Bhaskar Gollapudi
Bhaskar Gollapudi, Ph.D.
Senior Managing Scientist
Toxicology & Mechanistic Biology
  • Alexandria

Dr. Gollapudi specializes in genetic toxicology and chemical carcinogenesis with emphasis on the identification of mode of action and human relevance of toxicity findings. He has 31 years of experience at a major chemical company addressing the safety of a diverse portfolio of substances such as agrochemicals, pharmaceuticals, biocides, basic and specialty chemicals, food contact materials, solvents, polymers, personal care products, etc. He has published more than 100 papers in peer reviewed journals and has edited a book on the application of genomic technologies for safety and risk assessment. He is an Associate Editor of the journal Toxicological Sciences and serves on a number of scientific committees including the Committee on Toxicology of the National Academy of Sciences, Scientific Program Committee of the Society of Toxicology and the OECD Expert Committee on Genetic Toxicology Guidelines.

He is an invited speaker at a number of national and international scientific conferences. Dr. Gollapudi is the recipient of the 2014 Arnold J. Lehman Award from the Society of Toxicology in recognition of his contributions to the field of risk assessment and chemical regulation. He was recently appointed as the incoming Editor-in-Chief of the journal Environmental and Molecular Mutagenesis, the official journal of the U.S. Environmental Mutagenesis and Genomics Society.

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Biology, Dalhousie University, Nova Scotia, 1980
  • M.S., Genetics, Osmania University, India, 1974
  • B.S., Chemistry, Osmania University, India, 1969
  • Post Doc: Genetic Toxicology Laboratory, The Dow Chemical Company, Lake Jackson Research Center

    Post Doc: Molecule Biology; Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health

LANGUAGES

  • Telugu
  • Hindi

Publications

Recent (2013–2015) Invited Lectures at Scientific Meetings

Gollapudi BB. Dose-response assessment in genetic toxicology. Presented at the 36th Annual Meeting of American College of Toxicology, Summerlin, NV. November, 2015.

Gollapudi BB. The Journey towards a New Paradigm in Genetic Toxicology. Presented at the 46th Annual Meeting of the U.S. Environmental Mutagenesis and Genomics Society, New Orleans, LA. September, 2015.

Gollapudi BB. The Pig-a Assay. Presented at the Genetic Toxicology Association Annual Meeting, Newark, DE. May, 2014.

Gollapudi BB. Dose response assessment in genetic toxicology – Thresholds or point of departure? Presented at the European Environmental Mutagen Society Annual Meeting, Lancaster, U.K., July 2014.

Gollapudi BB. Quantitative approaches for assessing dose-response relationships. Presented at the Environmental Mutagenesis and Genomics Society Annual Meeting, Orlando, FL. September 2014.

Gollapudi BB. Effects of genotoxic substances on the genetic systems. Presented at the Elemental and Genotoxic Impurities Conference, Mumbai, India, November 2014.

Gollapudi BB. New approaches and changing regulatory requirements in genetic toxicology. Presented at the 34th Annual Conference of Society of Toxicology, Chennai, India. December 2014.

Gollapudi BB. Mechanistic studies to investigate and inform safety of pesticides to humans from a risk assessment perspective. Presented at the 34th Annual Conference of Society of Toxicology, Chennai, India. December 2014.

Gollapudi BB. Follow-up investigations to assess the in vivo relevance of bacterial mutagenicity findings. Presented at the Elemental and Genotoxic Impurities Conference, Mumbai, India, November 2014.

Gollapudi BB. New approaches for genotoxicity assessment and guidance on dealing with positive results. Presented at 52nd Annual Meeting of the Society of Toxicology, San Antonio, TX. March, 2013.

Gollapudi BB. A critical assessment of low dose response in genetic toxicology. Presented at the 13th International Congress of Toxicology, Seoul, Korea. July 2013.

Gollapudi BB. Scope, design and interpretation of the Pig-A assay. Presented at the 11th International Conference of Environmental Mutagens, Foz do Iguassu, Brazil, November 2013.

Gollapudi BB. Epigenetics: Are we ready to consider epigenetic effects in human health risk assessment? Presented at the 11th International Conference of Environmental Mutagens, Foz do Iguassu, Brazil, November 2013.

Gollapudi BB. Dose response and point of departure assessment in genetic toxicology. Presented at the 11th International Conference of Environmental Mutagens, Foz do Iguassu, Brazil, November 2013.

Publications 


Banda M, McKim KL, Haber LT, MacGregor JA, Gollapudi BB, Parsons BL. Quantification of Kras mutant fraction in the lung DNA of mice exposed to aerosolized particulate vanadium pentoxide by inhalation. Mutat Res Genet Toxicol Environ Mutagen. 2015; 789–790:53–60. 

Manjanatha MG, Shelton SD, Haber L, Gollapudi B, MacGregor JA, Rajendran N, Moore MM. Evaluation of cII mutations in lung of male Big Blue mice exposed by inhalation to vanadium pentoxide for up to 8 weeks. Mutat Res Genet Toxicol Environ Mutagen 2015; 789–790:46–52. 

Whitwell J, Smith R, Jenner K, Lyon H, Wood D, Clements J, Aschcroft-Hawley K, Gollapudi B, Kirkland D, Lorge E, Pfuhler S, Tanir JY, Thybaud V. Relationships between p53 status, apoptosis and induction of micronuclei in different human and mouse cell lines in vitro: Implications for improving existing assays. Mutat Res Genet Toxicol Environ Mutagen 2015; 789–790:7–27. 

Black MB, Dodd DE, McMullen PD, Pendse S, MacGregor JA, Gollapudi BB, Andersen ME. Using gene expression profiling to evaluate cellular responses in mouse lungs exposed to V(2)O(5) and a group of other mouse lung tumorigens and non-tumorigens. Regul Toxicol Pharmacol 2015; 73:339–347.

Ji Z, LeBaron MJ, Schisler MR, Zhang F, Bartels MJ, Gollapudi BB, Pottenger LH. Dose-Response for Multiple Biomarkers of Exposure and Genotoxic Effect Following Repeated Treatment of Rats with the Alkylating Agents, MMS and MNU. Mutagenesis 2015 Jun 3. [Epub ahead of print] PubMed PMID: 26040483.

