Mark Schocken
Mark J. Schocken, Ph.D., R.Ph.
Senior Managing Scientist
Chemical Regulation & Food Safety
  • District of Columbia

Dr. Schocken has worked in the agrochemical industry since 1985 for registrant companies, a major contract research organization, and consultancies. His areas of expertise include environmental fate and ecological effects, metabolism, analytical and residue chemistry, and the use of soil microbes for synthesizing metabolite reference standards as an alternative to conventional chemical synthesis. Dr. Schocken has been responsible for placing and monitoring studies at contract laboratories in the United States and Europe for over 25 years, as well as reviewing and interpreting such studies in devising regulatory strategies. He has addressed all aspects of the study placement and monitoring process, including laboratory selection, pricing, technical oversight, and review of draft and final reports. Dr. Schocken also applies this study placement and monitoring expertise in data compensation cases.

Dr. Schocken conducts environmental computer modeling with numerous tools including SciGrow, GENEEC, PRZM/EXAMS, EpiSuite, ECOSAR, PBT Profiler, AgDrift, and others for the purpose of predicting pesticide exposure and preparing ecological and endangered species risk assessments. He has represented companies in face-to-face meetings with regulatory agencies in the United States, Canada and Europe.

His natural products chemistry training provides him with expertise in such areas as microbial biosynthesis and metabolism, fermentation techniques, structural elucidation (particularly interpretation of NMR and MS spectra) and chromatography (HPLC and TLC). This training makes Dr. Schocken highly capable of identifying unknown metabolites and postulating degradation pathways.

Dr. Schocken’s three-year postdoctoral fellowship in applied environmental microbiology under the direction of David T. Gibson provided him with a broad-based knowledge of microbial strategies for degrading recalcitrant organic compounds such as PAHs and PCBs. The particular combination of chemistry and microbiology training has helped Dr. Schocken understand and characterize degradation processes in various environmental compartments and has allowed him on numerous occasions to prepare successful position papers and data-requirement waivers. Furthermore, applying this knowledge and experience has helped Dr. Schocken play a significant role for his clients in achieving new pesticide registrations as well as maintaining registrations.

Prior to joining Exponent, Dr. Schocken was an independent consultant. He has been a director/manager, a regulatory scientist, a study director, and a technical study monitor for studies conducted at contract laboratories. Dr. Schocken is also a registered pharmacist and uses his pharmacy training in various areas of his work.

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Pharmacy, University of Maryland, 1982
  • B.S., Pharmacy, University of Maryland, 1971, with high honors

LICENSES & CERTIFICATIONS

Registered Pharmacist, State of Pennsylvania, License Number RP037223R (inactive)

Publications

Schocken MJ. Degradation of compounds in soil. More than chemistry—What about the microbes? Poster presentation, ACS/IUPAC Meeting, August 2014.

Hillwalker W, Stafford J, Brewer L, Schocken M, Staveley J. Regurgitation and avoidance in passerine acute studies—A case study and a path forward. Poster presentation, SETAC Meeting, Nashville, TN, 2013.

Poletika NN, Teply M, Dominguez LG, Cramer SP, Schocken MJ, Habig C, Kern M, Ochoa-Acuña H, Mitchell GC. A spatially and temporally explicit risk assessment for salmon from a prey base exposed to agricultural insecticides. Integrated Environmental Assessment and Management 2012; 8(2):285–300.

Schocken MJ. Using microbes for synthesizing agrochemical metabolites. American Chemical Society National Meeting, Presentation #134, August 2011.

Poletika N, Schocken M, Habig C, Kern M, Ochoa-Acuna H, Mitchell G, Teply M, Cramer S. Spatially and temporally explicit risk assessment for Upper Willamette Spring Chinook Salmon exposed to organophosphate and carbamate insecticides. SETAC North American Annual Meeting, Presentation #533, Portland, OR, November 10, 2010.

Cramer SP, Poletika N, Everich R, Schocken M, Habig C, Reiss R. Framework for estimating exposure of ESA-listed salmon to pesticides. American Chemical Society National Meeting, August 2008. 

Schocken M, Coody P, Gustafson D, Hertl P, Jones R, Russell M. Case studies on removal of pesticide residues by commercial water treatment. Scientist-to-Scientist Workshop, USEPA, Crystal City, VA, January 28–29, 2004. 

Hertl P, Phelps W, Gustafson D, Jackson S, Jones R, Russell M, Schocken M. A comparison of USEPA’s Tier 1 and 2 Index Reservoir Model estimates in drinking water reservoir monitoring results in selected US systems in 1999/2000. 10th IUPAC International Congress of the Chemistry of Crop Protection, Basle, Switzerland, August 2002. 

Schocken, MJ. In-vitro methods in metabolism and environmental fate studies. In: Pesticide Biotransformation in Plants and Microorganisms, ACS Symposium Series 2000; 777:30–39. 

