Jacqueline Heilman
Jacqueline M. Heilman, Ph.D.
Managing Scientist
Chemical Regulation & Food Safety
  • District of Columbia

Dr. Heilman’s expertise includes chemistry, chemical and mechanistic toxicology, and in vitro and animal models of toxicity as well as gene expression, genomics, and gene regulation. She currently conducts chemistry reviews, chemical and biological study design and data interpretation, and toxicology review for a variety of compounds in food, consumer products, and environmental media. She also provides scientific support for pesticide registration through the placement and monitoring of toxicology studies, as well as performing literature review and composing written scientific analyses.

In Dr. Heilman’s experience at Exponent, she has reviewed complex chemistries and equilibria in food and other matrices including the fate and form of sulfur dioxide in foods, the chemical properties and safety of contaminants present in pharmaceuticals and consumer products, and the chemistry and toxicology of impurities in foods and beverages. She has also performed research comparing genetic similarity between genetically modified (GMO) foods and unmodified foods to support assessments of substantial equivalence.

Prior to joining Exponent, Dr. Heilman conducted research for 9 years in a variety of disciplines including the chemical carcinogenesis of nitrosamines—carcinogens encountered in consumer products and formed in food as a result of nitrate treatment, genetic responses to environmental stress, the toxicology of and cellular response to reactive oxygen species, cigarette smoke-induced pulmonary injury and related gene expression alterations, and antioxidant modulation of gene expression and signaling pathways relevant to lung cancer and inflammation. Dr. Heilman has hands-on expertise in a variety of techniques and approaches including a broad array of analytical chemistry methodologies such as high performance liquid chromatography (HPLC) coupled to a variety detection methods, nuclear magnetic resonance (NMR) spectroscopy, Fourier transform infrared spectroscopy (FT-IR), and several types of mass spectroscopy. She also has expertise in molecular biological techniques including cloning, polymerase chain reaction (PCR), and gene modification and protein expression, as well as biological techniques including enzyme activity analysis and protein and DNA isolation, manipulation, and detection. She has experience in cellular and whole animal approaches to toxicology research including cell culture and in vitro systems as well as genetic animal models of disease. Her credentials manifest a diverse training in academic coursework, experimental research, and chemical risk assessment.

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Environmental Health Sciences, Johns Hopkins University, 2009
  • B.S., Chemistry, University of Maryland, Baltimore County, 2004
  • Research Associate, Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 2002–2004

    NIEHS Post-doctoral Training Grant Fellow, 2009–2010

    NIEHS Pre-doctoral Trainee, 2004–2009

LICENSES & CERTIFICATIONS

Certificate in Risk Sciences and Public Policy, Johns Hopkins University, Bloomberg School of Public Health, 2008

Publications

Heilman JM1, Burke TJ, McClain CJ, Watson WH. Transactivation of gene expression by NF-κB is dependent on thioredoxin reductase activity. Free Radical Biology and Medicine 2011 Oct 15; 51(8):15331542. doi: 10.1016/j.freeradbiomed.2011.06.028. Epub 2011 Jul 4.

Bogen KT, Heilman JM. Reassessment of MTBE cancer potency considering modes of action for MTBE and its metabolites. Critical Reviews in Toxicology 2015 Oct; 45 Suppl 1:1-56. doi: 10.3109/10408444.2015.1052367.

Heilman J, Anyangwe N, Tran N, Edwards, J, Beilstein P, Lopez J. Toxicological evaluation of an olive extract, H35: Subchronic toxicity in the rat. Food and Chemical Toxicology 2015; 84:18e28

Tran NL, Barraj LM, Heilman JM, Scrafford CG. Egg consumption and cardiovascular disease among diabetic individuals: A systematic review of the literature. Diabetes, Metabolic Syndrome and Obesity 2014 Mar; 7:121–137.

Watson WH, Heilman JM, Hughes LL, Spielberger JC. Thioredoxin reductase-1 knock down does not result in thioredoxin-1 oxidation. Biochemical and Biophysical Research Communications 2008 Apr; 68(3):832–836.

Lu X, Heilman JM, Blans P, Fishbein JC. The structure of DNA dictates purine atom site selectivity in alkylation by primary diazonium ions. Chemical Research in Toxicology 2005 Sep; 18(9):1462–1470.

Selected Presentations and Published Abstracts

Heilman JM. Thioredoxin reductase depletion inhibits NF-B in a thioredoxin independent manner. Poster, Society of Toxicology Annual Meeting, 2009.

Heilman JM. Thioredoxin reductase activity modulates NF-B-signaling at the nuclear compartment. Poster, American Association for Cancer Research Annual Meeting, 2008.

Heilman JM. Thioredoxin reductase is required for maximal NF-B-mediated gene expression. Poster, Society of Toxicology Annual Meeting, 2007.

Prior Experience

Post-Doctoral Fellow, Laboratory of Shyam Biswal, Ph.D., Johns Hopkins University, Bloomberg School of Public Health, 2009–2010

Graduate Research Assistant, Laboratory of Walter H. Watson, Ph.D., Johns Hopkins University, Bloomberg School of Public Health, 2004–2009

Teaching Assistant, graduate course in Terrorism and Public Health, Johns Hopkins University, Bloomberg School of Public Health, 2005–2006

Undergraduate Research Assistant, Laboratory of James C. Fishbein, Ph.D., University of Maryland, Baltimore County, 2002–2004

Professional Affiliations

American Chemical Society, 2003–2005, 2010–present

Society of Toxicology, 2007–present

American Public Health Association, 2010–present

Project Experience

Provided toxicology review and support for Generally Recognized as Safe (GRAS) dossiers, food additive petitions, and food contact notifications.

Conducted toxicological literature search and data review to support pesticide registrations and inert tolerance petitions.

Placed and monitored toxicology studies in support of pesticide registration.

Performed toxicology reviews and conducted risk assessments for consumer products, food ingredients, and pharmaceutical and food contaminants.

Designed, placed, and monitored contracted analytical chemistry studies in support of safety assessments for foods and consumer products.

Reviewed dietary and nutrition literature to evaluate the potential for health effects of a food in a susceptible subpopulation.

Additional Information

Research Grants

Research Awards

Co-editor, Advances in Molecular Toxicology, 2012–present

National Institute of Environmental Health Sciences, Post-doctoral fellowship award recipient, T32 ES003819, 2009–2012

NIEHS Training Grant Workshop, 1st place poster presentation, 2009

Society of Toxicology, Carl C. Smith Award for Mechanisms in Toxicology, Finalist, 2007

National Institute of Environmental Health Sciences – Pre-doctoral training grant award recipient, T32 ES003819, 2004-2009

Provost’s Undergraduate Research Award Scholar in Chemistry, University of Maryland, Baltimore County, 2003

Undergraduate Research Symposium, University of Maryland Baltimore County, 1st place poster, Chemical Sciences section, 2003

News & Events

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Environmental Health Sciences, Johns Hopkins University, 2009
  • B.S., Chemistry, University of Maryland, Baltimore County, 2004
  • Research Associate, Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 2002–2004

    NIEHS Post-doctoral Training Grant Fellow, 2009–2010

    NIEHS Pre-doctoral Trainee, 2004–2009

LICENSES & CERTIFICATIONS

Certificate in Risk Sciences and Public Policy, Johns Hopkins University, Bloomberg School of Public Health, 2008