James Lamb
James C. Lamb, IV, Ph.D., DABT, Fellow ATS
Principal Scientist
Health Sciences
  • Alexandria, VA

Dr. Lamb has extensive experience in toxicology, risk assessment, and scientific and regulatory policy.  His publications reflect his unique experience in endocrine disrupting chemicals, reproductive and developmental toxicants, carcinogens, and systemic toxicity.  He is a Diplomate of the American Board of Toxicology and a Fellow of the Academy of Toxicological Sciences.  Dr. Lamb served as President of the American Board of Toxicology and served on numerous other scientific boards or committees.  He also served as the President of the Academy of Toxicological Sciences.

Dr. Lamb has worked in various federal government positions.  Dr. Lamb was the Head of the Fertility and Reproduction Group at the National Toxicology Program (NTP), where he developed new toxicology testing systems, evaluated new systems, and tested substances for reproductive and developmental toxicity.  He also served as a chemical manager for general toxicity assessment for various chemicals at the NTP.  Dr. Lamb then moved to the U.S. Environmental Protection Agency as the Special Assistant to the Assistant Administrator for Pesticides and Toxic Substances.  Dr. Lamb has provided consulting services to numerous clients for over twenty years.  Over the years he has worked on issues affecting pesticides, industrial chemicals, consumer products, pharmaceuticals, medical devices, and food additives.

Dr. Lamb served on several National Academy of Sciences committees on risk assessment, endocrine disruption, and toxicology.  He has been an adjunct faculty member of the Johns Hopkins School of Public Health and the University of the North Carolina School of Public Health.  He has served on various ILSI panels, including one that made substantial contributions in Agricultural Chemicals Safety Assessment, and still serves as an academic advisor to the ILSI Committee on Developmental and Reproductive Toxicology.  He sits on the SOT’s Awards Committee and the Professional Needs Assessment Task Force.  He has recently served on contract review committees for the National Institute of Mental Health and the National Institute of Environmental Health Sciences.  He served as an Associate Editor and is currently on the Editorial Board of the journal Environmental Health Perspectives.  He has published over a hundred peer-reviewed publications and numerous abstracts and book chapters.  

CREDENTIALS & PROFESSIONAL HONORS

  • J.D., North Carolina Central University, 1986, magna cum laude
  • Ph.D., Pathology, University of North Carolina, Chapel Hill, 1975
  • A.B., Chemistry, University of North Carolina, Chapel Hill, 1973

LICENSES & CERTIFICATIONS

Admitted to the Bar of the District of Columbia, 1988

Diplomate of the American Board of Toxicology, 1981

Fellow, Academy of Toxicological Sciences (ATS)

Publications

Lamb JC, Boffetta P, Foster WG, Goodman JE, Hentz KL, Rhomberg LR, Staveley J, Swaen G, Van Der Kraak G, Williams AL. Critical comments on the WHO-UNEP State of the Science of Endocrine Disrupting Chemicals – 2012. Regul Toxicol Pharm 2014; 69:22–40.

Marty MS, Neal BH, Zablotny CL, Yano BL, Andrus AK, Woolhiser MR, Boverhof DR, Saghir SA, Perala AW, Passage JK, Lawson MA, Bus JS, Lamb JC, Hammond L. An F1 –extended one –generation reproductive toxicity study in Crl:CD(SD) rats with 2,4-dichlorophenoxyacetic acid. Toxicol Sci 2013.

Juberg DR, Borghoff SJ, Becker RA, Casey W, Hartung T, Holsapple M, Marty MS, Mihaich EM, Van Der Kraak G, Wade MG, Willett CE, Andersen ME, Borgert CJ, Coady KK, Dourson ML, Fowle III JR, Gray LE, Lamb JC, OrtegoLS, Schug TT, Toole CM, Zorrilla LM, Kroner OL, Patterson J, Rinckel LA, Jones BR. Lessons learned, challenges, and opportunities: The U.S. Endocrine Disruptor Screening Program. ALTEX 2014; 31:63–78.

Reiss R, Neal B, Lamb JC, Juberg DR. Acetylcholinesterase inhibition dose-response modeling for chlorpyrifos and chlorpyrifos-oxon. Regul Toxicol Pharmacol 2012; 63:124–131.

Lamb J, Hentz K, Schmitt D, Tran N, Jonker D, Junker K. A one-year oral toxicity study of sodium stearoyl lactylate (SSL) in rats. Food Chem Toxicol 2010; 48:2663–2669.

Neal BH, Collins JJ, Strother DE, Lamb JC. Weight-of-the-evidence review of acrylonitrile reproductive and developmental toxicity studies. Crit Rev Toxicol 2009; 39(7):589–612.

Lamb JC 4th, Neal BH, Goodman JI. Risk assessment of toxaphene and its breakdown products: time for a change? Crit Rev Toxicol 2008; 38(9):805–815. Review.

Nichols BR, Hentz KL, Aylward L, Hays SM, Lamb JC. Age-specific reference ranges for polychlorinated biphenyls (PCB) based on the NHANES 2001-2002 survey. J Toxicol Environ Health A 2007; 70(21):1873–1877.

Lamb JC, Hentz KL. Toxicological review of male reproductive effects and trichloroethylene exposure: Assessing the relevance to human male reproductive health. Reprod Toxicol 2006; 22(4):557–563.

Carmichael NG, Barton HA, Boobis AR, Cooper RL, Dellarco VL, Doerrer NG, Fenner–Crisp PA, Doe JE, Lamb JC Pastoor TP. Agricultural chemical safety assessment: a multi–sector approach to the modernization of human safety requirements. Crit Rev Toxicol 2006 36(1):1–7.

Cooper RL, Lamb JC, Barlow SM, Bentley K, Brady AM, Doerrer NG, Eisenbrandt DL, Fenner–Crisp PA, Hines RN, Irvine LFH, Kimmel CA, Koeter H, Li AA, Makris SL, Sheets LP, Speijers GJA, Whitby KE. A tiered approach to life stages testing for Agricultural Chemical Safety Assessment. Crit Rev Toxicol 2006 36(1):69–68.

Aylward LL, Lamb JC, Lewis SC. Issues in risk assessment for developmental effects of 2,3,7,8–tetrachlorodibenzo–p–dioxin and related compounds. Toxicol Sci 2005; 87(1):3–10.

Lamb JC, Koeter HBWM, Becker R, Gies A, Davies L, Inoue T, Jacobs A, Lyons G, Matsumoto M, Timm G. Risk management options for endocrine disruptors in national and international programs. Pure Appl Chem 2003; 75(11–12):2549–2553.

Hentz KL, Oredugba BO, Lamb JC. A review of the epidemiological evidence for risk of breast cancer associated with exposure to polychlorinated biphenyls (PCBs). Int J Toxicol 2002; 21(6):526–527.

Brown NA, Lamb JC, Brown SM, Neal BH. A review of the developmental and reproductive toxicity of styrene. Regul Toxicol Pharmacol 2000; 32(3):228–247.

Goodman JI, Brusick DJ, Busey WM, Cohen SM, Lamb JC, Starr TB. Reevaluation of the cancer potency factor of toxaphene: Recommendations from a peer review panel. Toxicol Sci 2000; 55:3–16.

Gray GM, Goldstein BD, Bailar J, Davis DL, Delzell E, Dost F, Greenberg RS, Hatch M, Hodgson E, Ibrahim MA, Lamb JC, Lavy T, Mandel J, Monson R, Robson M, Shore R, Graham JD. The Federal Government’s Agricultural Health Study: A criticial review with suggested improvements. Hum Ecol Risk Assess 2000; 6(1):47–71.

Lamb JC, Brown SM. Chemical testing strategies for predicting health hazards to children. Reprod Toxicol 2000; 14(2):83–94.

Lemasters GK, Perreault SD, Hales BF, Hatch M, Hirshfield AN, Hughes CL, Kimmel GL, Lamb JC, Pryor JL, Rubin C, Seed JG. Workshop to identify critical windows of exposure for children's health: reproductive health in children and adolescents work group summary. Environ Health Perspect 2000; 108(3):505–509.

Safe SH, Foster WG, Lamb JC, Newbold RR, Van Der Kraak G. Estrogenicity and endocrine disruption. CAST 2000; p. 16.

Hill MO, Lamb JC. Implications of EPA’s proposed policy for its endocrine disruptor screening program: a rose is a rose, but is a flower a rose? EPA Administrative Law Reporter 1999; 13:341–356.

Lamb JC. Endocrine disruptors: the biological basis for concern. ABA Section of Natural Resources, Energy, and Environmental Law Newsletter 1999; 30(4):6–7.

Wilkinson CF, Lamb JC. The potential health effects of phthalate esters in children’s toys: A review and risk assessment. Regul Toxicol Pharmacol 1999; 30:140–155.

Moore JA, Callahan M, Chapin R, Daston GP, Erickson D, Faustman E, Foster P, Friedman JM, Goldman L, Golub M, Hughes C, Kavlock RJ, Kimmel CA, Lamb JC, Lewis SC, Lunchick C, Morseth S, Mortensen BK, O'Flaherty EJ, Palmer AK, Ramlow J, Rodier PM, Rudo K, Ryan L, Schewtz BA, Scialli A, Selevan S, Tyl R, Campbell M, Carney E, Faber W, Hellwig J, Murphy SR, Smith MA, Strong PL, Weiner M. An assessment of boric acid and borax using the IEHR Evaluation Process for Assessing Human Developmental and Reproductive Toxicity of Agents. Reprod Toxicol 1997; 11(1):123–160.

