Suresh H. Moolgavkar, M.D., Ph.D.

Dr. Suresh Moolgavkar has more than 30 years of experience in the fields of epidemiology, biostatistics, and quantitative risk assessment. He is internationally known for his work in developing mechanistically based dose-response models for carcinogenesis, and, in particular, for the two-mutation clonal expansion model, also known as the Moolgavkar-Venzon-Knudson (MVK) model. For the past decade, Dr. Moolgavkar has also been keenly interested in air pollution epidemiology. Dr. Moolgavkar retired from his position as a Full Member of the Fred Hutchinson Cancer Research Center in August 2008. He continues to be an Affiliate Investigator at the Center and Professor of Epidemiology and Adjunct Professor of Applied Mathematics at the University of Washington in Seattle. Dr. Moolgavkar has served on the faculties of Johns Hopkins University, Indiana University, University of Pennsylvania, and Fox Chase Cancer Center. He has been a visiting scientist at the Radiation Effects Research Foundation in Hiroshima, the International Agency for Research on Cancer in Lyon, and the German Cancer Research Center in Heidelberg. Dr. Moolgavkar has served on numerous review panels and as a consultant to the National Cancer Institute, EPA, Health and Welfare, Canada, The International Agency for Research on Cancer (IARC), the California Air Resources Board (CARB), and the CIIT Centers for Health Research, among others.

Dr. Moolgavkar is the author or co-author of more than 160 papers and contributed chapters in the areas of epidemiology, biostatistics, and quantitative risk assessment, and has edited three books in these areas. He was the senior editor of a monograph, Quantitative Estimation and Prediction of Human Cancer Risk, published by the International Agency for Research on Cancer. He is an elected member of the American Epidemiological Society. Dr. Moolgavkar has served on the editorial boards of Genetic Epidemiology and Inhalation Toxicology, and is currently Associate Editor for Health and Environment of Risk Analysis—An International Journal. Dr. Moolgavkar has published numerous epidemiological and toxicological papers on lung cancer, including lung cancer following radiation and exposure to fibers. Dr. Moolgavkar was a member of the working group involved in the writing of the IARC monograph on tobacco smoking in 1986 (IARC monograph 38).

Dr. Moolgavkar was given the Founders’ Award by the CIIT Centers for Health Research in 1990 and the Distinguished Achievement Award by the Society for Risk Analysis in 2001. He is an elected member of the American Epidemiological Society and a Fellow of the Society for Risk Analysis, the premier international organization for risk assessment.

Dr. Moolgavkar’s research has been supported largely by grants from the National Institutes of Health, the U.S. Department of Energy, and EPA.

Mathematical

Ewing J, Moolgavkar S, Smith L, Stong RE. Stable parallelizability of lens spaces. J Pure Appl Algebra 1977; 10:177–191.

Ewing J, Moolgavkar S. Euler characteristics of complete intersections. Proc Am Math Soc 1976; 56:390–391.

Ewing J, Gustafson E, Halmos P, Moolgavkar S, Wheeler W, Ziemer W. American mathematics from 1940 to the day before yesterday. Am Math Monthly 1976; 83:503-516.

Ewing J, Moolgavkar S. On a conjecture of Atiyah and Thom. Preprint, Indiana University, 1976.

Ewing J, Moolgavkar S. On the group of holomorphic line bundles on an algebraic surface. Preprint, Indiana University, 1976.

Moolgavkar S. On the existence of a universal germ of deformations for elliptic pseudo group structures on compact manifolds. Trans Am Math Soc 1975; 212:173–197.

Ewing J, Moolgavkar S. On the signature of Fermat surfaces. Michigan Math J 1975; 22:257-268.

Biomedical

McCarthy WJ, Meza R, Jeon J, Moolgavkar SH. Lung cancer in never-smokers. Risk Analysis, in press.

Hazelton WD, Jeon J, Meza R, Moolgavkar SH. FHCRC lung cancer model. Risk Analysis, in press.

Moolgavkar SH. Multistage carcinogenesis and epidemiologic studies of cancer. In: Modeling and Inference in Biomedical Science—In Memory of Andrei Yakovlev. Almudevar AL, Hall WJ, Oakes D (eds), Institute of Mathematical Statistics Collections Series, in press.

Moolgavkar SH, Holford TR, Levy DT, et al. Impact of reduced tobacco smoking on lung cancer mortality in United States during 1975–2000. JNCI 2012; doi. 10.1093/jnci/djs 136.

Meza R, Jeon J, Moolgavkar SH. Quantitative cancer risk assessment of nongenotoxic carcinogens. In: Cancer Risk Assessment: Chemical Carcinogenesis, Hazard Evaluation, and Risk Quantification. New York, Joh, Wiley & Sons, 2010.

Moolgavkar SH, Turim J, Alexander D, Lau E, Cushing C. Potency factors for risk assessment at Libby, Montana. Risk Analysis – An International Journal, 2010; 30:1240–1248.

McClellan RO, Frampton MW, Koutrakis P, McDonnell WF, Moolgavkar S, et al. Critical considerations in evaluating scientific evidence of health effects of ambient ozone: A conference report. Inhalation Toxicology, 2009; 21(S2):1–36.

Moolgavkar SH, Meza R, Turim J. Pleural and peritoneal mesothelioma in SEER: Age effects and temporal trends, 1973–2005. Cancer Causes Control 2009. Epub ahead of print.

Meza R, Jeon J, Moolgavkar SH, Luebeck EG. The age-specific incidence of cancer: phases, transitions and biological implications. Proceedings, Natl Acad Sci, U.S.A, 2008 105:16284–16289.

Meza R, Jeon J, Moolgavkar SH, Luebeck EG. The age-specific incidence of cancer: Phases, transitions and biological implications. PNAS, in press.

