Dr. Frohbergh’s primary expertise focuses on bone and cartilage tissue engineering, orthopedic biomaterials, in vivo biocompatibility, small animal models for wound healing and cell/molecular biology techniques. He is proficient in biomechanical testing, histology, cell and molecular biology techniques, immunohistochemistry, scaffold fabrication methods, small animal surgery, microscopy and microCT analysis. He has experience with small animal performance analysis, drug and enzyme delivery from polymeric microspheres, and 3D printing for orthopedic implant designs.
Dr. Frohbergh has worked in academic exploratory research and aided in developing a number of projects throughout his career. He developed an electrospun, crosslinked chitosan/hydroxyapatite scaffold for non-load bearing cranial bone. He also developed the rodent osteochondral defect model and protocol used at the Icahn School of Medicine at Mt. Sinai. Prior to joining Exponent, Dr. Frohbergh worked as a postdoctoral fellow at Mt. Sinai in the department of Genetics and Genomic Sciences where he worked on articular cartilage repair using enzymatically treated cells in rodent models. He also worked on rare lysosomal storage disease mechanisms including mucopolysaccharidosis (MPS) and Farber disease. He was also involved in helping to develop the Mt. Sinai Institute of Technology (MSIT) and a mentor/assistant for the Design, Technology and Entrepreneurship (DTE) graduate classes. His thesis work was completed at Drexel University. Along with his research, Dr. Frohbergh was a teaching assistant for Tissue Engineering and the Biomaterials laboratory classes for three years, and a mentor for Drexel’s STAR, and Mini-Med summer programs.
CREDENTIALS & PROFESSIONAL HONORS
- Ph.D., Biomedical Science, Drexel University, 2012
- B.S., Chemistry and Biochemistry, LaSalle University, 2007
International Cartilage Repair Society Postdoctoral Travel Award
LaSalle University Founder’s Scholarship
Simonaro CM, Tomatsu S, Sikora T, Kubaski F, Frohbergh M, Guevara JM, Wang RY, Vera M, Kang JL, Smith LJ, Schuchman EH and Haskins ME. Pentosan Polysulfate: Oral Versus Subcutaneous Injection in Mucopolysaccharidosis Type I Dogs. PloS one. 2016; 11 (4): e0153136.
Frohbergh ME, Guevara JM, Grelsamer R, Barbe M, He X, Simonaro CM and Schuchman EH. Acid Ceramidase Treatment Enhances the Outcome of Autologous Chondrocyte Implantation in a Rat Osteochondral Defect Model. Osteoarthritis and Cartilage. 2016; 24 (4): 752-62.
Frohbergh ME, Katsman A, Mondrinos MJ, Stabler CT, Hankenson KD, Oristaglio JT and Lelkes PI. Osseointegrative Properties of Electrospun Hydroxyapatite-Containing Chitosan Nanofibrous Scaffolds. Tissue Eng Part A. 2015; 21 (5-6): 970-81.
Frohbergh M, Ge Y, Mang FL, Karabul N, Solyom A, Lai A, Iatridis J, Schuchman EH and Simonaro CM. Dose Responsive Effects of Subcutaneous Pentosan Polysulfate Injection in Mucopolysaccharidosis Type VI Rats and Comparison to Oral Treatment. PloS one. 2014; 9 (6): e100882.
Frohbergh ME, Katsman A, Botta GP, Lazarovici P, Schauer CL, Wegst UG and Lelkes PI. Electrospun Hydroxyapatite- Containing Chitosan Nanofibers Crosslinked with Genipin for Bone Tissue Engineering. Biomaterials. 2012; 33 (36): 9167-78.
Review Articles / Book Chapters
Frohbergh ME, He X and Schuchman EH. The Molecular Medicine of Acid Ceramidase. Biol Chem. 2015; 396 (6-7) : 759- 765.
Frohbergh ME and Lelkes PI. Biomimetic Scaffolds for Craniofacial Bone Tissue Engineering: Understanding the Role of the Periosteum. Book chapter from A Tissue Regeneration Approach to Bone and Cartilage Engineering, Zreiqat H, Dunstan C and Rosen V, 147 – 162, 2014.
