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Dr. Mann specializes in biomedical and electrical engineering systems, with particular emphasis in those containing MEMS and VLSI components. She is knowledgeable in design and fabrication techniques, utilizing layout software, working in class-100 cleanroom facilities, and operating related equipment (mask aligner, reactive ion etching, electron beam metal deposition, DekTak profilometer, and SEM). Dr. Mann has experience analyzing devices using finite-element modeling. She has also verified biomedical device functionality in both laboratory and animal model environments. Dr. Mann previously worked for The BioSTAR Group, Inc., where she helped prototype, characterize, and analyze devices for emergency personnel. These devices included a portable ventilator, a triage device for military medics, and a modified pulse oximeter for determination of heat exhaustion in fire fighters. Prior to joining Exponent, Dr. Mann was a research assistant in the Department of Biomedical Engineering at the University of Southern California, where she collaborated with ophthalmic surgeons to develop the first MEMS intraocular drug delivery device designed to provide spatial and temporal control of a drug regimen to treat chronic ocular diseases. Additionally, she helped create an arrayed and standardized interconnect method for providing rapid and on-demand connections for microfluidic devices.
Meng E, Li P-Y, Lo R, Sheybani R, Gutierrez C. Implantable MEMS drug delivery pumps for small animal research. IEEE Engineering in Medicine and Biology Conference, pp. 6696–6698, Minneapolis, MN, September 2–6, 2009.
Lo R, Li P-Y, Saati S, Agrawal R, Humayun MS, Meng E. A passive MEMS drug delivery pump for treatment of ocular diseases. Biomedical Microdevices 2009; 11(5):959–970.
Saati S, Lo R, Li P-Y, Meng E, Varma R, Humayun MS. Mini-drug pump for ophthalmic use. The 145th Meeting of the American Ophthalmological Society, Half-Moon Bay, CA, May 14–17, 2009.
Lo R, Meng E. In-plane bandpass regulation check valve in heat-shrink packaging for drug delivery. The 20th IEEE International Conference on Micro Electro Mechanical Systems, Sorrento, Italy, January, 25–29, 2009.
Lo R, Li P-Y, Agrawal R, Humayun MS, Meng E. A passive refillable intraocular MEMS drug delivery device. Lab on a Chip 2008; 8:1027–1030.
Lo R, Meng E. Integrated and reusable in-plane microfluidic interconnects. Sensors and Actuators B: Chemical 2008; 132(2):531–539.
Li P-Y, Shih J, Lo R, Agrawal R, Saati S, Humayun MS, Tai YC, Meng E. An electrochemical intraocular drug delivery device. Sensors and Actuators A-Physics 2008; 143(1):41–48.
Lo R, Meng E. Characterization and fabrication of high-density, on-demand, reusable, in-plane polymer interconnects towards standardized microfluidic packaging. The 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, San Diego, CA, October 12–15, 2008.
Lo R, Meng E. High-density reusable In-plane microfluidic interconnects. BMES Annual Fall Meeting, St. Louis, MO, October 2–4, 2008.
Lo R, Li P-Y, Saati S, Agrawal R, Humayun MS, Meng E. In vivo studies demonstrating feasibility and biocompatibility of a MEMS ocular drug delivery system. BMES Annual Fall Meeting, St. Louis, MO, October 2–4, 2008.
Saati S, Lo R, Li P-Y, Shih J, Tai YC, Meng E, Agrawal RN, Humayun MS. Surgical methods to place a novel refillable ocular Microelectromechanical System (MEMS) drug delivery device. ARVO 2008, Ft. Lauderdale, FL, April 27–May 1, 2008.
Li P-Y, Lo R, Shih J, Saati S, Agrawal R, Tai YC, Humayun MS, Meng E. Surgical testing of a Microelectromechanical System (MEMS) ocular drug delivery system. BMES 2007 Annual Meeting, Los Angeles, CA, September 26–29, 2007.
Lo R, Meng E. A reusable in-plane polymer integrated microfluidic interconnect. The 14th International Conference on Solid-State Sensors, Actuators and Microsystems, Lyon, France, pp. 2067–2070, June 10–14, 2007.
Lo R, Li P-Y, Shih J, Saati S, Agrawal R, Tau Y-C, M. Humayun, Meng E, “Refillable MEMS Drug Delivery Pump for Chronic Ocular Diseases,“ 2007 ARVO Annual Meeting, pp. 110, Fort Lauderdale, Florida, May 6-10, 2007.
