Ken Bogen
Kenneth T. Bogen, DrPH, M.P.H., DABT
Managing Scientist
Health Sciences
  • Oakland

Dr. Bogen is a consulting toxicologist and has nationally recognized expertise in risk assessment for environmental carcinogens and in related exposure, pharmacokinetic, dose-response and uncertainty analysis. Before joining Exponent in 2007, he led experimental, epidemiological, and mathematical-modeling research on health risks posed by environmental exposures to chemicals and ionizing radiation, as a University of California environmental scientist for 20 years at Lawrence Livermore National Laboratory.

Dr. Bogen consults as an expert on quantitative exposure and health-risk assessments addressing dose response, carcinogen risk and mode-of-action, dermal absorption of organic chemicals, toxicokinetics, and mathematical (including physiologically based pharmacokinetic [PBPK], biologically based, toxicodynamic, and statistical) modeling and data analysis, and related occupational, consumer-product, Proposition 65, and groundwater issues. He authored or co-authored more than 100 peer-reviewed scientific journal publications on these topics, and provides related expert, litigation-support, regulatory evaluation, and technical-analysis services. His publications and research have addressed agents including: asbestos, allergic contact sensitizers, arsenic, benzene, chromium, 1,3-dichloropropanol, diethanolamine, dibenzo[a,l]pyrene, formaldehyde, hydrogen sulfide, lead, malathion, 3-methylchloropropanol, 4-methylimidazole, methyl isobutyl ketone (MIBK), methyl tert-butyl ether (MTBE), musks, β-myrcene, naphthalene, nickel, paperboard chemicals, PhIP, phthalates, radon, and VOCs.

Dr. Bogen served as a Member of the National Academy of Sciences/National Research Council (NRC) committees that issued Science and Judgment in Risk Assessment (1994) and Review of the Army’s Technical Guides on Assessing and Managing Chemical Hazards to Deployed Personnel (2004); chaired the U.S. Consumer Product Safety Commission’s Chronic Hazards Advisory Panel on Diisononyl Phthalate (DINP) (2000–2001); chaired the Metabolism and Mode of Action Panel, Naphthalene State of the Science Symposium (NS3), Monterey, CA (2006); and served as expert panelist at the NRC Standing Committee on Risk Analysis Issues and Reviews, Workshop on Uncertainty in Cancer Risk Based on Bioassay Data (2007). Dr. Bogen served as President (1995) and Councilor (2004–2006) of the Northern California Chapter of the Society for Risk Analysis (SRA), and currently is Chair-Elect of the SRA Dose-Response Specialty Group (2016–present).

CREDENTIALS & PROFESSIONAL HONORS

  • Dr.P.H., Environmental Health Science, University of California, Berkeley, 1986
  • M.P.H., Environmental Health Science, University of California, Berkeley, 1982
  • M.A., Science, Technology, and Public Policy, George Washington University, 1979
  • A.B., Biology, Princeton University, 1978

LICENSES & CERTIFICATIONS

Diplomate of the American Board of Toxicology

Publications

Bogen, KT. Linear-no-threshold default assumptions for noncancer and nongenotoxic-cancer risks: A mathematical and biological critique. Risk Anal 2015 (in press)6; 36(3):589–604. Open access: http://onlinelibrary.wiley.com/doi/10.1111/risa.12460/epdf

Bogen, KT, Heilman JM. Reassessment of MTBE cancer potency considering modes of action for MTBE and its metabolites. Crit Rev Toxicol 2015 doi.10.3109/10408444.2015.1052367 (in press).

Bogen KT. Stem cell division, mutations, and cancer risk. Science 2015; 26 Jan [online comment]. http://comments.sciencemag.org/content/10.1126/science.1260825

Bogen, KT. Unveiling variability and uncertainty for better science and decisions on cancer risks from environmental chemicals. Risk Anal 2014; 34(10):1795–1806.

Bogen KT. Does EPA underestimate cancer risks by ignoring susceptibility differences? Risk Anal 2014; 34(10):1780–1784.

Sheehan PS, Brorby GP, Berman DW, Bogen KT. Protecting good science. Ann Occup Hyg 2014; 58(2):267–268.

Bogen KT. Mechanistic models fit to ED001 data on >40,000 trout exposed to dibenzo[a,l]pyrene indicate mutations do not drive increased tumor risk. Dose Response 2014; 12(3):386–403.

Bogen KT, Sheehan PS. Dermal vs.ersus total uptake of benzene from mineral spirits solvent during parts washing. Risk Anal 2014; 34(7):1336–1358.

Bogen KT. Efficient tumorigenesis by mutation-induced failure to terminate microRNA-mediated adaptive hyperplasia. Medical Hypotheses 2013; 80(1):83–93.

Bogen KT. Dermal uptake of 18 dilute aqueous chemicals: In vivo disappearance-method measures greatly exceed in vitro-based predictions. Risk Anal 2013; 33(7):1334–1352.

Brorby GP, Sheehan PJ, Berman DW, Bogen KT, Holm SE. Exposures from chrysotile-containing joint compound: Evaluation of new model relating respirable dust to fiber concentrations. Risk Anal 2013; 33(1):161–176.

Berman DW, Brorby GP, Sheehan PJ, Bogen KT, Holm SE. More on the dynamics of dust generation: the effects of mixing and sanding chrysotile, calcium carbonate, and other components on the characteristics of joint-compound dusts. Ann Occup Hyg 2012; 56(7):852–867.

Bogen KT, Reiss R. Generalized Haber's law for exponential concentration decline, with application to riparian-aquatic pesticide ecotoxicity. Risk Anal 2012; 32(2):250–258.

Sheehan PJ, Brorby GP, Berman DW, Bogen KT, Holm SE. Chamber for testing asbestos-containing products: validation and testing of re-created chrysotile-containing joint compound. Ann Occup Hyg 2011; 55(7):797–809.

Bogen KT, Brorby G, Berman DW, Sheehan P, Floyd M. Measuring mixed cellulose ester (MCE) filter mass under variable humidity conditions. Ann Occup Hyg 2011; 55(5):485–494.

Brorby GP, Sheehan P, Berman DW, Bogen KT, Holm SE. Potential artifacts associated with historical preparation of joint compound samples and reported airborne asbestos concentrations. J Occup Environ Hygiene 2011; 8(5):271–278.

Bogen KT. Generic Hockey-Stick model for estimating benchmark dose and potency: performance relative to BMDS and application to anthraquinone. Dose-Response 2011; 9(2):182–208.

Sheehan P, Bogen KT, Hicks J, Goswami E, Brorby G, Lau EC, Ott B. Benzene inhalation by parts washers: new estimates based on measures of occupational exposure to solvent coaromatics. Risk Anal 2010; 30(8):1249–1267.

Bogen KT, Goswami E. Screening-Level Hazard Assessment for Six Phthalates Under A.B. 1108 and Proposition 65 (Rev. 1). Technical Report prepared by Exponent, Inc., for the Environment Section, Office of the Attorney General, California Department of Justice (CalDOJ), May 2009 (made public by CalDOJ, August 2009). Exponent Doc. no. 0800736.000 0601 0509 KB01. Exponent, Inc., Oakland, CA, 97 pp.

Bogen KT, Cullen AC, Frey HC, Price PS. Probabilistic exposure analysis for chemical risk characterization. Toxicol Sci 2009; 109(1):4–17.

Bogen KT. An adjustment factor for mode of action uncertainty with dual-mode carcinogens: The case of naphthalene-induced nasal tumors in rats. Risk Anal 2008; 28(4):1033–1051.

