Susan Mackintosh
Susan Mackintosh, Ph.D.
Scientist
Polymer Science & Materials Chemistry
  • Menlo Park

Dr. Mackintosh is a formally trained analytical chemist and has extensive experience working with novel analytical approaches and advanced instrumentation to identify and quantify organic molecules in a variety of complex matrices. She uses spectrometry to support the investigation of leachable and contaminant compounds in applications such as consumer electronics, medical devices, wearables, and various plastic failures. In addition, she has expertise in developing and applying chromatographic and mass spectrometric techniques for detection, quantification, and evaluation of the fate and transport of persistent organic pollutants, flame retardants, and pharmaceuticals in environmental and biological matrices.

Dr. Mackintosh has expertise in optimizing and utilizing a variety of sample preparation procedures, including pressure liquid extraction (PLE) and solid phase extraction (SPE). She has utilized a number of characterization techniques including spectroscopy (UV-Vis and FTIR) and chromatographic techniques such as gas chromatography- mass spectrometry (GC-MS), comprehensive two dimensional gas chromatography- mass spectrometry (GCxGC-MS), liquid chromatography (LC-MS), inductively coupled plasma- mass spectrometry (ICP-MS), and gel permeation chromatography (GPC) and has worked with a broad range of mass spectrometry instruments, including time of flight (TOF)-MS, triple quadrupole-MS, high resolution-MS, ion trap-MS, and single quadrupole-MS. She also has experience working with and characterizing radioactive compounds by LC-radiochromatographic detection and liquid scintillation counting. 

Prior to joining Exponent, Dr. Mackintosh worked with the Scripps Institute of Oceanography and San Diego State University Center for Oceans and Human Health (COHH) as a postdoctoral researcher. At COHH she applied a non-targeted screening approach for the detection of a broad range of organic chemicals in marine mammal blubber and human breast milk samples. Using this approach, she discovered, identified, and quantified previously unknown halogenated compounds, including naturally occurring halogenated products. Before working at COOH, Dr. Mackintosh’s Ph.D. research at the University of Buffalo focused on evaluating the environmental fate and transport of flame retardants and pharmaceuticals with targeted chromatographic and mass spectrometric techniques. 

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Analytical Chemistry, University at Buffalo-SUNY, 2013
  • B.S., Chemistry, College at Oneonta-SUNY, 2008
  • Postdoctoral Scholar, Scripps Institute of Oceanography and San Diego State University Center for Oceans and Human Health, 2013–2015

    National Science Foundation (NSF) Doctorate Fellowship, University at Buffalo/Buffalo Public School Interdisciplinary Science and Engineering Partnership (UB/BPS ISEP) program, Department of Chemistry, SUNY-University at Buffalo, 2011–2013

    Otto Hutzinger Student Award, Dioxin Conference, Cairns, Australia, August 26–31, 2012

    NSF Integrated Graduate Education through Research and Training (IGERT) Poster Competition Winner, Washington D.C., May 25, 2011

    NSF IGERT Doctorate Fellowship, Grant: Ecosystem Restoration through Interdisciplinary Exchange (ERIE), Department of Environmental Engineering, SUNY-University at Buffalo, 2009–2011

    Dean’s Interdisciplinary CAMBI Fellowship, Chemistry Department, SUNY- University at Buffalo, 2008

    Academic Achievement Award in Chemistry, Chemistry Department, SUNY-Oneonta, 2008

Publications

Mackintosh SA, Wallace JS, Gross MS, Navarro DD, Pérez-Fuentetaja A, Alaee M, Montecastro D, Aga DS. Review on the occurrence and profiles of polybrominated diphenyl ethers in the Philippines. Environment International 2015; in press.

Millow CJ, Mackintosh SA, Lewison RL, Dodder NG, Hoh E. Identifying bioaccumulative halogenated organic compounds using a nontargeted analytical approach: seabirds as sentinels. PLOS One May 28, 2015. DOI:10.1371/journal.pone.0127205.