Martus HJ, Hayashi M, Honma M, Kasper P, Gollapudi B, Mueller L, Schoeny R, Uno Y, Kirkland DJ. Summary of major conclusions from the 6th International Workshop on Genotoxicity Testing (IWGT), Foz do Iguaçu, Brazil. Mutat Res Genet Toxicol Environ Mutagen 2015; 783:1–5. 

Sura R, Settivari RS, LeBaron MJ, Rowlands JC, Carney EW, Gollapudi BB. A critical assessment of the methodologies to investigate the role of inhibition of apoptosis in rodent hepatocarcinogenesis. Toxicol Mech Methods 2015; 25:192–200.

Zhang F, Bartels MJ, LeBaron MJ, Schisler MR, Gollapudi BB, Moore NP. A novel approach for concurrent quantitation of glutathione, glutathione disulfide, and 2-hydroxyethylated glutathione in lungs of mice exposed to ethylene oxide, using liquid chromatography-positive electrospray tandem mass spectrometry. Biomed Chromatogr 2015; 29: 1364–1374..

Zhang F, Bartels MJ, LeBaron MJ, Schisler MR, Jeong YC, Gollapudi BB, Moore NP. LC-MS/MS simultaneous quantitation of 2-hydroxyethylated, oxidative, and unmodified DNA nucleosides in DNA isolated from tissues of mice after exposure to ethylene oxide. J Chromatogr B Analyt Technol Biomed Life Sci. 2015; 976–977: 33–48..

Zeiger E, Gollapudi B, Aardema MJ, Auerbach S, Boverhof D, Custer L, Dedon P, Honma M, Ishida S, Kasinski AL, Kim JH, Manjanatha MG, Marlowe J, Pfuhler S, Pogribny I, Slikker W, Stankowski LF Jr, Tanir JY, Tice R, van Benthem J, White P, Witt KL, Thybaud V. Opportunities to integrate new approaches in genetic toxicology: An ILSI-HESI workshop report. Environ Mol Mutagen. 2015; 56: 277–185. .

Gollapudi BB, Lynch AM, Heflich RH , Dertinger SD, Dobrovolsky VN, Froetschle R, Horibata K, Kenyon MO, Kimoto T, Lovell D, Stankowski Jr. LF, White PA, Witt KL, Tanir JY. The in vivo Pig-a assay: A report of the International Workshop On Genotoxicity Testing (IWGT) Workgroup. Mutat. Res. 2015; 783: 23–35.

Johnson GE, Slob W, Doak S, Fellows M, Gollapudi B, Heflich RH, Rees B, Soeteman-Hernández LG, Verma J, Wills J, Jenkins G, and White P. New Approaches to Advance the use of Genetic Toxicology Analyses for Human Health Risk Assessment and Regulatory Decision-Making, Toxicology Res., 2015; 4: 667-676. 

LeBaron MJ, Rasoulpour RJ, Gollapudi BB, Sura R, Kan HL, Schisler MR, Pottenger LH, Papineni S, Eisenbrandt DL. Characterization of Nuclear Receptor-Mediated Murine Hepatocarcinogenesis of the Herbicide Pronamide and Its Human Relevance. Toxicol Sci. 2014:142:74-92.

Johnson GE, Soeteman-Hernández LG, Gollapudi BB, Bodger OG, Dearfield KL, Heflich RH, Hixon JG, Lovell DP, MacGregor JT, Pottenger LH, Thompson CM, Abraham L, Thybaud V, Tanir JY, Zeiger E, van Benthem J, White PA. Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment. Environ Mol Mutagen 2014 Oct;55(8):609–623.

LeBaron MJ, Gollapudi BB, Terry C, Billington R, Rasoulpour RJ. Human relevance framework for rodent liver tumors induced by the insecticide sulfoxaflor. Crit Rev Toxicol 2014; 44 Suppl 2:15–24.

Terry C, Rasoulpour RJ, Saghir S, Marty S, Gollapudi BB, Billington R. Application of a novel integrated toxicity testing strategy incorporating “3R” principles of animal research to evaluate the safety of a new agrochemical sulfoxaflor. Crit Rev Toxicol 2014; 44 Suppl 2:1–14. 

Geter DR, Bhat VS, Gollapudi BB, Sura R, Hester SD. Dose-response modeling of early molecular and cellular key events in the CAR-mediated hepatocarcinogenesis pathway. Toxicol Sci 2014; 138:425–445. 

Alyea RA, Gollapudi BB, Rasoulpour RJ. Are we ready to consider transgenerational epigenetic effects in human health risk assessment? Environ Mol Mutagen 2014; 55:292–298. 

Rowlands JC, Budinsky R, Gollapudi B, Black MB, Wolfinger RD, Cukovic D, Dombkowski A, Thompson CM, Urban JD, Thomas RS. A genomics-based analysis of relative potencies of dioxin-like compounds in primary rat hepatocytes. Toxicol Sci 2013; 136:595–604. 

Parsons BL, Manjanatha MG, Myers MB, McKim KL, Shelton S, Wang Y, Gollapudi BB, Moore NP, Haber LT, Moore MM. Temporal changes in K-ras mutant fraction in lung tissue of Big Blue B6C3F1 mice exposed to ethylene oxide. Toxicological Sciences 2013 Sep 12. [Epub ahead of print].

Schisler MR, Moore MM, Gollapudi BB. In vitro mouse lymphoma (L5178Y Tk (+/-) -3.7.2C) forward mutation assay. Methods in Molecular Biology 2013; 1044:27–50. 

Budinsky R, Gollapudi B, Albertini RJ, Valentine R, Stavanja M, Teeguarden J, Fensterheim R, Rick D, Lardie T, McFadden L, Green A, Recio L. Nonlinear responses for chromosome and gene level effects induced by vinyl acetate monomer and its metabolite, acetaldehyde in TK6 cells. Environmental and Molecular Mutagenesis 2013 Aug 28. [Epub ahead of print].

