Nicholas G. Horton

Nicholas G. Horton, Ph.D.

Managing Scientist
Electrical Engineering & Computer Science
Menlo Park

Dr. Horton’s expertise includes the design, construction, risk assessment, and failure analysis of optical systems, medical devices, and electronics. He has worked with clients on product design issues for devices ranging from prototypes to field returns. His optics work includes optical hazard assessments of laser-based and LED-based systems as well as the design of laser-based medical devices and consumer-grade optical systems. He is experienced in optical ray trace analysis and has used this technique to simulate devices under nominal and failure conditions. His work also includes hazard assessments of electronic systems intended for explosive environments as well as safety risk assessments of device failures.

Dr. Horton received a Ph.D. in Applied Physics from Cornell University in 2015. As a graduate student he developed, tested, and used novel laser-based fluorescence microscopes for deep, high resolution imaging within the intact, in vivo mouse brain.

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Applied Physics, Cornell University, 2015
  • M.S., Applied Physics, Cornell University, 2013
  • B.A., Physics, Rollins College, 2009
  • William Nichols Findley Award, Cornell University, 2013

    National Science Foundation (NSF) Graduate Research Fellowship Program, 2010

    NSF East Asia and Pacific Summer Institutes for U.S. Graduate Students Fellowship, 2010

    Presidential Life Sciences Fellowship (Cornell University), 2009

    Barry M. Goldwater Scholarship, 2008

Publications

Horton NG, Pollock KL, Fei ET, Lau EK. Retinal hazard analysis for laser and LED illumination for close-in, long duration exposure. International Laser Safety Conference Proceedings 2019, paper #1204.

Pollock KL, Horton NG, Lau EK, Fei ET. The Effect of Liquid Droplets on Laser Safety for Consumer Products: A Numerical Model. International Laser Safety Conference Proceedings 2019, paper #1301.

Li F-C, Lee S-L, Lin H-M, Lin C-J, Wang S-S, Lee Y-Y, Lo S-Y, Sun T-L, Chen W-L, Lo W, Horton N, Xu C, Chiang S-J, Chen Y-F, Lee H-S, Dong C-Y. Dynamic visualization of the recovery of mouse hepatobiliary metabolism to acetaminophen-overdose damage, Journal of Biophotonics 2019; e201800296

Wang T, Ouzounov DG, Wu C, Horton NG, Zhang B, Wu C-H, Zhang Y, Schnitzer MJ, Xu C. Three-Photon Imaging of Mouse Brain Structure and Function through the Intact Skull. Nature Methods 2018; 15:789-792.

Ouzounov DG, Wang T, Wang M, Feng DD, Horton NG, Cruz-Hernández JC, Cheng Y-T, Reimer J, Tolias AS, Nishimura N, Xu C. In vivo three photon imaging of activity of GCaMP6-labeled neurons deep in intact mouse brain, Nature Methods 2017; 14:388-390.

Lin C-J, Li F-C, Lee Y-Y, Tseng T-Y, Chen W, Hovhannisyan V, Kang N, Horton NG, Chiang S-J, Xu C, Lee H-S, Dong C-Y. Direct visualization of functional heterogeneity in hepatobiliary metabolism using 6-CFDA as model compound, Biomedical optics express 2016; 7:3574-3584.

Horton NG, Xu C. Dispersion compensation in three photon fluorescence microscopy at 1,700 nm, Biomedical Optics Express 2015; 6:1392-1397.

Cheng L-C, Horton NG, Wang K, Chen S, and Xu C. Measurements of multiphoton action cross sections for multiphoton microscopy, Biomedical Optics Express 2014; 5:3427-3433.

Wang K, Horton NG, Charan C, Xu C. Advanced Fiber Soliton Sources for Nonlinear Deep Tissue Imaging in Biophotonics, IEEE Journal of Selected Topics in Quantum Electronics 2014; 20:6800311.

Horton NG, Wang K, Kobat D., Clark CG, Wise FW, Schaffer CB and Xu C. In vivo three-photon microscopy of subcortical structures within an intact mouse brain, Nature Photonics 2013; 7: 205-209.