Luebeck EG, Moolgavkar SH, Liu A, Ulrich N. Does folic acid supplementation prevent or promote colon cancer? Results from model-based predictions. Cancer Epidemiol Biomarkers Prevent 2008; 17:1360–1367.

Little M, Heidenreich W, Moolgavkar SH, Schoellnberger H, Thomas DC. Systems biological and mechanistic modelling of radiation-induced cancer. Rad Environ Biophys 2008; 47:39–47.

Meza R, Hazelton WD, Colditz GA, Moolgavkar SH. Analysis of lung cancer incidence in the nurses’ health and the health professionals’ follow-up studies using a multistage carcinogenesis model. Cancer Causes Control 2008; 19:317–328.

Jeon J, Meza R, Moolgavkar SH, Luebeck EG. The evaluation of cancer screening strategies using multistage carcinogenesis models. Math Biosci 2008; 213:56–70.

Reiss R, Anderson EL, Cross CE, Hidy G, Hoel D, McClellan R, Moolgavkar S. Evidence of health impacts of sulfate and nitrate containing particles in ambient air. Inhal Toxicol 2007; 19:419-449.

Moolgavkar SH. Pollution analysis flawed by statistical model. Correspondence. Nature 2007; 445:21.

Hazelton WD, Moolgavkar SH, Curtis SB, Zielinski JM, Ashmore JP, Krewski D. Biologically based analysis of lung cancer incidence in a large Canadian occupational cohort with low-dose ionizing radiation exposure, and comparison with Japanese atomic bomb survivors. J Toxicol Environ Health 2006; 69:1013–1038.

Moolgavkar SH. Fine particles and mortality. Inhal Toxicol 2006; 18:93–94.

Jeon J, Luebeck EG, Moolgavkar SH. Age effects and temporal trends in adenocarcinoma of esophagus and gastric cardia. Cancer Causes Control 2006; 17:971–981.

Clements MS, Hakulinen T, Moolgavkar SH. Bayesian projections: What are the effects of excluding data from the younger age groups? Am J Epidemiol 2006; 164:292–293.

Luebeck EG, Moolgavkar SH. Biological and mathematical aspects of multistage carcinogenesis. In: Quantitative Methods for Cancer and Human Health Risk Assessment. Edler I, Kitsos CP (eds), Wiley-Liss, 2005.

Luebeck EG, Buchmann A, Schneider D, Moolgavkar SH, Schwarz M. Modulation of liver tumorigenesis in Connexin32-deficient mouse. Mutat Res 2005; 570:33–47.

Moolgavkar SH. A review and critique of the EPA’s rationale for a fine particle standard. Regulat Toxicol Pharmacol 2005; 42:123–144.

Hazelton WD, Clements MS, Moolgavkar SH. Multistage carcinogenesis and lung cancer mortality in three cohorts. Cancer Epidemiol Biomarkers Prevent 2005; 14:1171–1181.

Clements MS, Armstrong B, Moolgavkar SH. Lung cancer rate predictions using generalized additive models. Biostatistics 2005; 6:576–589.

Dewanji A, Luebeck EG, Moolgavkar SH. A generalized Luria-Delbruck process. Math Biosci 2005; 197:140–152.

Meza R, Luebeck EG, Moolgavkar SH. Gestational mutations and carcinogenesis. Math Biosci 2005; 197:188–210.

Zheng CJ, Luebeck EG, Byers B, Moolgavkar SH. On the number of founding germ cells in humans. Theor Biol Med Model 2005; 24:2, 32.

Curtis SB, Hazelton WD, Luebeck EG, Moolgavkar SH. From mechanism to risk estimation—bridging the chasm. Adv Space Res 2004; 34:1404–1409.

Moolgavkar SH. Fifty years of the multistage model: Remarks on a landmark paper. Int J Epidemiol 2004; 33:1182–1183.

Little MP, Blettner M, Boice JD Jr, Bridges BA, Cardis E, Charles MW, de Vathaire F, Doll R, Fujimoto K, Goodhead D, Grosche B, Hall P, Heidenreich WF, Jacob P, Moolgavkar SH, Muirhead CR, Niwa O, Paretzke HG, Richardson RB, Samet JM, Sasaki Y, Shore RE, Straume T, Wakeford R. Potential funding crisis for the Radiation Effects Research Foundation. Lancet 2004; 364:557–558.

Heidenreich WF, Luebeck EG, Hazelton WD, Paretzke HG, Moolgavkar SH. Response to the commentary of Donald A. Pierce (Radiat Res 2003; 160:718–723). Radiat Res 2004; 161:369-370.

Heidenreich WF, Luebeck EG, Moolgavkar SH. Effects of exposure uncertainties in the TSCE model and application to the Colorado miners data. Radiat Res 2004; 161:72–81.

Moolgavkar SH, Luebeck EG. Multistage carcinogenesis and the incidence of human cancer. Genes Chromosomes Cancer 2003; 38:302–306.

Moolgavkar SH. Air pollution and daily mortality in two U.S. counties: season-specific analyses and exposure-response relationships. Inhal Toxicol 2003; 15:877-907.

Moolgavkar SH. Air pollution and daily deaths and hospital admissions in Los Angeles and Cook counties. pp. 183-198. In: Health Effects Institute Special Report, Revised Analyses of Time-Series Studies of Air Pollution and Health. Health Effects Institute, 2003.

Krewski D, Zielinski JM, Hazelton WD, Garner MJ, Moolgavkar SH. The use of biologically based cancer risk models in radiation epidemiology. Radiat Prot Dosimetry 2003; 104:367–76.

Gregori G, Hanin L, Luebeck G, Moolgavkar S, Yakovlev A. Testing goodness of fit for stochastic models of carcinogenesis. Math Biosci 2002; 175:13–29.

Heidenreich WF, Luebeck EG, Hazelton WD, Paretzke HG, Moolgavkar SH. Multistage models and the incidence of cancer in the cohort of A-bomb survivors. Rad Res 2002; 158:607-614.

