Derek Holyoak
Derek Holyoak
Associate
Biomedical Engineering
Philadelphia

Dr. Holyoak’s expertise focuses on the biocompatibility of medical devices and the role of mechanical loading in disease pathology. He has extensive experience with MRI compatibility testing for medical devices, scanning electron microscopy (SEM), wear particle characterization, and analysis of women’s health products. Working with in vivo models, he gained skills in micro-surgeries, intra-articular injections, and custom-made loading fixtures. Additional areas of expertise include micro-computed tomography (µCT), histology, immunohistochemistry, image processing, and protocol development. Dr. Holyoak has experience in biomaterials characterization techniques, including uniaxial mechanical testing, fatigue analysis, and rheology. In addition, he has research, teaching, and work experience with human studies, gait analysis, motion capture systems, electromyography (EMG), and force plates. Dr. Holyoak’s primary research interests are osteoarthritis, biomechanics, medical devices, arthroplasty, trauma, and exercise science.

Prior to joining Exponent, Dr. Holyoak obtained his Ph.D. in Biomedical Engineering from Cornell University where he developed and tested novel approaches to treat osteoarthritis. Specifically, he applied novel loading regimens to attenuate the progression of osteoarthritis in animal models. He designed, fabricated, and tested synthetic hydrogel systems for intra-articular drug delivery. Dr. Holyoak was a key contributor to preclinical studies investigating the role of the gut microbiome, obesity, and metabolic syndrome in osteoarthritis onset and progression.

In addition to his Ph.D. work, Dr. Holyoak contributed to a clinical study at the Hospital for Special Surgery that examined the effects of malnutrition on post-operative infection after total hip replacement. He also worked with the Cornell University College of Veterinary Medicine to understand pre- and post-operative canine walking gait. At Cybex, International, Dr. Holyoak performed exercise biomechanics studies to investigate the effects of body position on lower limb joint stresses during the forward lunge exercise. Finally, he was a Teaching Assistant for Measurements and Instrumentation in Biomedical Engineering.

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Biomedical Engineering, Cornell University, 2018
  • M.S., Biomedical Engineering, Cornell University, 2016
  • B.S., Biomedical Engineering, University of Connecticut, 2013, summa cum laude
  • Cornell Biomedical Engineering Teaching Assistant of the Year, 2018

    Cornell Three Minute Thesis Competition Runner-up, 2018

Publications

Guss J, Ziemian S, Luna M, Sandoval T, Holyoak D, Guisado G, Roubert S, Callahan R, Brito I, van der Meulen M, Goldring S, Hernandez C. The effects of metabolic syndrome, obesity, and the gut microbiome on load-induced osteoarthritis. Osteoarthritis Cartilage 2019; 27(1):129-139.

Holyoak D, Otero M, Armar N, Ziemian S, Otto A, Cullinane D, Goldring S, Wright T, Goldring M, van der Meulen M. Collagen XI mutation lowers susceptibility to load-induced cartilage damage in mice. Journal of Orthopaedic Research 2018; 36:711-720.

Hofmann C, Holyoak D, Juris P. Body position influences lead and trail limb patellofemoral stress during the forward lunge. Journal of Orthopaedic & Sports Physical Therapy 2017; 47:31-40.

Holyoak D, Tian Y, van der Meulen M, Singh A. Osteoarthritis: Pathology, mouse models, and nanoparticle injectable systems for targeted treatment. Annals of Biomedical Engineering 2016; 44:2062-2075.

Presentations

Holyoak D, Chlebek C, Kim M, Wright T, Otero M, van der Meulen M. Low-level cyclic tibial compression attenuates osteoarthritis progression after joint injury in mice. Podium presentation, Orthopaedic Research Society, Austin, TX, 2019.

Wheeler T, Holyoak D, van der Meulen M, Singh A. Intra-articular injection of synthetic hydrogels attenuates symptoms of load-induced osteoarthritis. Poster presentation, Orthopaedic Research Society, Austin, TX, 2019.

Holyoak D, Wheeler T, Rebollo N, van der Meulen M, Singh A. Injectable hydrogels with tunable mechanical durability and on-demand drug release for intra-articular osteoarthritis treatment. Poster presentation, 8th World Congress of Biomechanics, Dublin, Ireland, 2018.