Louis ED, Keating GA, Bogen KT, Rios E, Pellegrino KM, Factor-Litvak P. Dietary epidemiology of essential tremor: Meat consumption and meat cooking practices. Neuroepidemiol 2008; 30(3):161–166.

Bogen KT, Benson JM, Yost GS, Morris JB, Dahl AR, Clewell HJ, Krishnan K, Omiecinski CJ. Naphthalene metabolism in relation to target tissue anatomy, physiology, cytotoxicity and tumorigenic mechanism of action. Regul Toxicol Pharmacol 2008; 51(2 Suppl 1):S27–S36.

Griego FY, Bogen KT, Price PS, Weed DL. Exposure, epidemiology and human cancer incidence of naphthalene. Regul Toxicol Pharmacol 2008; 51(2 Suppl 1):S22–S26.

Bogen KT, Gouveia FJ. Impact of spatiotemporal fluctuations in airborne chemical concentration on toxic hazard assessment. J Hazard Mater A 2008; 152(1):228–240.

Robison WL, Hamilton TF, Bogen KT, Conrado CL, Kehl SR. 137Cs inter-plant concentration ratios provide a predictive tool for coral atolls with distinct benefits over transfer factors. J Environ Radioact 2008; 99(1):181–189.

Bogen KT, Jones ED, Fischer LE. Hurricane destructive power predictions based on historical storm and sea surface temperature data. Risk Anal 2007; 27(6):1497–1517.

Bogen KT, Keating II GA, Chan JM, Paine LJ, Simms EL, Nelson DO, Holly EA. Highly elevated PSA and dietary PhIP intake in a prospective clinic-based study among African Americans. Prostate Cancer Prostatic Dis 2007; 10(3):261–269.

Keating GA, Bogen K, Chan J. Development of a meat frequency questionnaire for use in diet and cancer studies. J Am Dietetic Assoc 2007; 107(8):1356–1362.

Louis ED, Zheng W, Jiang W, Bogen KT, Keating GA. Quantification of the neurotoxic β carboline harmane in barbecued/grilled meat samples and correlation with level of doneness. J Toxicol Environ Health A 2007; 70(12):1014–1019.

Bogen KT. Comment on “Steady state solutions to PBPK models and their applications to risk assessment I: Route to route extrapolation of volatile chemicals.” Risk Anal 2006; 26(6):1415.

Bogen KT, Jones ED. Risks of mortality and morbidity from worldwide terrorism: 1968-2004. Risk Anal 2006; 26(1):45-59.

Bogen KT. Risk analysis for environmental health triage. Risk Anal 2005; 25(5):1085-1095.

Keating GA, Bogen KT. Estimates of heterocyclic amine intake in the U.S. population. J Chromatogr B 2004; 802:127-133.

Bogen KT, Marchetti A, Brown TA. Use of a correlated compound-binomial model to assess absence of non-counting noise in Pu-isotope ratios measured by AMS at LLNL. Nucl Instr Meth Phys Res B 2004; 223:209-215.

Enns L, Bogen KT, Wizniak J, Murtha AD, Weinfeld M. Low dose radiation hypersensitivity is associated with p53-dependent apoptosis. Molec Cancer Res 2004; 2:557-566.

Raber MS, Carlsen TM, Folks KJ, Kirvel RD, Daniels JI, Bogen KT. How clean is clean enough? Recent developments in response to threats posed by chemical and biological warfare agents. Int J Health Res 2004; 14:31-41.

Robison WL, Conrado CL, Bogen KT, Stoker AC. The effective and environmental half-life of 137Cs at coral islands at the former U.S. nuclear test site. J Environ Radioact 2003; 69:207-223.

Bogen KT, Cullen J. Residential radon in U.S. counties vs. lung cancer in women who predominantly never smoked. Environ Geochem Health 2002; 24:229-247.

KT, Witschi HP. Lung tumors in A/J mice exposed to environmental tobacco smoke: estimated potency and implied human risk. Carcinogenesis 2002; 23:511-519.

Bogen KT. Biologically based prediction of empirical nonlinearity in lung cancer risk vs. residential/occupational radon exposure. Hum Ecol Risk Assess 2001; 7:811-827.

Bogen KT, Keating GA. U.S. dietary exposures to heterocyclic amines. J Expos Anal Environ Epidemiol 2001; 11:155-168.

Cullen J, Bogen KT. Historical residential coal use and female lung cancer mortality. Hum Ecol Risk Assess 2001; 7:369-385.

Keating GA, Bogen KT. Methods to estimate heterocyclic amine concentrations in cooked meats in the U.S. diet. Food Chem Toxicol 2001; 39:29-43.

Bogen KT, Enns L, Hall LC, Keating GA, Weinfeld M, Murphy G, Wu RW, and Panteleakos FN. Gel microdrop flow cytometry assay for low-dose studies of chemical and radiation cytotoxicity. Toxicol 2001; 160:5-10.

Daniels JI, Bogen KT, Hall LC. Analysis of uncertainty and variability in exposure to characterize risk: Case study involving trichloroethylene groundwater contamination at Beale Air Force Base in California. Water Air Soil Pollut 2000; 123:273-298.

Keating GA, Sinha R, Layton D, Salmon CP, Knize MG, Bogen KT, Lynch CF, Alavanja M. Comparison of heterocyclic amine levels in home-cooked meats with exposure indicators. Cancer Causes Control 2000; 11:731-739.

Bogen KT. Comments on papers by Andersen and Conolly and by Downs and Franowski. Hum Exper Toxicol 1998; 17:711-712.

Bogen KT. Mechanistic model predicts a U-shaped relation of radon exposure to lung cancer risk reflected in combined occupational and U.S. residential data. Hum Exper Toxicol 1998; 17:691-696.

Bogen KT. Response to reviewer comments. Hum Exper Toxicol 1998; 17:716-718.

Bogen KT, Layton DW. Risk management for plausibly hormetic environmental carcinogens: the case of radon. Hum Exper Toxicol 1998; 17:463-467.

Bogen KT, Keating GA, Meissner S, Vogel JS. Initial uptake kinetics in human skin exposed to dilute aqueous trichloroethylene in vitro. J Expos Anal Environ Epidemiol 1998; 8:253-271.

Bogen KT. Do U.S. county data disprove linear no-threshold predictions of lung cancer risk for residential radon?—A preliminary assessment of biological plausibility. Hum Ecol Risk Assess 1997; 3:157-186.

Bogen KT, Swirsky Gold L. Trichloroethylene cancer risk: simplified calculation of PBPK-based MCLs for cytotoxic endpoints. Regul Toxicol Pharmacol 1997; 25:26-42.

Robison WL, Bogen KT, Conrado CL. An updated dose assessment for a U.S. nuclear test site—Bikini Atoll. Health Phys 1997; 73:100-114.

Bogen KT, Conrado CL, Robison WL. Uncertainty and variability in updated estimates of potential dose and risk at a U.S. nuclear test site—Bikini Atoll. Health Phys 1997; 73:115-126.

Bogen KT. Improved prediction of carcinogenic from mutagenic potencies for chemicals positive in rodents and the Ames test. Molec Environ Mutagen 1995; 25(1):37-49.

Bogen KT. Methods to approximate joint uncertainty and variability in risk. Risk Anal 1995; 15(3):411-419.

Layton DW, Bogen KT, Knize MG, Hatch FT, Johnson VM, Felton J. Cancer risk assessment of heterocyclic amines in cooked foods: An analysis and implications for research. Carcinogenesis 1995; 16:39-52.

Bogen KT. Applicability of alternative models of variance in replicate Ames-revertants measured for 121 mutagenic rodent carcinogens. Mutat Res 1994; 322:265-273.