Dewanji A, Moolgavkar SH. Choice of stratification in Poisson process analysis of recurrent event data with environmental covariates. Statist Med 2002; 21:3383–3393.

Curtis SB, Luebeck EG, Hazelton WD, Moolgavkar SH. Does radiation enhance promotion of already-initiated cells via a bystander effect? Int Congress Series 2002; 1236:283-287.

Curtis SB, Luebeck EG, Hazelton WD, Moolgavkar SH. A new perspective of carcinogenesis from protracted high-LET radiation arises from the two-stage clonal expansion model. Adv Space Res 2002; 30:937–944.

Luebeck EG, Moolgavkar SH. Multistage carcinogenesis and the incidence of colorectal cancer. Proc National Acad Sci 2002; 99:15095-15100.2.

Moolgavkar SH, Turim J, Brown RC, Luebeck EG. Long man-made fibers and lung cancer risk. Regulat Toxicol Pharmacol 2001; 33:138–146.

Hazelton WD, Luebeck EG, Heidenreich WF, Moolgavkar SH. Analysis of a historical cohort of Chinese tin miners with arsenic, radon, cigarette, and pipe smoke exposures using the biologically-based two-stage clonal expansion model. Rad Res 2001; 156:7–94.

Moolgavkar SH, Turim J, Brown RC. The power of the European Union protocol to test for carcinogenicity of inhaled fibers. Regulat Toxicol Pharmacol 2001; 33:350–355.

Moolgavkar SH, Brown RC, Turim J. Biopersistence, fiber length, and cancer risk assessment for inhaled fibers. Inhal Toxicol 2001; 13:755–772.

Moolgavkar SH, Luebeck EG, Turim J, Brown RC. Lung cancer risk associated with exposure to man-made fibers. Drug Chem Toxicol 2000; 23:223–242.

Moolgavkar SH, Hazelton WF, Luebeck EG, Levy D, Sheppard L. Air pollution, pollens, and admissions for chronic respiratory disease in King County. Inhal Toxicol 2000; 12(Supplement 1):157–171.

Dewanji A, Moolgavkar SH. A Poisson process approach for recurrent event data with environmental covariates. Environmetrics 2000; 11:665–673.

Moolgavkar SH. Air pollution and hospital admissions for diseases of the circulatory system in three U.S. metropolitan areas. J. Air Waste Manage Assoc 2000; 50:1199–1206.

Moolgavkar SH. Air pollution and daily mortality in three U.S. counties. Environ Health Perspect 2000; 108:777–784.

Moolgavkar SH. Air pollution and hospital admissions for chronic obstructive pulmonary disease in three metropolitan areas in the US. Inhal Toxicol 2000; 12(Suppl 4):75–90.

Luebeck EG, Buchmann A, Stinchcombe S, Moolgavkar SH, Schwarz M. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on initiation and promotion of GSTP-positive foci in rat liver: A quantitative analysis of experimental data using a stochastic model. Toxicol Appl Pharmacol 2000; 167:63–73.

Grasl-Kraupp B, Luebeck G, Wagner A, Loew-Baselli A, De Gunst M, Waldhor T, Moolgavkar S, Schulte-Hermann R. Quantitative analysis of tumor initiation in rat liver: Role of cell replication and cell death (apoptosis). Carcinogenesis 2000; 21:1411–1421.

Moolgavkar SH, Moller H, Woodward A. Principles of the epidemiologic approach to quantitative estimation and prediction of cancer risk. pp. 61-74. In: Quantitative Estimation and Prediction of Cancer Risk. Moolgavkar SH, Krewski D, Zeise L, Cardis E, Moller H (eds), IARC Scientific Publications, 1999.

Moolgavkar SH, Krewski D, Schwarz M. Mechanisms of carcinogenesis and biologically-based models for quantitative estimation and prediction of cancer risk. pp. 179-238. In: Quantitative Estimation and Prediction of Cancer Risk. Moolgavkar SH, Krewski D, Zeise L, Cardis E, Moller H (eds), IARC Scientific Publications, 1999.

Moolgavkar SH, Woodward A, Krewski D, Cardis E, Zeise L. Future perspectives and research needs. pp. 305-322. In: Quantitative Estimation and Prediction of Cancer Risk. Moolgavkar SH, Krewski D, Zeise L, Cardis E, Moller H (eds), IARC Scientific Publications, 1999.

Cardis E, Zeise L, Schwarz M, Moolgavkar S. Review of specific examples of QEP. pp. 239-304. In: Quantitative Estimation and Prediction of Cancer Risk. Moolgavkar SH, Krewski D, Zeise L, Cardis E, Moller H (eds), IARC Scientific Publications, 1999.

Moolgavkar SH, Luebeck EG, Turim J, Hanna L. Quantitative assessment of the risk of lung cancer associated with occupational exposure to refractory ceramic fibers. Risk Anal 1999; 19:599–611.

Dewanji A, Goddard M, Krewski D, Moolgavkar SH. Two stage model for carcinogenesis: Number and size distributions of premalignant clones in longitudinal studies. Math Biosci 1999; 155:1–12.

Luebeck EG, Heidenreich WF, Hazelton WD, Paretzke HG, Moolgavkar SH. Biologically-based analysis of the data for the Colorado Plateau uranium miners cohort: Age, dose and dose-rate effects. Rad Res 1999; 152:339–351.

Moolgavkar SH. Stochastic models for estimation and prediction of cancer risk. pp. 237-259. In: Statistics for the Environment 4: Pollution Assessment and Control. Barnett V, Stein A, Feridun Turkman K (eds), John Wiley, NY, 1999.

Moolgavkar SH, Luebeck EG, Anderson EL. Estimation of unit risk for coke oven emissions. Risk Anal 1998; 18:813–825.

