Sydney Gladman
A. Sydney Gladman, Ph.D.
Senior Associate
Polymer Science & Materials Chemistry
Natick

Dr. Gladman’s research interests include the design, formulation and characterization of advanced polymeric materials, many of which are tailored for additive manufacturing processes such as 3D printing. In particular, Dr. Gladman has synthesized autonomous and biomimetic materials such as 4D-printed programmable shape-changing polymers, 3D-printed human tissue constructs, and self-healing composite biomaterials.

Dr. Gladman has considerable experience in the processing and formulation of polymers, hydrogels, and composites. She has extensive experience with traditional and non-traditional additive manufacturing methods including the design of novel 3D printed “ink” formulations, mammalian cell culture and tissue engineering techniques, and microencapsulation of solvents and polymers. She is also familiar with a variety of polymer characterization techniques including rheological characterization, mechanical characterization including tensile tests, fracture tests, and dynamic mechanical analysis (DMA), thermal characterization including thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), imaging including optical, confocal, and scanning electron microscopy (SEM), and spectroscopy including infrared (IR) and ultraviolet-visible (UV-Vis).

As a graduate researcher at the University of Illinois at Urbana-Champaign in the Autonomous Materials Systems group, Dr. Gladman developed a novel microcapsule-based self-healing method to repair fracture damage in acrylic bone cement, a thermoplastic biomaterial utilized in joint replacement surgeries. She continued her academic career at Harvard University as a graduate and postdoctoral researcher with a focus on patent-pending 3D/4D printed shape-changing hydrogel composites for “smart” materials systems and 3D bioprinting of vascularized human tissue. Dr. Gladman’s innovative research in 4D printing has enabled shape changing behavior in a variety of fiber-reinforced acrylamide ink formulations, with the resulting programmable transformation triggered by water, heat, or light.

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Engineering Sciences, Harvard University, 2016
  • B.S., Materials Science and Engineering, University of Florida, 2010, magna cum laude
  • Gordon Research Conference Travel Award, 2016

    Materials Research Society Best Poster: Symposium B, 2014

    Hamer Fellowship Graduate Researcher, University of Illinois at Urbana-Champaign, Materials Science and Engineering Department, 2010-2012

    Vladimir Grodsky Memorial Scholarship, Materials Science and Engineering, UF, 2007-2009

    Bright Future’s Scholarship, State of Florida, 2006-2010

Publications

McCracken JM, Badea A, Kandel ME, Gladman AS, Wetzel DJ, Popescu G, Lewis JA, Nuzzo RG. Programming mechanical and physicochemical properties of 3D hydrogel cellular microcultures via direct ink writing. Advanced Heathcare Materials 2016; 5:1025–1039.

Gladman AS, Matsumoto EA, Nuzzo RG, Mahadevan L, Lewis JA. Biomimetic 4D printing. Nature Materials 2016; 15:413–418.

Gladman AS, Celestine AN, Sottos NR, White S.R. Autonomic healing of acrylic bone cement. Advanced Healthcare Materials 2015; 4:202–207.

Kolesky DB, Truby RL, Gladman AS, Busbee TA, Homan KA, Lewis JA. 3D bioprinting of vascularized, heterogeneous cell-laden tissue constructs. Advanced Materials 2010; 26:3124–3130.

Presentations

Gladman AS. Biomimetic 4D printing. Gordon Research Conference: Multifunctional Materials Structures, Ventura, CA, 2016.

Gladman AS. Biomimetic 4D printing. Materials Research Society Conference, Boston, MA, 2015.

Gladman AS. 4D printing of nanocomposite hydrogel architectures. Materials Research Society Conference, Boston, MA, 2014. 

Gladman AS. Autonomic healing of acrylic bone cement. Soft Materials Seminar, UIUC, 2012.

Gladman AS. Autonomic healing of acrylic bone cement. Materials Research Society Conference, Boston, MA, 2011.

Gladman AS. Self-healing of acrylic bone cement. 48th Annual Technical Meeting of the Society of Engineering Sciences, Evanston, IL, 2011.

Patents

Provisional Patent Application 62260981: Hydrogel composite ink formulation and method of 4D printing a hydrogel composite structure, 2015 (Lewis, J.A., Gladman AS, Matsumoto, E.A., Mahadevan, L., and Rittner, M.N.).

Non-Provisional Patent Application 14954228: Method of 4D printing a hydrogel composite structure, 2015 (Lewis, J.A., Gladman AS, and Rittner, M.N.).

International Patent Application Number PCT/US2014/063810: Method of printing a tissue construct with embedded vasculature, 2014 (Lewis, J.A., Kolesky, D.B, Scott, M.A., Homan, K.A., Truby, R.L., Gladman AS, and Rittner, M.N.).

Professional Affiliations

Materials Research Society

News & Events

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Engineering Sciences, Harvard University, 2016
  • B.S., Materials Science and Engineering, University of Florida, 2010, magna cum laude
  • Gordon Research Conference Travel Award, 2016

    Materials Research Society Best Poster: Symposium B, 2014

    Hamer Fellowship Graduate Researcher, University of Illinois at Urbana-Champaign, Materials Science and Engineering Department, 2010-2012

    Vladimir Grodsky Memorial Scholarship, Materials Science and Engineering, UF, 2007-2009

    Bright Future’s Scholarship, State of Florida, 2006-2010