Reel J, Lamb J, Neal B. Survey and assessment of mammalian estrogen biological assays for hazard characterization. Fundam Appl Toxicol 1996; 34:288–305.

Moore JA, Daston GP, Faustman E, Golub MS, Hart WL, Hughes C Jr, Kimmel C, Lamb JC, Schwetz BA, Scialli AR. An evaluative process for assessing human reproductive and developmental toxicity of agents. Reprod Toxicol 1995; 9:61–95.

Lamb JC, Chapin RE. Testicular and germ cell toxicity: In vitro approaches. Reprod Toxicol 1993; 7:17–22.

Bossert NL, Reel JR, Lawton AD, George JD, Lamb JC. Reproductive toxicity of triethylene glycol and its diacetate and dimethyl ether derivatives in a continuous breeding protocol in Swiss CD–1 mice. Fundam Appl Toxicol 1992; 18:602–608.

Reel JR, Tyl RW, Lawton AD, Lamb JC. Reproductive toxicity evaluation of acetaminophen in Swiss CD–1 mice using a continuous breeding protocol. Fundam Appl Toxicol 1992; 18(2):233–239.

Reel JR, Tyl RW, Lawton AD, Lamb JC. Reproductive toxicity of sulfamethazine in Swiss CD–1 mice during continuous breeding. Fundam Appl Toxicol 1992; 18:609–615.

Lamb JC. Regulating carcinogenic pesticides. Chemtech 1991; 21(1):43–49.

George JD, Reel JR, Myers CB, Lamb JC, Heindel JJ. Reproductive toxicity of trichloroethylene (TCE) in mouse and rat breeding pairs. Toxicologist 1990; 10(1):209.

Heindel JJ, Gulati DK, Russell S, Reel JR, Lawton AD, Lamb JC. Assessment of ethylene glycol monobutyl and monophenyl ether reproductive toxicity using a continuous breeding protocol in Swiss Cd–1 mice. Fundam Appl Toxicol 1990;15:683–696.

Williams J, Reel JR, George JD, Lamb JC. Reproductive effects of diethylene glycol and diethylene glycol monoethyl ether in Swiss CE–1 mice assessed by a continuous breeding protocol. Fundam Appl Toxicol 1990; 14:622.

Heindel JJ, Gulati DK, Mounce RC, Russell SR, Lamb JC. Reproductive toxicity of three phthalic acid esters in a continuous breeding protocol. Fundam Appl Toxicol 1989; 12:508–518.

Lamb JC. How to implement alternatives to the draize eye irritation test for pesticides. J Toxicol Cutaneous Ocul Toxicol 1989; 8:93–101.

Morrissey RE, Lamb JC, Morris RW, Chapin RE, Gulati DK, Heindel JJ. Evaluation of the reproductive assessment by continuous breeding. Teratology 1989; 39(5):469–470.

Morrissey RE, Lamb JC, Morris RW, Chapin RE, Gultai D, Heindel JJ. Results and evaluations of 48 continuous breeding reproduction studies conducted in mice. Fundam Appl Toxicol 1989; 13(4):747–777.

Treinen KA, Chapin RE, Gulati DK, Mounce R, Morris LZ, Lamb JC. Reproductive toxicity of 2,2–bis (bromomethyl)–1,3–propanediol in a continuous breeding protocol in Swiss (CD–1) mice. Fundam Appl Toxicol 1989; 13:245–255.

Chapin RE, George JD, Lamb JC. Reproductive toxicity of tri–o–cresyl phosphate in a continuous breeding protocol in Swiss (CD–1) mice. Fundam Appl Toxicol 1988; 10:344–354.

Collins JJ, Elwell MR, Lamb JC, Manus AG, Heath JE, Makovec GT. Subchronic toxicity of orally–administered (gavage and dosed–feed) theophylline in Fischer 344 rats and B6C3F1 mice. Fundam Appl Toxicol 1988; 11(3):472–484.

Francis EZ, Kimmel GL, Chitlik L, Christian M, Collins T, Lamb J, Palmer A, Ruddick J, Zenick H. Proceedings, workshop on one- and two-generation reproductive effects studies. J Am Coll Toxicol 1988; 7:911–925.

Lindamood C, Lamb JC, Bristol DW, Collins JJ, Heath JE, Prejean JD. Studies on the short–term toxicity of theophylline in rats and mice. Fundam Appl Toxicol 1988; 10(3):477–489.

Lindstrom P, Harris M, Ross M, Lamb JC, Chapin RE. Comparison of changes in serum androgen binding protein with germinal epithelial damage in infertility induced by di–n–pentylphthalate. Fundam Appl Toxicol 1988; 11(3):528–539.

Morrissey RE, Collins JJ, Lamb JC, Manus AG, Gulati DK. Reproductive effects of theophylline in mice and rats. Fundam App. Toxicol 1988; 10(3):525–536.

Morrissey RE, Lamb JC, Schwetz BA, Teague JL, Morris RW. Association of sperm, vaginal cytology, and reproductive organ weight data with results of continuous breeding reproduction studies in Swiss (CD–1) mice. Fundam Appl Toxicol 1988; 11:359–371.

Morrissey RE, Schwetz BA, Lamb JC, Ross MD, Teague JL, Morris RW. Evaluation of rodent sperm, vaginal cytology, and reproductive organ weight data from national toxicology program 13–week studies. Fundam Appl Toxicol 1988; 11:343–358.

Steele VE, Morrissey RE, Elmore EL, Gurganus–Rocha D, Wilkinson BP, Curren RD, Schmetter BS, Louie AT, Lamb JC, Yang LL. Evaluation of two in vitro assays to screen for potential developmental toxicants. Fundam Appl Toxicol 1988; 11:673–684.

Lamb JC 4th, Chapin RE, Teague J, Lawton AD, Reel JR. Reproductive effects of four phthalic acid esters in the mouse. Toxicol Appl Pharmacol 1987; 88:255–269.

Somkuti SG, Lapadula DM, Chapin RE, Lamb JC, Abou-Donia MD. Reproductive tract lesions resulting from subchronic administration (63 days) of tri-o-cresyl phosphate in male rats. Toxicol Appl Pharmacol 1987; 89:49–63.

Somkuti SG, Lapadula DM, Chapin RE, Lamb JC, Abou-Donia MD. Testicular toxicity following oral administration of tri-o-cresyl phosphate (TOCP) in roosters. Toxicol Lett 1987; 37(3):279–290.

Somkuti SG, Lapadula DM, Chapin RE, Lamb JC, Abou-Donia MD. Time course of the tri-o-cresyl phosphate-induced testicular lesion in F344 rats: Enzymatic, hormonal, and sperm parameter studies. Toxicol Appl Pharmacol 1987; 89:64–72.

Steele VE, Morrissey RE, Lamb JC, Wilkinson BP, Rocha DG, Murphy DD, Elmore EL. Evaluation of two in vitro assays to screen for potential teratogens. Environ Mutagen 1987; 9(Suppl. 8):103.

Agarwal DK, Eustis S, Lamb JC 4th, Jameson CW, Kluwe WM. Influence of dietary zinc on di(2–ethylhexyl)phthalate–induced testicular atrophy and zinc depletion in adult rats. Toxicol Appl Pharmacol 1986; 84:12–24.

Agarwal DK, Eustis S, Lamb JC 4th, Reel JR, Kluwe WM. Effects of di(2–ethylhexyl)phthalate on the gonadal pathophysiology, sperm morphology and reproductive performance of male rats. Environ Health Perspect 1986; 65:343–350.

Birnbaum LS, Harris MW, Miller CP, Pratt RM, Lamb JC. Synergistic interaction of 2,3,7,8–tetrachlorodibenzo–p–dioxin and hydrocortisone in the induction of cleft palate in mice. Teratology 1986; 33:29–35.

Dunnick JK, Harris MW, Chapin RE, Hal, LB, Lamb JC 4th. Reproductive toxicology of methyldopa in male F344/N rats. Toxicology 1986; 41:305–318.

Lamb JC, Harris MW, McKinney JD, Birnbaum LS. Effects of thyroid hormones on the induction cleft palate by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57B1/6N mice. Toxicol Appl Pharmacol 1986; 84:115–124.

Lamb JC, Huff JE, Haseman JK, Murthy AS, Lilja H. Carcinogenesis studies of 4,4'–methylenedianiline dihydrochloride given in drinking water to F344/N rats and B6C3F1 mice. J Toxicol Environ Health 1986; 18:325–337.

Lamb JC, Ross MD, Chapin RE. Experimental methods for studying male reproductive function in standard toxicology studies. J Amer Toxicol 1986; 5:225–234.

Schrader SM, Chapin RE, Turner TW, Ratcliffe JM, Burg JR, Ross MD, Lamb JC. The effect of ethylene dibromide on sperm characteristics. J Androl 1986; 7(2):27.

Steele VE, Elmore EL, Lamb JC, Morrissey RE, Gurganus DJ, Murphy DD, Curren RD, Schmetter BS, Yang LL. Validation of two short–term in vitro assays to identify potential teratogens. Teratology 1986; 33(3):61C.

Yang LL, Steele VE, Lamb JC, Schechtman LM, Curren RD, Conklin PM, Toney S, Elmore EL. Evaluation and validation of two in vitro teratology systems: Results from the first twelve coded compounds. Environ Mutagen 1986; 8(Suppl 6):94.