Ziemian S, Adebayo O, Rooney A, Kelly N, Holyoak D, Ross F, van der Meulen M. ERα deletion from mature osteoblasts increases severity of load-induced osteoarthritis in female mice. Podium presentation, 8th World Congress of Biomechanics, Dublin, Ireland, 2018.

Earle A, Holyoak D. Instructor and student opinions on an online versus written feedback system for homework. Podium presentation, Connecting Research and Teaching, Ithaca, NY, 2018.

Holyoak D, Wheeler T, Rebollo N, van der Meulen M, Singh A. Injectable hydrogels for intra-articular delivery demonstrate mechanical integrity and on-demand drug release. Podium presentation, Orthopaedic Research Society, New Orleans, LA, 2018.

Ziemian S, Adebayo O, Rooney A, Kelly N, Holyoak D, Ross P, van der Meulen M. ERα deletion from mature osteoblasts increases severity of load-induced osteoarthritis in mice. Podium presentation, Orthopaedic Research Society, New Orleans, LA, 2018.

Guss J, Ziemian S, Luna M, Holyoak D, Guisado G, Sandoval T, Roubert S, van der Meulen M, Goldring S, Hernandez C. Relationships between metabolic syndrome, adiposity, and the gut microbiome in a mouse model of load induced osteoarthritis. Podium presentation, Orthopaedic Research Society, New Orleans, LA, 2018.

Holyoak D, Wheeler T, van der Meulen M, Singh A. Injectable hydrogels for intra-articular delivery maintain mechanical integrity after cyclic compression hydrolytic degradation. Poster presentation, Orthopaedic Research Society Upstate New York and Northeast Regional Symposium, Rochester, NY, 2017.

Guss J, Ziemian S, Luna M, Sandoval T, Holyoak D, Guisado G, van der Meulen M, Goldring S, Hernandez C. Metabolic syndrome resulting from disturbances in the gut microbiome does not exacerbate cartilage pathology in a mouse model of load induced osteoarthritis. Poster presentation, Orthopaedic Research Society Upstate New York and Northeast Regional Symposium, Rochester, NY, 2017.

Earle A, Holyoak D, Shah S. Evaluating efficacy and student response to a two-stage homework system in an introductory thermodynamics class. Podium presentation, Connecting Research and Teaching, Ithaca, NY, 2017.

Holyoak D, Otero M, Armar N, Wright T, Goldring S, Goldring M, van der Meulen M. Collagen XI mutation in mice results in thinner, less dense cortical bone and lower susceptibility to load-induced cartilage damage. Poster presentation, Orthopaedic Research Society, San Diego, CA, 2017.

Holyoak D, Otero M, Armar N, Wright T, Goldring S, Goldring M, van der Meulen M. Mice with a collagen XI mutation are less susceptible to load-induced cartilage damage and have thinner, less dense cortical bone. Poster presentation, Albert Einstein College of Medicine Musculoskeletal Repair and Regeneration Symposium, Bronx, NY, 2016.

Holyoak D, Otero M, Kulley K, Wright T, Goldring S, Goldring M, van der Meulen M. Abnormal cartilage matrix in mice does not influence the response of the knee joint to mechanical loading. Poster presentation, Orthopaedic Research Society, Orlando, FL, 2016.

Hofmann C, Holyoak D, Juris P. Trunk position and shank angle alter the biomechanics of the lead and trail limb during the forward lunge. Poster presentation, 7th World Congress of Biomechanics, Boston, MA, 2014.

Prior Experience

Graduate Research Assistant, Cornell University, 2013-2018

Graduate Teaching Assistant, Cornell University, 2016-2018

Research Assistant, Hospital for Special Surgery, 2014

Research Assistant, Cybex, International (Now Life Fitness), 2012-2013

Professional Affiliations

Orthopaedic Research Society

Biomedical Engineering Society

Knowledge

News & Events

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Biomedical Engineering, Cornell University, 2018
  • M.S., Biomedical Engineering, Cornell University, 2016
  • B.S., Biomedical Engineering, University of Connecticut, 2013, summa cum laude
  • Cornell Biomedical Engineering Teaching Assistant of the Year, 2018

    Cornell Three Minute Thesis Competition Runner-up, 2018