Bogen KT. Cancer potencies of heterocyclic amines found in cooked foods. Food Chem Toxicol 1994; 32:505-515.

Bogen KT. Models based on steady-state in vitro dermal permeability data underestimate short-term in vivo exposures to organic chemicals in water. J Expos Anal Environ Epidemiol 1994; 4:457-476.

Bogen KT. A note on compounded conservatism. Risk Anal 1994; 14(4):379-381.

Hamilton LD, Holtxman S, Meinhold AF, Morris SC, Pardi R, Rowe MD, Sun C, Anspaugh LR, Bogen KT, Layton DW, McKone TE, Straume T, Andricevic R, Jacobson RL. Pilot study risk assessment for selected problems at three U.S. Department of Energy facilities. Environ Int 1994; 20:585-604.

Bogen KT. An intermediate-precision approximation of the inverse cumulative normal distribution. Commun Statist Simulat 1993; 22:797-801.

Bogen KT. Reassessment of human peripheral T-lymphocyte lifespan deduced from cytogenetic and cytotoxic effects of radiation. Int J Radiat Biol 1993; 64(2):195–204.

McKone TE, Bogen KT. Uncertainties in health-risk assessment: An integrated case study based on tetrachloroethylene in California groundwater. Regul Toxicol Pharmacol 1992; 15(1):86-103.

Bogen KT, Colston BW, Machicao LK. Dermal absorption of dilute aqueous chloroform, trichloroethylene and tetrachloroethylene in hairless guinea pigs. Fund Appl Toxicol 1992; 18(1):30-39.

McKone TE, Bogen KT. Predicting the uncertainties in risk assessment. Environ Sci Technol 1991; 25(10):1674-1681.

Bogen KT. CKM carcinogenesis models: Response. J Natl Cancer Inst 1990; 82(21):1723-1724.

Bogen KT. Of apples, alcohol, and unacceptable risk [guest editorial]. Risk Anal 1990; 10(2):199-200.

Bogen KT. Risk extrapolation for chlorinated methanes as promoters vs. initiators of multistage carcinogenesis. Fund Appl Toxicol 1990; 15(3):536-557.

Bogen KT. Cell proliferation kinetics and multistage cancer risk models. J Natl Cancer Inst 1989; 81(4):267-277.

Bogen KT. Letter to the editor. J Natl Cancer Inst 1989; 82:320.

Bogen KT, Hall LC. Pharmacokinetics for regulatory risk analysis: The case of 1,1,1-trichloroethane (methyl chloroform). Regul Toxicol Pharmacol 1989; 10(1):26-50.

Lichtenberg E, Zilberman D, Bogen K. Regulating environmental health risks under uncertainty: Groundwater contamination in California. J Environ Econ Management 1989; 17(1):22-34.

KT. Pharmacokinetics for regulatory risk analysis: The case of trichloroethylene. Regul Toxicol Pharmacol 1988; 8(4):447-466.

Bogen KT, McKone TE. Linking indoor air and pharmacokinetic models to assess tetrachloroethylene risk. Risk Anal 1988; 8(4):509-520.

Bogen KT, Spear RC. Integrating uncertainty and inter-individual variability in environmental risk assessment. Risk Anal 1987; 7(4):427-436.

Zweig G, Gao R, Witt JM, Poppendorf W, Bogen KT. Dermal exposure to carbaryl by strawberry harvesters. J Agric Food Chem 1984; 32(6):1232-1236.

Bogen KT. Quantitative risk-benefit analysis in regulatory decision-making: A fundamental problem and an alternative proposal. J Health Politics Policy Law 1983; 8(1):120-143.

Bogen KT. Coordination of regulatory risk analysis: Current framework and legislative proposals. Environ Econ J 1982; 1:53-84.

Bogen KT, Carr GM. 1981. Agent Orange: Veteran’s complaints concerning exposure to herbicides in South Vietnam. Issue Brief No. IB 80040, updated May 12, 1981. U.S. Library of Congress, Congressional Research Service, Science Policy Research Division, Washington, DC.

Bogen KT. Public policy and technological risk. IDEA: J Law Technol 1980; 21:37-74.

Bogen KT. Managing technical dissent in private industry. Indust Labor Relations Forum 1979; 13:3-32.

Books and Monographs

Bogen KT. Uncertainty in Environmental Health Risk Assessment. Garland, New York, 1990.

Bogen KT. Uncertainty in environmental health risk assessment: A framework for analysis and an application to a chronic exposure situation involving a chemical carcinogen. Doctoral Dissertation, University of California Berkeley, School of Public Health, Berkeley, CA, 1986.

Book Chapters

Bogen KT, Fischer LE, Jones ED. 2011. Hurricane intensity, sea surface temperature, and stochastic variation. In: Lupo A, ed. Recent Hurricane Research - Climate, Dynamics, and Societal Impacts. ISBN: 978-953-307-238-8. InTech, Rijeka, Croatia, pp. 103-118. Available from: http://www.intechopen.com/articles/show/title/hurricane-intensity-sea-surface-temperature-and-stochastic-variation.

Bogen KT, Homann SG, Gouveia FJ, Neher LA. 2009. A prototype near-field GIS model to characterize acute risks of sequestered CO2 release through orphan wells. In: Carbon Dioxide Sequestration in Geological Media—State of the Science. Grobe M, Pashin J, Dodge R (eds), Am Assoc Petroleum Geologists (AAPG) Studies in Geology 59, pp. 587–593.

Keating GA, Bogen KT, Vogel JS. Measurement of short-term dermal uptake in vitro using accelerator mass spectrometry. pp. 475-486. In: Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methodology, Third Edition. R.L. Bronaugh and H.I. Maiback (eds), Marcel Dekker, Inc., New York (Drugs Pharmaceutical Sci 97), 1999.

Bogen KT, Keating GA, Vogel JS. Chloroform and trichloroethylene uptake from water into human skin in vitro: Kinetics and risk assessment. pp. 195-198. In: Prediction of Percutaneous Penetration, Volume 4b. V.J. Brain, V.J. James, K.A. Walters (eds), STS Publishing Ltd., Cardiff, UK, 1996.

Bogen KT, Colston BW, Machicao LK. Percutaneous absorption of dilute aqueous chlorinated organic solvents in the hairless guinea pig. pp. 321-345. In: Drinking Water Contamination and Health. R. Wang (ed), Marcel Dekker, Inc., New York, NY, 1994.

Daniels JI, McKone TE, Hall LC, Layton DW, Bogen KT. Remedial investigation of a Superfund site. pp. 67-82. In: Effective and Safe Waste Management: Interfacing Sciences and Engineering with Monitoring and Risk Analysis. R.L. Jolley, R.G. Wang (eds), Lewis Publishers, Boca Raton, FL, 1993.

Bogen KT. Cancer-risk prediction for carbon tetrachloride using pharmacokinetic and cell-kinetic multistage models. pp. 445470. In: Risk Analysis: Prospects and Opportunities. Plenum Press, New York, NY, 1991.

Bogen KT, McKone TE. Tetrachloroethylene metabolism resulting from domestic respiratory exposure: Pharmacokinetic considerations relevant to risk assessment. pp. 593-608. In: Risk Assessment in Setting National Priorities. J.J. Bonin and D.E. Stevenson (eds), Plenum, New York, NY, 1989.

Zweig G, Gao R, Witt JM, Poppendorf W, Bogen KT. Exposure of strawberry harvesters to carbaryl. pp. 123-138. In: Dermal Exposure Related to Pesticide Use: Discussion of Risk Assessment. N.N. Ragsdale (ed), American Chemical Society, Washington, DC, 1985.