Agarwal DK, Maronpot RR, Lamb JC 4th, Kluwe WM. Adverse effects of butylbenzylphthalate on the reproductive and hematopoietic systems of male rats. Toxicology 1985; 35:189–206.

Birnbaum LS, Weber H, Harris MW, Lamb JC 4th, McKinney JC. Toxic interaction of specific polychlorinated biphenyls and 2,3,7,8–tetrachlorodibenzo–p–dioxin: Increased incidence of cleft palate in mice. Toxicol Appl Pharmacol 1985; 77:292–302.

Chapin RE, Dutton SL, Ross MD, Lamb JC 4th. Effects of ethylene glycol monomethyl ether (EGME) on mating performance and epididymal sperm parameters in F344 rats. Fundam Appl Toxicol 1985; 5:182–189.

Chapin RE, Dutton SL, Ross MD, Swaisgood RW, Lamb JC 4th. The recovery of the testis over 8 weeks after short–term dosing with ethylene glycol monomethyl ether: Histology, cell specific enzymes, and retetestis fluid protein. Fundam Appl Toxicol 1985; 5:515–525.

Lamb JC 4th. Reproductive toxicity testing: Evaluating and developing new testing systems. J Am Coll Toxicol 1985; 4:163–172.

Lamb JC 4th, Jameson CW, Choudhury H, Gulati DK. Fertility assessment by continuous breeding: Evaluation of diethylstilbestrol and a comparison of results from two laboratories. J AmColl Toxicol 1985; 4:173–191.

Lamb JC 4th, Maronpot RR, Gulati DK, Russell VS, Hommel–Barnes L, Sabharwal PS. Reproductive and developmental toxicity of ethylene glycol in the mouse. Toxicol Appl 1985; Pharmacol 81:100–112.

Reel JR, Lawton HD, Wolkowski–Tyl R, Davis GW, Lamb JC 4th. Evaluation of a new reproductive toxicology protocol using diethylstilbestrol (DES) as a positive control compound. J Am Coll Toxicol 1985; 4:147–162.

Chapin RE, Lamb JC 4th. Effects of ethylene glycol monomethyl ether on various parameters of testicular function in the F344 rat. Environ Health Perspect 1984; 57:219–224.

Chapin RE, Dutton SL, Ross MD, Sumrell BM, Lamb JC 4th. Development of reproductive tract lesions in male F344 rats after treatment with dimethyl methylphosphonate. Experiment Molec Pathol 1984; 41:126–140.

Chapin RE, Dutton SL, Ross MD, Sumrell BM, Lamb JC 4th. The effects of ethylene glycol monoethyl ether on testicular histology in F344 rats. J Androl 1984; 5:369–380.

Chapin RE, Ross MD, Lamb JC 4th. Immersion fixation methods for glycol methacrylate embedded testis. Toxicol Pathol 1984; 12:221–227.

Dunnick JK, Gupta BN, Harris MW, Lamb JC 4th. Reproductive toxicity of dimethyl methyl phosphonate in the male Fischer 344 rat. Toxicol Appl Pharmacol 1984; 72:379–387.

Dunnick JK, Solleveld HA, Harris MW, Chapin J, Lamb JC 4th. Dimethyl methylphosphonate induction of dominant lethal mutations in male mice. Mutat Res 1984; 138(2–3):213–218.

Hudson PM, Yoshikawa K, Ali SF, Lamb JC 4th, Reel JR, Hong JS. Estrogenic activity of chlorodecone (Kepone) on the hypothala–micpituitary axis: Effects on the pituitary enkephalin system. Toxicol Appl Pharmacol 1984; 74:383–389.

Lamb JC 4th, Gulati DK, Russell VS, Hommel L, Sabharwal PS. Reproductive toxicity of ethylene glycol monoethyl ether tested by continuous breeding of CD–1 mice. Environ Health Perspect 1984; 57:85–90.

Weber H, Lamb JC, Harris MW, Moore JA. Teratogenicity of 2.3.7.8–tetrachlorodibenzofuran (TCDF) in mice. Toxicol Lett 1984; 20:183–188.

Weisburger EK, Murthy AS, Lilja HS, Lamb JC. Neoplastic response of F344 rats and B6C3F1 mice to 4,4'–methylenebis (n,n–dimethyl) benzeneamine, 4,4'–oxydianiline and 4,4'–methylenedianiline. J Natl Cancer Inst 1984; 72:1457–1463.

Kluwe WM, Gupta BN, Lamb JC 4th. Comparative effects of 1.2–dibromo–3–chloropropane (DBCP) and its metabolites 3–chloro–1,2–propaneoxide (epichlorohydrin), 3–chloro–1,2–propanediol (alphachlorohydrin) and oxalic acid, on the urogenital system of male rats. Toxicol Appl Pharmacol 1983; 70:67–86.

Kluwe WM, Lamb JC, IV, Greenwell A, Harrington FW. 1.2–Dibromo–3–chloropropane (DBCP)–induced fertility in male rats mediated by a post–testicular effect. Toxicol Appl Pharmacol 1983; 71:294–298.

Sim FRP, Matsumoto N, Goulding EH, Denny KH, Lamb J, Keeler RF, Pratt RM. Specific craniofacial defects induced by Jervine in the cultured rat embryo. Teratog Carcinog Mutagen 1983; 3:111–121.

Ali SF, Hong JS, Wilson WE, Lamb JC 4th, Moore JA, Mason GA, Bondy SC. Subchronic dietary exposure to rats to chlordecone (Kepone) modifies levels of hypothamamic B–endorphin. Neurotoxicology 1982; 3:119–124.

Kimmel CA, Lamb JC 4th, Hardin BD. Approaches to reproductive and development toxicology testing in the National Toxicology Program. Contracept Deliv Syst 1982; 3(3–4):84.

Lamb JC 4th, Moore JA. Effects of phenoxy acid herbicides on male reproductive function. Contracept Deliv Syst 1982; 3(3–4):171.

Lamb JC, Ross MD, Allen KM, Dozier MM, Reel JR. Differential estrotgenic response of the pituitary and uterus to kepone chlordecone in the F–344 rat. Biol Reprod 1982; 26(Suppl. 1):109A.

Korach KS, Lamb JC 4th. Estrogen action in the mouse uterus: differential nuclear localization of estradiol in uterine cell types. Endocrinology 1981; 108:1989–1991.

Lamb JC 4th, Marks TA, Gladen BC, Allen JW, Moore JA. Male fertility, sister chromatid exchange, and germ call toxicity following exposure to mixtures of chlorinated phenoxy acids containing 2,3,7,8–tetrachlorodibenzo–p–dioxin. J Toxicol Environ Health 1981; 8:825–834.

Lamb JC 4th, Marks TA, McConnell EE, Abeywickrama K, Moore JA. Toxicity of chlorinated phenoxy acids in combination with 2,3 7,8–tetrachlorodibenzo–p–dioxin in C57BL/6 male mice. J Toxicol Environ Health 1981; 8:815–824.

Lamb JC 4th, Moore, JA, Marks TA, Haseman JK. Development and viability of offspring of male mice treated with chlorinated phenoxy acids and 2.3.7.8–tetrachlorodibenzo–p–dioxin. J Toxicol Environ Health 1981; 8:835–844.

Lamb JC 4th, Newbold RR, McLachlan JA. Visualization by light microscopy and scanning electron microscopy of reproductive tract lesions in female mice treated transplacentally with diethylstilbestrol. Cancer Res 1981; 41:4057–4062.

Lamb JC 4th, Ingram P. Drying of biological specimens for scanning electron microscopy directly from ethanol. SEM 1979; 3:459–464.

Lamb JC 4th, McLachlan JA. Structural abnormalities on the surface of the female mouse genital tract exposed to diethylstilbestrol. Anat Rec 1979; 193(3):597.

Lamb JC 4th, Newbold, RR, McLachlan JA. Evaluation of the transplacental toxicity of diethylstilbestrol with the scanning electron microscope. J Toxicol Environ Health 1979; 5:599–603.

Suzuki Y, Lamb JC 4th, McLachlan JA. Age dependent morphological changes in the seminal colliculus in male mice: light microscopic and scanning electron microscopic study. Anat Embryol (Berl) 1979; 158:1–12.

Lamb JC 4th, Newbold RR, McLachlan JA. Modulation of the female genital tract by hormones. Scan Electron Microsc 1978; 2:773–778.

Lamb JC 4th, Newbold RR, McLachlan JA. PERI pubertal development of the female genital tract scanning electron microscopic studies. J Toxicol Environ Health 1978; 4(2/3):487.

Lamb JC 4th, Newbold RR, Stumpf WE, McLachlan JA. Transitional changes in the surface epithelium of the cycling mouse vagina, cervix and uterus: Scanning electron microscopic studies. Biol Rep 1978; 19:701–711.

McLachlan JA, Metzler M, Lamb JC 4th. Possible role of peroxidase in the diethylstilbestrol-induced lesions of the Syrian hamster kidney. Life Sci 1978; 23:2521–2524.

McLachlan JA, Lamb JC 4th, Stumpf WW, Newbold RR. Altered surface epithelium in the female mouse genital tract following prenatal exposure to diethylstilbestrol. J Toxicol Environ Health 1977; 3(1–2):366.

McLachlan JA, Newbold RR, Lamb JC. Genital tract abnormalities in mice following gestational exposure to diethylstilbestrol. Environ Health Perspect 1977; 20:240.

