Health Insights | Volume 3, 2017

Exponent's scientists, physicians, and regulatory specialists provide unparalleled, interdisciplinary expertise to evaluate the full range of environmental, occupational, and public health issues that face our nation and the world. See what's been in the news lately, and how it may affect you, your company, and your clients.


  • New Exponent US Chemical Regulation and Food Safety Offering: Waiver from the (OCSPP 870.1200) Testing Requirement for Acute Dermal Toxicity Testing for Formulated Products

    Exponent is now offering waiver support services for clients that are subject to from the OCSPP 870.1200 testing requirements for acute dermal toxicity testing of formulated pesticide products. The waiver is based on the EPA’s Office of Pesticide Programs (OPP), waiver guidance for acute dermal toxicity studies for formulated pesticide products, which includes the retrospective analysis and rationale for the waiver.

  • EPA TSCA Nanotechnology Reporting and Recordkeeping Requirements Rule
    On August 14, 2017, the U.S. Environmental Protection Agency (EPA) issued guidance for the Toxic Substances Control Act (TSCA) Nanotechnology Reporting and Recordkeeping Requirements Rule. The new rule establishes reporting and recordkeeping requirements for chemical substances that are manufactured or processed at the nanoscale.
  • TSCA “Active/Inactive” Inventory Notification Requirements
    On August 11, 2017, the Environmental Protection Agency (EPA) published the TSCA Inventory Notification (Active/Inactive) Requirements final rule. Under this rule, pursuant with TSCA Section 8(b), EPA will require electronic notification of nonexempt chemical substances on the TSCA Inventory manufactured (including imported) during the 10-year time period ending June 21, 2016.
  • Are You Ready for Proposition 65 Changes in 2018?
    Dramatic changes to California’s Prop 65 warning regulations will take effect on August 30, 2018. The new regulations significantly alter the safe harbor rules for providing Prop 65 warnings. If you are a company that sells product in California, you will need to prepare now before the law goes into effect.
  • Hurricanes Harvey, Irma, and Maria

    The past several weeks have seen unprecedented hurricane impacts across the Caribbean islands, Texas, and Florida. These areas have suffered billions of dollars in wind and water damage. Our hearts and prayers go out to everyone affected by Harvey, Irma, and Maria, including the staff at our Houston and Miami offices whose lives have been disrupted by these terrible storms.


  • Conflicting Views on the Potential Carcinogenicity of Glyphosate: How Did We Get Here and What Should We Do
    The advent of the internet and the information age has allowed the public to become keenly aware of the perceived dangers to health from polluted air and water, pesticide residues in foods, and global warming. Much of the available information on the worldwide web is not vetted, resulting in opinions that are based on anecdotal, emotional and alarming misinformation that runs counter to well-established, science-based medical knowledge.
  • How Well Can Carcinogenicity Be Predicted By High Throughput “Characteristics Of Carcinogens” Mechanistic Data?
    The International Agency for Research on Cancer (IARC) has begun using ToxCast/Tox21 data in an effort to represent key characteristics of carcinogens to organize and weigh mechanistic evidence in cancer hazard determinations. To determine how well ToxCast/Tox21 data can explicitly predict cancer hazard, this approach was evaluated with statistical analyses and machine learning prediction algorithms.
  • Therapeutic Radiation for Lymphoma and Risk of Second Primary Malignant Mesothelioma
    The article describes a study of nearly 50,000 Hodgkin lymphoma patients and over 250,000 non-Hodgkin lymphoma patients across the United States who were followed for up to 41 years after lymphoma diagnosis, from 1973 through 2014, for the occurrence of second primary malignant mesothelioma, a rare cancer of the thin layer of tissue that lines certain parts of the body, including the chest and abdomen.


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