Lebaron MJ, Geter DR, Rasoulpour RJ, Gollapudi BB, Thomas J, Murray J, Kan HL, Wood AJ, Elcombe C, Vardy A, McEwan J, Terry C, Billington R. An integrated approach for prospectively investigating a mode-of-action for rodent liver effects. Toxicology and Applied Pharmacology 2013; 20(270):164–173.

Gollapudi BB, Johnson GE, Hernandez LG, Pottenger LH, Dearfield KL, Jeffrey AM, Julien E, Kim JH, Lovell DP, MacGregor JT, Moore MM, van Benthem J, White PA, Zeiger E, Thybaud V. Quantitative approaches for assessing dose-response relationships in genetic toxicology. Environmental and Molecular Mutagenesis 2013; 54:8–18.

LeBaron MJ, Schisler MR, Torous DK, Dertinger SD, Gollapudi BB. Influence of counting methodology on erythrocyte ratios in the mouse micronucleus test. Environmental and Molecular Mutagenesis 2013; 54:222–228.

Alyea RA, Moore NP, Lebaron MJ, Gollapudi BB, Rasoulpour RJ. Is the current product safety assessment paradigm protective for epigenetic mechanisms? Journal of Pharmacological and Toxicological Methods 2012; 66:207–214.

Geter DR, Zhang F, Schisler MR, Wood AJ, Kan HL, Jeong YC, Bartels MJ, McFadden L, Gollapudi BB Genetic damage, but limited evidence of oxidative stress markers in diethyl maleate-induced glutathione depleted mouse lymphoma L5178Y (TK(+/-)) cell cultures. Toxicology Mechanisms and Methods 2012; 22:547–554.

Stagg N, Lebaron M, Eisenbrandt D, Gollapudi B, Klaunig J. Assessment of possible carcinogenicity of oxyfluorfen to humans using mode of action analysis of rodent liver effects. Toxicological Sciences 2012; 128:334–345.

Adenuga D, Woolhiser MR, Gollapudi BB, Boverhof DR. Differential gene expression responses distinguish contact and respiratory sensitizers and nonsensitizing irritants in the local lymph node assay. Toxicological Sciences 2012; 126:413–425.

Pottenger LH, Price PS, Gollapudi BB. Needed: Improved dose selection in genetic toxicology studies. Human and Ecological Risk Assessment 2012; 18:4–12.

Schuler M, Gollapudi BB, Thybaud V, Kim JH. Need and potential value of the Pig-ain vivo mutation assay-a HESI perspective. Environmental and Molecular Mutagenesis 2011; 52:685–689.

Rowlands JC, Budinsky R, Gollapudi B, Novak R, Abdelmegeed M, Cukovic D, Dombkowski A. Transcriptional profiles induced by the aryl hydrocarbon receptor agonists 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran and 2,3,4,7,8-pentachlorodibenzofuran in primary rat hepatocytes. Chemosphere 2011; 85:232–238.

Suitable top concentration for tests with mammalian cells: mouse lymphoma assay workgroup. Moore MM, Honma M, Clements J, Awogi T, Douglas GR, van Goethem F, Gollapudi B, Kimura A, Muster W, O'Donovan M, Schoeny R, Wakuri S. Mutation Research 2011; 16(723):84–86.

Rasoulpour RJ, LeBaron MJ, Ellis-Hutchings RG, Klapacz J, Gollapudi BB. Epigenetic screening in product safety assessment: Are we there yet? Toxicology Mechanisms and Methods 2011; 21:298–311.

Boverhof DR, Chamberlain MP, Elcombe CR, Gonzalez FJ, Heflich RH, Hernández LG, Jacobs AC, Jacobson-Kram D, Luijten M, Maggi A, Manjanatha MG, Benthem J, Gollapudi BB Transgenic animal models in toxicology: historical perspectives and future outlook. Toxicological Sciences 2011; 121:207–233.

Kirkland DJ, Hayashi M, Jacobson-Kram D, Kasper P, Gollapudi B, Müller L, Uno Y. Summary of major conclusions from the 5th IWGT, Basel, Switzerland, August 17–19, 2009. Mutation Research 2011; 16(723):73–76.

Gollapudi BB, Thybaud V, Kim JH, Holsapple M. Strategies for the follow-up of positive results in the in vitro genotoxicity assays—An international collaborative initiative. Environmental and Molecular Mutagenesis 2011; 52:174–176.

Application of Toxicogenomics in Safety Evaluation and Risk Assessment. Boverhof DR, Gollapudi BB (eds), John Wiley and Sons, Inc., 2011.

Boverhof DR, Geter DR, Hollnagel HM, Gollapudi BB Practical considerations for the application of toxicogenomics to risk assessment—Early experience, current drivers, and a path forward. In: Application of Toxicogenomics in Safety Evaluation and Risk Assessment. John Wiley and Sons, Inc., p. 41–64, 2011.

Boverhof DR, Gollapudi BB. Toxicology, “omics” technologies, and toxicogenomics: A primer. In: Applications of Toxicogenomics in Safety Evaluation and Risk Assessment. John Wiley and Sons, Inc. p.1–12, 2011.

Pottenger LH, Gollapudi BB. Genotoxicity testing: Moving beyond qualitative “screen and bin” approach towards characterization of dose response and thresholds. Environmental and Molecular Mutagenesis 2010; 51:792–799.

Rowlands CJ, Staskal DF, Gollapudi B, Budinsky R. The human AHR: Identification of single nucleotide polymorphisms from six ethnic populations. Pharmacogenetic Genomics 2010; 20:283–290.

LeBaron MJ, Rasoulpour RJ, Klapacz J, Ellis-Hutchings RG, Hollnagel HM, Gollapudi BB Epigenetics and chemical safety assessment. Mutation Research 2010; 705:83–95. 

Boverhof DR, Gollapudi BB, Hotchkiss JA, Osterloh-Quiroz M, Woolhiser MR. A draining lymph node assay (DLNA) for assessing the sensitizing potential of proteins. Toxicology Letters 2010; 15:193:144–151.

