Ariel Ketcherside, Ph.D.

Scientist
Human Factors
Austin

Dr. Ketcherside is a cognitive neuroscientist with expertise in the underlying factors that drive decision-making. Through her training, research, and experience, Dr. Ketcherside has expertise in emotion, reward, and decision making, as well as visual perception, attention, driver behavior, and the effects of alcohol and other drugs on human performance. She applies her knowledge to help clients understand such issues as consumer purchase decisions, consumer product use, and effectiveness of safety- and product-related information. Her expertise is also leveraged across a variety of failure analysis and safety-related contexts, including slip, trip, and falls, motor vehicle accidents, and incidents involving consumer products and medical devices.

Dr. Ketcherside’s research and consulting experience has included a wide variety of methodologies to understand human behavior. These include neuroimaging, statistical modeling, genetics and biomarker assessment, and neuropsychological testing. She also has experience in pre-clinical drug discovery and testing, as well as with clinical trial research. Dr. Ketcherside is skilled in study design, execution, and advanced analysis of data from human participant research, including experimental, observational, survey, interview, and focus group studies.

Prior to joining Exponent, Dr. Ketcherside earned a BA in Biology at Austin College. She worked at UT Southwestern Medical Center, where her work contributed to pre-clinical research, before obtaining her PhD in Cognitive Neuroscience at the University of Texas at Dallas. Her graduate research investigated addiction, how the brain responds to reward-related stimuli, and the influence of drugs and emotions on cognition. She also completed a postdoctoral fellowship at the University of Pennsylvania, where she evaluated the efficacy of a medication for smoking cessation.

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Cognition and Neuroscience, University of Texas, Dallas, 2017
  • M.Sc., Applied Cognition and Neuroscience, University of Texas, Dallas, 2014
  • B.A., Biology, Austin College, 2010

Publications

Ketcherside, A, Jagannathan, K, Dolui, S, Hager, N, Spilka, NH, Rao, H, Wetherill, R, Franklin, T. (2020). Baclofen-induced changes in the resting brain modulate smoking cue reactivity: A double-blind placebo-controlled fMRI study in cigarette smokers. Clinical Psychopharmacology and Neuroscience. In press.

Ely, AV, Jagannathan, K, Ketcherside, A, Hager, N, Franklin, TR, Wetherill, RR. (2019). Double jeopardy: Comorbid obesity and cigarette smoking linked to neurobiological alterations in inhibitory control during smoking cue exposure. Addiction Biology. May 8:e12750. doi: 10.1111/adb.12750 3.

Franklin, TR, Jagannathan, K, Ketcherside, A, Spilka, N, Wetherill, RR. (2019). Menstrual cycle phase modulates responses to smoking cues in the putamen: Preliminary evidence for a novel target. Drug and Alcohol Dependence. Mar 15;198:100-104. doi:10.1016/j.drugalcdep.2019.01.039 4.

Ketcherside, A, Filbey, FM, Seibyl, JP, Price, JL, Adinoff, B. (2018). Brain intrinsic network connectivity in individuals with frequent tanning behavior. The American Journal of Drug and Alcohol Abuse.

Ketcherside, A, McIntyre, CK, Filbey, FM. (2017). Cannabinoid Receptor 1 Gene by Cannabis Use Interaction on CB1 Receptor Density. Cannabis and Cannabinoid Research, 2:1. 202-209. https://doi.org/10.1089/can.2017.0007 6.

Volkov, OA, Cosner, CC, Brockway, AJ, Zhong, S, Ketcherside, A., Kramer, M, Booker, M, Richardson, TR, Schock, S., Wring, SA, Peel, M, Klinger, JD, Posner, B, De Brabander, J, Phillips, MA. (2017). Identification of Trypanosoma brucei AdoMetDC inhibitors using a high-throughput mass spectrometry based assay. ACS Infectious Diseases. 3:7, 512-526. DOI: 10.1021/acsinfecdis.7b00022.

