Ryan Wade
Ryan Wade, Ph.D.
Associate
Polymer Science & Materials Chemistry
  • Philadelphia

Dr. Wade’s area of expertise is in polymer design, synthesis, and characterization, with an emphasis on the development of polymeric systems for biomedical applications including drug delivery, regenerative medicine, and tissue engineering. His areas of focus include hydrogel development, micro and nano-particle formulation, polymeric biodegradation, biocompatibility of materials, and drug delivery.

The interdisciplinary nature of Dr. Wade’s background has given him extensive experience in chemical, mechanical, and biological characterization of polymeric materials. In particular, he is well versed in polymer synthesis, solid-phase peptide synthesis, and a wide variety of chemical characterization techniques including UV-Visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), 1H nuclear magnetic resonance spectroscopy (NMR), mass spectroscopy (MALDI-TOF), and gel permeation chromatography (GPC). Additionally, he is proficient in mechanical characterization techniques including nano-indentation, oscillatory rheometry, and dynamic mechanical analysis with a particular focus on the mechanical behavior of hydrogels. He is experienced in both in vitro (cell culture, enzymatic degradation and protein release from polymers, confocal and scanning electron microscopy) and in vivo (material erosion, protein staining, near-infrared imaging) characterization for the evaluation of the biocompatibility of polymeric materials.

Prior to joining Exponent, Dr. Wade’s academic research developed multiple hydrogel systems to control cell-material interactions by designing biophysical and biochemical signals into polymeric materials. Before completing his Ph.D., Dr. Wade worked at Merck & Co. as a Manufacturing Facilitator for bulk protein purification of the Gardasil® vaccine and is experienced in GMP compliant manufacturing practices.

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Materials Science & Engineering, University of Pennsylvania, 2015
  • B.S., Materials Science & Engineering, Johns Hopkins University, 2008
  • National Science Foundation Graduate Research Fellow, University of Pennsylvania, 2011–2015


    Materials Science Senior Achievement Award, Johns Hopkins University, 2008

    Senior Design Research Award, Johns Hopkins University, 2008

    Tau Beta Pi Appreciation Award, National Engineering Honor Society, Johns Hopkins University, 2008

Publications

Rodell CB, Wade RJ, Purcell BP, Dusaj N, Burdick JA. Selective proteolytic degradation of guest-host assembled, injectable hyaluronic acid hydrogels. ACS Biomaterials Science & Engineering 2015; 1.

Wade RJ, Bassin EJ, Rodell CB, Burdick JA. Protease-degradable electrospun fibrous hydrogels. Nature Communications 2015; 6.

Wade RJ, Bassin EJ, Gramlich WM, Burdick JA. Nanofibrous hydrogels with spatially patterned biochemical signals to control cell behavior. Advanced Materials 2015; 27.

Rodell CB, MacArthur JW, Dorsey SM, Wade RJ, Wang LL, Woo YJ, Burdick JA. Shear-thinning supramolecular hydrogels with secondary autonomous covalent crosslinking to modulate viscoelastic properties in vivo. Advanced Functional Materials 2014; 25.

Wade RJ, Burdick JA. Advances in nanofibrous scaffolds for biomedical applications: From electrospinning to self-assembly. Nano Today 2014.

Highley CB, Rodell CB, Kim IL, Wade RJ, Burdick JA. Ordered, adherent layers of nanofibers enabled by supramolecular interactions. Journal of Materials Chemistry B 2014; 2.

Purcell BP, Lobb D, Charati MB, Dorsey SM, Wade RJ, Zellars KN, Doviak H, Pettaway S, Logdon CB, Shuman JA, Novak C, Gorman JH, Gorman RC, Spinale FG, Burdick JA. Injectable and bioresponsive hydrogels for on-demand matrix metalloproteinase inhibition. Nature Materials 2014; 13.

Wade RJ, Burdick JA. Engineering ECM signals into biomaterials. Materials Today 2012; 15.

Presentations


Wade RJ, Burdick JA. Patterning biochemical signals into nanofibrous hydrogels to spatially control cell behavior. Society for Biomaterials, Charlotte, NC, 2015.

Rodell CB, MacArthur JW, Wade RJ, Dorsey SM, Burdick JA. Injectable dual-crosslinking hydrogels to decouple material retention and mechanical properties in vivo. Society for Biomaterials, Charlotte, NC, 2015.

Wade RJ, Gramlich WM, Bassin EJ, Burdick JA. Biomimetic patterned biochemical and biophysical properties within electrospun nanofibrous hydrogels. Materials Research Society Spring Meeting, San Francisco, CA, 2014.

Wade RJ, Bassin EJ, Burdick JA. Engineered MMP sensitivity within electrospun nanofibrous hydrogels. Materials Research Society Spring Meeting, San Francisco, CA, 2014.

Wade RJ, Burdick JA. Fibrous hyaluronic acid scaffolds with engineered degradation through MMP sensitivity. Society for Biomaterials, Boston, MA, 2013.

Burdick JA, Kim IL, Wade RJ. Engineered fibrous scaffolds that mimic features of natural ECM. ASME 2nd Global Congress on Nanoengineering for Medicine and Biology, Boston, MA, 2013.

Wade RJ, Burdick JA. MMP-sensitive and photopolymerizable hyaluronic acid macromers to fabricate biomimetic fibrous scaffolds. 244th American Chemical Society Meeting, Philadelphia, PA, 2012.

Wade RJ, Burdick JA. Hyaluronic acid macromers in tissue engineering. Penn Polymer Seminar Series, Philadelphia, PA, 2012.

Wade RJ, Burdick JA. MMP-sensitive and photopolymerizable hyaluronic acid macromers to fabricate biomimetic fibrous scaffolds. Gordon Research Conference: Signal Transduction by Engineered Extracellular Matrices, Biddeford, ME, 2012.

Prior Experience

Graduate Research Assistant, University of Pennsylvania, 2010–2015

Manufacturing Facilitator, Merck, 2008–2010

Teaching Assistant – Materials Lab I, Johns Hopkins University, 2008

Professional Affiliations

Society for Biomaterials

Tau Beta Pi Engineering Honor Society

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Materials Science & Engineering, University of Pennsylvania, 2015
  • B.S., Materials Science & Engineering, Johns Hopkins University, 2008
  • National Science Foundation Graduate Research Fellow, University of Pennsylvania, 2011–2015


    Materials Science Senior Achievement Award, Johns Hopkins University, 2008

    Senior Design Research Award, Johns Hopkins University, 2008

    Tau Beta Pi Appreciation Award, National Engineering Honor Society, Johns Hopkins University, 2008