Min-Sun Son
Min-Sun Son, Ph.D.
Manager
Biomedical Engineering
  • Menlo Park

Dr. Son specializes in conducting magnetic resonance imaging (MRI) compatibility evaluation of medical devices, according to the relevant ASTM standards and ISO technical specification for active implants. She has experience with FDA submissions and works with clients to formulate technical responses to regulatory questions raised regarding MRI conditional labeling. Her breadth of experimental experience spans a wide range of implants (orthopedic, cardiovascular, gastrointestinal) and other medical systems intended for use in an MR environment (imaging guidance devices, gas delivery systems, delivery pumps).

Complimentary to experimental evaluation of devices, Dr. Son uses computational modeling to evaluate complicated device systems and product families. She is an active member of the ASTM MRI committee and is the technical lead for ASTM F2978, Guide to Optimize Scan Sequences for Clinical Diagnostic Evaluation of Metal-on-Metal Hip Arthroplasty Devices using Magnetic Resonance Imaging. She is also involved in the Joint Working Group.

Dr. Son’s additional area of expertise includes soft tissue biomechanics, osteoarthritis, and tissue engineering. In her graduate work, she conducted research studies on diagnosis and treatment of knee osteoarthritis, focusing on cartilage and meniscus. She evaluated the use of MRI parameters as functional, quantitative indicators of tissue degeneration, with the goal of using them in early diagnosis of osteoarthritis. Through this process, she has gained extensive experience in MR image acquisition, imaging data analysis (MATLAB), tissue characterization, and mechanical testing. In addition, she developed a simple analytical approach to evaluate and characterize the heterogeneity of the meniscus using gene expression profiles and statistical methods for the purpose of providing a standard for engineered tissue. She has working knowledge of various experimental techniques, including cell and tissue culture, reverse transcription polymerase chain reaction (RT-PCR), histology, and protein purification.

Previously, Dr. Son has worked as a mechanical engineering co-op at the Cardiac Rhythmic Management Division at St. Jude Medical and designed tooling and parts for pacemakers and implantable cardioverter defibrillators (ICD) using ProE. She has obtained Six Sigma Orange Belt certification in this process. She has also worked as a research assistant in a cell biomechanics lab, developing cyclic cell stretching protocols.

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Bioengineering, Stanford University, 2013
  • M.S., Bioengineering, Stanford University, 2009
  • B.S., Biomedical Engineering, Washington University in St. Louis, 2007, magna cum laude
  • Stanford Ignite (Summer Institute of Entrepreneurship), Graduate School of Business, Stanford University (2012)

    Siebel Scholarship (2011–2012)

    Bio-X Fellowship (2007–2010)

    American Society of Mechanical Engineers Bioengineering Conference 3rd Place Poster Competition 

LICENSES & CERTIFICATIONS

Six Sigma – Orange Belt

LANGUAGES

  • Korean
  • French

Publications

Shapiro LM, McWalter EJ, Son MS, Levenston M, Hargreaves BA, Gold GE. Mechanisms of osteoarthritis in the knee: MR imaging appearance. Journal of Magnetic Resonance Imaging 2014; 39:1346–1356.

Son M, Goodman SB, Chen W, Hargreaves BA, Gold GE, Levenston ME. Regional variation in T1ρ and T2 times in osteoarthritic human menisci: Correlation with mechanical properties and matrix composition. Osteoarthritis and Cartilage 2013; 21(6):796–805.

Son M, Levenston ME. Discrimination of meniscal cell phenotypes using gene expression profiles. European Cells and Materials 2012; 23:195–208.

Presentations

Son MS. Levenston ME, Hargreaves BA, Gold GE. T1rho and T2 show regional variation in degenerate human menisci: Correlation with biomechanics and Matrix Composition. ISMRM 20th Annual Meeting, 2012.

Son, MS. Goodman SB, Hargreaves BA, Chen W, Gold GE, Levenston ME. Regional variation of short echo time T2 and T1rho measurements in menisci from osteoarthritic subjects. ORS 58th Annual Meeting, 2012.

Son MS, Keenan E, Levenston ME. Quantitative tracking of passage and 3D culture effects on chondrocyte and fibrochondrocyte gene expression. ORS 57th Annual Meeting, 2011.

Son MS, Levenston ME. Are passaged chondrocytes phenotypically similar to meniscal fibrochondrocytes? ASME SBC, 2010.

Son MS, Chen W, Han E, Takahashi A, Goodman SB, Levenston ME, Gold GE. Comparison of short echo time T2 and T1rho measurements in menisci from subjects with osteoarthritis. ISMRM 18th Annual Meeting, 2010.

Son MS, Levenston ME. Discrimination of regional phenotypes using gene expression profiles. ORS 56th Annual Meeting, 2010.


Professional Affiliations

Engineering Honor Societies: Tau Beta Pi (Engineering), Pi Tau Sigma (Mechanical Engineering), Alpha Eta Mu Beta (Biomedical Engineering)

News & Events

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Bioengineering, Stanford University, 2013
  • M.S., Bioengineering, Stanford University, 2009
  • B.S., Biomedical Engineering, Washington University in St. Louis, 2007, magna cum laude
  • Stanford Ignite (Summer Institute of Entrepreneurship), Graduate School of Business, Stanford University (2012)

    Siebel Scholarship (2011–2012)

    Bio-X Fellowship (2007–2010)

    American Society of Mechanical Engineers Bioengineering Conference 3rd Place Poster Competition 

LICENSES & CERTIFICATIONS

Six Sigma – Orange Belt

LANGUAGES

  • Korean
  • French