Schocken, MJ. Review: Microbial synthesis of agrochemical metabolites. Journal of Industrial Microbiology and Biotechnology 1997; 19:392–400. 

Schocken, MJ, Mao J, Schabacker DJ. Microbial transformations of the fungicide cyprodinil (CGA-219417). Journal of Agricultural and Food Chemistry 1997; 45:3647–3651. 

Boyd, DR, Sharma ND, Agarwal R, Resnick SM, Schocken MJ, Gibson DT, Sayer JM, Yagi H, Jerina DM. Bacterial dioxygenase-catalyzed dihydroxylation and chemical resolution routes to Enantiopure cis-dihydrodiols of chrysene. Journal of the Chemical Society, Perkin Transactions 1; 1997; 1715–1723. 

Liu, Song Yu, Schocken MJ, Rosazza JPN. Microbial transformations of Clomazone. Journal of Agricultural and Food Chemistry 1996; 44:313–319. 

Spanggord RJ, Gordon GR, Schocken MJ, Starr RI. Bioconcentration and metabolism of [14C]3-Chloro-p-Toluidine Hydrochloride by Bluegill Sunfish. Environmental Toxicology and Chemistry 1996; 15(10):1655–1663. 

Gibson DT, Resnick SM, Lee K, Brand JM, Torok DS, Wachett LP, Schocken MJ, Haigler BE. Desaturation, dioxygenation, and monooxygenase reactions catalyzed by naphthalene dioxygenase from Pseudomonas sp. Strain 9816-4. Journal of Bacteriology 1995; 2615–2621. 

ElNaggar, Shaaban F, Creekmore RW, Schocken MJ, Rosen RT, Robinson RA. Metabolism of Clomazone in soybeans. Journal of Agricultural and Food Chemistry 1992; 40:880–883. 

ElNaggar SF, Tullman RH, Creekmore RW, Rosen RT, Schocken MJ, Robinson RA. Metabolism, disposition and pharmacokinetics of Bifenthrin in Rats. Gordon Research Conference on Drug Metabolism, T-6, 1991. 

Schocken MJ, Creekmore RW, Theodoridis G, Nystrom GJ, Robinson RA. Microbial transformation of the Tetrazolinone Herbicide F5231. Applied and Environmental Microbiology 1989; 1220–1222. 

Nadim LM, Schocken MJ, Higson FK, Gibson DT, Behard DL, Bopp LH, Mondello FJ. Bacterial oxidation of polychlorinated biphenyls. Proceedings, 13th Annual Research Symposium on Land Disposal, Remedial Action, Incineration and Treatment of Hazardous Waste, pp 395 – 402, EPA/600/9-87/015, US EPA, Cincinnati, OH, 1987. 

Rosler, Karl-Heinz A, Blomster RN, Schocken MJ. A three-piece, all-glass system for radial chromatography. Journal of Chemical Education 1986; 63:813–814. 

Schocken MJ, Speedie MK. Physiological aspects of Atrazine Degradation by higher marine fungi. Archives of Environmental Contamination and Toxicology 1984; 13:707–714. 

Schocken MJ, Gibson DT. Bacterial oxidation of the polycyclic hydrocarbons acenaphthene and acenaphthylene. Applied and Environmental Microbiology 1984; 48:10–16. 

Schocken MJ, Speedie MK. Interaction of higher marine fungi with the herbicide Atrazine. III. Adsorption of Atrazine to the Marine Fungus Dendryphiella salina. Chemosphere 1982; 11(9):885–890. 

Schocken MJ, Speedie MK. Interaction of higher marine fungi with the herbicide Atrazine. II. Sorption of Atrazine to four species of marine fungi. Bulletin of Environmental Contamination and Toxicology 1982; 29:101–106. 

Schocken MJ, Speedie MK, Kirk, Jr PW. Interaction of higher marine fungi with the herbicide Atrazine. I. Survey of interactive modes. Mycologia 1982; 74(5):801–808. 

Prior Experience

Independent Consultant for Agrochemical Industry, 2008–2011

Manager of Registration Chemistry and Toxicology/Risk Assessment, Crop Protection Division, Chemtura (formerly Crompton, Uniroyal Chemical), 1996–2008

Manager of Environmental Fate and Metabolism Programs, Springborn Laboratories Inc., 1992–1996

Senior Research Chemist, later Manager of Metabolism and Environmental Chemistry, Agricultural Chemicals Group, FMC Corporation, 1987–1992

Senior Chemist, Agricultural Chemicals Group, Mobay Corporation (now Bayer Crop Science), 1985–1987

Postdoctoral Fellow, Applied Microbiology, University of Texas at Austin, 1982–1985

Professional Affiliations

Reviewer, Journal of Agricultural and Food Chemistry

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Pharmacy, University of Maryland, 1982
  • B.S., Pharmacy, University of Maryland, 1971, with high honors

LICENSES & CERTIFICATIONS

Registered Pharmacist, State of Pennsylvania, License Number RP037223R (inactive)