Technical Reports

Bogen KT, Goswami E. Screening-Level Hazard Assessment for Six Phthalates Under A.B. 1108 and Proposition 65 (Rev. 1). Doc. no. 0800736.000 0601 0509 KB01 (May 9, 2009). Technical Report prepared for the Office of the Attorney General, California Department of Justice. Exponent, Inc., Oakland, CA, 97 pp., 2009.

Bogen KT. Mode-of-action uncertainty for dual-mode carcinogens: Lower bounds for naphthalene-induced nasal tumors in rats implied by PBPK and 2-stage stochastic cancer risk models. Report to DOE-Oak Ridge Associated Universities. UCRL-TR-227766-Rev-1. Lawrence Livermore National Laboratory, Livermore, CA, 2007.

Bogen KT, Hamilton TF, Brown TA, Martinelli RE, Marchetti AA, Kehl SR, Langston RG. Statistical basis for interpreting urinary excretion of plutonium based on accelerator mass spectrometry (AMS) data from the Marshall Islands. Technical Basis Document UCRL-TR-230705. Lawrence Livermore National Laboratory, Livermore, CA, 2007.

Bogen KT. RiskQ 5.0: Summary of updates to RiskQ computer software. UCRL-SM-205904. Lawrence Livermore National Laboratory, Livermore, CA, 2004.

Bogen KT, Daniels JI, Wilder LA, Neher LA. Strategic Environmental Assessment and Risk Characterization for Effective Response and Recovery (SEARCHER): A proposal for strategic systems development to support the U.S. Department of Homeland Security. UCRL-TR-201949 (limited distribution). Lawrence Livermore National Laboratory, Livermore, CA, 2004.

Bogen KT, Hickman DP, Hamilton TF, Brown TA, Cox CC, Marchetti AA, Martinelli RE. Application of accelerator mass spectrometry to analyze 239Pu in archived occupational samples. LDRD 01-ERD-108 Final Report. UCRL-TR-205744. Lawrence Livermore National Laboratory, Livermore, CA, 2004.

Bogen KT. Recommendations for SZ/TSPA model uncertainty analysis concerning the Yucca Mountain project. UCRL-TR-201447. Lawrence Livermore National Laboratory, Livermore, CA, 2003. https://e-reports-ext.llnl.gov/pdf/302344.pdf

Bogen KT. RiskQ 4.2: An interactive approach to probability, uncertainty and statistics for use with Mathematica®. UCRL-MA-110232 Rev. 3. Lawrence Livermore National Laboratory, Livermore, CA, 2002.

Bogen KT. Methods for addressing uncertainty and variability to characterize potential health risk from trichloroethylene contaminated ground water at Beale Air Force Base in California: Integration of uncertainty and variability in pharmacokinetics and dose-response, UCRL-ID-135978 Rev. 1, Lawrence Livermore National Laboratory, Livermore, CA, 2001. https://e-reports-ext.llnl.gov/pdf/244403.pdf

Robison WL, Noshkin VE, Hamilton TF, Conrado CL, Bogen KT. An assessment of the current day impact of various materials associated with the U.S. Nuclear Test Program in the Marshall Islands. UCRL-LR-143980. Lawrence Livermore National Laboratory, Livermore, CA, 2001.

Bogen KT. RiskQ 4.0: An interactive approach to probability, uncertainty and statistics for use with Mathematica®. UCRL-MA-110232, Rev. 1. Lawrence Livermore National Laboratory, Livermore, CA, 2000.

Bogen KT. Lung cancer risk of low-level exposures to alpha emitters: Critical reappraisal and experiments based on a new cytodynamic model: Final Report on LDRD Project 97-ERD-050, UCRL-ID-133251, Lawrence Livermore National Laboratory, Livermore, CA, 1999.

Daniels JI, Bogen KT, Hall LC. Procedures for addressing uncertainty and variability in exposure to characterize potential health risk from trichloroethylene contaminated groundwater at Beale Air Force Base in California, UCID-CR-135784, Rev. 1, Lawrence Livermore National Laboratory, Livermore, CA, 1999.

Robison WL, Conrado CL, Bogen KT. Utirik Atoll dose assessment, UCRL-LR-135953, Lawrence Livermore National Laboratory, Livermore, CA, 1999.

Bogen KT. A cytodynamic two-stage model that predicts radon hormesis (decreased, then increased lung-cancer risk vs. exposure). UCRL-JC-123219. Lawrence Livermore National Laboratory, Livermore, CA, 1996.

Robison WL, Bogen KT, Conrado CL. A dose assessment for a U.S. nuclear test site—Bikini Atoll. In: Assessing the Radiological Impact of Past Nuclear Activities and Events, IAEA-TECDOC-755, pp. 11-24, International Atomic Energy Agency, Vienna, Austria, 1994.

Robison WL, Bogen KT, Conrado CL. An updated dose assessment for Rongelap Island. UCRL-LR-107036. Lawrence Livermore National Laboratory, Livermore, CA, 1994.

Bogen KT. Uncertainty vs. inter-individual variability. In: EPA/UVA Workshop on When and How Can You Specify a Probability Distribution Function When You Don’t Know Much? April 19-21, 1993, Haimes YY, Barry TM (eds), Center for Risk Management of Engineering Systems, University of Virginia, Charlottesville, VA; and U.S. Environmental Protection Agency, Office of Policy, Planning and Evaluation, Washington, DC, 1993.

Bogen KT, Seilkop S. Investigation of independence in inter-animal tumor-type occurrences within the NTP rodent-bioassay database, UCRL-ID-115092, Report prepared for the National Research Council, Board on Environmental Studies and Toxicology, Committee on Risk Assessment of Hazardous Air Pollutants. Lawrence Livermore National Laboratory, Livermore, CA, 1993. http://www.osti.gov/bridge/purl.cover.jsp?purl=/10121101-Kga1eS/native/

Layton DW, Anspaugh LR, Bogen KT, Straume T. Risk assessment of soil-based exposures to plutonium at experimental sites located on the Nevada Test Site and adjoining areas. In: Pilot Study Risk Assessment for Selected Problems at the Nevada Test Site (NTS), UCRL-LR-113891, pp. 19-67, Daniels JI (ed,), Lawrence Livermore National Laboratory, Livermore, CA, 1993.


Bogen KT. RiskQ: An interactive approach to probability, uncertainty and statistics for use with Mathematica. UCRL-MA-110232. Lawrence Livermore National Laboratory, Livermore, CA, 1992.

Bogen KT, Hall LC, McKone TE. Health risk assessment of chloroform in California ground water. UCRL-21170. Lawrence Livermore National Laboratory, Livermore, CA, 1992.

Bogen KT, Hall LC, Wright K, McKone TE. Health risk assessment of dichloromethane (methylene chloride) in California ground water. UCRL-CR-21218. Lawrence Livermore National Laboratory, Livermore, CA, 1992.

Bogen KT, Lucas JN, Straume T. Cancer-risk assessment for chemicals. In: Laboratory Directed Research and Development FY1992, UCRL-53689-92, pp. 156-175, Struble GL, et al. (eds), Lawrence Livermore National Laboratory, Livermore, CA, 1992.

Layton DW, Anspaugh LR, Bogen KT, Straume T. Risk assessment of soil-based exposures to plutonium at safety-shot sites located on the Nevada Test Site and adjoining areas. UCRL-ID-112605DR. Lawrence Livermore National Laboratory, Livermore, CA, 1992.

