Tissue Engineering & Regenerative Medicine

The opportunities that tissue engineering and regenerative medicine provide continue to expand. In the United States alone, over half-trillion dollars are spent each year to care for patients who suffer from tissue loss or dysfunction. The tissue engineering and regenerative medicine development process can be described by the following triad: Scaffolds, Cells and Signaling. Our multidisciplinary team provides technological expertise traditionally associated with the design and manufacture of 3D and 2D scaffolds, characterization of cellular responses to defined chemical and mechanical stimuli and culturing and differentiation of animal and human derived cells including human embryonic cells and adult stem cells. Exponent is uniquely qualified to address the multidisciplinary needs of clients in the development and characterization of tissue-engineered structures. Our wide ranging capabilities allow Exponent to rapidly support the design and optimization of scaffolds and novel cell based assays.


The following includes a list of Exponent’s capabilities in the Tissue Engineering and Regenerative Medicine field:


  • Design of 3D and 2D structures from synthetic materials as well as biologic tissues
  • Characterization of the mechanical properties of scaffolds and tissues
  • Characterization of microfluidic and microscale systems
  • Design of bioreactors and finite element analysis of mass transfer
  • Constitutive modeling (linear and non-linear) of isotropic and aligned constructs 


  • Culturing of embryonic stem cells, clonal and primary cells in 2D-3D environments
  • Epi fluorescent microscopy techniques including confocal microscopy
  • Characterization of cells, cellular aggregates and tissue response to the mechanical environment 
  • Characterization of cells and tissues to the environment through:
    • Mechanical testing
    • Assaying for matrix protein accumulation
    • Measurement of radiolabel incorporation to determine biomatrix synthesis


  • Real-time quantitative RT-PCR to determine gene expression
  • Real-time physiologic measures using fluorescent intra-extracellular probes
  • Characterization of cellular responses to soluble factor gradients
  • Cell migration assays and autocrine/paracrine interaction assay development


  • Development and implementation of custom testing fixtures
  • Complete tissue culture facilities
  • Complete small scale materials test facility with environmental control