Gaylor DW, Moolgavkar S, Krewski D, Goldstein LS. Recent bioassay results on coal tars and benzo[a]pyrene: Implications for risk assessment. Regul Toxicol Pharmacol 1998; 28:178-179.

Moolgavkar SH. Comments on papers on U-shaped dose-response relationships for carcinogens. Hum Exper Toxicol 1998; 17:708–710.

Moolgavkar SH. Two-mutation carcinogenesis model. pp. 4635–4639. In: Encyclopedia of Biostatistics. Armitage P, Colton T (eds), John Wiley, 1998.

Moolgavkar SH, Lee JAH, Stevens RG. Analysis of vital statistical data. In: Modern Epidemiology. 2nd edition. Rothman K, Greenland S (eds), Lippincott-Raven, PA, 1998.

Moolgavkar SH, Luebeck EG, Anderson, EL. Air pollution and hospital admissions for respiratory causes in Minneapolis-St. Paul and Birmingham. Epidemiology 1997; 8(4):364-370.

Heidenreich W, Luebeck EG, Moolgavkar SH. Some properties of the hazard function of the two-mutation clonal expansion model. Risk Anal 1997; 17:391–399.

Moolgavkar SH. Stochastic cancer models: application to analyses of solid cancer incidence in the cohort of A-bomb survivors. Nucl Ener 1997; 36(6):447–451.

Kai M, Luebeck EG, Moolgavkar SH. Analysis of solid cancer incidence among atomic bomb survivors using a two-stage model of carcinogenesis. Rad Res 1997; 148:348–358.

Luebeck EG, Moolgavkar SH. Biologically based cancer modelling. Drug Chem Toxicol 1996; 19:221-243.

Luebeck EG, Curtis SB, Cross FT, Moolgavkar SH. Two-stage model of radon-induced malignant lung tumors in rats: effects of cell killing. Rad Res 1996; 145:163–173.

Moolgavkar SH, Luebeck EG, Buchmann A, Bock KW. Quantitative analysis of enzyme-altered foci in rats initiated with dieethylnitrosamine and promoted with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 1,2,3,4,6,7,8-heptachloro-p-dioxin. Toxicol Appl Pharmacol 1996; 138:31-42.

Moolgavkar SH, Luebeck EG, Hall TA, Anderson EL. Particulate air pollution and mortality. Letter to the Editor. Epidemiology 1996; 7:212–213.

Moolgavkar SH, Luebeck EG. A critical review of the evidence on particulate air pollution and mortality. Epidemiology 1996; 7:420–428.

Leroux BG, Lesenring WM, Moolgavkar SH, Faustman EM. A biologically based dose-response model for developmental toxicology. Risk Anal 1996; 16:449–458.

Dewanji A, Luebeck EG, Moolgavkar SH. A biologically-based model for the analysis of premalignant foci of arbitrary shape. Math Biosci 1996; 135:55–68.

Moolgavkar SH, Luebeck EG, Hall TA, Anderson EL. Particulate air pollution, sulfur dioxide, and daily mortality: A reanalysis of the Steubenville data. Inhal Toxicol 1995; 7:35-44.

Schwarz M, Buchmann A, Stinchcombe S, Luebeck EG, Moolgavkar SH, Bock KW. Role of receptors in human and rodent hepatocarcinogenesis. Mutat Res 1995.

Luebeck EG, Grasl-Kraupp B, Timmermann-Trosiener I, Bursch W, Schulte-Hermann R, Moolgavkar SH. Growth kinetics of enzyme altered liver foci in rats treated with phenobarbital or α-hexachlorocyclohexane. Toxicol Appl Pharmacol 1995; 130:30–315.

Luebeck EG, Moolgavkar SH. Biologically based cancer modeling. pp. 533-555. In: Toxicology and Risk Assessment. Fan AM, Chang LW (eds), Marcel Dekker, Inc., New York, 1995.

Moolgavkar SH. When and how to combine results from multiple epidemiological studies in risk assessment. pp. 77–90. In: The Proper Role of Epidemiology in Regulatory Risk Assessment. Graham J (ed), Elsevier, New York, 1995.

Moolgavkar SH, Luebeck EG, Hall TA, Anderson EL. Air pollution and daily mortality in Philadelphia. Epidemiology 1995; 6:476–484.

Moolgavkar SH, Luebeck EG. Incorporating cell proliferation kinetics into models for cancer risk assessment. Toxicology 1995; 102:141–147.

Stayner L, Smith R, Bailer J, Luebeck EG, Moolgavkar SH. Methods for modelling occupational studies for cancer risk assessment. Am J Indust Med 1995; 27:155–170.

Luebeck EG, Moolgavkar SH. Simulating the process of carcinogenesis. Math Biosci 1994; 123:127–146.

Moolgavkar SH. Air pollution and mortality (letter). N Eng J Med 1994; 330:1237–1238.

Moolgavkar SH. Biological models of carcinogenesis and quantitative cancer risk assessment. Guest Editorial. Risk Anal 1994; 14:879–882.

Moolgavkar SH. Cell proliferation and carcinogenesis models: General principles with illustrations from the rodent liver system. Environ Health Perspect 1993; 101(Suppl. 5):91-94.

Moolgavkar SH, Luebeck EG, Krewski D, Zielinski JM. Radon, cigarette smoke, and lung cancer: A reanalysis of the Colorado Plateau miners’ data. Epidemiology 1993; 4:204–217.

Moolgavkar SH, Luebeck EG. A two-mutation model for radiation carcinogenesis in humans and rodents. pp. 199–210. In: New Frontiers in Cancer Causation. Iversen OH (ed). Taylor and Francis, Washington, DC, 1993.

Zheng CJ, Byers B, Moolgavkar SH. Allelic instability in mitosis: A unified model for dominant disorders. Proc Natl Acad Sci 1993; 90:10178–10182.

Moolgavkar SH, Luebeck EG. Interpretation of labelling indices in the presence of cell death. Carcinogenesis 1992; 13:1007–1010.