McKone TE, Bogen KT. Uncertainties in assessing risks from groundwater contamination. In: Energy and Technology Review, pp. 62-63, UCRL-JC-52000-91-7/8, Lawrence Livermore National Laboratory, Livermore, CA, 1991.

Hall LC, Bogen KT. Appendix D: Toxicity assessment of VOCs. In: Baseline Public Health Assessment for CERCLA Investigations at the LLNL Livermore Site, pp. D-1 to D-41, Layton, DW, Daniels JI, Isherwood WF (eds.), UCRL-53953. Lawrence Livermore National Laboratory, Livermore, CA, 1990.

Bainer R, Bogen K, Carlsen T, et al. CERCLA remedial investigations report for the LLNL Livermore Site. UCAR-10299. Lawrence Livermore National Laboratory, Livermore, CA, 1990.

Layton DW, McKone TE, Hall, LC Bogen KT. In: Baseline Public Health Assessment for CERCLA Investigations at the LLNL Livermore Site, pp. 5-1 to 5-36, Layton, DW, Daniels JI, Isherwood WF (eds.), UCRL-53953. Lawrence Livermore National Laboratory, Livermore, CA, 1990.

Bogen KT, Hall LC, Perry L, Fish R, McKone TE, Dowd P, Patton SE, Mallon B. Health risk assessment of trichloroethylene in California drinking water. UCRL-21007. Lawrence Livermore National Laboratory, Livermore, CA, 1988.

Bogen KT, Hall LC, McKone TE, Layton DW, Patton SE. Health risk assessment of tetrachloroethylene (PCE) in California drinking water. UCRL-15831. Lawrence Livermore National Laboratory, Livermore, CA, 1987.

Layton D, Mallon B, Mitchell W, Hall L, Fish R, Perry L, Snyder G, Bogen K, Malloch W, Ham C, Dowd P. Conventional weapons demilitarization: A health and environmental effects database assessment, explosives and their co-contaminants. Final Report, Phase II. UCRL 21109. Lawrence Livermore National Laboratory, Livermore, CA, 1987.

Reed NR, Olsen HE, Marty M, Beltran LM, McKone TE, Bogen KT, Tablante NL, Hsieh DPH. Health risk assessment of 1,2 dibromo 3-chloropropane (DBCP) in California drinking water. Department of Environmental Toxicology, University of California, Davis, CA, 1987.

U.S. Congress, Committee on Science and Technology, Subcommittee on Science Research and Technology. The National Science Board: Organization and activities, 1968-1981. Report by Knezo GK, Bogen KT, U.S. Government Printing Office, Washington, DC, 1983.

Bogen KT, Goldin AH. Population exposure to external natural radiation background in the United States. Technical Note ORP/SEPD-80-12. U.S. Environmental Protection Agency, Office of Radiation Programs, Washington, DC, 1981.

U.S. Congress, Committee on Science and Technology, Subcommittee on Science Research and Technology. The National Bureau of Standards: A review of its organization and operations 1971-1980. Report by Blankenship VL, Bogen KT, U.S. Government Printing Office, Washington, DC, 1981.

Bogen KT. High voltage electric power transmission lines: Impact on public and environmental health. Report No. 80-199. U.S. Library of Congress, Congressional Research Service, Washington, DC, 1980.

Presentations at Scientific Meetings

Singhal A, Bogen K, Kalmes R, Sheehan P. A quantitative model to predict allergic contact dermatitis from wearable technology products. To be presented at the 2016 Annual Meeting of the American Industrial Hygiene Association, AIHce 2016, Baltimore, MD, May 21–26, 2016.

Singhal A, Bogen K, Kalmes R, Sheehan P. Formaldehyde Emissions from Laminate Flooring: Is There a Proposition 65 Exposure Issue? To be presented at the 2016 Annual Meeting of the American Industrial Hygiene Association, AIHce 2016, Baltimore, MD, May 21–26, 2016.

Bogen KT, Reiss R. A physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for malathion in rats. To be pPresented at the Society of Toxicology 55th Annual Meeting, New Orleans, LA, March 22–26, 2016.

Bogen KT, Singhal A. How malathion dermal absorption varies with dermal load, based on
physiologically based pharmacokinetic modeling of in vivo human data. To be pPresented at the Society of Toxicology 55th Annual Meeting, New Orleans, LA, March 22–26, 2016.

Sheehan P, Bogen K, Singhal A, Kalmes R. Evaluating the Proposition 65 health significance of formaldehyde exposures from Chinese manufactured laminate flooring. To be pPresented at the Society of Toxicology 55th Annual Meeting, New Orleans, LA, March 22–26, 2016.

Singhal A, Bogen K, Kalmes R, Sheehan P. Formaldehyde Emissions from Laminate Flooring: Is There a Proposition 65 Exposure Issue? To be presented at the 2016 Annual Meeting of the American Industrial Hygiene Association, AIHce 2016, Baltimore, MD, May 21–26, 2016.

Bogen KT, Arnold L, Pennington K, Cohen S. High-resolution, low-dose dose-response for arsenic-induced cytotoxicity: Preliminary results. Presented at the Electric Power Research Institute (EPRI) and Air & Waste Management Association (A&WMA), Environmental-Vision (ENV-VISION) Conference, Crystal City, VA, May 12–14, 2015.

Bogen KT, Garry MR, Volberg V. Risks of allergic contact dermatitis elicited by nickel, chromium, and (meth)acrylates: Modeled comparisons of published patch-test data on ~5,000 sensitive individuals. Presented at the Society of Toxicology 54th Annual Meeting, San Diego, CA, March 22–26, 2015. The Toxicologist 2015; 144(1):139.

Sheehan P, Bogen K, Singhal A, Kalmes R, Roberts M, Fedoruk J. Risks of allergic contact dermatitis elicited by nickel, chromium, and (meth)acrylates: Wearable products and allergic contact dermatitis: a new risk assessment challenge. Presented at the Society of Toxicology 54th Annual Meeting, San Diego, CA, March 22–26, 2015.

Posson M, Bogen K, Glomski M, Sheehan PJ. A suite of integrated predictive models for the evaluation of consumer exposures to organic chemicals in paper products. SETAC North America 36th Annual Meeting, Salt Lake City, Utah, November 1–5, 2015.

Bogen KT, Chen C-L, Tsuji JS. Significant nonlinearity of lung cancer risk in relation to arsenic in drinking water in northeastern Taiwan. Presented at the Society of Toxicology 53rd Annual Meeting, Phoenix, AZ, March 23–27, 2014.

Sheehan S, Bogen KT, Singhal A, Hellerstein J. Estimating an acceptable daily intake of anthraquinone (AQ) in paper packaged food. Presented at the Society of Toxicology 53rd Annual Meeting, Phoenix, AZ, March 23–27, 2014.

Singhal A, Bogen KT. Benchmark dose analysis of NTP data on tumors induced in rodents chronically exposed to dietary anthraquinone. Presented at the Society of Toxicology 53rd Annual Meeting, Phoenix, AZ, March 23–27, 2014.

Posson M, Bogen KT, Glomski M, Sheehan S. Organic chemical exposure and dose from paper products: a new suite of integrated predictive models. Presented at the Society of Toxicology 53rd Annual Meeting, Phoenix, AZ, March 23–27, 2014.

Bogen KT. Mutagenic mode of action inconsistent with tumor response in >40,000 trout exposed to the potent mutagen dibenzo[a,l]pyrene, contrary to somatic mutation cancer theory. Presented at the Meeting of the Society for Risk Analysis, Baltimore, MD, December 8–12, 2013.