Stumpf WE, Hellreich WA, Aumuller G, Lamb JC 4th, Sar M. The collicular recess organ: Evidence for structural and secretory specialization of ventricular lining in the collicular recess. Cell Tissue Res 1977; 184:29–44.

Nopanitaya W, Lamb JC 4th, Grisham JW, Carson JL. Effect of hepatic venous outflow obstruction on pores and fenestrations in sinusoidal epithelium. Br J Exp Pathol 1976; 57:604–609.

Geratz JD, Lamb JC 4th. Influence of bile duct ligation on exocrine pancreatic secretory activity in the rat. Am J Physiol 1974; 228:119–122.

Letters to Editor, Books and Book Chapters


Lamb, JC. Chapter 3.01. Introduction to toxicology testing and evaluation. Comprehensive Toxicology, Second Edition 2010, Volume 3 Toxicology Testing and Evaluation. Lamb JC (ed), Elsevier: Oxford, 2010.

Lamb JL, Hentz KL. Chapter 3. Impact of endocrine disruptor policies and regulations. In: Endocrine Toxicology, Volume 27 in Target Organ Toxicology. Eldridge JS, Stevens JT (eds), New York: Informa Healthcare, 2010.

Lamb JC, Neal BH, Ginevan ME, Bus JS, Mahlburg WM. Herbicide effects on embryo implantation and litter size. Environ Health Perspect 2003; 111(9):A450.

Lamb JC. Current issues in toxicity testing. New endpoints in reproductive toxicology and their relevance to risk assessment. pp. p. 98–99. In: An Evaluation and Interpretation of Reproductive Endpoints for Human Health Risk Assessment. ILSI Press, 1998.

Lamb JC. Introduction to exposures to endocrine–active substances in the human diet. pp. 131–134. In: Human Diet and Endocrine Modulation, Estrogenic and Androgenic Effects. ILSI Press, 1998.

Lamb JC. New endpoints in reproductive toxicology and their relevance to risk assessment. Chapter III–Current Issues in Toxicity Testing. In: Evaluation and Interpretation of Reproductive Endpoints for Human Health Risk Assessment, 1998.

Lamb JC. Testing chemicals for endocrine–modulating activity and using the test data in risk assessments. pp. 220–228. In: Human Diet and Endocrine Modulation, Estrogenic and Androgenic Effects. ILSI Press, 1998.

Lamb JC, Balcomb R, Bens C, Cooper R, Gorsuch, Matthiessen P, Peden-Adams M, Voit E. Hazard identification and epidemiology. Chapter 2, pp. 17–37. In: Principles and Processes for Evaluating Endocrine Disruption in Wildlife, 1998.

Lamb JC, Petersen BJ, Tomerlin R, Barraj LM, Driver JH, Ginevan ME, Pandian MD, Sielken RL, Valez–Flores C. Aggregate exposure assessments for pesticides. pp. D1–D143. In: Aggregate Exposure Assessment. An ILSI Risk Science Institute Workshop Report, 1998.

Lamb JC. Can today’s risk assessment paradigms deal with endocrine active chemicals? Inside EPA’s Risk Policy Report, Vol. 4, No. 9, September 1997.

Lamb JC, IV. Assessment of risk for chemicals affecting the endocrine system. pp. 5.1–5.10. In: Endocrine Disruptors: Advances in Measuring and Analyzing Their Effects. Guttry P, Savatge LM (eds), Massachusetts: International Business Communications, Inc., 1997.

Stevens JT, Tobia A, Lamb JC, Tellone C, O’Neal F. FIFRA subdivision F testing guidelines: Are these tests adequate to detect potential hormonal activity for crop protection chemicals? J Tox Environ Health 1997; 50:415–431.

Johnson EM, Grabowski CT, Jensh RP, Juchau MR, Kimmel CA, Lamb J, Manson JM, Marks TA, Scott WJ, Sheehan D, Staples RE, Sullivan FM, Trosko TE. Developmental toxicology. pp. 391–402. In: Advances in Modern Environmental Toxicology. Volume XVIII, 1990.

Lamb JC. The design and use of multigeneration breeding studies for the identification of reproductive toxicants. pp. 131–155. In: Toxicology of the Male and Female Reproductive Systems. Washington, DC, Hemisphere Publishing Corp, 1989.

Foster PMD, Lamb JC. Introduction. pp. 1–6. In: Physiology and Toxicology of Male Reproduction. Lamb JC and Foster PMD (eds), Orlando, FL: Academic Press, 1988.

Lamb JC. How EPA weighs risk and benefits in pesticide regulation. pp. 39–51. In: Regulation of Pesticides: Science, Law and Media. Rockville, MD: Government Institutes Inc., 1988.

Lamb JC. Male reproductive toxicity testing. pp. 137–154. In: Physiology and Toxicology of Male Reproduction. Lamb JC, Foster PMD (eds), Orlando, FL: Academic Press, 1988.

Lamb JC. Pesticide regulation related to carcinogenicity. In: ACS Symposium Series. 414 Carcinogenicity and Pesticides: Principles, Issues, and Relationships. Ragsdale NN, Menzer RE (eds), 196th National Meeting of the American Chemical Society, Los Angeles, CA, September 25–30, 1988.

Lamb JC, IV. Fundamentals of male reproductive toxicity testing. pp. 137–154. In: Physiology and Toxicology of Male Reproduction. Lamb JC, IV, Foster PMD (eds), San Diego, CA: Academic Press, 1988.

Lamb JC, IV, Foster PMD. Physiology and toxicology of male reproduction. In: Physiology and Toxicology of Male Reproduction. Lamb JC, IV, Foster PMD (eds), San Diego, CA: Academic Press, 1988.

Lamb JC, IV, Chapin RE. Experimental models of male reproductive toxicology. pp. 85–115. In: Target Organ Toxicology Series: Endocrine Toxicology. Thomas JA, Korach KS, McLachlan JA (eds), New York: Raven Press, 1985.

Reel JR, Lamb JC. Reproductive toxicology of chlordecone (kepone). pp. 357–392. In: Thomas JA, Korach KS, McLachlan JA (eds), Target Organ Toxicology Series: Endocrine Toxicology, New York: Raven Press, 1985.

Lamb JC, IV and Moore JA Effects of phenoxy acid herbicides and TCDD on male reproductive function. pp. 269–286. In: Male Fertility and its Regulation. Lobl TJ, Hafez ESE (eds), Boston: MTP Press, Ltd., 1984.

McLachlan JA, Newbold RR, Korach KS, Lamb JC, IV, Suzuki Y. Transplacental toxicology: Prenatal factors influencing postnatal fertility. pp. 213–232. In: Kimmel CA, Buelke–Sam JB (eds), Developmental Toxicity, New York: Raven Press, 1981.

Lamb JC, IV, Newbold RR, Stumpf WE, McLachlan JA The development of the luminal surface of the vagina, cervix and uterus of the mouse. Vol. II, pp. 355–360. In: Scanning Electron Microscopy. Johari OM, Becker RP (eds), Biological Applications of the SEM, 1977.

Stumpf WE, Lamb JC, IV, Hellreich MA, Aumuller G. Scanning electron microscopy of the collicular recess, the collicular recess organ and the velum medullar anterius of the brain. Vol. II, pp. 579–586. In: Scanning Electron Microscopy. Johari OM, Becker RP (eds), Biological Applications of the SEM, 1977.

Technical Reports

George JD, Myers CB, Lamb JC. Final contract report: Fertility assessment by continuous breeding. NTP–86–__. NTIS PB 86, 1986.

George JD, Reel JR, Myers CB, Lawton AD, Lamb JC, IV. Methoxy acetic acid: Reproduction and fertility assessment in CD–1 mice when administered in drinking water. National Toxicology Program, NTP–86–040, 1986. NTIS No. PB–86–164274/as.

George JD, Reel JR, Myers CB, Lawton AD, Lamb JC, IV. Trichloroethylene: Reproduction and fertility assessment in F344 rats when administered in the feed. NTP–86–085, 1986.

Gulati, D.K, Lamb JC, IV. 1986. Final contract report: Fertility assessment by continuous breeding. NTP–86–__. NTIS PB 86.

Gulati DK, Hommel–Barnes L, Russell S, Poonacha KB, Lamb JC, IV. 9–aminoacridine hydrochloride: Reproduction and fertility assessment in CD–1 mice when administered in feed. National Toxicology Program, NTP–86–022, 1986. NTIS PB–86–163128/as.

Gulati DK, Hommel L, Russell S, Poonacha KB, Lamb JC, IV. Ethylene glycol monomethyl ether: Reproduction and fertility assessment in CD–1 mice when administered in drinking water. National Toxicology Program. NTP–86–023, 1986. NTIS PB–86–163136/as.

Gulati DK, Hommel L, Russell S, Poonacha KB, Lamb JC, IV. Propantheline bromide: Reproduction and fertility assessment in CD–1 mice when administered in drinking water. National Toxicology Program. NTP–86–001, 1986. NTIS PB–86–160330/as.

Gulati DK, Hommel–Barnes L, Welch M, Russell S, Lamb JC, IV. Propylene glycol monomethyl ether: Reproduction and fertility assessment in CD–1 mice when administered in drinking water. National Toxicology Program. NTP–86–062, 1986. NTIS PB–86–170578/as.