Pottenger LH, Gollapudi BB. A case for a new paradigm in genetic toxicology testing. Mutation Research 2009; 678:148–151.

Boverhof DR, Gollapudi BB, Hotchkiss JA, Osterloh-Quiroz M, Woolhiser MR. Evaluation of a toxicogenomic approach to the local lymph node assay (LLNA). Toxicological Sciences 2009; 107:427–439.

Zhang F, Bartels MJ, Pottenger LH, Schisler MR, Grundy JJ, Gollapudi BB. Quantitation of methylated hemoglobin adducts in a signature peptide from rat blood by liquid chromatography/negative electrospray ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry 2008; 22:1455–1460.

Delker DA, Geter DR, Kleinert KM, Gollapudi BB Frequency and spectrum of lacI mutations in the liver of Big Blue mice following the administration of genotoxic carcinogens singly and in series. International Journal of Toxicology 2008; 27:35–42.

Geter DR, Kan HL, Lowe ER, Rick DL, Charles GD, Gollapudi BB, Mattsson JL. Investigations of oxidative stress, antioxidant response, and protein binding in chlorpyrifos exposed rat neuronal PC12 cells. Toxicology Mechanisms and Methods 2008; 18:17–23.

Boverhof DR, Billington R, Gollapudi BB, Hotchkiss JA, Krieger SM, Poole A, Wiescinski CM, Woolhiser MR. Respiratory sensitization and allergy: Current research approaches and needs. Toxicology and Applied Pharmacology 2008; 226:1–13.

Zhang F, Stott WT, Clark AJ, Schisler MR, Grundy JJ, Gollapudi BB, Bartels MJ. Quantitation of 8-hydroxydeoxyguanosine in DNA by liquid chromatography/positive atmospheric pressure photoionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry 2007; 21:3949–3955.

Thybaud V, Aardema M, Casciano D, Dellarco V, Embry MR, Gollapudi BB, Hayashi M, Holsapple MP, Jacobson-Kram D, Kasper P, MacGregor JT, Rees R. Relevance and follow-up of positive results in in vitro genetic toxicity assays: An ILSI-HESI initiative. Mutation Research 2007; 633:67–79.

Pottenger LH, Bus JS, Gollapudi BB. Genetic toxicity assessment: Employing the best science for human safety evaluation part VI: When salt and sugar and vegetables are positive, how can genotoxicity data serve to inform risk assessment? Toxicological Sciences 2007; 98:327–331.

Induction of micronuclei by phenol in the mouse bone marrow: I. Association with chemically induced hypothermia. Spencer PJ, Gollapudi BB, Waechter JM Jr. Toxicological Sciences 2007; 97:120–127.

Zhang F, Bartels MJ, Pottenger LH, Gollapudi BB, Schisler MR. Quantitation of lower levels of the DNA adduct of thymidylyl(3'-5')thymidine methyl phosphotriester by liquid chromatography/negative atmospheric pressure chemical ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry 2007; 2:1043–1048.

Moore MM, Honma M, Clements J, Bolcsfoldi G, Burlinson B, Cifone M, Clarke J, Clay P, Doppalapudi R, Fellows M, Gollapudi B, Hou S, Jenkinson P, Muster W, Pant K, Kidd DA, Lorge E, Lloyd M, Myhr B, O'Donovan M, Riach C, Stankowski LF Jr, Thakur AK, Van Goethem F. Mouse lymphoma thymidine kinase gene mutation assay: meeting of the International Workshop on Genotoxicity Testing, San Francisco, 2005, recommendations for 24-h treatment. Mouse Lymphoma Assay Workgroup, IWGT. Mutation Research 2007; 3;627:36–40.

Zhang F, Bartels MJ, Pottenger LH, Gollapudi BB and Schisler MR (2005): Quantitation of DNA adduct of thymidylyl(3'-5')thymidine methyl phosphotriester by liquid chromatography/negative electrospray tandem mass spectrometry, Rapid Communications in Mass Spectrometry 19:2767-2772.

Zhang F, Bartels MJ, Pottenger LH, Gollapudi BB Differential adduction of proteins vs. deoxynucleosides by methyl methanesulfonate and 1-methyl-1-nitrosourea. Rapid Communications in Mass Spectrometry 2005; 19:438–448. 

Zeiger E, Gollapudi B, Spencer P. Genetic toxicity and carcinogenicity studies of gluteraldehyde—A review. Mutation Research 2005; 589:136–151.

Charles GD, Spencer PJ, Schisler MR, Cifone M, Budinsky RA, Gollapudi BB Mode of mutagenic action for the biocide Bioban CS-1246 in mouse lymphoma cells and implications for its in vivo mutagenic potential. Toxicological Sciences 2005; 84:73–80.

Sander M, Cadet J, Casciano D, Galloway S, Marnett L, Novak R, Pettit S, Preston R, Skare J, Williams G, Van Houten B, Gollapudi B. Proceedings of a Workshop on DNA Adducts: Biological Significance and Applications to Risk Assessment. Toxicology and Applied Pharmacology 2005; 208:1–20.

Charles GD, Kan HL, Schisler MR, Gollapudi BB, Marty MS. A comparison of in vitro and in vivo EDSTAC test battery results for detecting antiandrogenic activity. Toxicology and Applied Pharmacology 2005; 202:108–120.

Spencer PJ, Yano BL, Gollapudi BB The Tg.AC transgenic mouse as a screening tool for anticarcinogens: Broccoli juice protected against 12-O-tetradecanoylphorbol-13-acetate (TPA)- but not Benozo[a]pyrene (B[a]P)-induced skin tumors. Toxicology Mechanisms and Methods 2004; 16:189–198.

Stott WT, Kan HL, McFadden LG, Sparrow BR, Gollapudi BB Effect of strain and diet upon constitutive and chemically induced activities of several xenobiotic-metabolizing enzymes in rats. Regulatory Toxicology and Pharmacology 2004; 39:325–333.