Bogen KT. Application of the dysregulated adaptive hyperplasia (DAH) tumorigenesis model to estimate low-dose dibenzo[a,l]pyrene tumor risk. Presented at the 12th Annual Meeting of the International Dose-Response Society, University of Massachusetts at Amherst, Amherst, MA, April 23–24, 2013.

Sheehan P, Heilman J, Bogen KT. An evaluation of the human carcinogenic potency of methyl tert-butyl ether (MTBE): Considering new data and mode of action. Presented at the Society of Toxicology 52nd Annual Meeting, San Antonio, TX, March 10–14, 2013.

Sheehan P, Bogen KT, Posson M, Hellerstein J. Characterizing potential chemical exposures and associated risks from food packaging: A product stewardship challenge. Presented at the American Industrial Hygiene Conference & Exposition, Montreal, Canada, May 18–23, 2013.

Sheehan P, Bogen KT. Cumulative chrysotile fiber exposures from sanding historical joint compound formulations: Inter- vs. intra-individual variability. Presented at the Society for Risk Analysis Meeting, San Francisco, CA, December 9–12, 2012.

Bogen KT. Dermal uptake of dilute aqueous chemicals: In vivo disappearance-method measures are ~10-fold greater than in vitro-based predictions. Presented at the 22nd Annual Meeting of the International Society of Exposure Science, Seattle, WA, October 28–November 1, 2012.

Sheehan P, Bogen KT. Dermal uptake of benzene in mineral spirits solvent during parts washing: An immersion/splash-wipe mode and its predicted dermal fraction of total dose. Presented at the 22nd Annual Meeting of the International Society of Exposure Science, Seattle, WA, October 28–November 1, 2012.

Bogen KT. In vivo dermal uptake of dilute aqueous organic chemicals is underestimated ~10-fold by models based on in vitro data. Presented at the 50th Annual Meeting of the Society of Toxicology, San Francisco, CA, March 11–15, 2012.

Sheehan P, Bogen K, Brorby G, Holm S. Considering mode of action in estimating a No-Significant Risk for 3-MCPD. Presented at the 50th Annual Meeting of the Society of Toxicology, San Francisco, CA, March 11–15, 2012.

Reiss R, Bogen K. Modeling risk to aquatic species subject to realistic, dynamic exposures using a generalized form of Haber’s law. American Chemical Society AGRO Meeting, Denver, CO, August 31, 2011.

Sheehan P, Brorby G, Bogen K, Berman, W, Holm S. New basis for interpreting historical exposures to dust from chrysotile-containing joint compound. Presented at the 2011 Annual Meeting of the American Industrial Hygiene Association, AIHce2011, Portland, OR, May 14–19, 2011.

Tsuji J, Bogen KT. Human biokinetic model of nickel release from medical devices. Presented at the 50th Annual Meeting of the Society of Toxicology, Washington, DC, March 6–10, 2011.

Bogen KT. In vivo dermal uptake pattern for 20 dilute aqueous organic chemicals is poorly predicted by models based on in vitro data. Presented at the 50th Annual Meeting of the Society of Toxicology, Washington, DC, March 6–10, 2011.

Bogen KT. Generic Hockey-Stick model performs as well or better than USEPA Benchmark Dose methodology. Presented at the 2010 Annual Meeting of the Society for Risk Analysis, Salt Lake City, UT, December 5–8, 2010.

Bogen KT. Generic Hockey-Stick model outperforms USEPA Benchmark Dose method to characterize dose-response. Presented at the NorCal Society of Toxicology Fall Symposium, Northern California Chapter of the Society of Toxicology, Genentech Campus, South San Francisco, CA, November 4, 2010.

Bogen KT. Generic Hockey-Stick model for estimating benchmark-dose and potency estimation. Presented at the 9th Annual Meeting of the International Dose-Response Society (Dose-Response 2010: Implications for Toxicology, Medicine and Risk Assessment), University of Massachusetts at Amherst, Amherst, MA, April 27-28, 2010.

Tsuji J, Hentz K, Rosenbloom S, Bogen K, Yost L. Health risk of internal nickel exposure from medical devices. Presented at the 49th Annual Meeting of the Society of Toxicology, Salt Lake City, UT, March 7–11, 2010.

Sheehan P, Bogen KT, Brorby G, Goswami E. Improved estimates of worker exposure to benzene during parts washing based on a new approach analyzing solvent and air data for other aromatic constituents. Presented at the 2009 American Industrial Hygiene Conference and Expo, Denver, CO, May 22–27, 2010.

Bogen KT. A Screening assessment of potential hazard posed by six phthalates in children’s consumer products in California. Presented at The Toxicology Forum, 35th Annual Winter Meeting, 2–4 February 2010, Washington DC, 2010.

Sheehan P, Bogen KT, Brorby G, Goswami E. Worker inhalation exposure to benzene from solvents during parts washing. Presented at the 2009 Annual Meeting of the Society for Risk Analysis, Baltimore, MD, December 6–19, 2009.

Bogen KT. Human cancer risk of soluble cobalt: Biokinetic extrapolation from rodent bioassay data. Presented at the 48th Annual Meeting of the Society of Toxicology, Baltimore, MD, March 15–19, 2009.

Bogen KT. Mode of action (MOA) uncertainty for “dual mode” carcinogens: Impact on risk estimated from naphthalene-induced nasal tumors in rats. Presented at the 47th Annual Meeting of the Society of Toxicology, Seattle, WA, March 16–20, 2008.

Bogen KT. An adjustment factor to address mode of action (MOA) uncertainty for dual-mode carcinogens: The case of naphthalene-induced nasal tumors in rats. Presented at the Society for Risk Analysis 2007 Annual Meeting, San Antonio, TX, December 9–12, 2007.

Keating GA, Bogen KT, Chan J, Keating GA, Paine LJ, Simms EL, Holly EA, Felton JS. Elevated prostate-specific antigen in African American men with high meat-carcinogen intake: A prospective clinic-based study. Abstract. 2007 U.S. DOD Prostate Cancer Research Program, Atlanta, GA, September 14-18, 2007.

Bogen KT, Chan J, Keating GA, Paine LJ, Simms EL, Holly EA, Felton JS. Prostate-specific antigen levels and dietary PhIP in African Americans: A prospective clinic-based study. Abstract. 2007 Annual Meeting of the American Association for Cancer Research, Los Angeles, CA, April 14-18, 2007.

Bogen K. An adjustment factor to address mode of action (MOA) uncertainty for dual-mode carcinogens: The case of naphthalene-induced nasal tumors in rats. Presentation given as expert panelist at the National Research Council Standing Committee on Risk Analysis Issues and Reviews, Workshop on Uncertainty in Cancer Risk Based on Bioassay Data, Washington, DC, June 5, 2007.

Bogen KT, Burton EA, Freidmann SJ, Gouveia F. Source terms for CO2 risk modeling and GIS/simulation based tools for risk characterization. GHGT8: 8th International Conference on Greenhouse Gas Technologies, Trondjheim, Norway, June 19-22, 2006.

Bogen KT, Homann SG, Gouveia FJ, Neher LA. Prototype near-field/GIS model for sequestered-CO2 risk characterization and management. In: Proc. International Symposium on Site Characterization for CO2 Geological Storage (CO2SC 2006), pp. 237-239, Lawrence Berkeley National Laboratory, Berkeley, CA, March 20-22, 2006.

Pickles WL, Gouveia F, Bogen K, Rau G, Burton E. Integrated monitoring and modeling of CO2 leakage risk using remote sensing, ground-based monitoring, atmospheric models and risk-indexing tools. Abstract. Session H42. American Geophysical Union Meeting, Fall 2006.