Gulati DK, Mounce RC, Shaver S, Russell S, Poonacha KB, Lamb JC, IV. 2,2–Bis(bromomethyl)–1,3–propanediol: Reproduction and fertility assessment in CD–1 mice when administered in feed. NTP–86–063, 1986.

Gulati DK, Hommel–Barnes L, Welch M, Russell S, Poonacha KB, Lamb JC, IV. Ethylene glycol: Reproduction and fertility assessment in CD–1 mice when administered in drinking water. NTP 86–078, 1986.

Heindel JJ, Lamb JC, Chapin RE, Gulati DK, Hope E. Reproductive toxicity testing by continuous breeding test protocols in Swiss (CD–1) Mice. NTIS PB 89–152425, 1989.

Reel JR, Lawton AD, Myers CB, Lamb JC, IV. Trichloroethylene: reproduction and fertility assessment in F344 rats when administered in microcapsules in the feed. National Toxicology Program. NTP–86–085, 1986. NTIS No. PB–86–190782/as.

Reel JR, Lawton AD, Myers CB, Lamb JC, IV. Triethylene glycol diacetate: Reproduction and fertility assessment in CD–1 mice when administered in drinking water. National Toxicology Program. NTP–86–039, 1986. NTIS No. PB–86–161999/as.

George JD, Reel JR, Myers CB, Lawton AD, Lamb JC, IV. Trichloroethylene: Reproduction and fertility assessment in CD–1 mice when administered in the feed. National Toxicology Program. NTP–86–068, 1985. NTIS No. PB–86–173150/as.

George JD, Reel JR, Myers CB, Lawton AD, Lamb JC, IV. Tricresyl phosphate: Reproduction and fertility assessment in CD–1 mice when administered in the feed. National Toxicology Program. NTP–86–052, 1985. NTIS No. PB–86–167277/as.

Gulati DK, Chambers R, Shaver S, Poonacha KB, Russell S, Lamb JC, IV. Di–n–propylphthalate: Reproduction and fertility assessment in CD–1 mice when administered in feed. National Toxicology Program. NTP–85–188, 348 pp, 1985. NTIS PB 85–247856/as.

Gulati DK, Chambers R, Shaver S, Sabharwal PS, Lamb JC. Di–n–octylphthalate: Reproduction and fertility assessment in CD–1 mice when administered in feed. National Toxicology Program. NTP–85–140, 287 pp, 1985. NTIS No. PB85–218147.

Gulati DK, Chambers R, Shaver S, Sabharwal PS, Lamb JC, IV. Theophylline: Reproduction and fertility assessment in CD–1 mice when administered in drinking water. National Toxicology Program. Technical Report NTP–85–09, 330 pp, 1985. NTIS No. PB85–204659/as.

Gulati DK, Choudhury H, Chambers R, Lamb JC, IV. Lead acetate trihydrate: Reproduction and fertility assessment in CD–1 mice when administered in drinking water. National Toxicology Program. Technical Report NTP–85–098, 283 pp, 1985. NTIS No. PB85–203032/as.

Gulati DK, Choudhury H, Chambers R, Poonacha KB, Sabharwal PS, Lamb JC. Diethylstilbestrol: Fertility assessment in CD–1 mice when administered in feed. National Toxicology Program. NTP–85–016, 225 pp, 1985. NTIS No. PB85–167674/as.

Gulati DK, Choudhury H, Chambers R, Sabharwal PS, Lamb JC. Methyl salicylate: Fertility assessment in CD–1 mice when administered by gavage. National Toxicology Program. NTP–85–022, 180 pp, 1985. NTIS No. PB85–164283/as.

Gulati DK, Hommel L, Poonacha KB, Russell V, Russell S, Lamb JC Ethylene glycol monobutyl ether: Reproduction and fertility assessment in CD–1 mice when administered in drinking water. National Toxicology Program. NTP–85–155. 340 pp, 1985. NTIS No. 85–226827/AS.

Gulati DK, Hommel L, Russell S, Poonacha KB, Lamb JC, IV. 2,2–Bis(bromomethyl)1,2–propanediol reproduction and fertility assessment in CD–1 mice when administered in drinking water. National Toxicology Program. NTP–86–063,1985. NTIS PB–86–168341/as.

Gulati DK, Hommel L, Russell S, Poonacha KB, Lamb JC, IV. Ethylene glycol: Reproduction and fertility assessment in CD–1 mice when administered in drinking water. National Toxicology Program. NTP–86–078, NTIS PB–86–177383/as.

Gulati DK, Hommel L, Russell S, Poonacha KB, and Lamb JC, IV. 1985. Ethylene glycol monomethyl ether acetate: Reproduction and fertility assessment in CD–1 mice when administered in drinking water. National Toxicology Program. NTP–85–320, 1985. NTIS PB–86–139565/as.

Gulati DK, Hommel L, Russell S, Poonacha KB, Lamb JC, IV. Ethylene glycol monomethyl ether: Reproduction and fertility assessment in CD–1 mice when administered in drinking water. National Toxicology Program, NTP–85–214. 321 pp, 1985. NTIS PB–86–120128/as.

Gulati DK, Hommel L, Russell S, Poonacha KB, Lamb JC, IV. Oxalic acid: Reproduction and fertility assessment in CD–1 mice when administered in drinking water. National Toxicology Program. NTP–85–322, 1985. NTIS PB–86–167053/as.

Gulati DK, Hommel L, Russell S, Poonacha KB, Lamb JC, IV. Propylene glycol: Reproduction and fertility assessment in CD–1 mice when administered in drinking water. National Toxicology Program. NTP–85–321, 1985. NTIS PB–86–140662/as.

Gulati DK, Hommel L, Russell V, Sabharwal PS, Lamb JC, IV. Ethoxy acetic acid: Reproduction and fertility assessment in CD–1 mice when administered in drinking water. National Toxicology Program. Technical Report NTP–85–080. 313 pp, 1985. NTIS No. PB85–197960/as.

Gulati DK, Maunce R, Shaver S, Poonacha KB, Lamb JC, IV. Di–n–pentylphthalate: Reproduction and fertility assessment in CD–1 mice when administered in feed. National Toxicology Program. NTP–85–213, 322 pp, 1985. NTIS 86–118999.

Gulati DK, Russell VS., Hommel L, Poonacha KB, Sabharwal PS, Lamb JC, IV. Caffeine: Reproduction and fertility assessment in CD–1 mice when administered in drinking water. National Toxicology Program. Technical Report NTP–85–097. 243 pp, 1985. NTIS No. PB85–205052/as.

Gulati DK, Russell V, Hommel L, Poonacha KB, Sabharwal PS, Lamb JC, IV. Sodium saccharin: Reproduction and fertility assessment in CD–1 mice when administered in drinking water. National Toxicology Program. Technical Report NTP–85–078, 197 pp, 1985. NTIS No. PB85–188258/as.

Reel JR, George JD, Lawton AD, Myers CB, Lamb JC, IV. Bisphenol A: Reproduction and fertility assessment in CD–1 mice when administered in the feed. National Toxicology Program. NTP–85–192, 344 pp, 1985, NTIS 86–103207.

Reel JR, Lawton AD, George JD, Lamb JC. Diethylene glycol: Reproduction and fertility assessment in CD–1 mice when administered in the drinking water. National Toxicology Program. NTP–85–107, 242 pp, 1985. NTIS No. PB85–212926/as.

Reel JR, Lawton AD, George JD, Lamb JC, IV. Triethylene glycol dimethyl ether: Reproduction and fertility assessment in CD–1 mice when administered in the drinking water. National Toxicology Program. Technical Report NTP–85–007, 194 pp., 1985. PB85–150456/as.

Reel JR, Lawton DA, Lamb JC, IV. Acetaminophen: Reproduction and fertility assessment in CD–1 mice when administered in water. National Toxicology Program. Technical Report NTP–85–095, 207 pp, 1985. NTIS No. PB85–204667/as.

Reel JR, Lawton AD, Myers CB, Lamb JC, IV. Di–n–hexyl phthalate: Reproduction and fertility assessment in CD–1 mice when administered in feed. National Toxicology Program. NTP–85–187. 244 pp, 1985. NTIS No. PB–85–249332/as.

Reel JR, Lawton AD, Myers CB, Lamb JC, IV. Ethanol: Reproduction and fertility assessment in CD–1 mice when administered in drinking water. National Toxicology Program. NTP–85–334, 1985. NTIS No. PB–86–144979/as.

Gulati DK, Choudhury H, Chambers R, Poonacha KB, Sabharwal PS, Lamb JC, IV. Theobromine: Fertility assessment in CD–1 mice when administered in feed. National Toxicology Program. Technical Report NTP–84–265, 253 pp, 1984. NTIS No. PB85–120368.

Gulati DK, Russell VS, Hommel L, Poonacha KB, Sabharwal PS, Lamb JC 2–Ethoxyethanol: Fertility assessment in CD–1 mice when administered in drinking water. National Toxicology Program. Technical Report NTP–84–264, 275 pp, 1984. NTIS No. PB85–118651.

Gulati DK, Russell VS., Hommel L, Poonacha KB, Sabharwal PS, Lamb JC, IV. Ethylene glycol: Fertility assessment in CD–1 mice when administered in drinking water. National Toxicology Program. Technical Report NTP–84–155, 234 pp, 1984. NTIS PB 84 241108.

Reel JR, Lawton AD, and Lamb JC, IV. Diethylphthalate: Reproduction and fertility assessment in CD–1 mice when administered in the feed. National Toxicology Program. Technical Report NTP–84–262, 187 pp, 1984. NTIS No. PB85–118636.

