Ethan Daley
Ethan Daley, Ph.D.
Senior Associate
Biomedical Engineering
Philadelphia

Dr. Daley has expertise in multiple aspects of research and development, including drafting of specifications, concept generation, new product development, verification, and mechanical design. With a background spanning the mechanical and biomedical engineering fields in both industrial and academic settings, Dr. Daley offers a range of experience, including the design and/or characterization of biomaterials, skeletal tissues, and mechanical hardware such as medical devices.

Dr. Daley’s academic research focused on musculoskeletal tissue and reparative scaffolds. He has developed a family of modular multiphase constructs for bone, cartilage and vascular repair, as well as an associated perfusion bioreactor system. His thesis was an investigation of an unusual model of mammalian bone regeneration, the deer antler. In addition, he researched bone structure/function interactions and performed mechanical testing of medical devices for spinal fixation.

Dr. Daley’s work in the private sector includes four years as a Research and Development Hardware Engineer in the semiconductor test and measurement industry. While there, he undertook the mechanical design and release to production of test system components and also developed a patented biofilm sampling device.

Dr. Daley has hands-on experience with IP generation, working in a regulated environment, assay/protocol development, and laboratory techniques including micro-computed tomography (microCT), fluorescence microscopy, several modes of mechanical testing (bending, torsion, rheometry, nanoindentation), ELISA, immunohistochemistry (IHC), histology, cell culture, laser Doppler perfusion imaging (LDPI), image analysis, and computer aided design (CAD).

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Biomedical Engineering, University of Michigan, Ann Arbor, 2013
  • M.S., Biomedical Engineering, University of Michigan, Ann Arbor, 2009
  • M.S., Mechanical Engineering, University of Michigan, Ann Arbor, 2007
  • B.S., Mechanical Engineering, Oregon State University, 2000
  • Dennis Kayner Award in Orthopedic Research, University of Michigan, 2013

    GEM Fellowship Award, sponsor: Johnson & Johnson, 2007

    Continuing Rackham Engineering Award Fellowship, University of Michigan, 2006

    Rackham Engineering Award Fellowship, University of Michigan, 2005

    Presidential Scholarship, Oregon State University, 1995

    Pi Tau Sigma, mechanical engineering honorary society, Oregon State University

    Golden Key Society, academic honorary society, Oregon State University

Publications

Daley ELH, Coleman RM, Stegemann, JP. Biomimetic microbeads containing a chondroitin sulfate/chitosan polyelectrolyte complex for cell-based cartilage therapy. Journal of Materials Chemistry B 2015; 3:7920-7020.

Daley EL, Alford AI, Miller JD, Goldstein SA. Phenotypic differences in white-tailed deer antlerogenic progenitor cells and marrow-derived mesenchymal stromal cells. Tissue Engineering Part A 2014; 20(9-10):1416-1425.

Daley E, Streeten E, Sorkin J, Shapses S, Carleton S, Shuldiner A, Marini J, Phillips C, Goldstein S, Leikin S, McBride D. Variable bone fragility associated with an Amish COL1A2 variant and a knock-in mouse model. Journal of Bone and Mineral Research 2010; 25(2):247-261.

Presentations

Daley ELH, Rioja AY, Putnam AJ, Stegemann, JP. Endothelial Cell Sprouting in Agarose-Hydroxyapatite-Fibrinogen Microbeads for Vasculogenesis. Biomedical Engineering Society Annual Meeting, 2015.

Daley ELH, Coleman RM, Stegemann, JP. Chondrogenesis in cell-encapsulating chondroitin sulfate-chitosan polyelectrolyte complex microbeads for cartilage tissue engineering. Tissue Engineering and Regenerative Medicine International Society Americas Conference, 2014. 

Daley ELH. White-tailed deer antlerogenic progenitor cells: a promising model of bone regeneration. University of Quebec at Montreal, BioMed seminar series, 2013. 

Conference Abstracts 

Daley ELH, Stegemann JP. Use of Hydroxyapatite Particles to Selectively Modulate Cell-Matrix Interactions in Perfusable Agarose-Based Constructs for Musculoskeletal Regeneration. Tissue Engineering and Regenerative Medicine International Society World Congress, 2015. 

Daley ELH, Alford AI, Goldstein SA. Phenotypic differences in white-tailed deer antlerogenic progenitor cells and marrow-derived MSC. Tissue Engineering and Regenerative Medicine International Society Americas Conference, 2013. 

Daley ELH, Alford AI, Goldstein SA. Proliferation colony formation and trilineage differentiation of whitetail deer antlerogenic progenitor cells and animal matched marrow-derived mesenchymal stromal cells. American Society for Bone and Mineral Research Annual Meeting, 2012. 

Daley ELH, Alford AI, Goldstein SA. In vitro investigation of white-tailed deer antlerogenic progenitor cells. International Bone & Mineral Society Sun Valley Workshop on Musculoskeletal Biology, 2012. 

Daley ELH, Paige-Koh A, McCauley LK, Miller JD, Alford AI, Goldstein SA. Whitetail deer antlerogenic progenitor cells show robust mineralization in a murine ossicle growth model. American Society for Bone and Mineral Research Annual Meeting, 2011. 

Daley ELH, Mcbride DJ, Sorkin JD, Marini JC, Shapses SA, Goldstein SA. Amish OI mouse femurs share a phenotype that has strain-dependent severity. Orthopaedic Research Society Annual Meeting, 2009. 

Daley ELH, McBride DJ, Uveges TE, Kuznetsova NV, Leikin S, Marini JC, Goldstein SA. Age-associated changes in the material properties of the G610C (Amish) OI mouse model. American Society for Bone and Mineral Research Annual Meeting, 2008. 

Daley ELH, Ruberte-Thiele RA, Poulter GT, Goldstein SA, Graziano GP. Comparison of anterior 3-hole plate and paired/single anterior cages for anterior lumbar interbody fusion. American Society of Biomechanics Annual Meeting, 2008.

Patents

US Patent No 7,614,286: Methods for sampling equipment and fluid conditions

US Patent No 7,143,640: Fluid sampling device, tubular sampling coupon, and system and method for sampling equipment and fluid conditions

Professional Affiliations

Biomedical Engineering Society, Translation Committee, 2015-present

Additional Information

Peer Reviewer

Regeneration

Connective Tissue Research

Journal of Tissue Engineering and Regenerative Medicine

BMC Genomics

Journal of Cellular Physiology

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Biomedical Engineering, University of Michigan, Ann Arbor, 2013
  • M.S., Biomedical Engineering, University of Michigan, Ann Arbor, 2009
  • M.S., Mechanical Engineering, University of Michigan, Ann Arbor, 2007
  • B.S., Mechanical Engineering, Oregon State University, 2000
  • Dennis Kayner Award in Orthopedic Research, University of Michigan, 2013

    GEM Fellowship Award, sponsor: Johnson & Johnson, 2007

    Continuing Rackham Engineering Award Fellowship, University of Michigan, 2006

    Rackham Engineering Award Fellowship, University of Michigan, 2005

    Presidential Scholarship, Oregon State University, 1995

    Pi Tau Sigma, mechanical engineering honorary society, Oregon State University

    Golden Key Society, academic honorary society, Oregon State University