Bogen KT. Cancer risk and hormesis: Plausibility and implications. 45th Annual Meeting of the Society of Toxicology, San Diego, CA, March 5-9, 2006.

Bogen KT, Keating GA, Holly EA, Chan J, Paine L, Simms EL, Nelson DO, Felton J. Prostate serum antigen levels and dietary heterocyclic amines in African Americans: A prospective clinic-based study. Abstract 2103. 97th Annual Meeting of the American Association for Cancer Research, Washington, DC, April 1-5, 2006.

Bogen KT, Hamilton TF, Brown TA, Marchetti AA, Martinelli RE, Kehl SR. Age-related trend in elevated plutonium-239 measured by AMS in urine samples collected in 1998-2003 from Enewetak residents and Rongelap resettlement workers. Presented at the 51st Annual Radiobioassay and Radiochemical Measurements Conference, Stateline, NV, October 24-28, 2005.

Bogen KT, Hickman DP, Hamilton TF, Brown TA, Cox CC, Marchetti AA, Martinelli RE. AMS analysis of 239Pu in archived occupational samples. Presented at the 51st Annual Radiobioassay and Radiochemical Measurements Conference, Stateline, NV, October 24-28, 2005.

Keating G, Bogen K, Holly E, Baker W, Paine L, Felton J. Prostate cancer screening and heterocyclic amine intake in African Americans. Presented at the 95th Annual Meeting of the American Association for Cancer Research, Anaheim, CA, April 16-20, 2005.

Bogen K, Baker W, Chan J, Nelson D, Holly E, Keating G, Paine L, Felton J. Prostate cancer screening and dietary HA exposure in African-Americans. Presented at the University of California Davis Health System Future Fair, Sacramento, CA, May 5, 2005.

Hamilton TF, Brown TA, Martinelli RE, Tumey SJ, Kehl SR, Bogen KT, Buchholz BA, Hickman DP, Wood-Zika AR, Langston RG. Urinary excretion of plutonium isotopes based on accelerator mass spectrometry: Baseline measurements from the Marshall Islands. UCRL-ABS-234231. Abstract, Health Physics Society 41st Midyear Topical Meeting (Oakland, January 2008), Lawrence Livermore National Laboratory, Livermore, CA. https://marshallislands.llnl.gov/pdf/Hamilton_UCRL-ABS-234231.pdf

Bogen KT. Chemical risk analysis for environmental health triage and consequence management. Abstract. Presented at 2004 Annual Meeting of the Society for Risk Analysis Palm Springs, CA, December 5-8, 2004.

Bogen KT, Holly EA, Baker W, Keating GA, Paine L. Cooked meat carcinogens and prostate cancer screening in African Americans. Abstract. Presented at 14th Annual Conference of the International Society of Exposure Analysis, Philadelphia, PA, October 17-21, 2004.

Bogen KT, Holly EA, Baker W, Keating GA, Paine L. Cooked meat carcinogens and prostate cancer screening in African Americans. Presented at the 10th Annual Cancer Research Symposium, University of California Davis Cancer Center, Sacramento, CA, October 20-21, 2004.

Bogen KT, Keating GA, Holly EA. Prostate cancer screening and heterocyclic amine intake in African Americans. Abstract #1101. Presented at the 2004 Annual Meeting of the American Association for Cancer Research, Orlando FL, March 27-31, 2004.

Bogen K. Hypersensitivity to gamma radiation: LLNL/CCI Collaborative Studies Sponsored by the USDOE Low Dose Research Program. UCRL-PRES-152527. Lawrence Livermore National Laboratory, Livermore, CA, 2003.

Bogen KT, Marchetti A, Brown TA. Use of a correlated compound-binomial model to assess absence of non-counting noise in Pu-isotope ratios measured by AMS at LLNL. Presented at the 9th International Conference on Accelerator Mass Spectrometry, Nagoya University, Chikusa, Nagoya, Japan, September 9-13, 2002.

Bogen KT, Cullen J. Residential radon and lung cancer mortality in U.S. women who predominantly never smoked. Abstract 26.08. p. 90. In: 12th Conference of the International Society of Exposure Analysis (ISEA) and 14th Conference of the International Society for Environmental Epidemiology (ISEE), Vancouver, BC, August 11-15, 2002.

Enns, L, Murtha A, Bogen K, Weinfeld M. Low-dose dose-response of proliferating human cells exposed to low dose rate γ-radiation. Abstract. U.S. Department of Energy Office of Biological and Environmental Research Low Dose Radiation Research Program Workshop III, March 25-27, 2002.

Enns L, Weinfeld M, Hall L, Keating G, Murphy G, Bogen K Langlois R. Low dose rate gamma radiation increases cytotoxicity as revealed by gel-microdrop (GMD) flow cytometry. Abstract. Annual Meeting of the Society of Toxicology, San Francisco, CA, March 2001.

Enns L, Weinfeld M, Bogen K, Murtha A. Hypersensitive-nonlinear low-dose dose-response for arrested proliferation of human A549 cells exposed to low-dose gamma radiation, detected by gel-microdrop flow cytometry. Abstract. p. 247. In: DOE/NASA Radiation Investigators’ Workshop. U.S. Department of Energy, Washington, DC, June 2001.

Bogen KT. A unified approach to characterizing risks involving an uncertain carcinogenic mechanism: Groundwater trichloroethylene at a USAF Base [Abstract]. Toxicologist 2000; 54(1):421.

Witschi HP, Bogen KT. Carcinogenic potency of environmental tobacco smoke (ETS) in strain A/J mice [Abstract]. Toxicologist 2000; 54(1):183-184.

Keating GA, DuTeaus SB, Bogen KT. The effect of surface contact on dermal absorption of pesticides from house dust. Abstract. Presented at the 10th Annual Conference of the International Society of Exposure Analysis, Pacific Grove, CA, October 24-27, 2000.

Keating GA, Bogen KT. Cooked-meat carcinogen exposure: New data and proposed study of possible effects on prostate cancer risk in African-Americans. Abstract. p. 1F-10o. 10th Annual Conference of the International Society of Exposure Analysis, Pacific Grove, CA, October 24-27, 2000.

Keating GA, Sinha R, Layton D, Salmon CP, Knize MG, Bogen KT, Lynch CF, Alavanja M. Comparison of heterocyclic amine levels in home-grilled meats with exposure indicators. Abstract. p. 1F-11p. 10th Annual Conference of the International Society of Exposure Analysis, Pacific Grove, CA, October 24–27, 2000.

Bogen KT, McKone TE. Prediction of risk from indoor exposure to tetrachloroethylene: Pharmacokinetic considerations under steady state and dynamic exposure conditions. Proc. 80th Annual Meeting, Air Pollution Control Association, New York City, NY, June 21–26, 1987.

Patents

Patent 6,270,972: Kit for detecting nucleic acid sequences using competitive hybridization probes, August 7, 2001 (with J.N. Lucas and T. Straume).

Patent 6,027,879: Detection and isolation of nucleic acid sequences using a bifunctional hybridization probe, February 22, 2000 (with J.N. Lucas and T. Straume).

Patent 5,783,387: Method for identifying and quantifying nucleic acid sequence aberrations, July 21, 1998 (with J.N. Lucas and T. Straume).

Patent 5,731,153: Identification of random nucleic acid sequence aberrations using dual capture probes which hybridize to different chromosome regions, March 24, 1998 (with J.N. Lucas and T. Straume).

Patent 5,616,465: Detection and isolation of nucleic acid sequences using competitive hybridization probes, April 1, 1997 (with J.N. Lucas and T. Straume).