Moolgavkar SH, Luebeck EG. Risk assessment of non-genotoxic carcinogens. Toxicol Lett 1992; 64/65:631–636.

Moolgavkar SH. A population perspective on multistage carcinogenesis. pp. 381-392. In: Multistage Carcinogenesis. Proc. 22nd International Symposium of The Princess Takamatsu Cancer Research Fund. Harris CC, Hirohashi S, Ito N, Pitot HC, Sugimura T, Terada M Yokota J (eds), Japan Scientific Societies Press, Tokyo, 1992.

Moolgavkar SH. Cancer models. pp. 239–252. In: Biophysical Modelling of Radiation Effects. Chadwick K, Moschini G, Varma M (eds), Adam Hilger, Bristol, 1992.

Moolgavkar SH. Carcinogenesis models: An overview. pp. 767–781. In: Indoor Radon and Lung Cancer: Reality or Myth? Cross FT (ed), Battelle Press, 1992.

Luebeck EG, Moolgavkar SH. Stochastic analysis of intermediate lesions in carcinogensis experiments. Risk Anal 1991; 11:149–157.

Dewanji A, Moolgavkar SH, Luebeck EG. Two-mutation model for carcinogenesis: Joint analysis of premalignant and malignant lesions. Math Biosci 1991; 104:97–109.

Nandakumar A, Davis S, Moolgavkar S, Witherspoon R, Schwartz S. Myeloid leukemia following therapy for a first primary cancer. Br J Cancer 1991; 63:782–788.

Moolgavkar SH. Cell proliferation in carcinogenesis (letter). Science 1991; 251:143.

Moolgavkar SH, Luebeck EG. The role of somatic mutations and cell replication kinetics in quantitative cancer risk assessment. pp. 469–479. In: Chemically Induced Cell Proliferation: Implications for Risk Assessment. Butterworth BE, Slaga TJ, Farland W, McClain M (eds), Wiley Liss, 1991.

Luebeck EG, Moolgavkar SH, Buchman A, Schwarz M. Effects of polychlorinated biphenyls in rat liver: Quantitative analysis of enzyme altered foci. Toxicol Appl Pharmacol 1991; 111:469-484.

Moolgavkar SH, Luebeck EG. Multistage carcinogenesis: A population-based model for colon cancer. JNCI 1991; 84:610–618.

Luebeck EG, Moolgavkar SH. Stochastic description of initiation and promotion in experimental carcinogenesis. Annali dell’Istituto Superiore di Sanita 1991; 27: 575–580.

Moolgavkar SH. Stochastic models of carcinogenesis. pp. 373–393. In: Handbook of Statistics, Volume 8. Rao CR, Chakraborty R (eds), Elsevier, 1991.

Moolgavkar SH, Cross FT, Luebeck G, Dagle GE. A two-mutation model for radon-induced lung tumors in rats. Rad Res 1990; 121:28–37.

Moolgavkar SH, Luebeck G. Two-event model for carcinogenesis: Biological, mathematical and statistical considerations. Risk Anal 1990; 10:323–341.

Moolgavkar SH, Luebeck G, DeGunst M. Two mutation model for carcinogenesis: Relative roles of somatic mutations and cell proliferation in determining risk. pp. 136-152. In: Scientific Issues in Quantitative Cancer Risk Assessment. Moolgavkar SH (ed), Birkhauser, Boston, 1990.

Moolgavkar SH, Luebeck G., de Gunst M, Port RE, Schwarz M. Quantitative analysis of enzyme altered foci in rat hepatocarcinogenesis experiments. Carcinogenesis 1990; 11:1271-1278.

Moolgavkar SH. Cancer models, invited editorial. Epidemiology 1990; 1:419–420.

Dewanji A, Venzon DJ, Moolgavkar SH. A stochastic two-stage model for cancer risk assessment II: The number and size of premalignant clones. Risk Anal 1989; 9:179–186.

Moolgavkar SH. Multistage models for cancer risk assessment. pp. 9-20. In: Biologically Based Methods for Cancer Risk Assessment. Travis C (ed). NATO ASI Series A: Life Science Vol. 159, Plenum NY, 1989.

Moolgavkar SH, Dewanji A, Luebeck G. Cigarette smoking and lung cancer: A reanalysis of the British doctors’ data. JNCI 1989; 81:415–420.

Moolgavkar SH. Dominant inheritance of colonic polyps and adenocarcinomas. N Engl J Med 1989; 320:316.

Hahn RA, Moolgavkar SH. Nulliparity, decade of first birth and breast cancer in Connecticut cohorts. Am. J. Public Health 1989; 79:1503–1507.

Moolgavkar SH. A two-stage carcinogenesis model for risk assessment. Cell Biol Toxicol 1989; 5:445–460.

Moolgavkar SH, Dewanji A. Combined effect of childbearing, menstrual events, and body size on age-specific breast cancer risk. Am J Epidemiol 1988; 128:1177–1178.

Venzon DJ, Moolgavkar SH. Origin invariant relative risk functions for case-control and survival studies. Biometrika 1988; 75:325–333.

Venzon DJ, Moolgavkar SH. An algorithm for computing profile-likelihood-based confidence intervals. Appl Stat 1988; 37:87–94.

Moolgavkar SH, Dewanji A. Biologically-based models for cancer risk assessment: A cautionary note. Risk Anal 1988; 8:5–6.

Moolgavkar SH, Dewanji A. Discussion of “From Mouse to Man: The Quantitative Assessment of Cancer Risks” by D.A. Freedman and H. Zeisel. Stat Sci 1988; 3:39-41.

Moolgavkar SH, Dewanji A, Venzon DJ. A stochastic two-stage model for cancer risk assessment. I: The hazard function and the probability of tumor. Risk Anal 1988; 8:383-392.