Reel JR, Lawton AD, Lamb JC, IV. Diethylene glycol monoethyl ether: Reproduction and fertility assessment in CD–1 mice when administered in the drinking water. National Toxicology Program. Technical Report NTP–84–406, 179 pp, 1984. NTIS No. PB85–137123.

Reel JR, Lawton AD, Lamb JC, IV. Diethylhexyl phthalate (DEHP): Reproduction and fertility assessment in CD–1 mice when administered in the feed. National Toxicology Program. Technical Report NTP–84–079, 217 pp, 1984. NTIS PB 84 181734.

Reel JR, Lawton AD, Lamb JC, IV. Di–n–butyl phthalate: Reproductive and fertility assessment in CD–1 mice when administered in the feed. National Toxicology Program. Technical Report NTP–84–411, 197 pp, 1984. NTIS PB85–144798.

Reel JR, Lawton AD, Lamb JC, IV. Ethylene glycol monophenyl ether: Reproductive and fertility assessment in CD–1 mice when administered in the feed. National Toxicology Program. Technical Report NTP–84–410. 244 pp, 1984. NTIS PB85–146140/AS.

Reel JR, Lawton AD, Lamb JC, IV. Triethylene glycol: Reproduction and fertility assessment in CD–1 mice when administered in drinking water. National Toxicology Program. Technical Report NTP–84–407, 187 pp, 1984. NTIS No. PB85–137073.

Reel JR, Wolkowski–Tyl R, Lawton AD, Lamb JC. Bisphenol A: Reproduction and fertility assessment in CD–1 mice when administered via subcutaneous silastic implants. National Toxicology Program. Technical Report NTP–84–015, 182 pp, 1984. NTIS PB 84 155308.

Reel JR, Woldowski–Tyl R, Lawton AD, Lamb JC, IV. Caffeine: Reproductive and fertility assessment in CD–1 mice when administered in the drinking water. National Toxicology Program. Technical Report NTP–84–158, 203 pp, 1984. NTIS PB 85 101202.

Reel JR, Wolkowski–Tyl R, Lawton AD, Lamb JC. Dibromochloropropane: Reproduction and fertility assessment in CD–1 mice when administered by gavage. National Toxicology Program. Technical Report NTP–84–263, 202 pp, 1984. NTIS No. PB85–118644.

Reel JR, Wolkowski–Tyl R., Lawton AD, Lamb JC, IV. Lead acetate (PbAc): Reproduction and fertility assessment in CD–1 mice when administered in the drinking water. National Toxicology Program. Technical Report NTP–84–108, 208 pp, 1984. NTIS PB 84 208016.

Reel JR, Wolkowski–Tyl R, Lawton AD, Lamb JC, IV. Methyl salicylate: Reproduction and fertility assessment in CD–1 mice when administered by gavage. National Toxicology Program. NTP–84–156, 207 pp, 1984. NTIS PB 84 241140.

Reel JR, Wolkowski–Tyl R, Lawton AD, Lamb JC, IV. Sulfamethazine: Reproductive and fertility assessment in CD–1 mice when administered via the diet. National Toxicology Program. Technical Report NTP–84–092. 218 pp, 1984. NTIS PB 84 192160.

Reel JR, Wolkowski–Tyl R, Lawton D, Lamb JC. Diethylstilbestrol (DES): Reproduction and fertility assessment in Cd–1 mice when administered in feed. National Toxicology Program. Technical Report NTP–83–284, 205 pp, 1983. NTIS PB 84 136746.

Lamb JC, IV (Chemical Manager). Toxicology and Carcinogenesis Studies of 1,2–Dichloropropane (propylene dichloride) (CAS No. 78–87–5) in F344/N Rats and B6C3F1 Mice. National Toxicology Program. Technical Report No. 263, NIH Publ. No. 86–2519, 182 pp.

Lamb JC, IV (Chemical Manager). NTP Technical Report on the carcinogenesis Bioassay of 4,4'–Methylenedianiline dihydrochloride (CAS No. 13552–44–8) in F344/N rats and B6C3F1/N mice. National Toxicology Program. Technical Report No. 81–143. NIH Publication No. 82–2504, 182 pp, 1982.

Lamb JC, IV, Moore JA, Marks TA. Evaluation of 2,4–dichlorophenoxyacetic acid (2,4–D), 2,4,5–trichlorophenoxyacetic acid (2,4,5–T), and 2,3,7,8–tetrachlorodibenzo–p–dioxin (TCDD) toxicity in C57BL/6 mice: Reproduction and fertility in treated male mice and evaluation of congenital malformations in their offspring. National Toxicology Program. Technical Report No. NTP–80–44, 1980. NTIS PB 86–132750.

Abstracts


Patterson J, Becker R, Borghoff S, Casey W, Dourson M, Fowle J, Hartung T, Holsapple M, Jones B, Juberg D, Kroner O, Lamb J, Mary s. Mihaich E, Rinckel L, Van Der Kraak G, Wade M, Willett C. Workshop on lessons learned, challenges, and opportunities: The U.S. Endocrine Disruptor Screening Program. Poster presented at Society for Risk Analysis, 2013.

Patterson J, Becker R, Borghoff S, Casey W, Dourson M, Fowle J, Hartung T, Holsapple M, Jones B, Juberg D, Kroner O, Lamb J, Mary s. Mihaich E, Rinckel L, Van Der Kraak G, Wade M, Willett C. Workshop on lessons learned, challenges, and opportunities: The U.S. Endocrine Disruptor Screening Program. Poster presented at Society for Risk Analysis, 2013.

Neal B, Staveley J, Freeman E, Williams A, Lamb J, DeSesso J. Weight of the evidence (WoE) evaluation of endocrine disruptor screening program tier 1 assays: Lessons learned. Poster presented at SETAC, 2013.

Hentz KL, Williams A, Lamb JC. Endocrine disruption: Weight of the evidence for low-dose effects of TCDD on sperm counts. Poster presented at Society of Toxicology Annual Meeting, 2013.

Hentz KL, Lamb JC. Proposed mechanism of action for toxicity in N-acetylcysteine overdose. Poster presented at Society of Toxicology Annual Meeting, 2011.

Neal B, Marty MS, Coady K, Lamb JC. 2,4-Dichlorophenoxyacetic acid (2,4-D): Evaluation of endocrine modulating potential. Poster presented at Society of Toxicology Annual Meeting, 2011.

Lamb JC, Walker CL, Neal BH, Klaunig JE. Inhibition of gap junction intercellular communication (GJIC) in mouse liver cells by technical toxaphene and toxaphene congeners. Poster presented at Society of Toxicology Annual Meeting, 2010.

Marty S, Lamb J. The evolution of the extended one-generation study design for agricultural and industrial chemical hazard identification. Roundtable session at Society of Toxicology Annual Meeting, 2010.

Lamb J, Ryan B, Gaylor D, Hentz K, Gerhart J. Derivation of an acceptable daily intact (ADI) using a benchmark dose (BMD) approach for a veterinary pharmaceutical residue in food-producing animals. Poster presented at Society of Toxicology Annual Meeting, 2007.

Neal B, Strother DE, Collins JJ, Lamb J.C. Acrylonitrile: evaluation of reproductive and developmental toxicity. Poster presented at Society of Toxicology Annual Meeting, 2006.

Lamb JC. Interviewing skills for a position in the private sector. Poster presented at Society of Toxicology Annual Meeting, 2005.

Lamb JC. Incorporating life stage testing into agricultural chemical safety assessment. Poster presented at Society of Toxicology Annual Meeting, 2004.

Norenberg KM, Hentz KL, Neal BH, Lamb JC. Evaluation of a common mechanism of action for dithiocarbamates. Toxicologist 2002; 66, 17S.

Oredugba BO, Hentz KL, Lamb JC. Review of toxicity data and assessment of the margin of exposure for Di–butyl Phthalate (DBP) as an inert ingredient in a generic drug. Toxicologist, 2002.

Soto AN, Hentz KL, McCarty JD, Lamb JC. Evaluation of the estrogenic activity of pyrethroid pesticides. Toxicologist 2002.

Lamb JC. Assessing the human health risks from exposures to hormonally active agents. International Symposium on Environmental Endocrine Disruptors. December 1999.

Lamb JC. Reproductive Toxicology. Ethylene glycol monomethyl ether. Swiss CD–1 mice at 0.0, 0.1, 0.2, 0.4% drinking water. Environ Health Perspect 1997; 105(Supplemental 1).

Lamb JC, George J, Reel J, Myers C, Lawton AD. Trichloroethylene. Environ Health Perspect 1997; 105(Supplemental 1).

Lamb JC. Risk assessment and risk management of worker exposures to pesticides: The next generation: Introduction. Fundamental and Applied Toxicology 1996; 30:1(2):308.

Lamb JC. Molecular mechanisms in hormonal carcinogenesis: Update and challenges for future research: Introduction. The Toxicologist 1993; 13:1.

Lamb JC. Endocrine tumorigenesis and the implications in risk assessment. The Toxicologist 1992; 12:2.

Lamb JC, Chapin RE, Singh DV. Gonadal control, growth factors, and tumorigenesis and their implications in risk assessment: Introduction. The Toxicologist 1992; 12:1.

George JD, Reel JR, Meyers CB, Lamb JC, Heindel JJ. Reproductive toxicity of trichloroethylene (TCE) in mouse and rat breeding pairs. The Toxicologist 1990; 10:209.