Howard S, Straub A, Horton NG, Kobat D, Xu C. Frequency-multiplexed in vivo multiphoton phosphorescence lifetime microscopy, Nature Photonics 2013; 7:33-37.

Wang K, Liu TM, Wu J., Horton NG, Lin CP, Xu C. Three-color femtosecond source for simultaneous excitation of three fluorescent proteins in two-photon fluorescence microscopy. Biomedical Optics Express 2012; 3:1972-1977.

Kobat D, Horton NG, Xu C. In vivo two-photon microscopy to 1.6-mm depth in mouse cortex. Journal of Biomedical Optics 2011; 16:106014.

Horton NG, Moore TR. Modeling the magnetic pickup of an electric guitar, American Journal of Physics 2009; 77:144-150.

Presentations

Horton NG, Pollock KL, Fei ET, Lau EK. Retinal hazard analysis for laser and LED illumination for close-in, long duration exposure. Oral presentation, International Laser Safety Conference, Kissimmee, FL, 2019.

Horton NG, Xu C. Dispersion compensation in three-photon fluorescence microscopy at 1,700 nm for in vivo imaging. Oral presentation, Novel Techniques in Microscopy, Vancouver, Canada, 2015.

Horton NG, Charan K, Ouzounov DG, Xu C. Multi-MW soliton pulse generation at 1700 nm in a photonic crystal rod. Oral presentation, Conference on Lasers and Electro-Optics, San Jose, CA, 2014.

Horton NG, Wang K, Wang C-C, Xu, C. In vivo three-photon imaging of subcortical structures of an intact mouse brain using quantum dots. Oral presentation, Conference on Lasers and Electro-Optics Europe, Munich, Germany, 2013.

Horton NG, Wang K, Kobat D, Wise, FW, Xu C. In Vivo Deep Penetration Three-Photon Imaging of Mouse Brain through an Unthinned, Intact Skull. Oral presentation, Novel Techniques in Microscopy, Waikoloa Beach, HI, 2013.

Horton NG, Wang K, Kobat D, Wise F, Xu C. In vivo three-photon microscopy of subcortical structures within an intact mouse brain. Oral presentation, Conference on Lasers and Electro-Optics, San Jose, CA, 2012.

Horton NG, Kobat D, Wang K, Xu C. In vivo, deep tissue three-photon imaging at the 1700-nm spectral window. Oral presentation, Biomedical Optics, Miami, FL, 2012.

Kobat D, Horton NG, Xu C. In vivo two-photon imaging of cortical vasculature in mice to 1.5-mm depth with 1280-nm excitation. Oral presentation, Conference on Lasers and Electro-Optics, Baltimore, MD, 2011.

Prior Experience

National Security Analyst, Johns Hopkins University Applied Physics Laboratory, 2015-2018

Project Experience

Optical ray trace analysis:

  • Optical safety assessments of laser-based and LED-based systems including LIDAR, VR/AR headsets, and diffractive element projectors under nominal and failure conditions

  • Field-of-view determination of reflective surfaces

  • Scene recreation from first-person perspective

Optical system design, construction, and testing:
  • Laser-based medical devices

  • Devices utilizing miniature optical elements

  • Consumer-grade optical systems

  • Laser scanning microscopes

Optical system characterization:

  • Optical hazard classification of laser products

  • Variability testing of consumer products

Hazard assessments of devices in explosive environments:

  • Battery-powered medical devices intended for Ethylene Oxide sterilization

  • Laser-based consumer electronics devices

Device performance characterization:

  • Safety-related testing and risk assessments of electrical devices (e.g. lighting systems, power adapters)

  • Characterization of ultrasonic detection systems

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Applied Physics, Cornell University, 2015
  • M.S., Applied Physics, Cornell University, 2013
  • B.A., Physics, Rollins College, 2009
  • William Nichols Findley Award, Cornell University, 2013

    National Science Foundation (NSF) Graduate Research Fellowship Program, 2010

    NSF East Asia and Pacific Summer Institutes for U.S. Graduate Students Fellowship, 2010

    Presidential Life Sciences Fellowship (Cornell University), 2009

    Barry M. Goldwater Scholarship, 2008