Dr. Abraham’s expertise are in orthobiologics and translational research focused in bone regeneration after injury. She has used in vivo models to investigate the effect of bone morphogenetic protein-2 (BMP-2) and non-steroidal anti-inflammatory drugs (NSAIDs) on fracture healing. She is proficient in running pre-clinical trials, small and large animal surgical techniques, miroCT analysis, histology, statistical analysis, and failure analysis of bone. Her current interests involve spine biomechanics, bone biologics, and the manufacturing processes of medical devices and surgical instruments. Additionally, she has experience in developing Institutional Animal Care and Use Committee (IACUC) and Institutional Review Board (IRB) protocols.
Prior to joining Exponent, Dr. Abraham earned her Ph.D. in Biomedical Engineering from a joint program at Rutgers University and the New Jersey Institute of Technology. During the course of her Ph.D. she worked with orthopaedic surgeons and research scientists resulting in journal publications and academic conference posters. Her research included the use of in vivo and in vitro models to assess the safety and efficacy of orthobiologic adjuncts, biomaterials, and pharmaceuticals.
Dr. Abraham has prior experience working in the private sector at Arthrex, Inc. with the Validation Engineering group. Here she gained skills for Class II and III medical device validation conforming to ISO 13485 standards. Dr. Abraham drafted and executed IQ/OQ/PQ protocols for equipment and processes adhering to cGMP and 21 CFR 820. Her primary focus here was to validate and incorporate new manufacturing processes into the current manufacturing system.
CREDENTIALS & PROFESSIONAL HONORS
- Ph.D., Biomedical Engineering, Rutgers University, 2016
- B.S., Biomedical Engineering, University of Florida, 2009
Koerner J, Vives M, O’Connor JP, Chirichella P, Breitbart E, Chaudhary S, Uko L, Subramanian S, Benevenia J, Lin S. Zinc has insulin-mimetic properties which enhance spinal fusion in a rat model. The Spine Journal; 2016.
Mitchell AM, Kim BD, Engler SS, Subramanian S, Uhrich KE, O’Connor JP. Use of salicylic acid polymers and BMP-2 to promote bone regeneration in rabbit parietal bone defects. Journal of Bioactive and Compatible Polymers; 2015.
Subramanian S, Mitchell AM, Yu W, Engler SS, Uhrich KE, O’Connor JP. Salicylic acid-based polymers for guided bone regeneration using BMP-2. Tissue Engineering Part A; 2015.
O’Connor JP, Manigrasso MB, Kim BD, Subramanian S. Fracture healing and lipid mediators. BoneKEy Reports 2014; 3.
Subramanian S, Schussler S, Bakhtina A, Lin S, Arinzeh, T. A nanocomposite scaffold for bone tissue engineering. 62nd Annual Orthopaedic Research Society Meeting, Orlando, FL, March 5-8, 2016.
Vives MJ, O’Connor JP, Subramanian S, Cottrell JA, Chaudhary S, Shah NP, Munoz III W, Lin SS. Local insulin application has a dose-dependent effect on lumbar fusion in a rabbit model. 62nd Annual Orthopaedic Research Society Meeting, Orlando, FL, March 5-8, 2016.
Cottrell JA, Vives MJ, Lin SS, Abraham SS, Uko L, O’Connor JP. Locally applied immediate release insulin has a dose-responsive effect on posterolateral lumbar fusion in a rabbit model. 62nd Annual Orthopaedic Research Society Meeting, Orlando, FL, March 5-8, 2016.
Subramanian S, Mitchell AM, Engler SS, Uhrich KE, O’Connor JP. The use of BMP-2 and novel polymers for guided bone regeneration. 60th Annual Orthopaedic Research Society Meeting, New Orleans, LA, March 15-18, 2014. Also 2nd Annual Musculoskeletal Repair and Regeneration Symposium, Bronx, NY, October 10, 2013.