Matthew Glassman
Matthew J. Glassman, Ph.D.
Associate
Polymer Science & Materials Chemistry
  • Menlo Park

Dr. Glassman’s expertise includes chemical and biological synthesis of functional polymers and their modification, nanostructure analysis, rheology of viscoelastic materials (SAOS, LAOS), and mechanical testing (compression and tensile testing). He has applied his synthesis and characterization experience to address challenges in the development of injectable biomaterials, gels, bioconjugates, adhesives, and functional micelles, targeting biomedical and industrial applications for fillers and adhesives.

He is experienced in spectroscopic and chromatographic analytical techniques including NMR, UV/Vis, IR, MALDI-TOF, and GPC, as well as thermal analysis, including TGA and DSC.  He has extensive experience in nondestructive, in situ small angle X-ray, neutron, and light scattering methods (SAXS, SANS, DPLS, SLS, DLS) to understand the mechanisms of polymer assembly and the consequences on macroscopic performance.  He has studied nanostructure in samples under static conditions as well as under shear flow (rheo-SAXS).  He is also familiar with environmental chamber construction and material erosion/degradation studies, as well as in vitro biological characterization techniques, including tissue culture and biocompatibility testing.

Dr. Glassman’s prior research focused on addressing responsive toughening needs in implantable biomaterials, particularly through the study of block copolymer self-assembly and arrested phase separation in shear-thinning hydrogels.  He has invented several strategies for forming injectable and reinforceable biomaterials from artificial polypeptides, as well as a synthetic route to new oxidatively-responsive adhesive polymers based on the adhesion chemistry employed by marine mussels.  Throughout his research work, he has applied his understanding of soft matter physics to study nanostructure formation in polymeric hydrogels through modeling and simulation of micro- and macrophase separation based on experimental data.  Furthermore, he employed rheology to measure relaxation spectra, creep, gelation kinetics, and viscoelastic nonlinearities to guide polymer design for improved toughness.  During his graduate studies, he also gained experience in startup biotech through an internship working on protein engineering and biosynthesis.

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Chemical Engineering, Massachusetts Institute of Technology (MIT), 2015
  • B.S., Chemical Engineering, California Institute of Technology (Caltech), 2009
  • ACS POLY Division Excellence in Polymer Graduate Research, 2014

    NIH/MIT Biotechnology Training Program, 2011–2014

Publications

Glassman MJ, Olsen BD. Arrested phase separation of elastin-like polypeptide solutions yields stiff, thermoresponsive gels. Biomacromolecules 2015; Article ASAP, DOI: 10.1021/acs.biomac.5b01026.

Kim M, Chen WG, Kang JW, Glassman MJ, Ribbeck K, Olsen BD. Artificially engineered protein hydrogels adapted from the nucleoporin nsp1 for selective biomolecular transport. Advanced Materials 2015; 27:4207–4212.

Glassman MJ, Olsen BD. End Block Design Modulates the Assembly and Mechanics of Thermoresponsive, Dual-Associative Protein Hydrogels. Macromolecules 2015; 48(6):1832–1842.

Qin G, Glassman MJ, Lam CN, Chang D, Schaible E, Hexemer A, Olsen BD. Topological effects on globular protein-ELP fusion block copolymer self-assembly. Advanced Functional Materials 2014; 25(5):729–738.

Zhou H, Schön E, Wang M, Glassman MJ, Liu J, Zhong M, Díaz Díaz D, Olsen BD, Johnson JA. Crossover experiments applied to network formation reactions: Improved strategies for counting elastically inactive molecular defects in PEG gels and hyperbranched polymers. JACS 2014; 136(26):9464–9470.

Tang S, Glassman MJ, Li S, Socrate S, Olsen BD. Oxidatively responsive chain extension to entangle engineered protein hydrogels. Macromolecules 2014; 47(2):791–799.

Glassman MJ Olsen BD. Structure and mechanical response of protein hydrogels reinforced by block copolymer self-assembly. Soft Matter 2013; 9:6814–6823.

Glassman MJ, Chan J, Olsen BD. Reinforcement of shear thinning protein hydrogels by responsive block copolymer self-assembly. Advanced Functional Materials 2013; 23:1182–1193.

Thomas CS, Glassman MJ, Olsen BD. Solid-state nanostructured materials from self-assembly of a globular protein-polymer diblock copolymer. ACS Nano 2011; 5:5697–5707.

Bloom JD, Glassman MJ. Inferring stabilizing mutations from protein phylogenies: Application to influenza hemagglutinin. PLoS Computational Biology 2009; 5(4).

Presentations


Glassman MJ, Avery RK, Vronay-Ruggles XT, Khademhosseini A, Olsen BD. Responsive gelation, toughening, and biocompatibility of nanostructured associative protein hydrogels containing elastin-like polypeptides. Oral presentation, Materials Research Society Fall Meeting, Boston, MA, 2014.

Glassman MJ, Li Q, Holten-Andersen N, Olsen BD. Engineering network associations for control of responsive reinforcement in nanostructured physical hydrogels. Oral presentation, American Chemical Society Spring Meeting, Dallas, TX, 2014.

Glassman MJ, Olsen BD. Double network physical gels from elastin-like polypeptide block copolymers: nansocale control of thermoresponsive reinforcement. Oral presentation, American Physical Society March Meeting, Denver, CO, 2014.

Glassman MJ, Olsen BD. Control of double network structure and mechanical behavior of thermoresponsively reinforced, shear thinning protein hydrogels. Oral presentation, Materials Research Society Fall Meeting, Boston, MA, 2013.

Glassman MJ, Chan J, Olsen BD. Molecular origins of reinforcement in responsively nanostructured, shear thinning double network hydrogels. Oral presentation, American Physical Society March Meeting, Baltimore, MD, 2013.

Glassman MJ, Li S, Chan J, Olsen BD. Block copolymer self-assembly for the responsive reinforcement of injectable protein hydrogels. Oral presentation, American Physical Society March Meeting. Boston, MA, 2012.

Glassman MJ, Li S, Olsen BD. Responsively nanostructured injectable protein hydrogels. Oral presentation, Materials Research Society Fall Meeting, Boston, MA, 2011.

Patents

US Patent No. 8916683: Nanostructured Physically-Associating Hydrogels for Injectable, Responsive, and Tough Biomaterials, December 2014(Olsen BD, Glassman MJ, and Chan J).

Professional Affiliations

American Institute of Chemical Engineers

Materials Research Society

American Physical Society

American Chemical Society

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Chemical Engineering, Massachusetts Institute of Technology (MIT), 2015
  • B.S., Chemical Engineering, California Institute of Technology (Caltech), 2009
  • ACS POLY Division Excellence in Polymer Graduate Research, 2014

    NIH/MIT Biotechnology Training Program, 2011–2014