Mr. Dupont has completed all requirements to earn his Ph.D. in mechanical engineering from the Georgia Institute of Technology in spring of 2010. He specializes in issues involving the biomechanics of biological systems at a variety of size scales, including the performance and design of prosthetic devices at the macro scale, preclinical in vivo studies involving bioengineered tissue system mechanical testing at the intermediate scale, and finally micro scale design and biomechanical testing of cell-based systems. His research has included design of biomechanical testing systems to create mechanical stimuli for use in the study of vascular cell biomechanics. He has additional research experience in tissue engineering and regenerative medicine, particularly stem cell and gene therapy based therapies for treating musculoskeletal pathologies, with a focus on large bone defects. He has experience with various imaging modalities including micro-CT as well as knowledge of numerous biological assays in both in vitro and in vivo systems.
Dupont KM, Sharma K, Stevens HY, Boerckel JD, García AJ, Guldberg RE. Human stem cell delivery for treatment of large segmental bone defects. PNAS 2010 Feb 23; 107(8):3305–3310. Epub 2010 Jan 19.
Wojtowicz AM, Shekaran A, Oest ME, Dupont KM, Templeman KL, Hutmacher DW, Guldberg RE, García AJ. Coating of biomaterial scaffolds with the collagen-mimetic peptide GFOGER for bone defect repair. Biomaterials 2009, Dec 26. Epub ahead of print.
Boerckel JD, Dupont KM, Kolambkar YM, Lin ASP, Guldberg RE. In vivo model for evaluating the effects of mechanical stimulation on tissue-engineered bone repair. J Biomech Eng 2009 Aug; 131(8):084502.
Guldberg RE, Oest ME, Dupont K, Peister A, Deutsch E, Kolambkar Y, Mooney D. Biologic augmentation of polymer scaffolds for bone repair. J Musculoskelet Neuronal Interact. 2007 Oct-Dec; 7(4):333–334.
Oest ME, Dupont KM, Kong HJ, Mooney DJ, Guldberg RE. Quantitative assessment of scaffold and growth factor-mediated repair of critically sized bone defects. J Orthop Res 2007 Jul; 25(7):941–950.
Rai B, Oest ME, Dupont KM, Ho KH, Teoh SH, Guldberg RE. Combination of platelet-rich plasma with polycaprolactone-tricalcium phosphate scaffolds for segmental bone defect repair. J Biomed Mater Res A. 2007 Jun 15; 81(4):888–899.
Book Chapters
Guldberg RE, Peister A, Boerckel JD, Dosier CR, Dupont KM, Johnson MR, Lin ASP, Oest ME, O’Keefe RJ. Chapter 7, pp. 125–144. Translational Approaches for Engineering Bone Repair. In: Translational Approaches in Tissue Engineering and Regenerative Medicine. Mao J, Vunjak-Novakovic G, Mikos A, Atala A (eds), Artech House, 2007.
Presentations / Abstract and Conference Proceedings
Dupont KM, Stevens HY, Boerckel JD, Diab T, Takahata M, Schwarz EM, Guldberg RE. Synthetic scaffold functionalization by adeno-associated virus encoding BMP2 for orthotopic bone defect repair. Short talk. 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, March 2010.
Boerckel JD, Dupont KM, Kolambkar YM, Lin ASP, Guldberg RE. Load-bearing enhances segmental bone defect repair by altering bone distribution. Short talk. 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, March 2010.
Johnson MR, Boerckel JD, Dupont KM, Cool S, Guldberg RE. Integration of heparin in collagen delivery systems for BMP2-induced bone repair. Short talk. 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, March 2010.
Kolambkar YM, Boerckel JD, Dupont KM, Bajin M, Huebsch N, Mooney D, Hutmacher D, Guldberg RE. Spatiotemporal BMP delivery enhances functional repair of segmental bone defects. Short talk and poster presentation. 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, March 2010.
Boerckel JD, Dupont KM, Kolambkar YM, Lin ASP, Guldberg RE. In vivo model for assessing the role of load‐bearing in tissue‐engineered bone repair. Short talk and poster presentation, Hilton Head Regenerative Medicine Workshop, Hilton Head, SC, March 2009.
Dupont KM, Sharma K, Garcia AJ, Guldberg RE. Tracking human adult and fetal stem cells during segmental bone repair. Short talk and poster presentation, 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, NV, February 2009.
Boerckel JD, Dupont KM, Kolambkar YM, Lin ASP, Guldberg RE. In vivo model for assessing the role of load-bearing on tissue-engineered bone repair. Poster presentation, 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, NV, February 2009.
Kolambkar YM, Dupont KM, David Mooney, Dietmar Hutmacher, Guldberg RE. Effect of nanofiber mesh design on bmp-mediated segmental bone defect repair. Short talk and poster presentation, 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, NV, February 2009.
Dupont KM, Sharma K, Garcia AJ, Guldberg RE. Tracking human adult and fetal stem cells during segmental bone repair. Short talk and poster presentation, Georgia Tech/Emory Center for the Engineering of Living Tissues Industrial Partners Symposium, Atlanta, GA, October 2008.
Wojtowicz AM, Oest ME, Dupont KM, Burns KL, Hutmacher DW, Guldberg RE, García AJ. Collagen-mimetic Scaffold Coating Enhances Healing of Critically-Sized Bone Defects. Short talk, Society for Biomaterials Annual Meeting, Atlanta, GA, September 2008.
Oest ME, Dupont KM, Kong HJ, Mooney DJ, Guldberg RE. Effects of co-delivering low-dose VEGF with osteogenic growth factors on bone formation and revascularization of critically-sized defects. Poster presentation, 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA, March 2008.
Oest ME, Dupont KM, et al. Delivery of BMP-2 and TGF-Beta3 additively enhances functional repair of segmental bone defects. Poster presentation, Hilton Head Regenerative Medicine Workshop, Hilton Head, SC, March 2007.