Dr. Sandra J. Hong is a Managing Scientist in Exponent’s Health Sciences Center for Toxicology and Mechanistic Biology. Dr. Hong has over 10 years of consulting experience, performing risk assessments and toxicology evaluations of numerous industrial chemicals and petroleum products. Dr. Hong’s experience at Exponent covers a wide range of toxicants, including chemical mixtures, aromatic hydrocarbons, pathogens in water, and metals in the environment.
In the petrochemical industry, Dr. Hong’s work focused on product stewardship risk assessments and laboratory methods development. Dr. Hong refined short-term test methodologies and data analysis approaches for predicting the carcinogenic potential of petroleum streams based on polycyclic aromatic hydrocarbons content. Dr. Hong also investigated the dermal sensitization potential of a range of industrial chemicals, and for two years led the toxicology emergency response team in responding to health concerns arising from accidental spills, explosions, and worker exposures.
Dr. Hong’s doctoral training focused on the neuroactivity of organic compounds, including dioxins, polychlorinated biphenyls, and organophosphorus pesticides and chemical warfare agents. Dr. Hong has also conducted behavioral research on monkeys in the study of learning and memory processes, and the neuroanatomical mechanisms underlying the observations.
Fedoruk M, Hong S. Gastrointestinal toxicology. In: Information Resources in Toxicology, 4th Edition. Wexler P (ed), Elsevier, in press.
Proctor DM, Gatto NM, Hong SJ, Allamneni KP. Mode-of-action framework for evaluating the relevance of rodent forestomach tumors in cancer risk assessment. Toxicol Sci 2007; 98(2):313–326.
Tiffany-Castiglioni E, Hong S, Qian Y, Tang Y, Donnelly KC. In vitro models for assessing neurotoxicity of mixtures. Neurotoxicology 2006; 27(5):835–839.
Hong MS, Hong SJ, Barhoumi R, Burghardt RC, Donnelly KC, Wild JR, Venkatraj V, Tiffany-Castiglioni E. Neurotoxicity induced in differentiated SK-N-SH-SY5Y human neuroblastoma cells by organophosphorus compounds. Toxicol Appl Pharmacol 2003; 186:110–118.
Hong SJ, Grover CA, Safe SH, Tiffany-Castiglioni E, Frye GD. Halogenated aromatic hydrocarbons suppress CA1 field excitatory postsynaptic potentials in rat hippocampal slices. Toxicol Appl Pharmacol 1998; 148:7–13.
Dorandeu F, Hong MS, Hong SJ, Draganov D, Wild JR, Furlong C. Neurotoxicity associated with organophosphates. Proc. NATO Advanced Research Workshop on Demilitarization, Decontamination and Detoxification of Chemical Warfare Agents, Moscow, Russia, May 1996.
Tiffany-Castiglioni E, Legare ME, Schneider LA, Hanneman WH, Zenger E, Hong SJ. Astroglia and lead neurotoxicity. pp. 167–192. In: The Role of Glia in Neurotoxicity, Aschner M, Kimelburg HK (eds). CRC Press, Inc., 1996.
Presentations with Published Abstracts
Hong SJ, Aylward L, Edwards M, Maltby C, Fedoruk MJ. Effect of PCB contaminated soils on serum PCB levels in trailer park residents. Society of Toxicology 47th Annual Meeting, Seattle, WA, March 2008.
Hong S, Proctor D, Finley B. Assessment of LA sewage spills on Santa Monica Bay beaches. Society of Toxicology 45th Annual Meeting, San Diego, CA, March 2006.
Hong SJ, Proctor DM, Finley BL. Exposure to sewage spill-related pathogens at Santa Monica Bay beaches. Fourth Society of Environmental Toxicology and Chemistry World Congress and 25th Annual Meeting, Portland, OR, November 2004.
Hong SJ, Forgash RC, Nessel CS, Coker DT, Mumford DL. Evaluation of proton NMR spectroscopy for predicting carcinogenicity of heavy petroleum oils. 20th Annual Meeting of the American College of Toxicology, McLean, VA, November 1999.
Hong MS, Hong SJ, Barhoumi R, Burghardt RC, Donnelly KC, Wild JR, Tiffany-Castiglioni E. Organophosphate-induced neurotoxicity in differentiated SK-N-SH-SY5Y human neuroblastoma cells. Society of Toxicology 37th Annual Meeting, Seattle, WA, March 1998.
Hong S, Hong M, Barhoumi R, Burghardt R, Donnelly KD, Wild JR, Safe S, Tiffany-Castiglioni E. Effects of TCDD and PCB on intracellular calcium in SH-SY5Y human neuroblastoma cells. Southwestern and Rocky Mountain Division, American Association for the Advancement of Science, 73rd Annual Meeting, College Station, TX, 1997.
Hong SJ, Grover CA, Frye GD, Safe SH, Tiffany-Castiglioni E. Inhibition of excitatory post-synaptic potentials in rat hippocampal slices by 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,2’,5,5’-tetrachlorobephenyl. Society of Toxicology 35th Annual Meeting, Anaheim, CA, March 1996.
Hong SJ, Grover CA, Frye GD, Safe SH, Tiffany-Castiglioni E. Inhibition of excitatory post-synaptic potentials in rat hippocampal slices by 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,2’,5,5’-tetrachlorobephenyl. 13th International Neurotoxicology Conference, Hot Springs, AR, October 29–November 1, 1995.
Hong SJ, Frye GD, Safe SH, Tiffany-Castiglioni E. Excitatory post-synaptic potentials in rat hippocampal slices: a model for neurotoxicity screening of halogenated aromatic hydrocarbons. College of Veterinary Medicine Fall Forum, Texas A&M University, College Station, TX, August 1995.
Hong SJ, Grover CA, Frye GD, Safe SH, Tiffany-Castiglioni E. Region-specific effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on excitatory post-synaptic potentials in rat hippocampal slices. Society of Toxicology 34th Annual Meeting, Baltimore, MD, March 1995.
Tiffany-Castiglioni E, Hanneman WH, Legare ME, Hong SJ, Barhoumi R, Safe S. Congener-specific effects of dioxins on neural cells. 25th Annual Meeting of the American Society for Neurochemistry, Albuquerque, NM, 1994.
Tiffany-Castiglioni E, Hanneman WH, Legare ME, Hong SJ, Barhoumi R, Burghardt RC, Safe S. Congener-specific effects of dioxins on neural cell cultures and brain slices. 9th Annual Conference on Hazardous Waste Remediation, Bozeman, MT, June 1994.
Hong SJ, Lu Y-F, Tiffany-Castiglioni E, Safe S. Aryl hydrocarbon receptor-mediated responsiveness in cultured neural cell lines. Gulf Coast Chapter Society of Toxicology 10th Annual Meeting, Galveston, TX, November 1993.
Other Recent Published Abstracts
Proctor D, Gujral J, Hong SJ, Gatto N. Airborne exposures to hexavalent chromium in the chromate production and aerospace industries. 15th Annual Conference of the International Society of Exposure Analysis, Tucson, AZ, November 2005.
Shrestha PL, Hamilton D, Jordan N, Doroudian M, Hong S, Proctor D. Impact of sewage line spills on pathogen levels in recreational waters. World Water and Environmental Resources Congress 2005, Anchorage, AK, May 2005.
Proctor D, Hong S. Relevance of rodent forestomach tumors in cancer risk assessment. Society of Toxicology 44th Annual Meeting, New Orleans, LA, March 2005.