Gennings C, Carter WH, Jr, Carney EW, Charles GD, Gollapudi BB, Carchman R. A novel flexible approach for evaluating fixed ratio mixtures of full and partial agonists. Toxicological Sciences 2004; 80:134–150.

Seidel SD, Sparrow BR, Kan HL, Stott WT, Schisler MR, Linscombe VA, Gollapudi BB. Profiles of gene expression changes in L5178Y mouse lymphoma cells treated methyl methanesulfonate and sodium chloride. Mutagenesis 2004; 19:1–7. 
Seidel SD, Kan HL, Stott WT, Schisler MR, Gollapudi BB Identification of transcriptome profiles for the DNA-damaging agents bleomycin and hydrogen peroxide in L5178Y mouse lymphoma cells. Environmental and Molecular Mutagenesis 2003; 42:19–25.

Gennings C, Charles G, Gollapudi B, Zacharewski T, Carney E. Analysis of resulting data from estrogen receptor reporter gene assays. Journal of Agricultural, Biological, and Environmental Statistics 2003; 8:84–104.

Moore MM, Honma M, Clements J, Bolcsfoldi G, Cifone M, Delongchamp R, Fellows M, Gollapudi B, et al. Mouse lymphoma thymidine kinase locus gene mutation assay. International Workshop on Genotoxicity Tests Workgroup Report, Plymouth, UK 2002. Mutation Research 2002; 540:127–140.

Moore MM, Honma M, Clements J, Harrington-Brock K, Awogi T, Bolcsfoldi G, Cifone M, Collard D, Fellows M, Flanders K, Gollapudi B, et al. Mouse lymphoma thymidine kinase gene mutation assay: Follow-up. International Workshop on Genotoxicity Test Procedures, New Orleans, LA, April 2000. Environmental and Molecular Mutagenesis 2002; 40:292–299.

Charles G, Linscombe V, Tornesi B, Mattsson J, Gollapudi B. An in vitro screening paradigm for extracts of whole foods for detection of potential toxicants. Food and Chemical Toxicology 2002; 40:1391–1402.

Charles G, Gennings C, Zacharewski T, Gollapudi B, Carney E. Assessment of interactions of diverse ternary mixtures in an estrogen receptor-alpha reporter assay. Toxicology and Applied Pharmacology 2002; 180:11–21.

Charles G, Gennings C, Zacharewski T, Gollapudi B, Carney E. An approach for assessing estrogen receptor-mediated interactions in mixtures of three chemicals—A pilot study. Toxicological Sciences 2002; 68:349–360.

Gollapudi B. Complementary Genetic Toxicology Assays, in Genetic Toxicology and Cancer Risk Assessment. Choy WN (ed), Marcel Dekker Inc., New York, NY, pp. 115–140, 2001.

Pauluhn J, Gollapudi B, Hammond T, Linscombe A, Thiel A, Zischka-Kubbier D. Bone marrow micronucleus assay in Brown-Norway rats exposed to dephenyl-methane-4,4'-diisocyante. Archives of Toxicology 2001; 75:234–242. 

Gollapudi BB, Krishna G. Practical aspects of mutagenicity testing strategy: An industrial perspective. Mutation Research 2000; 455:21–28. 

Stott WT, Gollapudi BB, Rao KS. Mammalian toxicity of 1,3-dichloropropene. Reviews of Environmental Contamination and Toxicology 2000; 168:1–42.

Charles GD, Gennings C, Clemons J, Zacharewski TR, Gollapudi BB, Carney EW. Optimization of an estrogen receptor-α transcriptional activation assay for testing a diverse spectrum of chemicals. Journal of Applied Toxicology 2000; 20:449–454.

Moore MM, Honma M, Clements J, Awagi T, Bolcsfoldi G, Cole J, Gollapudi BB, et al. Mouse lymphoma thymidine kinase locus gene mutation assay. International Workshop on Genotoxicity Test Procedure’s Working Group Report, Environmental and Molecular Mutagenesis 2000; 35:185–190.

Delker DA, Yano BL, Gollapudi BB Evaluation of cytotoxicity, cell proliferation, and genotoxicity induced by p-cresidine in hetero- and nullizygous transgenic p53 mice. Toxicological Sciences 2000; 55:361–369.

Charles GD, Bartels MJ, Zacharewski TR, Gollapudi BB, Freshour NL, Carney EW. Activity of benzo[a]pyrene and its hydroxylated metabolites in an estrogen receptor- reporter gene assay. Toxicological Sciences 2000; 55:320–326.

Gollapudi B, Burns C. Genotoixcity from domestic use of organophosphate pesticides. Journal of Occupational and Environmental Medicine 1999; 41:416–418.

Marty MS, Singh NP, Holsapple MP, Gollapudi BB Influence of p53 zygosity on select sperm parameters of the mouse. Mutation Research 1999; 427:39–45.

Charles JM, Cunny HC, Wilson RD, Bus JS, Lawlor TE, Cifone MA, Fellows M, Gollapudi BB Ames assays and unscheduled DNA synthesis assays on 2,4-dichlorophenoxyacetic acid and its derivatives. Mutation Research 1999; 444:207.

Charles JM, Cunny HC, Wilson RD, Ivett JL, Murli H, Bus JS, Gollapudi BB In vivo micronucleus assays on 2,4-dichlorophenoxyacetic acid and its derivatives. Mutation Research 1999; 444:227–234.

Gollapudi BB, Charles JM, Linscombe VA, Day SJ, Bus JS. Evaluation of the genotoxicity of 2,4-dichlorophenoxyacetic acid and its derivatives in mammalian cell cultures. Mutation Research 1999; 444:217–225.

Delker DA, Yano BL, Gollapudi BB. v-ha-ras gene expression in liver and kidney of transgenic mice following tissue injury. Toxicological Sciences 1999; 50:90–97.

Gollapudi BB, Stott WT, Yano BL, Bus JS. Mode of action considerations in the use of transgenic animals for mutagenicity and carcinogenicity evaluations. Toxicology Letters 1998; 479:102–103.