Saati S, Lo R, Li P-Y, Shih J, Tau Y-C, Meng E, Agrawal RN, Humayun MS. Surgical methods to place a novel refillable ocular Microelectromechanical System (MEMS) drug delivery device. 2007 ARVO Annual Meeting, pp. 279, Fort Lauderdale, FL, May 6–10, 2007.
Li P-Y, Shih J, Lo R, Adams B, Agrawal R, Saati S, Humayun MS, Tai Y-C, Meng E. An electrochemical intraocular drug delivery device. The 20th IEEE International Conference on Micro Electro Mechanical Systems, pp. 15–18, Kobe, Japan, January 21–25, 2007.
Rouhanizadeh M, Soundararajan G, Ascara D, Lo R, Browand F, Hsiai TK. MEMS sensors to resolve spatial variations in shear stress in A 3-D bifurcation model. IEEE Sensors 2006; 6(1):78–88.
Meng E, Shih J, Li P, Lo R, Humayun MS, Tai Y. Electrolysis-driven drug delivery for treatment of ocular disease. The 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, pp. 633–635, Tokyo, Japan, November 2006.
Lo R, Kuwahara K, Li P, Tai Y, Humayun MS, Meng E. A passive refillable intraocular MEMS drug delivery device. International Conference on Microtechnologies in Medicine and Biology, pp. 74–77, Okinawa, Japan, May 2006.
Van Gelder C, Pranger LA, Urias AR, Lo R, Wiesmann WP, Winchell RJ, Kolka MA, Stachenfeld N, Bogucki S. Physiologic monitoring in extreme environments: Application of microsensors and embedded processors to predict heat stress in fire fighters. Biomedical Diagnostic, Guidance, and Surgical-Assist Systems IV, Vol. 4615, pp. 71–81.
Ling GS, Urias A, Lo R, Yun C, Lee E, Becker J, Bogucki S, Rhee P, Alam H, Ecklund J. The Medical Triage Assistant: A Diagnostic Sensor Suite for Far Forward Medical Care. RTO HFM Symposium on “Combat Casualty Care in Ground Based Tactical Situations: Trauma Technology and Emergency Medical Procedures,” St. Pete Beach, FL, August 16–18, 2004. Published in RTO-MP-HFM-109.
Book Chapters
Lo R, Meng E. Chapter 21. Fabrication and Microfluidics. Lab Lab-on-a-Chip Technology, Vol. 1, Caister Academic Press, 2009.
- Research Assistant, Department of Biomedical Engineering at the University of Southern California, 2002–2009
- Director of Business Development and Engineer, The BioSTAR Group, Inc., 2001–2002
- Intern, Lawrence Livermore National Laboratory, 2000
- Biomedical Engineering Society—BMES
- Institute of Electrical and Electronics Engineers—IEEE
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- Ph.D., Biomedical Engineering, University of Southern California, 2009
- M.S., Electrical Engineering, University of Southern California, 2009
- M.S., Biomedical Engineering, University of Southern California, 2005
- B.S., Engineering, Harvey Mudd College, honors 2001
- USC Department of Biomedical Engineering Annual Research Symposium Platform Speaker Award, 2009
- Whitaker Foundation Biomedical Device Fellow, 2002–2005
- USC Department of Biomedical Engineering Fellow, 2002–2005
- Donald A. Strauss Public Service Foundation Grant, 2000
- U.S. Patent: Interconnect For MEMS Device Including A Viscoelastic Septum, submitted February 2009 (Meng E, Lo R).
- U.S. Patent: In-Plane Bandpass Regulation Check Valve In Heat-Shrink Packaging For Drug Delivery. Provisional Patent, submitted February 2009 (Meng E, Lo R).
- U.S. Patent: Implantable Drug-Delivery Devices, and Apparatus and Methods for Refilling the Devices, submitted January 2009 (Meng E, Humayun MS, Lo R, Li P).
- U.S. Patent: Implantable MEMS Ocular Drug Delivery System, submitted March 2007 (Meng E, Tai Y, Humayun M, Agrawal R, Lo R, Shih J, Li P, Rodger DC, Chen P).
- U.S. Patent: Home Care Monitor Systems, submitted August 2002 (Wiesmann WP, Urias AR, Pranger LA, Lo R).
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