Moolgavkar SH. Some remarks on general relative risk regression models. Proc. Biopharmaceutical Section of ASA, 1988.

Moolgavkar SH. Biologically motivated two-stage model for cancer risk assessment. Toxicol Lett 1988; 43:139–150.

Moolgavkar SH, Venzon DJ. Confidence regions in curved exponential families: Application to matched case-control and survival studies with general relative risk function. Ann Stat 1987; 15:346-359.

Moolgavkar SH, Venzon DJ. Confidence regions for parameters of the proportional hazards model: A simulation study. Scand J Stat 1987; 14:43–56.

Lustbader ED, Moolgavkar SH. Some problems of inference in cohort studies. J Chron Dis 1987; 40(Suppl. 2):133–137.

Moolgavkar SH, Prentice RL. Discussion of the paper “Parameter Orthogonality and Approximate Conditional Inference,” by D.R. Cox and N. Reid. JR Statist Soc 1987; B 49:34-35.

Moolgavkar SH, Venzon DJ. General relative risk models for epidemiologic studies. Am J Epidemiol 1987; 126:949–961.

Moolgavkar SH. Carcinogenesis modelling: From molecular biology to epidemiology. Ann Rev Pub Health 1986; 7:151–170.

Moolgavkar SH, Venzon DJ. Confidence regions for case-control and survival studies with general relative risk functions. In: Modern Statistical Methods in Chronic Disease Epidemiology. Proc. SIMS Conference. Moolgavkar SH, Prentice RL (eds), John Wiley, 1986.

Knudson AG, Moolgavkar SH. Inherited influences on susceptibility to radiation carcinogenesis. In: Radiation Carcinogenesis. Upton AC (ed), Elsevier/North Holland, 1986.

Prentice RL, Moolgavkar SH, Farewell VT. Biostatistical issues and concepts in epidemiologic research. J Chron Dis 1986; 38:1169–1183.

Moolgavkar SH. Hormones and multistage carcinogenesis. Cancer Surv 1986; 5:635–648.

Moolgavkar SH. Antioncogenes and cancer. pp. 19-30. In: Pathophysiological Aspects of Cancer Epidemiology. Mathe’ G, Reizenstein P (eds), Pergamon Press, 1985.

Moolgavkar SH. Mutation and human cancer. pp. 31-38. In: Pathophysiological Aspects of Cancer Epidemiology. Mathe’ G, Reizenstein P (eds), Pergamon Press, 1985.

Venzon DJ, Moolgavkar SH. Cohort analysis of malignant melanoma in five countries. Am J Epidemiol 1984; 119:1, 62–70.

Stevens RG, Moolgavkar SH. A cohort analysis of lung cancer and smoking in British males. Am J Epidemiol 1984; 119:624–641.

Stevens RG, Moolgavkar SH. Malignant melanoma: Dependence of site-specific risk on age. Am J Epidemiol 1984; 119:890–895.

Moolgavkar SH, Lustbader ED, Venzon DJ. A geometric approach to non-linear regression diagnostics with application to matched case-control studies. Ann Stat 1984; 12:816–826.

Stevens RG, Moolgavkar SH. Smoking and cancer in Britain. Proc. 5th World Conference on Smoking and Health, 1984.

Moolgavkar SH. Some comments on the resources at RERF. pp. 274-279. In: Utilization and Analysis of Radiation Effects Research Foundation Data. Proc. SIMS Conference. Prentice RL, Thompson DJ (eds), SIAM, 1984.

Lustbader ED, Moolgavkar SH, Venzon DJ. Tests of the null hypothesis in case-control studies. Biometrics 1984; 1017–1024.

Moolgavkar SH. Model for human carcinogenesis: Action of environmental agents. Environ Health Perspect 1983; 50:285–291.

Moolgavkar SH. A model for human carcinogenesis: Hereditary cancers and premalignant lesions. Proc. 7th Chicago Cancer Symposium, Cancer: Etiology and Prevention. Crispen RG (ed). Elsevier Science Publishing Co., Inc., 1983.

Stevens RG, Moolgavkar SH, Lee JAH. Temporal trends in breast cancer. Am J Epidemiol 1982; 115:759–777.

Moolgavkar SH. Risk assessment using vital data. pp. 175-192. In: Environmental Epidemiology: Risk Assessment. Proc. SIMS Conference. Prentice RL, Whittemore AS (eds), SIAM, 1982.

Moolgavkar SH, Knudson AG. Mutation and cancer: A model for human carcinogenesis. JNCI 1981; 66:1037–1052.

Moolgavkar SH, Stevens RG. Smoking and cancers of bladder and pancreas: Risks and temporal trends. JNCI 1981; 67:15–23.

Stevens RG, Lee JAH, Moolgavkar SH. No association between oral contraceptives and malignant melanoma. N Engl J Med 1980; 302:966.

Moolgavkar SH. The Neyman-Scott carcinogenesis model for low-dosage extrapolation. Math Biosci 1980; 50:155–156.

Moolgavkar SH, Day NE, Stevens RG. Two-stage model for carcinogenesis: Epidemiology of breast cancer in females. JNCI 1980; 65:550–569.

Moolgavkar SH. Multistage models for carcinogenesis. JNCI 1980; 65:25.

Moolgavkar S, Stevens RG, Lee JAH: The effect of age on the incidence of breast cancer in females. JNCI 1979; 62:493–501.

Moolgavkar SH, Venzon DJ. Two-event model for carcinogenesis: Incidence curves for childhood and adult tumors. Math Biosci 1979; 47:55–77.

Stevens RG, Moolgavkar SH. Estimation of relative risk from vital data: Smoking and cancers of the lung and bladder. JNCI 1979; 63:1351–1357.

Moolgavkar S, Lee JAH, Hade RD. Comparison of age-specific mortality from breast cancer in males in the U.S. and Japan. JNCI 1978; 60:1223–1225.