Gollapudi BB, Jackson KM, Stott WT. Hepatic lacI and cII mutations in transgenic (λLiz) rats treated with dimethylnitrosamine. Mutation Research 1998; 419:131–135.

Gollapudi BB, Cieszlak FS, Day SJ, Carney EW. Dominant lethal test with rats exposed to 1,3-dichloropropene by inhalation. Environmental and Molecular Mutagenesis 1998; 32:351.

Gollapudi BB, Barber ED, Lawlor TE, Lewis SA. Re-examination of the mutagenicity of ethyleneglycol monobutyl ether to Salmonella tester strain TA97a. Mutation Research 1996; 370:61–64.

Gollapudi BB, McFadden LG. Sample size for the estimation of polychromatic to normochromatic erythrocyte ratio in the bone marrow micronucleus test. Mutation Research 1995; 347:97–99.

Gollapudi BB, Linscombe VA, Wilmer JW. Clastogenicity of isoamylene oxide to rat lymphocytes in culture. Mutation Research 1995; 347:9–12.

Gollapudi BB, Mendrala AL, Linscombe VA. Evaluation of the genetic toxicity of the organophosphate insecticide chlorpyrifos. Mutation Research 1995; 342:25–36.

Gollapudi BB, McClintock ML, Sinha AK, Stack C. Toxicology of diethylene glycol butyl ether: 3 Genotoxicity evaluation in an in vitro gene mutation assay and an in vivo cytogenetic test. Journal of the American College of Toxicology 1993; 12:155–159.

Linscombe VA, Gollapudi BB, Sinha AK. Cytogenetic damage and cytokinetics in streptonigrin-treated human lymphocytes. In Vitro Cellular and Developmental Biology 1991; 27A:603–605.

Linscombe VA, Gollapudi BB, Sinha AK. Examination of cell toxicity and dosing regimen in an in vitro chromosomal aberration assay. In Vitro Cellular and Developmental Biology 1991; 29A:350–352.

Sinha AK, Linscombe VA, Gollapudi BB. Chromosomal aberrations in bone marrow and peripheral blood cells from the same rat. Mutation Research 1989; 226:65–67.

Sinha AK, Gollapudi BB, Linscombe VA, McClintock ML. Utilization or rat lymphocytes for the in vitro chromosomal aberration assay. Mutagenesis 1989; 4:147–153.

Sinha AK, Linscombe VA, Gollapudi BB, Zempel JA, Watanabe PG. Assessment of cell cycle duration on the incidence of sister chromatid exchanges in somatic and spermatogonial cells of the rat. Cancer Research 1988; 48:5953–5955.

Sinha AK, Bruce RJ, Gollapudi BB. Cytokinetics and SCE baselines in rat and human lymphocytes during successive divisions in the presence of different culture media. In Vitro 1988; 24:927–930.

Gollapudi BB, Sutcliffe DJ, Sinha AK. Assessment of cytogenetic response to folic acid deprivation in rat lymphocytes. In Vitro 1986; 22:681–684.

Sinha VK, Linscombe VA, Gollapudi BB, Jersey GC, Park CN. Cytogenetic variability of lymphocytes from phenotypically normal men: Influence of age, smoking, and sample storage. Journal of Toxicology and Environmental Health 1986; 17:327–345.

Gollaupdi BB, Bruce RJ, Linscombe VA, Watanabe PG, Sinha AK. Effect of food and water deprivation on the parameters of the mouse bone marrow micronucleus test. Mutation Research 1986; 173:121.

Gollapudi BB, Bruce RJ, Sinha AK. The role of feeding rejection in Drosophila mutation assays. Mutation Research 1985; 144:13–17.

Sinha AK, Gollapudi BB, Linscombe VA, Bruce RJ, McClintock ML. Analyses for in vitro growth conditions, cytokinetics and sister chromatid exchanges in lymphocytes cultured from the Sprague-Dawley rats. In Vitro 1985; 21:583–587.

Sinha AK, Linscombe VA, Gollapudi BB, Jersey GC, Park CN. Analysis of sister chromatid exchanges in lymphocytes cultured from 71 healthy men, Cell Biology and Toxicology 1985; 1:333–342.

Sinha VK, Linscombe VA, Gollapudi BB, Flake RE, Park CN. Supernumerary chromosomal elements in lymphocytes cultured from phenotypically normal human adult males. Cytobios 1985; 43:49–65.

Sinha AK, Linscombe VA, Gollapudi BB, McClintock ML, Flake RE, Bodner KM. The incidence of spontaneous cytogenetic aberrations in lymphocytes cultured from normal humans for 48 and 72 hr. Canadian Journal of Genetics and Cytology 1984; 26:528–531.

Gollapudi BB, McClintock ML, Linscombe VA, Sinha AK. Evaluation of the effects of food deprivation on micronucleus test results. Toxicology Letters 1984; 21:353–356.

Sinha AK, Linscombe VA, Gollapudi BB, Flake RE. Evaluation of culture media for effects on cell cycle kinetics and incidence of chromosomal aberrations in human blood cells. Canadian Journal of Genetics and Cytology 1983; 26:7–12.

Sinha AK, Linscombe VA, Gollapudi BB, McClintock ML, Thompson DJ. In vivo cytogenetic study in rats maintained for eight days on diets containing Probucol. Mutation Research 1983; 124:91–96.

Gollapudi BB, Linscombe VA, Sinha AK. A note on the utility of Fischer-344 rats in the micronucleus test. Toxicology Letters 1982; 17:201–204.

Blecher SR, Gollapudi B, Kamra OP. Preliminary evidence of genetic control of sex chromosomal synopsis in the mouse. Canadian Journal of Genetics and Cytology 1981; 23:155–157.

Kamra OP, Gollapudi BB. Mutagenicity test with a surfactant formulation, Toximul MP-8 in Drosophila and mouse bone marrow cells. Toxicology Letters 1981; 8:235–239.

Gollapudi BB, Kamra OP, Blecher SR. A search for genetic basis for gonosomal univalency in mice. Cytogenetics and Cell Genetics 1981; 29:241–249.

