Nicholas G. Horton
Nicholas G. Horton, Ph.D.
Senior Scientist
Electrical Engineering & Computer Science
Menlo Park

Dr. Horton’s experiences at Exponent include design and testing of consumer electronics and medical devices. As a graduate student at Cornell University he developed, tested, and used novel laser-based fluorescence microscopes for deep, high resolution imaging within the intact, in vivo mouse brain. He is skilled in areas related to microscopy, biomedical & tissue optics, nonlinear & femtosecond optics, optical system design, electronics, and image processing.

Dr. Horton previously served as a National Security Analyst at the Johns Hopkins University Applied Physics Laboratory, where he conducted rigorous, fact-based analyses independently and in multidisciplinary teams to support projects ranging from small studies to large multi-institution collaborations in the areas of healthcare, technology, infrastructure resilience, cyber-deterrence, and military doctrine.

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Applied Physics, Cornell University
  • M.S., Applied Physics, Cornell University, 2013
  • B.A., Physics, Rollins College, 2009
  • William Nichols Findley Award, Cornell University, 2013

    National Science Foundation (NSF) Graduate Research Fellowship Program, 2010

    NSF East Asia and Pacific Summer Institutes for U.S. Graduate Students Fellowship, 2010

    Presidential Life Sciences Fellowship (Cornell University), 2009

    Barry M. Goldwater Scholarship, 2008

Publications

Ouzounov DG, Wang T, Wang M, Feng DD, Horton NG, Cruz-Hernández JC, Cheng Y-T, Reimer J, Tolias AS, Nishimura N, Xu C. In vivo three photon imaging of activity of GCaMP6-labeled neurons deep in intact mouse brain, Nature Methods 2017; 14:388-390.

Lin C-J, Li F-C, Lee Y-Y, Tseng T-Y, Chen W, Hovhannisyan V, Kang N, Horton NG, Chiang S-J, Xu C, Lee H-S, Dong C-Y. Direct visualization of functional heterogeneity in hepatobiliary metabolism using 6-CFDA as model compound, Biomedical optics express 2016; 7:3574-3584.

Horton NG, Xu C. Dispersion compensation in three photon fluorescence microscopy at 1,700 nm, Biomedical Optics Express 2015; 6:1392-1397.

Cheng L-C, Horton NG, Wang K, Chen S, and Xu C. Measurements of multiphoton action cross sections for multiphoton microscopy, Biomedical Optics Express 2014; 5:3427-3433.

Wang K, Horton NG, Charan C, Xu C. Advanced Fiber Soliton Sources for Nonlinear Deep Tissue Imaging in Biophotonics, IEEE Journal of Selected Topics in Quantum Electronics 2014; 20:6800311.

Horton NG, Wang K, Kobat D., Clark CG, Wise FW, Schaffer CB and Xu C. In vivo three-photon microscopy of subcortical structures within an intact mouse brain, Nature Photonics 2013; 7: 205-209.

Howard S, Straub A, Horton NG, Kobat D, Xu C. Frequency-multiplexed in vivo multiphoton phosphorescence lifetime microscopy, Nature Photonics 2013; 7:33-37.

Wang K, Liu TM, Wu J., Horton NG, Lin CP, Xu C. Three-color femtosecond source for simultaneous excitation of three fluorescent proteins in two-photon fluorescence microscopy. Biomedical Optics Express 2012; 3:1972-1977.

Kobat D, Horton NG, Xu C. In vivo two-photon microscopy to 1.6-mm depth in mouse cortex. Journal of Biomedical Optics 2011; 16:106014.

Horton NG, Moore TR. Modeling the magnetic pickup of an electric guitar, American Journal of Physics 2009; 77:144-150.

Presentations

Horton NG, Xu C. Dispersion compensation in three-photon fluorescence microscopy at 1,700 nm for in vivo imaging. Oral presentation, Novel Techniques in Microscopy, Vancouver, Canada, 2015.

Horton NG, Charan K, Ouzounov DG, Xu C. Multi-MW soliton pulse generation at 1700 nm in a photonic crystal rod. Oral presentation, Conference on Lasers and Electro-Optics, San Jose, CA, 2014.

Horton NG, Wang K, Wang C-C, Xu, C. In vivo three-photon imaging of subcortical structures of an intact mouse brain using quantum dots. Oral presentation, Conference on Lasers and Electro-Optics Europe, Munich, Germany, 2013.

Horton NG, Wang K, Kobat D, Wise, FW, Xu C. In Vivo Deep Penetration Three-Photon Imaging of Mouse Brain through an Unthinned, Intact Skull. Oral presentation, Novel Techniques in Microscopy, Waikoloa Beach, HI, 2013.

Horton NG, Wang K, Kobat D, Wise F, Xu C. In vivo three-photon microscopy of subcortical structures within an intact mouse brain. Oral presentation, Conference on Lasers and Electro-Optics, San Jose, CA, 2012.

Horton NG, Kobat D, Wang K, Xu C. In vivo, deep tissue three-photon imaging at the 1700-nm spectral window. Oral presentation, Biomedical Optics, Miami, FL, 2012.

Kobat D, Horton NG, Xu C. In vivo two-photon imaging of cortical vasculature in mice to 1.5-mm depth with 1280-nm excitation. Oral presentation, Conference on Lasers and Electro-Optics, Baltimore, MD, 2011.

Prior Experience

National Security Analyst, Johns Hopkins University Applied Physics Laboratory, 2015-2018

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Applied Physics, Cornell University
  • M.S., Applied Physics, Cornell University, 2013
  • B.A., Physics, Rollins College, 2009
  • William Nichols Findley Award, Cornell University, 2013

    National Science Foundation (NSF) Graduate Research Fellowship Program, 2010

    NSF East Asia and Pacific Summer Institutes for U.S. Graduate Students Fellowship, 2010

    Presidential Life Sciences Fellowship (Cornell University), 2009

    Barry M. Goldwater Scholarship, 2008