Exponent’s Health Sciences professionals bring the skills and experience necessary to evaluate complex pharmacotoxicology questions. Our toxicology staff, who have expertise in numerous sub-disciplines of toxicology and clinical toxicology, provide consulting in nearly all phases of drug development from preclinical studies to post marketing safety assessment. Exponent scientists, with a long tradition in product safety research and evaluation, can assist pharmaceutical and biotechnology companies to meet the growing demands for the development, implementation, and analysis of post-marketing safety research and monitoring. The breadth of our multidisciplinary expertise allows for comprehensive evaluation of potential adverse health effects associated with ingestion of pharmaceuticals or mixtures of drugs. In addition, this expertise is applied in the development phases of pharmaceutical products through consulting in pharmacokinetic modeling and assessment of direct chemical/pharmaceutical age interactions or metabolite effect on biological and disease processes.
Our staff expertise and consulting services include:
Basic Toxicology Expertise
- Neurotoxicology
- Hepatotoxicology
- Pulmonary toxicology
- Immunotoxicology
- Reproductive toxicology
- Dose response and metabolism
- Organic chemistry analyses
- Developmental toxicology
- Cancer biology
- Behavioral assessment
- Data gap analysis
- Toxicology study interpretation
- Structure activity relationship analyses
Metabolism and Pharmacokinetic Modeling
- PBPK modeling
- Mechanisms of action
Clinical Toxicology
- Certified subspecialty medical toxicologists
- Multiple-drug interactions
- Pharmaceutical biomonitoring
Exponent’s pharmacotoxicology project experience has included:
- Evaluation of existing animal toxicology data
- Application of tocicological information to the design and interpretation of clinical trials
- Post market drug surveillance
- Human health risk assessment for a variety of chemical substances
- Regulatory support for the filing of FDA IND and NDA applications
- Intellectual property evaluations
Our unique organizational strength is the capability to rapidly assemble multidisciplinary teams of basic and clinical toxicologists, medical specialists, epidemiologists, and statistical modeling experts to solve complex pharmacotoxicology problems.
Our toxicology professionals have advanced degrees in their fields and many hold board certifications from the American Board of Toxicology. Exponent's toxicologists are active in professional societies and continually monitor scientific advancements in various areas of toxicology, biotechnology, nanotechnology and risk assessment. Our clinical toxicologists continue to practice patient care and our scientists have published numerous articles in peer-reviewed journals, and continue to present at scientific forums meetings, and serve on expert science advisory boards.