Ms. Da Silva holds a MChem in chemistry with medicinal chemistry and an M.S. in chemistry from the University of Manchester. During this time she worked on the development of a SmI2-mediated dialdehyde cyclisation cascade sequence that was successfully utilised in an efficient approach to the [5,6,8]-fused tricyclic diterpene antibiotic natural product pleuromutilin. Following graduation, Ms. Da Silva worked as a laboratory technician at University of California San Diego where she managed the laboratory databases. Her current work focuses on the compilation and submission of REACH registration dossiers and the provision of in-house expertise in the field of organic chemistry.
CREDENTIALS & PROFESSIONAL HONORS
- M.S., Chemistry, University of Manchester, UK, 2010
- MChem., Chemistry with Medicinal Chemistry, First class (Hons), University of Manchester, UK, 2008
Helm MD, Sucunza D, Da Silva M, Helliwell M, Procter DJ. SmI2-mediated dialdehyde cyclisation cascades. Tetrahedron Letters 2009; 50:3224–3226.
Helm MD, Da Silva M, Sucunza D, Helliwell M, Procter DJ. SmI2-mediated dialdehyde ‘radical then aldol’ cyclisation cascades: A feasibility study. Tetrahedron 2009; 65:10816–10829.
Helm MD, Da Silva M, Sucunza D, Helliwell M, Findley TJK, Procter DJ. A dialdehyde cyclisation cascade in an approach to pleuromutilin. Angewandte Chemie International Edition 2009; 48:9315–9317.
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