Peng-Meng Kou
Peng-Meng Kou, Ph.D.
Manager
Polymer Science & Materials Chemistry
  • Natick

Dr. Kou specializes in biomedical material characterization and host/device interactions. Her material characterization experience includes X-ray photoelectron (XPS), scanning electron microscopy (SEM), optical profilometry, 3-D confocal microscopy, H-NMR, mass spectrometry, time-of-flight secondary ion mass spectrometry (ToF-SIMS), endotoxin detection, and cytotoxicity of materials.

Dr. Kou has extensive experience in characterizing human immune cell response to dental titanium implants and polymeric biomaterials, including optical, fluorescent, and confocal microscopy, flow cytometry, immunochemistry, high-throughput cell-based assay development, human blood immune cell and cell-line culture, DNA transfection and transduction of cells, multiplex protein and DNA quantification, and cryopreservation of cells. Her human primary blood cell culture work involved blood fractionation for the isolation of leukocytes for further cell differentiation, processing, and analysis. She is also knowledgeable with microfabrication of silicon biosensing devices in a clean room environment.

Prior to joining Exponent, Dr. Kou was a research assistant in the Department of Biomedical Engineering at the Georgia Institute of Technology, where she studied correlations between biomaterial properties and human dendritic cell (an important immune cell type) response. She developed a high-throughput analysis platform to study dendritic cell/biomaterial interactions and created a statistical model to predict immune cell response from material properties. At Exponent, she has developed expertise in the areas of design review and failure analysis of medical devices and pharmaceutical products, customized test method and process development, clinical trial support, and reporting for FDA approval filing.

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Bioengineering, Georgia Institute of Technology (Georgia Tech), 2011
  • B.S., Biological and Environmental Engineering, Cornell University, 2005, magna cum laude
  • Nerem Travel Award for International Collaboration, Georgia Institute of Technology, 2008

    International Student Scholarship, Cornell University, 2003–2005

    Undergraduate Research Award, Cornell University, 2004–2005

    Undergraduate Achievement Award, American Chemical Society, 2003

LANGUAGES

  • Cantonese Chinese
  • Mandarin Chinese

Publications

Kou P, Clevenger J. A Coat for all weathers: The hydrophilic coatings market. MedicalDevice-Network.com, May 31, 2012.

Kou P, Pallassana N, Bowden R, Cunningham B, Joy A, Kohn J, Babensee JE. Predicting biomaterial property-dendritic cell phenotype relationships from multivariate analysis of responses to polymethacrylates. Biomaterials 2012; 33:1699–1713.

Kou PM, Schwartz Z, Boyan BD, Babensee JE. Dendritic cell responses to surface properties of clinical titanium substrates. Acta Biomaterialia 2011; 7:1354–1363.

Kou PM and Babensee JE. Macrophage and dendritic cell phenotypic diversity in the context of biomaterials. Journal of Biomedical Materials Research A 2011; 96:239–260.

Kou PM and Babensee JE. Validation of a high-throughput methodology to assess the effects of biomaterials on dendritic cell phenotype. Acta Biomaterialia 2010; 6:2621–2630.

DeLouise L, Kou PM, Miller BL. Cross-correlation of optical microcavity biosensor response with immobilized enzyme activity: Insights into biosensor sensitivity. Analytical Chemistry 2005; 77: 3222–3230.

Presentations

Kou PM, Pallassana N, Cunningham B, Kohn J, Babensee JE. Elucidation of dendritic cell response-biomaterial property relationships using polymethacrylates with varied material properties. Poster presentation, Georgia Life Sciences Summit, Atlanta, GA, 2010.

Kou PM, Pallassana N, Cunningham B, Kohn J, Babensee JE. Elucidation of dendritic cell response-biomaterial property relationships using polymethacrylates with varied material properties. Poster presentation, Industrial Partners Symposium, Atlanta, GA, 2010.

Kou PM, Pallassana N, Cunningham B, Kohn J, Babensee JE. Elucidation of dendritic cell response-biomaterial property relationships using polymethacrylates with varied material properties. Poster presentation, Biointerface, Atlanta, GA, 2010.

Kou PM, Joy A, Cunningham B, Kohn J, Babensee JE. Dendritic cell response to a library of terpolymers with graded variations in material properties. Podium presentation, Biomedical Engineering Society Annual Fall Meeting, Austin, TX, 2010.

Kou PM, Schwartz Z, Boyan BD, Babensee JE. Dendritic cell response to the roughness and chemistry of titanium surfaces. Podium presentation, Society for Biomaterials Annual Meeting, Seattle, WA, 2010.

Kou PM, Pallassana N, Cunningham B, Kohn J, Babensee JE. Dendritic cell responses to a library of polymethacrylates with varied material properties. Podium presentation, Society for Biomaterials Annual Meeting, Seattle, WA, 2010.

Hotaling N, Kou PM, Song X, Smith D, Cummings R, Babensee JE. Dendritic cell response to surfaces presenting defined glycans. Poster presentation, Society for Biomaterials Annual Meeting, Seattle, WA, 2010.

Hotaling N, Kou PM, Shankar S, Song Z, Smith D, Cummings R, Babensee JE. Denritic cells responses to glycan arrays. Poster presentation, Industrial Partners Symposium, Atlanta, GA, 2009.

Kou PM and Babensee JE. A high throughput methodology to study dendritic cell/biomaterial interactions. Poster presentation, Biomedical Engineering Society Annual Fall Meeting, St. Louis, MO, 2008.

Kou PM and Babensee JE. Validation of a high-throughput methodology to assess effects of biomaterials on dendritic cell phenotype. Poster presentation, Georgia Life Sciences Summit, Atlanta, GA, 2008.

Kou PM and Babensee JE. A simple, high-throughput methodology to study the effects of biomaterials on dendritic cell phenotype. Podium presentation, Society for Biomaterials Annual Meeting, Atlanta, GA, 2008.

Kou PM and Babensee JE. A simple, high-throughput methodology to study the effects of biomaterials of dendritic cell phenotype. Poster presentation, BME 10th Anniversary Symposium, Atlanta, GA, 2008.

Kou PM, Baumgart T, Webb WW. Protein affinity on co-existing fluid phases and its effect on biomembranes. Poster presentation, Learning Initiatives for Future Engineers, Ithaca, NY, 2005.

Kou PM, DeLouise L, Miller BL. Free-standing porous silicon microcavity as a biosensing element. Poster presentation, Graduate Education in Biomedical Sciences Program, University of Rochester, NY, 2004.


Prior Experience

Research Assistant, Department of Biomedical Engineering, Georgia Institute of Technology, 2005–2011

Visiting Scholar, Tissue Regeneration, University of Twente, Netherlands, 2009.

Professional Affiliations

Society for Biomaterials—SFB

Biomedical Engineering Society—BMES

Society of Women Engineers—SWE

News & Events

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Bioengineering, Georgia Institute of Technology (Georgia Tech), 2011
  • B.S., Biological and Environmental Engineering, Cornell University, 2005, magna cum laude
  • Nerem Travel Award for International Collaboration, Georgia Institute of Technology, 2008

    International Student Scholarship, Cornell University, 2003–2005

    Undergraduate Research Award, Cornell University, 2004–2005

    Undergraduate Achievement Award, American Chemical Society, 2003

LANGUAGES

  • Cantonese Chinese
  • Mandarin Chinese