Kamra OP, Gollapudi B. Mutagenic effects of sodium azide in Drosophila melanogaster. Mutation Research 1979; 66:381–384.

Gollapudi B, Kamra OP. Application of a simple Giemsa staining method in the micronucleus test. Mutation Research 1979; 64:45–46.


Invited Presentations at Recent Workshops and Symposia at National and International Scientific Meetings (2007–2013) 

Gollapudi B. New approaches for genotoxicity assessment and guidance on dealing with positive results. Annual Meeting of the Society of Toxicology, San Antonio, TX, 2013.

Gollapudi B. Genetic toxicity testing related to REACH program. Annual Meeting of the Genetic Toxicology Association, Newark, DE, 2012.

Gollapudi B. Strategies in the application of genetic toxicity data in risk assessment. Annual Meeting of the U.S. Environmental Mutagen Society, Bellevue, WA, 2012.

Gollapudi B. Evaluation and interpretation of genotoxicity data: An Industry Perspective. Annual Meeting of the U. S. Environmental Mutagen Society, Montreal, P.Q., 2011.

Gollapudi B. Beyond positive or negative: A quantitative approach for interpreting genotoxicity data. Annual Meeting of the Society of Toxicology, Salt Lake City, UT, 2010.

Gollapudi B. Genetic toxicology testing: How can we improve its utility to inform risk assessment? Annual Meeting of the Society of Toxicology, Seattle, WA, 2008.

Gollapudi B. Dose-related changes in the transcriptomic response of cells and tissues to genotoxic stress. Annual Meeting of the Society of Toxicology, Charlotte, NC, 2007.

Gollapudi B. Relevance and follow-up of positive results from in vitro genetic toxicity testing. Annual Meeting of the Society of Toxicology, Charlotte, NC, 2007. 

Posters and Oral Presentations Co-authored at Recent National and International Scientific Meetings (2011–2013) 

Alyea RA, LeBaron MJ, Sura R, Murray JA, Pogribny IP, Passage JK, Ellis-Hutchings RG, Moore NP, Carney EW, Gollapudi BB, Rasoulpour RJ. Is the current product safety assessment paradigm protective for transgenerational epigenetic effects? Presented at the Annual Meeting of the Society of Toxicology, San Antonio, TX, 2013.

LeBaron MJ, Kan HL, Schisler MR, Papineni S, Eisenbrandt DL, Gollapudi BB. Suicide inhibition is responsible for the paradoxical absence of CYP2B10 enzyme activity in mouse liver following nitrapyrin or pronamide-induced CAR activation. Presented at the Annual Meeting of the Society of Toxicology, San Antonio, TX, 2013.

Ellis-Hutchings RG, Alyea RA, Marshall VA, LeBaron MJ, Sura R, Moore NP, Gollapudi BB, Rasoulpour RJ. Evaluation of epigenetic and developmental effects in Danio rerio zebrafish embryos following diethylstilbestrol, 17β-estradiol and/or 5-azacytidine treatment. Presented at the Annual Meeting of the Society of Toxicology, San Antonio, TX, 2013.

Schisler MR, LeBaron MJ, Zhang F, Jeong YC, Bartels MJ, Sura R, Hotchkiss JA, Geter DR, Gollapudi B, Moore NP. Dose response and temporality of ethylene oxide-induced macromolecular changes and genotoxicity in mice. Presented at the Annual Meeting of the Society of Toxicology, San Antonio, TX, 2013.

Manjanatha MG, Shelton SD, Chen Y, Parsons BL, Gollapudi B, Moore N, Haber LT, Moore MM. cII mutant frequencies and types of mutations in the lung of big blue mice exposed to ethylene oxide for up to 12 weeks by inhalation. Presented at the Annual Meeting of the Society of Toxicology, San Antonio, TX, 2013.

Parsons BL, Manjanatha MG, Myers MB, McKim KL, Wang Y, Gollapudi B, Moore N, Haber LT, Moore MM. Gain loss of K-Ras mutations in mouse lungs following inhalation exposure to ethylene oxide. Presented at the Annual Meeting of the Society of Toxicology, San Antonio, TX, 2013.

Haber LT, Parsons BL, Moore N, Gollapudi B, Manjanatha MG, LeBaron M, Moore MM. Mode-of-action evaluation for lung tumors in mice exposed to ethylene oxide via Inhalation. Presented at the Annual Meeting of the Society of Toxicology, San Antonio, TX, 2013.

Adenuga D, Kimber I, Dearman R, Thomas R, Gollapudi BB, Woolhiser MR, Boverhof DR. Toxicogenomic investigation into false positive responses in the local lymph node assay (LLNA). Presented at the Annual Meeting of the Society of Toxicology, San Francisco, CA, 2012.

Budinsky R, Gollapudi BB, Albertini RJ, Valentine R, Stavanja M, Teeguarden J, Fensterheim R, Green A, Recio L. Vinyl acetate and acetaldehyde dose - response mutagenicity studies at the TK+- and HPRT locus in human - derived TK6 cells. Presented at the Annual Meeting of the Society of Toxicology, San Francisco, CA, 2012.

Gollapudi BB, Schisler MR, McDaniel LP, Moore MM Reevaluation of the U. S. National Toxicology Program’s (NTP) mouse lymphoma forward mutation assay (MLA) data using current standards reveals limitations of using the program's summary calls. Presented at the Annual Meeting of the Society of Toxicology, San Francisco, CA, 2012. 

Johnson GE, Hernandez LG, Gollapudi BB, Kim J, MacGregor JT, Pottenger LH, van Benthem J, White P, Thybaud V. Relationships between genotoxic thresholds in vitro and in vivo. Presented poster at NC3Rs, London, UK, 2012.

LeBaron MJ, Schisler MR, Kan HL, Sura R, Eisenbrandt DL, Gollapudi BB. Analysis of molecular, cellular, and biochemical changes in the liver of male CD-1 Mice Treated with the herbicide pronamide. Presented at the Annual Meeting of the Society of Toxicology, San Francisco, CA, 2012. 