Shaul NJ, Dodder NG, Aluwihare LI, Mackintosh SA, Maruya KA, Chivers SJ, Danil K, Weller DW, Hoh E. Non-targeted analysis reveals hundreds of unmonitored bioaccumulative compounds in bottlenose dolphins from Southern California. Environmental Science and Technology 2015; 49(3):1328–1338.

Pérez-Fuentetaja A, Mackintosh SA, Zimmerman LR, Clapsadl M, Alaee M, Aga DS. Trophic transfer of flame retardants (PBDEs) in the food web of Lake Erie. Canadian Journal of Fisheries and Aquatic Sciences 2015. DOI: 10.1139/cjfas-2015-0088

Mackintosh SA, Pérez-Fuentetaja A, Zimmerman LR, Pacepavicius G, Clapsadl M, Alaee M, Aga DS. Analytical performance of a triple quadrupole mass spectrometer compared to a high resolution mass spectrometer for the analysis of polybrominated diphenyl ethers in fish. Analytica Chimica Acta 2012; 747:67–75.

Yi T, Mackintosh SA, Aga DS, Harper Jr, WF. Exploring 17α-ethinylestradiol removal, mineralization, and bioincorporation in engineered bioreactors. Water Research 2011; 45:1369–1377.

Khunjar KO, Mackintosh SA, Skotnicka-Pitak J, Baik S, Aga DS, Love NG. Elucidating the relative roles of ammonia oxidizing and heterotrophic bacteria during the biotransformation of 17 α-ethinylestradiol and trimethoprim. Environmental Science and Technology 2011; 45:3605–3612.

Presentations

Mackintosh SA, Hoh E, Shaul NJ, Aluwihare LI, Dodder NG, Maruya KA, Weller DW, Chivers SJ. GCxGC/TOF-MS analysis of technical pesticide mixtures for characterization and occurrence in southern California Dolphins. Oral Presentation, 6th Multidimensional Chromatography Workshop, Toronto, ON, Canada, January 6–7, 2015.

Mackintosh SA, Hoh E, Shaul NJ, Aluwihare LI, Dodder NG, Maruya KA, Weller DW, Chivers SJ. Newly identified persistent and bioaccumulative contaminants with anthropogenic sources in Southern California Bight: importance and prioritization. Oral Presentation, 35th Society of Environmental Toxicology and Chemistry (SETAC) North America Annual Meeting, Vancouver, BC, Canada, November 9–13, 2014.

Mackintosh SA, Hoh E, Quintana PJ, Chambers C, Kim JH, Leff M. Comprehensive exposure assessment of human breast milk: A non-targeted analytical approach for organic contaminants identification and occurrence. Interactive Poster Presentation, 35th Society of Environmental Toxicology and Chemistry (SETAC) North America Annual Meeting, Vancouver, BC, Canada, November 9–13, 2014.

Mackintosh SA, Hoh E, Shaul NJ, Aluwihare LI, Dodder NG. Newly identified halogenated organic compounds in technical pesticide mixtures and their occurrence in Southern California pacific dolphins. Poster Presentation, 2014 American Society for Mass Spectrometry (ASMS) Conference, Baltimore, MD, May 15–19, 2014.

Mackintosh SA, Pérez-Fuentetaja A, Zimmerman LR, Pacepavicius G, Clapsadl M, Alaee M, Aga DS. Analysis of methoxylated and hydroxylated polybrominated diphenyl ethers in plasma of fish from eastern Lake Erie. Poster Presentation, 33rd Society of Environmental Toxicology and Chemistry (SETAC) North America Annual Meeting, Long Beach, CA, November 11–15, 2012.

Mackintosh SA, Pérez-Fuentetaja A, Zimmerman LR, Pacepavicius G, Clapsadl M, Alaee M, Aga DS. Levels and bioaccumulation of halogenated flame retardants in the Lake Erie aquatic food web. Oral Presentation, 2012 Dioxin Conference, Cairns, Australia, August 26–31, 2012.

