Christopher Bates
Christopher Bates, Ph.D.
Scientist
Health Sciences
  • Alexandria, VA

Dr. Bates has a background in metals toxicology, with a focus on the effects of copper and manganese on the nervous system. He also possesses expertise in Parkinson’s pathology and the physiology of blood-brain barrier systems.

Dr. Bates received his B.S. in Biochemistry and Ph.D. in Integrative Neuroscience from Purdue University. His doctoral work was funded in part through a minority fellowship award from the National Institutes of Health (NIH) and focused on the transport of α-synuclein (α-Syn), a protein integral to Parkinson’s disease pathology, at the blood-cerebrospinal fluid barrier (BCSFB). Using in vitro cell culture techniques, Dr. Bates examined the potential for intracellular α-Syn dysfunction as a result of manganese exposure and the possible effects of manganese exposure on α-Syn transport across a BCSFB cell monolayer. He also investigated α-Syn clearance from the cerebral spinal fluid in a rat animal model of Parkinson’s disease.

Dr. Bates is a participating member of the Society of Toxicology (SOT). He was awarded 1st Place for the Best Graduate Student Platform Presentation at the 2012 Annual Ohio Valley Regional Chapter SOT Meeting and was elected to serve as the Graduate Student Representative of the Ohio Valley SOT Chapter from May 2013 to May 2014.

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Integrative Neuroscience, Purdue University, 2014
  • B.S., Biochemistry, Purdue University, 2009
  • Awarded an NIH Minority Graduate Student Supplemental Fund, 2011–2013

    Awarded the School of Health Sciences Graduate Student Service Award, April 2013

    Graduate Student Representative of the Ohio Valley SOT Regional Chapter, 2013–2014

    Ohio Valley Regional Chapter Representative for SOT Graduate Student Leadership Committee, 2013–2014

    Ohio Valley SOT Graduate Student Platform Presentation, 1st Place, September 2013

    President of the Purdue Health Sciences Graduate Student Organization, 2013-2014

Publications

Bates CA, Zheng W. Brain disposition of α-synuclein: Roles of brain barrier systems and implications for Parkinson’s disease. Fluids Barriers CNS 2014; 11:17.

Fu X, Zhang Y, Jiang W, Monnot AD, Bates CA, Zheng W. Regulation of copper transport crossing brain barrier systems by Cu-ATPases: Effect of manganese exposure. ToxSci 2014; 139(2):432–451.

Presentations

Bates CA, Fu X, Ysselstein D, Rochet J, Zheng W. Transport of α-synuclein at the blood cerebrospinal fluid barrier and effects of heavy metal toxicities: Potential role in Parkinson’s disease pathoetiology. Presented at the 53rd Annual Society of Toxicology Conference, Phoenix, AZ, March 22–27, 2014. Toxicologist 2014; 138(1):1349.

Barthuly S, Bates CA, Zheng W. The Blood-CSF barrier expresses LRRK2, a kinase implicated in etiology of Parkinson’s disease. Presented at the Undergraduate Research Symposium, Purdue University, April 2013.

Bates CA, Fu X, Ysselstein D, Rochet J, Zheng W. Transport of α-synuclein at the blood-cerebrospinal fluid barrier and effects of heavy metal toxicities: Potential role in Parkinson’s disease pathoetiology. Presented at the Ohio Valley SOT Regional Chapter Annual Meeting, University of Louisville, September 23, 2013. 

Bates CA, Zheng G, Fu X, Zheng W. Expression and aggregation of α-synuclein in the blood-CSF barrier: Initial evidence for the influence of cellular manganese and copper status. Presented at the 52nd Annual Society of Toxicology Conference, San Antonio, TX, March 10–14, 2013. Toxicologist 2013; 132(1): 1862. 

Bates CA. Transport of α-synuclein by the blood-CSF barrier and the influence of manganese exposure. Presented at the Ohio Valley SOT Regional Chapter Meeting, Columbus, OH, September 2012. 

Bates, CA, Zheng, G, Fu, X, Zheng, W (2012). Expression and aggregation of α-synuclein at the blood-CSF barrier: Initial evidence for influence of manganese and copper status. Presented at the 51st Annual Society of Toxicology conference, San Francisco, CA, March 11–15, 2012. Toxicologist 2013; 126(1): 1010.

Professional Affiliations

Society of Toxicology (2012–present)

Neurotoxicology Specialty Section (2012–present)

Ohio Valley SOT Regional Chapter (2012–2014)

National Capital Area SOT Chapter (2014–present)

Toxicologists of African Origin (2012–present)

Purdue University Black Graduate Student Association (2012–2014)

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Integrative Neuroscience, Purdue University, 2014
  • B.S., Biochemistry, Purdue University, 2009
  • Awarded an NIH Minority Graduate Student Supplemental Fund, 2011–2013

    Awarded the School of Health Sciences Graduate Student Service Award, April 2013

    Graduate Student Representative of the Ohio Valley SOT Regional Chapter, 2013–2014

    Ohio Valley Regional Chapter Representative for SOT Graduate Student Leadership Committee, 2013–2014

    Ohio Valley SOT Graduate Student Platform Presentation, 1st Place, September 2013

    President of the Purdue Health Sciences Graduate Student Organization, 2013-2014