Morrissey RE, Lamb JC, Morris RW, Chapin RE, Gulati DK, Heindel JJ. Evaluation of the reproductive assessment by continuous breeding protocol. Teratology 1989; 39:469–470.

Collins JJ, Lamb JC, Manus AG, Heath J, Makovec T. Subchronic toxicity of orally–administered theophylline (gavage and dosed–feed) in F344 rats and B6C3F1 mice. The Toxicologist 1988; 8:345.

Lamb JC, IV Schwartz J. Pesticide regulatory issues. Abstracts of Papers American Chemical Society 1988; p. 196.

Lindstrom P, Harris M, Ross M, Lamb JC, Chapin R. Di–n–pentylphthalate (DPP) induced infertility: Correlation with Serum Androgen Binding Protein (sABP). The Toxicologist 1988; 8:55.

Morrissey RE, Lamb JC, Schwetz BA, Teague JL, Morris RW. Association of Sperm, Reproductive Organ Weight and Vaginal Cytology (SMVCE) Data with Fertility of Swiss (CD–1) Mice. The Toxicologist 1988; 8:248.

Elmore EL, Morrissey RE, Lamb JC, Rocha DG, Wilkinson BP, Murphy DD, Steele VE. Screening of coded teratogens in two in vitro assays. In Vitro 1987; 23:43A.

Gulati DK, Mounce RC, Poonacha KB, Lamb JC. Reproductive Toxicity of 3 Phthalate Esters in CD–1 Mice. The Toxicologist 1987; 7:577.

Lamb J Identification of occupational and environmental hazards to male reproduction. Amer. Chem Soc. Abstracts, Denver, CO, April 1987.

Lamb J. Scientific evaluation procedures: How EPA views the weight of scientific evidence on law while making regulatory decisions. Amer Chem Soc. Abstracts, Denver, CO, April 1987.

Lamb JC. Pesticide residue tolerances – The Government viewpoint. Amer. Chem Soc. Abstracts, New Orleans, LA, September 1987.

Lindstrom P, Harris M, Ross M, Lamb JC, Chapin R. Changes in Serum Androgen Binding Protein (ABP) indicate germinal epithelial damage. The Toxicologist 1987; 7:4.

Chapin RE, Gray TJB, Dutton SL, Lamb JC. The effects of 2,5–hexanedione (2,5–HD), and mono–(2–ethylhexyl)phthalate (MEHP) on Sertoli–cell enriched cultures. The Toxicologist 1986; 6:289.

George JD, Reel JR, Myers CB, Lawton AD, Lamb JC. Reproductive toxicity of methoxyacetic acid (MAA) in the drinking water to mouse breeding pairs. The Toxicologist 1986; 6:293.

Gulati DK, Hommel–Barnes L, Welch M, Poonacha KB, Lamb JC. Reproductive toxicity of 7 glycol ethers and oxalic acid. The Toxicologist 1986; 6:293.

Gulati DK, Mounce RC, Poonacha KB, Lamb JC. Reproductive toxicity of 3 phthalate esters in CD–1 mice. The Toxicologist 1986; 7:144.

Lamb JC, Chapin RE, Teague, J., Lawton AD, Reel JR. Reproductive toxicity of DEP, DBP, and DHP studied by a continuous breeding protocol. The Toxicologist 1986; 6:293.

Lamb JC, Gulati DK, George JD. Evaluation of reproductive effects of phthalate esters and glycol ethers using a continuous breeding protocol. Toxicology 1986. Presented at the 1986 Annual Meeting of the European Society of Toxicology, Harrogate, England).

Lindstrom, P., Harris, M., Ross M, Lamb JC, Chapin RE. Changes in serum androgen binding protein (ABP) indicate germinal epithelial damage. The Toxicologist 1986; 7:1. (The student presenting this poster won the SOT Reproductive and Developmental Toxicology Specialty Section Award for Excellence.)

Somkuti SG, Lapadula DM, Chapin RE, Lamb JC, and Aboudonia MB 1986. Testicular toxicity of tri–o–cresyl phosphate (TOCP) in F344 rats. The Toxicologist 6:290.

Somkuti SG, Lapadula DM, Chapin RE, Lamb JC, Aboudonia MB. The morphogenesis of ultrastructural changes of the tri–o–cresyl phosphate (TOCP)–induced testicular lesion in F344 rats. The Toxicologist 1986; 6:290.

Lindamood C, Lamb JC, Bristol DW, Collins JJ, Heath JE. Preliminary range—Finding studies on theophylline toxicity in rats and mice. The Toxicologist 1986; 6:123.

Agarwal DK, Eustis S, Lamb JC, Reel JR, Kluwe WM. Correlation of dose–dependent functional pathophysiological changes induced by di–(2–ethylhexyl)–phthalate (DEHP). The Toxicologist 1985; 5:117. (Also at SOT Annual Meeting, 1985).

Birnbaum LS, Harris MW, Miller CP, Pratt RC, Lamb JC, IV. Teratogenicity of TCDD in mice: Enhancement by hydrocortisone. The Toxicologist 1985; 5:201. (Also at SOT Annual Meeting, 1985).

Chapin RE, Dunnick JK, Harris MW, Lamb JC, IV. Reproductive toxicity of methyl DOPA in male F344 rats. J Androl 1985; 6:61.

Chapin RE, Swaisgood RR, Lamb JC, IV. Testicular sorbitol dehydrogenase activity increases after exposure to different toxicants. The Toxicologist 1985; 5:182. (Also at SOT Annual Meeting, 1985).

Chapin RE, Swaisgood RR, Lamb JC, IV. Testicular sorbitol dehydrogenase as a predictive indicator of testicular toxicity in F344 rats. J Androl 1985; 6:62.

Dunnick JK, Harris MW, Hall LB, Chapin RE, Lamb JC, IV. Reproductive toxicity of methyl DOPA in the male Fischer 344/N rat. The Toxicologist 1985; 5:188. (Also at SOT Annual Meeting, 1985).

Reel JR, Lawton AD, Tyl RW, Lamb JC, IV. Reproductive toxicity of dietary diethylhexylphthalate (DEHP) in mouse breeding pairs. The Toxicologist 1985; 5:117. (Also at SOT Annual Meeting, 1985).

Reel JR, Lawton AD, Wolkowski–Tyl R, Davis GW, Lamb JC, IV. Evaluation of a new reproductive toxicology protocol using diethylstilbestrol as a positive control compound. J Am Coll Toxicol 1985; 4(2):147–162.

Birnbaum LS, Harris MW, McKinney JD, Lamb JC. Toxic interaction of TCDD with thyroxin: Enhanced incidence of cleft palate in mice. The Pharmacologist 1984; 26:232. (1984 ASPET Meeting).

Chapin RE, Dutton SL, Ross MD, Lamb JC. Ethylene glycol monomethyl ether (EGME) as a testicular toxicant. J Androl 1984; 5:P13.

Chapin RE, Dutton SL, Ross MD, Lamb JC The testicular toxicity of ethylene glycol monomethyl ether (EGME) as characterized by mating success, sperm parameters, and histopathology. The Toxicologist 1984; 4:136 (1984 SOT Meeting).

Choudhury H, Lamb JC, IV, Gulati DK, Chambers RC, Sabharwal PS. Reproductive toxicity of theobromine in mice studied by a new continuous breeding protocol. The Toxicologist 1984; 4:191. (1984 SOT Meeting).

Kluwe WM, Maronpot RR, Lamb JC, IV, Agarwal DK. Adverse effects of butyl benzyl phthalate on bone marrow and the male reproductive system. The Toxicologist 1984; 4:136, 1984. (1984 SOT Meeting).

Lamb JC, IV, Harris MW, Weber H, McKinney JD, Birnbaum, L. Potentiation of 2,3,7,8–tetrachlorodibenzo–p–dioxin (TCDD) induced cleft palate (CP) by triiodothyronine (T3) in C57B1/6 (B6) mice. Biol Rep 1984; 30(suppl. 1):164. (1984 Society for the Study of Reproduction Meeting).

Lamb JC, Russell VS, Hommel L, Gulati DK, Sabharwal PS. Reproductive toxicity of ethylene glycol (EG) studies by a new continuous breeding protocol. The Toxicologist 1984; 4:136. (1984 SOT Meeting).

Reel JR, Lawton AD, Wolkowski-Tyl R, Lamb JC, IV. Validation of a new reproductive toxicology protocol using diethylstilbestrol (DES) as a model compound. The Toxicologist 1984; 4:136. (1984 SOT Meeting).

Agarwal D, Eustis S, Lamb J, Kluwe W. Relationship between Zinc and testicular atrophy induced by di–2(ethylhexyl)phthalate (DEHP). The Pharmacologist 1983. (1983 ASPET meeting).

Chapin R, Dutton S, Ross M, Lamb J. The pathogenesis of male reproductive tract lesions induced by 3–dimethyl methylphosphonate in F–344 rats. North Carolina Chapter, Society of Toxicology, 3rd Annual Meeting, 1983.

Dunnick JK, Harris MW, Gupta BN, Chapin RE, Lamb JC, IV. Reproductive toxicity of dimethyl methylphosphonate (DMMP) in the male Fischer 344 rat. The Toxicologist 1983; 3:19. (1983 Society of Toxicology meeting).