LeBaron MJ, Schisler MR, Zhang F, Jeong YC, Bartels MJ, Sura R, Hotchkiss J, Geter DR, Gollapudi BB, Moore NP. Bioanalytical, molecular, and genetic alterations in ethylene oxide exposed male B6C3F1 mice. Presented at the Annual Meeting of the Society of Toxicology, San Francisco, CA, 2012.

Terry C, Rasoulpour RJ, LeBaron MJ, Ellis-Hutchings RG, Gollapudi BB, Billington R. Mode of Action (MoA) and Human Relevance Framework (HRF) analysis for Fischer 344 rat leydig cell tumours. Presented at the Annual Meeting of the Society of Toxicology, San Francisco, CA, 2012. 

Woolhiser MR, Adenuga D, Gollapudi BB, Boverhof DR Differential gene expression responses distinguish between dermal and respiratory sensitizers and nonsensitizing irritants in the LLNA. Presented at the Annual Meeting of the Society of Toxicology, San Francisco, CA, 2012.

Carney EW, Rasoulpour RJ, LeBaron MJ, Murray J, Sura R, Ellis-Hutchings RG, Gollapudi BB. Lack of transgenerational effect for vaginal patency and uterine weight in CD-1 mice exposed to diethylstilbestrol or 17beta-estradiol. Presented at SOT 50th Anniversary Annual Meeting & ToxExpo, Washington, D.C., 2011.

Ellis-Hutchings RG, Rasoulpour RJ, Terry C, Gollapudi BB, Billington R. Mode of action evaluation and human relevance analysis for X11422208-induced fetal abnormalities and neonatal death in rats. Presented at SOT 50th Anniversary Annual Meeting & ToxExpo, Washington, D.C., 2011.

Geter DR, Kan HL, Wood A, LeBaron MJ, Gollapudi B, Murray J, Terry C, Rasoulpour RJ, Elcombe CR, Vardy A, Ross J, Billington R. Phenobarbital-like mode of action for liver tumors in CD1 mice and F344 rats exposed to a new developmental compound X11422208. Presented at SOT 50th Anniversary Annual Meeting & ToxExpo, Washington, D.C., 2011.

Gollapudi BB, Kan HL, Wood A, Murray J, Hester S, Goetz A, Currie RJ, Geter DR. Dose response characterization of dietary phenobarbital-induced gene expression, enzyme induction, and cell proliferation in the livers of male and female mice. Presented at SOT 50th Anniversary Annual Meeting & ToxExpo, Washington, D.C., 2011.

LeBaron MJ, Schisler MR, Kan HL, Thomas J, Eisenbrandt DL, Gollapudi BB. Analysis of molecular, cellular, and biochemical changes in the liver of male B6C3F1 mice treated with nitrapyrin – a nitrogen stabilizer. Presented at SOT 50th Anniversary Annual Meeting & ToxExpo, Washington, D.C., 2011.

Myers MB, McKim KL, Wang Y, Gollapudi BB, Moore NP, Haber LT, Moore MM, Parsons BL. Exposure to ethylene oxide for 4 weeks increases K-ras codon 12 GGT-GTT mutation in mouse lung. Presented at 42nd Annual Meeting of the Environmental-Mutagen Society, 2011.

Schisler MR, Gollapudi BB, Moore NP, Pottenger LH. Evaluation of propylene oxide (PO)-induced mutagenicity in a p53-competent, human-derived cell line, TK6. Presented at 42nd Annual Meeting of the Environmental-Mutagen Society, 2011.

Terry C, Ellis-Hutchings RG, Rasoulpour RJ, Gollapudi BB, Billington R. Mode of action evaluation and human relevance framework (HRF) analysis for foetal abnormalities and neonatal death observed in rats. Presented at 39th Annual Conference of the European Teratology Society, Gent, Belgium, 2011.

Terry C, Rasoulpour RJ, Gollapudi BB, Billington R. Innovations in toxicity testing – An integrated approach to testing of a new agrochemical based on sound science and the “3Rs” principles on animal research. Presented at SOT 50th Anniversary Annual Meeting & ToxExpo, Washington, D.C., 2011.

Terry C, Rasoulpour RJ, Gollapudi BB, Billington R. Innovations in toxicity testing—An integrated approach based on the “3R” principles of animal welfare and sound science. Presented at 47th Congress of the European-Societies-of-Toxicology (EUROTOX), Paris, France, 2011.


Prior Experience

Last position held: Director, Mammalian Toxicology, The Dow Chemical Company, 1981–2012

Senior Toxicology Consultant, Cardno ENTRIX, 2012–2013

Academic Appointments

Adjunct Associate Professor, School of Public Health, University of Michigan, 1999–present

Professional Affiliations

Member, Society of Toxicology Scientific Program Committee, 2011–2015

Member, Steering Committee, International Workshops on Genotoxicity Testing (IWGT), 2008–present

Member, OECD Expert Group for Genotoxicity Guidelines, 2009–present

Member, Global Product Strategy Task Force of ICCA, 2009–2012

Member, Board of Trustees, ILSI/HESI, Washington, D.C., 2009–2012

Chair, Emerging Issues Committee, ILSI/HESI, Washington, D.C., 2009–2011

Member, Society of Toxicology Career Resource and Development Committee, 2007–2010

Co-Chair, In Vitro Genotoxicity Committee, ILSI/HESI, Washington, D.C., 2006–2012

Councilor, U.S. Environmental Mutagen Society, 2004–2007


Additional Information

Editorships and Editorial Review Boards

Associate Editor, Toxicological Sciences, 2005–present

Incoming Editor-in-Chief, Environmental and Molecular Mutagenesis (Jan 2017–)

Member, Faculty 1000 Biology, 2006–present

Knowledge

News & Events

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Biology, Dalhousie University, Nova Scotia, 1980
  • M.S., Genetics, Osmania University, India, 1974
  • B.S., Chemistry, Osmania University, India, 1969
  • Post Doc: Genetic Toxicology Laboratory, The Dow Chemical Company, Lake Jackson Research Center

    Post Doc: Molecule Biology; Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health

LANGUAGES

  • Telugu
  • Hindi