Neuropathology methods in rodent developmental neurotoxicity (DNT) studies have evolved with experience and changing regulatory guidance. This article emphasizes principles and methods to promote more standardized DNT neuropathology evaluation, particularly procurement of highly homologous brain sections and collection of the most reproducible morphometric measurements.
Dr. Li has extensive experience addressing toxicology, human health risk assessment, and other regulatory science issues for pesticides, industrial chemicals, medical devices, and pharmaceuticals. She is recognized internationally for her expertise in regulatory neurotoxicology testing.
She recently led a panel of neuropathologists, toxicologists and regulatory scientists from industry, government and academia from U.S., Canada and Germany to complete a manuscript accepted by Neurotoxicology and Teratology entitled, "Recommendations for harmonization of data collection and analysis of developmental neurotoxicity endpoints in regulatory guideline studies." The accepted manuscript (unformatted and unedited PDF) is now available online.