Ms. Britton has 10 years of experience in life sciences consulting on a broad range of issues related to drugs, medical devices, and occupational and environmental exposures.
In the area of the human health effects of asbestos exposure, Ms. Britton has evaluated the available occupational epidemiology data and risk factors for lung cancer and mesothelioma. This work has included expert preparation and support during testimony. Other particular areas of experience include the human health effects of exposure to pesticides, trichloroethylene (TCE), PFOA, and methylmercury. She specializes in communicating scientific information to lay audiences, as well as conducting exhaustive, critical reviews of the state of the science on a given issue.
Prior to joining Exponent, Ms. Britton participated in the management of a large-scale epidemiological meta-analysis of the health of chemical workers, including database design and maintenance and statistical analysis. She also was integral to the preparation of a successful pre-market approval (PMA) application for saline breast implants and the presentation before the FDA-appointed advisory panel.
Mink PJ, Adami H-O, Trichopoulos D, MD, Britton NL, Mandel JS. Pesticides and prostate cancer: A review of epidemiologic studies with specific agricultural exposure information. Eur J Cancer Prev 2008; 17:97–110.
Goodman M, Barraj LM, Mink PJ, Britton NL, Yager JW, Flanders WD, Kelsh MA. Estimating uncertainty in observational studies of associations between continuous variables: Example of methylmercury and neuropsychological testing in children. Epidemiol Perspect Innovat 2007; 4:9.
Greenberg RS, Mandel JS, Pastides H, Britton NL, Rudenko L, Starr TB. A meta-analysis of cohort studies describing mortality and cancer incidence among chemical workers in the United States and Western Europe. Epidemiology 2001; 12:727–740.
Research
Participated in the census and recruitment phase of a community biomonitoring study. Included communication of study objectives and participation requirements and study documentation.
Participated in the management a meta-analysis of the mortality and morbidity experience of chemical workers. Designed and maintained an Access database and performed statistical analysis in Stata.
Engaged in research linking precipitation chemistry data and atmospheric transport. Maintained and manipulated large multi-year data sets of daily precipitation and atmospheric variable values for use in modeling air parcel back trajectories.
Literature Review Topics Methylmercury exposure and neurodevelopmental outcomes in children.
Indications, safety, and efficacy of an anticonvulsant drug. Preparation of a dossier meeting AMCP requirements.
Smoking as a risk factor for histologic types of lung cancer.
Dioxin exposure and nervous system disorders.
Safety and efficacy of three medical devices for PMA application submission. Comprehensive review of the published literature and presentation of the clinical trial data.
Drug compliance among Type 2 diabetics.
Litigation Support Evaluation of the epidemiology literature regarding occupational and environmental asbestos exposure and cancer causation. Preparation of an epidemiology experts for trial testimony; trials resulted in a favorable outcome for the clients.
Trichloroethylene exposure and disease causation.
Childhood lead exposure and neurological disorders in adulthood.