Greenwell A, Harrington F, Gupta B, Maronpot R, Lamb JC, Kluwe W. Interactions of 1,2–dibromo–3–chloropropane with the male reproductive system. North Carolina Chapter, Society of Toxicology, 3rd Annual Meeting, 1983. (Honorable Mention of Best Poster Competition).

Lamb JC, Ross MD, Dozier M, Allen K, Keel JR. Morphological and biochemical responses to continuous chlorlecone exposure. North Carolina Chapter, Society of Toxicology, 3rd Annual Meeting, 1983.

Kimmel CA, Lamb JC, IV, Hardin BD. Approaches to reproductive and developmental toxicology testing in the National Toxicology Program. Arch Androl 1982; 9:46.

Kimmel CA, Lamb JC, IV, Hardin BD. Approaches to reproductive and developmental toxicology testing in the National Toxicology Program. Contraceptive Delivery Systems 1982; 3:151A.

Kluwe WM, Gupta B, Lamb JC. Comparative effects of 1,2–dibromo–3–chloropropane (D) and its metabolites epichlorohydrin (E), alphachlorohydrin (A) and oxalic acid (O) in the urogenital tract. The Toxicologist 1982; 2:136. (1982 ASPET meeting).

Lamb JC, IV, Moore JA. Effects of phenoxy acid herbicides on male reproductive function. Arch Androl 1982; 9:47.

Lamb JC, IV, Moore JA. Effects of phenoxy acid herbicides on male reproductive function. Contraceptive Delivery Systems 1982; 3:297A.

Lamb JC, Harris MW, McConnell EE, Jameson CW, Allen JD, Ross MS, Moore JA. Effects of subchronic exposure to chlordecone on the fertility of female rats. North Carolina Chapter, Society of Toxicology, Second Annual Meeting, Research Triangle Park, North Carolina, January 1982.

Lamb JC, Ross MD, Allen KM, Dozier MM, Reel JR. Differential estrogenic response of the pituitary and uterus to Kepone (chlordecone) in the Fischer (F344). Rat Biol Reprod 1982; 26(suppl. 1):109A.

Lamb JC, IV, Marks TA, Moore JA. Evaluation of the toxicity of phenoxy acid mixtures in male mice. North Carolina Chapter, Society of Toxicology, 1st Annual Meeting, Research Triangle Park, NC, February 1981.

Lamb JC, IV, Korach KS. Differential uptake of labeled estradiol by various cell types of the mouse uterus. Endocrinology 1980; 106 (suppl.):128.

Lamb JC, IV, McLachlan JA. Structural abnormalities in the lumen of the female mouse genital tract following prenatal exposure to Diethylstilbestrol (DES). Anat Rec 1979; 193:597.

Lamb JC, IV, Suzuki, Y, McLachlan JA. Analogous structures in the male and female genital tract of mice treated in utero with diethylstilbestrol. Environ Health Perspect 1979; 33:318–319.

McLachlan JA, Lamb JC, IV, Stumpf WE. Altered surface epithelium in the female mouse genital tract following prenatal exposure to Diethylstilbestrol. J Tox Environ Health 1977; 3:366.

McLachlan JA, Newbold RR, Lamb JC, IV. Genital tract abnormalities in mice following gestational exposure to DES. Environ Health Perspect 1977; 20:240.

Stumpf WE, Hellreich MA, Aumuller G, Sar M, Lamb JC, IV. The Collicular Recess Organ, the Collicular Recess, and the Velum Medullar: Ependymal Specializations and Secretion. Ant Rec 1977; 189:273.

Lamb JC, IV, Nopanitaya W, Shinoda BA. Influence of vagotomy on duodenal fat absorption. Proceedings, 33rd Annual Electron Microscopy Society America, pp. 410–411, Las Vegas, NV, 1975.

Geratz JD, Lamb JC, IV. Reduced sensitivity of the rat pancreas to secretagogues following ligation of the proximal common bile duct. American Pancreatic Study Group, Chicago, IL, October 1974.

Geratz JD, Lamb JC, IV. Influence of bile duct ligation on exocrine pancreatic secretory activity in the rat. American Pancreatic Study Group, Chicago, IL, November 1973.

Prior Experience

  • The Weinberg Group
    Executive Vice President, 2008
    Senior Vice President, The Weinberg Group, 2003–2008
  • BBL Sciences, Blasland, Bouck & Lee
    Senior Vice President, 2000–2003
    Vice President, 1999–2000
  • Jellinek, Schwartz & Connolly, Inc.
    Vice President, Scientific and Technical Services, 1993–1999
    Vice President, Toxicology and Environmental Sciences, 1991–1993
    Director, Toxicology and Environmental Sciences, 1988–1991
  • U.S. Environmental Protection Agency
    Special Assistant to the Assistant Administrator for Pesticides and Toxic Substances, 1985–1988
  • National Institute of Environmental Health Sciences, National Toxicology Program
    Biologist and Head, Fertility and Reproduction Group, 1980–1985
  • University of North Carolina, UNC School of Health
    Adjunct Associate Professor, Biohazard Program, Department of Parasitology and Laboratory Practice, 1985–1989
  • National Institute of Environmental Health Sciences
    Senior Staff Fellow, National Toxicology Program, 1979–1980
    Developmental Pathologist, 1977–1979
  • University of North Carolina
    Cancer Research Center, Research Associate, 1977–1979
    Department of Anatomy and Cancer Research Center, N.R.S.A. Postdoctoral Fellow, 1976–1977
    Department of Pathology, N.I.H. Pre–doctoral Trainee, 1973–1975
    Department of Chemistry, Teaching Assistant, 1972–1975
    Department of Pathology, Research Assistant, 1972–1973

Professional Affiliations

  • Academy of Toxicological Sciences, Fellow, 2006–present
    – Board Member, 2009–2011
    – Vice President, 2011–2012
    – President, 2012–2013
    American Bar Association, Vice Chair, Special Committee on Science & Technology, 1996
  • American Board of Toxicology
    – President and Chairman of the Board, 1988–1989
    – Vice President, 1987–1988
    – Board Member, 1986–1990
    – Diplomate, 1981–present
  • American Chemical Society
  • American College of Toxicology
  • Endocrine Society
  • International Life Sciences Institute, HESI, Agricultural Chemical Safety Assessment Committee, Co–chair Life Stages Task Force, 2001–2006
  • International Life Sciences Institute, HESI, Developmental and Reproductive Toxicology Task Group, Academic Advisor, 1996–present
  • Johns Hopkins University School of Public Health and Hygiene, Risk Sciences and Public Policy Institute, Science Advisory Board and Adjunct Faculty, Member 1997–2001
  • Society of Toxicology
    – Member, TASCA Task Force, 2010–present
    – Elected Member, Awards Committee, 2008–2010
    – Member, Congressional Task Force, 2009–present
    – Member, Professional Needs Assessment Task Force, 2008–2011
    – President of the Regulatory and Safety Evaluation Specialty Section, 2009–2010; Vice President, 2008–2009; VP–Elect, 2007–2008
    – Strategic Communication Committee, 2006–2007
    – Committee on Public Communications, Member, 1997–2001
    – Regulatory Affairs and Legislative Assistance Committee Member, 1992–1995; Chair, 1993–1995
    – Reproductive Toxicology Specialty Section Member, President, 1992–1993; Vice President, 1991–1992; Vice President Elect, 1990–1991; Awards Committee, 1985–1986; Nominations Committee, 1995
    – Risk Assessment Specialty Section Member
    – North Carolina Chapter Member, Newsletter Editor, 1982; Councilor, 1983–1985; Secretary/Treasurer, 1985–1987
    – Capital Area Chapter Member, 1986–present
    – Liaison to the American Board of Toxicology, 1988
  • Toxicology Education Foundation
    – Trustee, 2002–2005
    – Secretary-Treasurer, 2003–2005
  • OECD Committee on Validation of Test Methods, Observer, In Utero Testing Committee, 2003–2005
  • National Academy of Sciences/ National Research Council
    – Committee on the Health Implications of Perchlorate Ingestion, National Academy of Sciences and National Research Council, Commission on Life Sciences, Board on Environmental Studies and Life Sciences, Member, 2003–2005
    – Committee on Hormone–Related Toxicants in the Environment, National Academy of Sciences and National Research Council, Commission on Life Sciences, Member 1995–1999
    – Committee on Risk Characterization, National Academy of Sciences and National Research Council, Commission on Behavioral Sciences and Education, Member, 1994–1996

Additional Information

Editorships and Editorial Review Boards

Environmental Health Perspectives

  • Editorial Board, 2008 – Present
  • Associate Editor, 2008-2010

Pure and Applied Chemistry, Implications of Endocrine Active Substances for Humans and Wildlife – A Scope/IUPAC Project Vol 75 Nos. 11-12

  • Associate Editor, 2003

Comprehensive Toxicology

  • Editorial Board, 2010 (2nd ed) and present (3rd ed)
  • Volume 3 Editor, 2010 and present

Knowledge

News & Events

CREDENTIALS & PROFESSIONAL HONORS

  • J.D., North Carolina Central University, 1986, magna cum laude
  • Ph.D., Pathology, University of North Carolina, Chapel Hill, 1975
  • A.B., Chemistry, University of North Carolina, Chapel Hill, 1973

LICENSES & CERTIFICATIONS

Admitted to the Bar of the District of Columbia, 1988

Diplomate of the American Board of Toxicology, 1981

Fellow, Academy of Toxicological Sciences (ATS)