Frohbergh ME, Newman P, Simonaro CM and Zreiqat H. Bone Tissue Engineering Nanomedicine Approach. Encyclopedia of Molecular Cell Biology and Molecular Medicine. 2015; 1: 153-178.
Schuchman EH, Frohbergh M, Guevara JM, He X, DeAngelis V, Simonaro CM. Cartilage and Bone Disease in a Mouse Model of Farber Lipogranulomatosis and Response to Treatment. Molecular Genetics and Metabolism. 2016; 117 (2): S103.
Frohbergh M, Guevara J, Grelsamer R, Scuchman EH and Simonaro CM. Acid Ceramidase Treatment Enhances the Effect of Autologous Chondrocyte Implantation in a Rat Osteochondral Defect Model. International Cartilage Repair Society World Congress. 2015; Panel Speaker.
Simonaro CM, Tomatsu S, Ge Y, Meng F, Frohbergh M, Haskins ME, Ruane T, Wang RY, Vera M, Solymon A, Schuchman EH. Pentosan Polysulfate: New Mechanistic Insights and Treatment of the Mucopolysaccharidoses. Molecular Genetics and Metabolism. 2015; 114 (2): S106-7.
Simonaro C, Frohbergh M, Ge Y, Meng F, DeAngelis V, Karabul N, Solymon A, Schuchman E. THU0361 Bone and Joint Disease in Mucopolysaccharidosis Involves Tlr4-Related Inflammation and Improves Upon Treatment with Pentosan Polysulfate. Annals of Rheumatic Diseases. 2014; 73 (Suppl 2): 307.
Simonaro C, Frohbergh M, Ge Y, Meng F, Schuchman E. A63: Treatment of Arthritis in Animal Models of the Mucopolysaccharidoses Using a Novel Anti-Inflammatory Drug, Pentosan Polysulfate. Arthritis & Rhuematology. 2014; 66 (S3): S93.
Simonaro C, Frohbergh M, Ge Y, Meng F, DeAngelis V, He X, Schuchman EH. Comparison of Subcutaneous and Oral Pentosan Polysulfate Treatment in a Rat Model of Mucopolysaccharidosis Type VI. Molecular Genetics and Metabolism. 2014; 111 (2): S98.
Frohbergh ME, Sachot S, Ge Y, He X, DeAngelis VA, Schuchman EH, Simonaro CM. A Novel Use for Acid Ceramidase in Cell-Based Therapies for Degenerative Joint Diseases. International Cartilage Repair Society World Congress. 2013; Panel Speaker.Frohbergh ME, Katsman A, Botta G and Lelkes PI. Electrospun Mineralized Chitosan Scaffolds as a Bioactive Aide in the Osseo-Integration of Autograft Substitutes. Biomedical Engineering Society Annual Fall National Meeting. 2011; Panel Speaker
Frohbergh ME, Katsman A, Botta G, Wegst U, Schauer C, Lelkes PI. Electrospun Mineralized chitosan nanofibers as a bioactive scaffold for craniofacial regeneration. Drexel University College of Medicine, October 6, 2011.
Frohbergh ME, Katsman A, Botta G, Lelkes PI. Mineralized Chitosan nanofibrous scaffolds for bone tissue engineering. Drexel University, Philadelphia, PA, April 8, 2011.
Frohbergh ME, Katsman, Lelkes PI. Electrospun mineralized chitosan fibers for bone tissue engineering. Drexel University College of Medicine, Philadelphia, PA, October 7, 2010.
Frohbergh ME and Lelkes PI. New PCT Patent Appl. No. PCT/US11/55209, filed October 7, 2011 (Claims priority to U.S. Prov’l Appl. No. 61/390,918, filed October 7, 2010). Title: Electrospun Mineralized Chitosan Nanofibers Crosslinked With Genipin For Bone Tissue Engineering.