Moolgavkar S. The multistage theory of carcinogenesis and the age distribution of cancer in man. JNCI 1978; 61:49-52.

Moolgavkar S. The multistage theory of carcinogenesis. Int J Cancer 1977; 19:730.

Jarabak R, Colvin M, Moolgavkar S, Talalay P. Δ5-3-ketosteroid isomerase of Pseudomonas Testosteroni. pp. 642-651. In: Methods in Enzymology, Vol. XV. Clayton RB (ed). Academic Press, NY, 1970.

Books

Moolgavkar SH, Krewski D, Zeise L, Cardis E, Moller H (eds). Quantitative estimation and prediction of human cancer risk. IARC Scientific Publications, Volume 131, 1999.

Moolgavkar SH (ed). Scientific issues in quantitative cancer risk assessment. Birkhauser Boston, 1990.

Moolgavkar SH, Prentice RL (eds). Modern statistical methods in chronic disease epidemiology. John Wiley, 1986.

Tobacco Smoking. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. IARC, Volume 38, Lyon, 1986 (member of the working group).

Selected Invited Presentations

Moolgavkar SH. False discoveries: Challenges for understanding the environment. AAAS annual meeting, San Diego, February 2010.

Moolgavkar SH. Effects of education and primary prevention on lung cancer mortality trends. Erasmus University, Rotterdam, June 2009.

Moolgavkar SH. Multistage carcinogenesis and epidemiologic studies of cancer. University of Rochester Symposium in honor of Professor Andrei Yakovlev, April 2009.

Moolgavkar SH. Clonal expansion and carcinogenesis. International Conference on Systems Biology in Radiation Carcinogenesis, Munich, Germany, February 2007.

Moolgavkar SH. Epidemiology of colon cancer. AEK Cancer Congress, Frankfurt, Germany, February 2007.

Moolgavkar SH. Multistage carcinogenesis and epidemiologic studies of cancer. Distinguished Seminar Series, Fox Chase Cancer Center, PA, October 2005.

Moolgavkar SH. Multistage carcinogenesis and lung cancer prevention. IARC Seminar Series, Lyon, France, July 2004.

Moolgavkar SH. Radiation-induced gestational mutations and cancer. COSPAR meeting, Paris, France, July 2004.

Moolgavkar SH. Multistage carcinogenesis and radiation risk assessment. International Congress of Radiation Research, Brisbane, Australia, August 2003.

Moolgavkar SH. Cancer models and risk assessment. Environmental Mutagen Society, Annual Meeting, Miami, May 2003.

Moolgavkar SH. Methodological issues in time-series analyses of air pollution data. Meeting the Environmental Challenge of the 21st Century, Monterey, CA, March 2003.

Moolgavkar SH. Multistage carcinogenesis and risk assessment. International Biometrics Conference, Homburg, Germany, March 2001.

Moolgavkar SH. Multistage models of carcinogenesis: Historical perspective, overview, implications for radiation carcinogenesis. International Workshop on Mathematical Models in Radiation Carcinogenesis, Kyoto, March 2001.

Moolgavkar SH. Modeling altered hepatic foci: issues and outstanding problems. 6th European Meeting on Hepatocarcinogenesis, Vienna, September 1999.

Moolgavkar SH. Intermediate lesions in carcinogenesis. Netherlands Institute for Health and the Environment Seminar Series, 1997.

Moolgavkar SH. Multistage model for lung cancer. International meeting of the Bernoulli Society, Calcutta, India, 1997.

Moolgavkar SH. Stochastic cancer models: Application to analyses of solid cancer incidence in the cohort of A-bomb survivors. Keynote Speaker, International symposium on low-dose and low-dose-rate radiation, Stratford-on-Avon, UK, 1997.

Moolgavkar SH. Stochastic models for estimation and prediction of cancer risk. International Symposium on Statistics in the Environment, Enschede, The Netherlands, 1997.

Moolgavkar SH. Time-series analyses of air pollution data. International Symposium on Health Effects of Particulate Air Pollution, Prague, 1997.

Moolgavkar SH. Multistage carcinogenesis, benzene exposure and leukemia risk. Berkeley Symposium on Benzene and Leukemia, Napa Valley, 1996.

Moolgavkar SH. Mutations and cell proliferation in cancer risk assessment. AACR International Workshop on Risk Assessment, Whistler BC, 1994.

Moolgavkar SH. Analysis of altered foci in rodent hepatocarcinogenesis experiments. European Toxicology Meeting, Mainz, Germany, 1993.

Moolgavkar SH. Biologically-based cancer risk assessment. International Symposium on Quantitative Risk Assessment, Research Triangle Park, NC, 1993.

Moolgavkar SH. Analysis of altered foci in rodent hepatocarcinogenesis experiments. International Workshop on Mouse Liver Tumors, Washington DC, 1992.

Moolgavkar SH. Cancer models and low-dose extrapolation of risk. Workshop on Risk Assessment and Low Dose Extrapolation, Zurich, Switzerland, 1992.

Moolgavkar SH. Cell proliferation and carcinogenesis. International Conference on Cell Proliferation in Carcinogenesis, NIEHS, North Carolina, 1992.

Moolgavkar SH. Multistage carcinogenesis and risk assessment. International Toxicology Conference, Rome, Italy, 1992.

Moolgavkar SH. A population perspective on multistage carcinogenesis. Princess Takamatsu Cancer Congress, Tokyo, Japan, 1991.

Moolgavkar SH. Cancer models. International Workshop on Biophysical Modelling of Radiation Carcinogenesis, Padua, Italy, 1991.

Moolgavkar SH. Carcinogenesis models: An overview. Hanford Symposium on Health and the Environment, Battelle PNL, Richland, WA, October 1990.

Moolgavkar SH. Analyses of altered foci in rat hepatocarcinogenesis experiments. University of Vienna Cancer Center, Vienna, Austria, July 1990.