Prior Experience

Environmental Scientist, Energy and Environment Directorate L-396, University of California, Lawrence Livermore National Laboratory, 1986–2007

Program Analyst, U.S. Environmental Protection Agency Region 9, Office of Policy, Technical and Resource Management, 1982

Science Policy Analyst, U.S. Library of Congress, Congressional Research Service, Science Policy Research Division, 1980–1981

Academic Appointments

Member, University of California Davis Cancer Center, 2002–2007

Professional Affiliations

Diplomate of the American Board of Toxicology (DABT); 5-year certification awarded October 28, 2008 (2009–2013), 5-year recertification awarded November 2012 (2014–2018)

Society of Toxicology (Full Member, 2008–present)

Society for Risk Analysis (1984–present)

Toxicology Forum (2008–present)

American Association for Advancement in Science (1979–present)

Additional Information

Advisory Appointments

Society for Risk Analysis, Dose-Response Specialty Group, Chair-Elect (2015–present)

National Academy of Sciences, National Research Council (NRC), Subcommittee on the Toxicological Risks to Deployed Military Personnel, member (2002-2004). Issued report: Review of the Army’s Technical Guides on Assessing and Managing Chemical Hazards to Deployed Personnel, 2004.

U.S. EPA, Draft Frame Work for Cumulative Risk Assessment, peer consultant (http://www.epa.gov/ncea/raf/pdfs/CumRisk/CumRiskWR042002.pdf, US EPA Risk Assessment Forum, EPA/630/R-01/005, April 2002)

U.S. Consumer Product Safety Commission (CPSC). Chronic Hazard Advisory Panel (CHAP) on Diisononyl Phthalate (DINP), Chairman (nominated by the President of the National Academy of Sciences; 2000–2001; CHAP report to USCPSC issued in June 2001, http://www.cpsc.gov/LIBRARY/FOIA/Foia01/os/dinp.pdf)

U.S. EPA, Ambient Water Quality Criteria Methodology: Human Health, panel member (1999)

U.S. EPA, Carcinogenicity, Reproductive/Developmental Toxicity and Systemic Toxicity of Drinking Water Disinfectant By-Products, panel member (1998)

National Academy of Sciences, National Research Council (NRC), Committee on Risk Assessment of Hazardous Air Pollutants, member (1991–1994); issued the report: Science and Judgment in Risk Assessment, 1994 [student ed., Taylor and Francis, Washington DC, 1996]

ILSI, International Life Sciences Institute, Dose-Response Working Group (1991–1992)

Research Grants

UC/LLNL Research Experience

As a University of California environmental scientist at Lawrence Livermore National Laboratory (LLNL), Dr. Bogen most recently served as PI and/or project leader of the following studies pertaining to environmental carcinogen risk assessment:

PI, “Mode-of-Action uncertainty for dual-mode carcinogens: Lower bounds for naphthalene-induced nasal tumors in rats implied by PBPK and 2-stage stochastic cancer risk models,” ORNL funded by USEPA ORD (2007). Project comprised drafting a white paper of USEPA regulatory interest addressing treatment of uncertainty in cancer risk estimated from animal bioassay data.

PI, “PSA-Based Screening Outcome, Dietary Heterocyclic Amine Exposure, and Prostate Cancer Risk in African Americans,” DOD Prostate Cancer Res. Prog. competitive award W81XWH-05-1-0153 (2005-2007). A LLNL-led 3-year, partially overlapping supplement/extension of the 5-year clinic-based epidemiological study described just below, to expand the study to 700 men through 2007 and to add an additional (percent-free) PSA measure to the other prostate-cancer screening tests performed as described below. Collaborating investigators were based at Alta Bates Summit Hospital (Oakland, CA) and UC San Francisco Medical School.

Project Leader, “Determining the Carcinogenic Significance of Heterocyclic Amines, Project 5: Prostate cancer screening and dietary HA exposure in African-Americans,” NIH/NCI P01 grant 2 NIH P01 CA55861-09A2 (2002-2006). A LLNL-led 5-year clinic-based epidemiological study of association between dietary exposure to cooked-meat (heterocyclic amine) mutagens (particularly, PhIP) and screening indicators of prostate cancer risk in 500 African-Americans. Collaborating investigators were based at Alta Bates Summit Hospital (Oakland, CA) and UC San Francisco Medical School.

Co-investigator, “Environmental Epidemiology of Essential Tremor,” NIH/NINDS grant R01 NS03422 (2006-2010). This 5-year study of environmental and occupational risk factors for essential tremor, led by Dr. Elan Louis, M.D. of Columbia University Medical School, uses an LLNL-developed dietary meat-intake questionnaire and corresponding data analysis for 900 subjects planned over the period of study. In this work, a total of 1,235 meat questionnaires will be provided to Columbia University in annual lots, together with initial training on questionnaire interpretation and administration, and annual analysis of resulting data on estimated daily dietary intake of total heterocyclic amines (HAs), including the primary dietary HA (PhIP), for each participant completing a questionnaire.

PI, “Retrospective Plutonium Biodosimetry by Modeling Urinary 239Pu from Archived Occupational Samples,” 3-year LLNL competitively awarded RandD project 01-ERD-108 (2001-2003). This project successfully developed and demonstrated the application of accelerator mass spectrometry (AMS)--which is ~20- to 40-fold more sensitive than traditional alpha spectrometry methods for the purpose of Pu-exposure assessment--¬to analyze archived alpha-spectrometry urinalysis disks obtained from LLNL Pu workers in accordance with an approved LLNL IRB protocol. This study showed that AMS can be used to recover otherwise inaccessible information on urinary Pu excretion patterns over 10- to 20-year periods.

PI, “DNA Damage vs. Cell Killing by Low-Dose-Rate Radiation: Ultrasensitive Measures, and Implications for Mechanistically Modeled Cancer Risk,” USDOE Low Dose Res. Prog. and Cross Cancer Institute, Alberta Cancer Board (2000-2002). This 3-year study developed and applied a gel-microdrop flow cytometry assay to assess low-dose dose-response of gamma-radiation-induced cell killing in human cells in vitro. This study showed that a previously well characterized “hyper-radiosensitivity” (HRS) low-dose dose-response phenomenon is induced very early after radiation exposure and that its underlying molecular mechanism involves dose-induced suppression of p53-triggered “apoptosis” or programmed cell death.


Research Awards

Society of Toxicology, Risk Assessment Specialty Section, Top 10 Publications in 2008 Demonstrating an Application of Risk Assessment (2008), for: Bogen (2008), supra.

Society for Risk Analysis Best Paper Award, Decision Science (2006), for: Bogen and Jones (2006), supra.

Peer Reviewer

Risk Anal (Editorial Board member, May 2008 – May 2013; Reviewer)

Adv Water Resources (Reviewer)

Chemosphere (Reviewer)

Crit Rev Toxicol (Reviewer)

Dose Response (Reviewer)

Fd Chem Toxicol (Reviewer)

J Expos Sci Environ Epi (Reviewer)

J Haz Materials (Reviewer)

Int J Oral Science (Reviewer)

Med Hypotheses (Reviewer)

Toxicol Sci (Reviewer)

Water Resources Res (Reviewer)

Knowledge

News & Events

CREDENTIALS & PROFESSIONAL HONORS

  • Dr.P.H., Environmental Health Science, University of California, Berkeley, 1986
  • M.P.H., Environmental Health Science, University of California, Berkeley, 1982
  • M.A., Science, Technology, and Public Policy, George Washington University, 1979
  • A.B., Biology, Princeton University, 1978

LICENSES & CERTIFICATIONS

Diplomate of the American Board of Toxicology