes study of the solid-fluid viscoelastic mechanisms in traumatic brain injury by simulating high-speed impact using a finite-element based computational model, and the development of experimental and computational methods for the multiphasic constitutive characterization of very soft hydrated materials (such as brain tissue). He has furthermore completed work related to the mathematical modeling of thermodynamic dissipation in tissue undergoing fiber reorientation (including developing image analysis methods to quantify structural anisotropy), and the mechanical and biological characterization of scaffoldless engineered tendon and ligament tissue for regenerative medicine. He is experienced with mammalian cell culture as well as cellular and molecular biology assay technologies and has also applied his expertise in developing a mathematical model of focal adhesions in order to study its dynamics in cell mechanotransduction.

Olberding JE. Growth and remodeling in engineered soft tissue. Doctoral Dissertation, University of Michigan, 2010.

Olberding JE, Thouless MD, Arruda EM, Garikipati K. The non-equilibrium thermodynamics and kinetics of focal adhesion dynamics. PLoS One 2010; 5(8):e12043.

Garikipati K, Olberding JE, Narayanan H, Arruda EM, Grosh K, Calve S. Biological remodelling: Stationary energy, configuration change, internal variables and dissipation. Journal of the Mechanics and Physics of Solids 2006; 54(7):1493–1515.

Olberding JE, Suh JKF. A dual optimization method for the material parameter identification of a biphasic poroviscoelastic hydrogel: Potential application to hypercompliant soft tissues. Journal of Biomechanics 2006; 39(13):2468–2475.

Olberding JE. Validation studies for the dual-optimization of indentation creep and stress relaxation of biological soft tissues using biphasic poroviscoelasticity: Potential Application for the mechanical analysis of brain tissue. Master’s Thesis, Tulane University, 2004.

Abstracts

Olberding JE, Garikipati K, Grosh K, Larkin LM, Arruda EM. Role of oxygen content on the brogenesis of bone marrow stromal cells. Proceedings, Biomedical Engineering Society 2009 Annual Fall Scientific Meeting, Pittsburgh, PA, October 2009.

Olberding JE, Thouless MD, Arruda EM, Garikipati K. A theoretical study of the thermodynamics and kinetics of focal adhesion dynamics. Proceedings, IUTAM Symposium on Cellular, Molecular and Tissue Mechanics, Vol. 16, pp. 181–192. Springer, New York, NY, 2010.

Olberding JE, Thouless MD, Arruda EM, Garikipati K. Focal adhesion dynamics: Reaction domination. Proceedings, Biomedical Engineering Society 2007 Annual Fall Meeting, Los Angeles, CA, September 2007.

Olberding JE, Grosh K, Arruda EM, Garikipati K. Quantification of collagen fibril reorientation in volumetric image data by confocal microscopy. Proceedings, Biomedical Engineering Society 2006 Annual Fall Meeting, Chicago, IL, October 2006.

Olberding JE, Garikipati K, Arruda EM, Garikipati K. Fibroblast-mediated collagen fibril reorientation in three dimensions using confocal reaction microscopy. Proceedings, 15th U.S. National Congress on Theoretical and Applied Mechanics, Boulder, CO, June 2006.

Olberding JE, Garikipati K, Kuhl E, Grosh K, Arruda EM. Thermodynamic considerations for remodeling in biological tissue. Proceedings, 8th U.S. National Congress on Computational Mechanics, Austin, TX, July 2005.

Olberding JE, Garikipati K, Kuhl E, Narayanan H, Arruda EM, Grosh K, Calve S. Constitutive relations for fibril reorientation in embryonic tendon: Thermodynamic admissibility and restrictions. Proceedings, 2005, Summer Bioengineering Conference, Vail, CO, June 2005.

Olberding JE, Garikipati K, Kuhl E, Narayanan H, Arruda EM, Grosh K, Calve S. Remodeling of biological tissue: Collagen fibril reorientation in tendon under uniaxial extension. Proceedings, 2005 Joint ASCE/ASME/SES Conference on Mechanics and Materials, Baton Rouge, LA, June 2005.

Olberding JE, Suh JKF. Validation studies for the dual-optimization of indentation creep and stress relaxation of biological soft tissues using biphasic poroviscoelasticity: Potential method for brain tissue. Proceedings, 2004, ASME International Mechanical Engineering Congress, Anaheim, CA, November 2004.

Olberding JE, Suh JKF. A comparative study of viscoelastic and biphasic poroviscoelastic computational models of the brain for simulating traumatic injury. Proceedings, 11th Annual Pre-ORS Symposium, New Orleans, LA, February 2003. Department of Biomedical Engineering, Tulane University; Orthopaedic Research Society (invited).

• Research Fellow, University of Michigan Department of Mechanical Engineering, 2010
• Graduate Student Instructor, University of Michigan Department of Mechanical Engineering, 2008–2009
• Lab Instructor, Tulane University School of Engineering, 2003
• Summer Research Associate, Tulane University School of Engineering, 2003

• American Society of Mechanical Engineers
• Biomedical Engineering Society