Moolgavkar SH. Multistage models of carcinogenesis. University of Tübingen Seminar Series, Tübingen, July 1990.

Moolgavkar SH. Analyses of intermediate lesions in experimental carcinogenesis. German Cancer Research Center, Heidelberg, Germany, June 1990.

Moolgavkar SH. Analyses of altered foci in rat hepatocarcinogenesis experiments. BASF, Toxicology Group, Mannheim, 1990.

Moolgavkar SH. Cell proliferation and carcinogenesis. International Cancer Congress, Hamburg, 1990.

Moolgavkar SH. Multistage carcinogenesis. University of Pittsburgh, Department of Biostatistics Seminar Series, 1990.

Moolgavkar SH. Analysis of altered foci in hepatocarcinogenesis experiments. McArdle Laboratory, University of Wisconsin, Madison, WI, 1989.

Moolgavkar SH. Biologically-based cancer risk assessment. Society for Risk Analysis, Annual Meeting, San Francisco, CA, 1989.

Moolgavkar SH. Multistage carcinogenesis and radiation risk assessment. Radiation Research Society, Annual Meeting, Seattle, WA, 1989.

Moolgavkar SH. The role of somatic mutations and cell replication kinetics in quantitative cancer risk assessment. International Conference on Chemically Induced Cell Proliferation: Implications for Risk Assessment, Austin, TX, 1989.

Moolgavkar SH. Two mutation model for carcinogenesis: Relative roles of somatic mutations and cell proliferation in determining risk. SIMS Conference on Scientific Issues in Quantitative Cancer Risk Assessment, Alta, Utah, 1989.

Moolgavkar SH. Cancer models and risk assessment. NATO Workshop on Biologically-based Methods for Cancer Risk Assessment, Corfu, Greece, June 1988.

Moolgavkar SH. A two-stage model for carcinogenesis and its implications for risk assessment. University of Nebraska Medical Center, May 1988.

Moolgavkar SH. Biologically-based carcinogenesis models for risk assessment. Risk Assessment Workshop, Washington, DC, March 1988.

Moolgavkar SH. Biologically-based carcinogenesis models for risk assessment. Health and Welfare, Ottawa, Canada, March 1988.

Moolgavkar SH. Curvature and inference in exponential families: Application to Relative Risk Regression Models. Carleton University, Ottawa, Canada, March 1988.

Moolgavkar SH. Cox regression for the innocent bystander. Fox Chase Cancer Center Seminar, Philadelphia, PA, December 1987.

Moolgavkar SH, Prentice R. Modern statistical methods in chronic disease epidemiology. Biopharmaceutical Section of ASA (tutorial and short course), Newark, NJ, December 1987.

Moolgavkar SH. Biologically motivated two-stage model for carcinogenesis. 17th Conference on Toxicology, Wright-Patterson Air Force Base, Dayton, OH, November 1987.

Moolgavkar SH. Two-stage model for carcinogenesis. University of Wisconsin Seminars, “Curvature and Inference in Exponential Families: Application to Relative Risk Regression Models,” Department of Human Oncology, Madison, OH, November 1987.

Moolgavkar SH. Two mutation model for cancer risk assessment. EPA Toxicology and Microbiology Seminar Series, Cincinnati, OH, October 1987.

Moolgavkar SH. Origin invariant relative risk functions: Multi-stage models for cancer risk assessment. American Statistical Association Annual Meeting, San Francisco, CA, August 1987.

Moolgavkar SH. Biologically-based carcinogenesis models for risk assessment. Risk Assessment Workshop, Washington, DC, March 1987.

Moolgavkar SH. Two-stage model for carcinogenesis: Implications for risk assessment. Symposium on Quantitative Assessment of Cancer Risk, Washington, DC, February 1987.

Moolgavkar SH. A cohort analysis of smoking and cancers of the lung, bladder and pancreas. School of Public Health grand rounds, Department of Biostatistics Seminar on General Relative Risk Regression Models for Epidemiologic Studies, University of Pittsburgh, Pittsburgh, PA, January 1987.

Moolgavkar SH. Two-stage model for carcinogenesis and the IPI protocol. Battelle PNL, Richland, WA, 1986.

Moolgavkar SH. Modern statistical methods in chronic disease epidemiology. SIMS conference, Alta, UT, June 1985.

Moolgavkar SH. Time related factors in cancer epidemiology. NIH International Symposium, April 1985.

Moolgavkar SH. General relative risk models for case-control studies. Johns Hopkins University, School of Public Health, Baltimore, MD, 1985.

Moolgavkar SH. Stochastic models for carcinogenesis and risk assessment. EPA, Washington, DC, 1985.

Moolgavkar SH. Risk assessment using vital data. SIMS Conference on Environmental Epidemiology and Risk Assessment, Alta, UT, June 1982.

• Adjunct Professor, Department of Applied Mathematics, University of Washington, 2004–present
• Adjunct Professor, Department of Biostatistics, University of Washington, 1984–present
• Member, The Fred Hutchinson Cancer Research Center, Seattle, 1984–present
• Member, Graduate Faculty, University of Washington, 1984–present
• Professor, Department of Epidemiology, University of Washington, 1984–present
• Adjunct Associate Professor, Department of Research Medicine, University of Pennsylvania School of Medicine, 1980-1984
• Research Physician, The Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, 1979–1984
• Clinical Assistant Professor, Department of Research Medicine, University of Pennsylvania School of Medicine, 1977–1980
• Associate, American Oncologic Hospital, Philadelphia, 1977–1984
• Epidemiologist, The Fox Chase Cancer Center, Philadelphia, 1977–1984
• Member, Graduate Group in Epidemiology, University of Pennsylvania, 1977–1984
• Assistant Professor of Mathematics, Indiana University, Bloomington, 1973–1977
• Instructor in Mathematics, Johns Hopkins University, 1972–1973