Mackintosh SA, Pérez-Fuentetaja A, Zimmerman LR, Pacepavicius G, Clapsadl M, Alaee M, Aga DS. Analysis of brominated flame retardants in the Lake Erie food web: levels, bioaccumulation, and trophic transfer. Oral Presentation, 2012 International Association for Great Lakes Research (IAGLR) Conference, Cornwall, ON Canada, May 13–17, 2012.

Mackintosh SA, Pérez-Fuentetaja A, Zimmerman LR, Pacepavicius G, Clapsadl M, Alaee M, Aga DS. Catch of the day-brominated flame retardants’ in the food web of Lake Erie. Poster Presentation, 2011 NSF IGERT Poster Competition, NSF, Washington D.C., May 25 2011. http://www.igert.org/posters2011/posters/117

Mackintosh SA, Zimmerman LR, Pacepavicius G, Alaee M, Aga DS. Advantages and limitations of tandem mass spectrometry, high resolution mass spectrometry, and electron capture detection for analysis of polybrominated diphenyl ethers (PBDEs) in fish. Oral Presentation, 2011 PittCon Conference, Atlanta, GA, March 13–18, 2011.

Mackintosh SA, Pérez-Fuentetaja A, Zimmerman LR, Pacepavicius G, Clapsadl M, Alaee M, Aga DS. Determination of levels of polybrominated diphenyl ethers (PBDEs) in fish from eastern Lake Erie providing insights on food web-mediated transport and bioaccumulation. Oral Presentation, 2010 Dioxin Conference, San Antonio, TX, September 12–17, 2010.

Mackintosh SA, Khunjar KO, Skotnicka-Pitak J, Aga DS, Love NG, Harper Jr WF. Metabolite identification by LC/MS/MS to understand the role of ammonia oxidizing and heterotrophic bacteria during treatment of 17α-ethinylestradiol in wastewater. Poster Presentation, 2010 American Society for Mass Spectrometry (ASMS) Conference, Salt Lake City, UT, May 23–27, 2010.

Prior Experience

Postdoctoral Scholar, Scripps Institute of Oceanography and San Diego State University Center for Oceans and Human Health, 2013–2015

Visiting Scholar, Ontario Ministry of the Environment, Toronto ON, January 2015

Research Assistant, University at Buffalo-SUNY, 2008–2013

Teaching Assistant, University at Buffalo-SUNY, 2008–2012

Visiting Scholar, Environment Canada, Burlington ON, January-August 2010

Professional Affiliations

American Chemical Society—ACS, Analytical Division (2008–2015)

American Society for Mass Spectrometry—ASMS (2009–2015)

Society of Environmental Toxicology and Chemistry—SETAC (2012–2015)

University of Buffalo Graduate Chemistry Club—UB-GCC (2008–2013)

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Analytical Chemistry, University at Buffalo-SUNY, 2013
  • B.S., Chemistry, College at Oneonta-SUNY, 2008
  • Postdoctoral Scholar, Scripps Institute of Oceanography and San Diego State University Center for Oceans and Human Health, 2013–2015

    National Science Foundation (NSF) Doctorate Fellowship, University at Buffalo/Buffalo Public School Interdisciplinary Science and Engineering Partnership (UB/BPS ISEP) program, Department of Chemistry, SUNY-University at Buffalo, 2011–2013

    Otto Hutzinger Student Award, Dioxin Conference, Cairns, Australia, August 26–31, 2012

    NSF Integrated Graduate Education through Research and Training (IGERT) Poster Competition Winner, Washington D.C., May 25, 2011

    NSF IGERT Doctorate Fellowship, Grant: Ecosystem Restoration through Interdisciplinary Exchange (ERIE), Department of Environmental Engineering, SUNY-University at Buffalo, 2009–2011

    Dean’s Interdisciplinary CAMBI Fellowship, Chemistry Department, SUNY- University at Buffalo, 2008

    Academic Achievement Award in Chemistry, Chemistry Department, SUNY-Oneonta, 2008