Feldstein-Ewing, S, Chung, T, Caouette, JD, Ketcherside, A, Hudson, KA, Filbey, FM. (2016). Orbitofrontal cortex connectivity as a mechanism of adolescent behavior change. NeuroImage. DOI: 10.1016/j.neuroimage.2016.12.076

Ketcherside, A, Baine, JL, Filbey, FM. (2016). Sex effects of marijuana on brain structure and function. Current Addiction Reports, 3:2. DOI: 10.1007/s40429-016-0114-y

Ketcherside, A, Filbey, FM, Jeong-Slaughter, H. (2016). Personality profiles discriminate marijuana users from concomitant marijuana-tobacco users. Psychiatry Research, 238, 356–362. DOI: http://dx.doi.org/10.1016/j.psychres.2016.02.024

Filbey, FM, Dunlop, J, Ketcherside, A, Baine, J, Rhinehardt, T, Kuhn, B, Alvi, T, DeWitt, S. (2016). fMRI study of neural sensitization to hedonic stimuli in long-term, daily cannabis users. Human Brain Mapping, 37:3431–3443. DOI: 10.1002/hbm.23250

Ketcherside, A, and Filbey, FM. (2015). Addictions neuroscience. In Neuroimaging and Psychosocial Addiction Treatment: An Integrative Guide for Researchers and Clinicians. Sarah Feldstein Ewing, Katie Witkiewitz, Francesca Filbey (eds.), Palgrave MacMillan, Basingstone, Hampshire, UK

Filbey, FM, McQueeny, T, Kadamangudi, S, Bice, C, Ketcherside, A. (2015). Combined effects of marijuana and nicotine on memory performance and hippocampal volume. Behavioral Brain Research 293 (2015) 46–53. DOI: http://dx.doi.org/10.1016/j.bbr.2015.07.029

Dewitt, S*, Ketcherside, A*, Dunlop, J, McQueeny, T, Filbey, FM. (2015). The hypersentient addict: an exteroception model of addiction. American Journal of Drug and Alcohol Abuse, 41(5) 374-381. DOI: 10.3109/00952990.2015.1049701 *co-first authors

Ketcherside, A, Filbey, FM. (2015). Mediating processes between stress and problematic marijuana use. Addictive Behaviors, Jun;45:113–8. DOI: 10.1016/j.addbeh.2015.01.015 14.

Ketcherside, A, Matthews, I, Filbey, FM. (2013). The serotonin link between alcohol use and affective disorders. Journal of Addiction Prevention 1(2):3.

Kozikowski, AP, Gunosewoyo, H, Guo, S, Gaisina, IN, Walter, RL, Ketcherside, A, McClung, CA, Mesecar, AD, Caldarone, B. (2011). Identification of a glycogen synthase kinase-3beta inhibitor that attenuates hyperactivity in CLOCK mutant mice. ChemMedChem, 6, 1593–1602. DOI: 10.1002/cmdc.201100188.

Presentations

Ketcherside, A."Evidence for GABA B agonists as smoking cessation aids: A placebo-controlled perfusion fMRI study", the College on Problems of Drug Dependence 81st Annual Scientific Meeting, San Antonio, TX. June 16, 2019.

Ketcherside, A. “Health Disparities in Substance Use Disorders: Lessons from imaging and genetics”. The 14th Annual Texas Conference on Health Disparities, Ft. Worth, TX. June 6, 2019.

Ketcherside, A, Jagannathan, K, Dolui, S, Hager, N, Spilka N, Rao, H, Wetherill, R, Franklin, T. Baclofen-induced changes in the resting brain modulate smoking cue reactivity: A double-blind placebo-controlled fMRI study in cigarette smokers. Presented at the Philadelphia Society for Neuroscience Annual Meeting in Philadelphia, PA. May, 2019.

Ketcherside, A., Jagannathan, K., Hager, N., Pelosi, D., Darnley, S., Yang, N., Rao, H., Detre, J., Dolui, S., Franklin, T., Wetherill, R. Lighting Up: Neural responses to cigarette smoking. The College on Problems of Drug Dependence, San Diego, CA, June 11, 2018.

Ketcherside, A., Prashad, S. Rao, M., Goldsmith, A., Filbey, F.M. Regularized Linear Regression to determine a Multilocus Genetic Profile Score for Cannabis Use Disorder. The Society of Biological Psychiatry annual meeting, New York, NY, May 11, 2018.

Ketcherside, A. “Determining Individual Risks for Problematic Marijuana Use.” Center for Studies of Addiction, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA. Apr. 21, 2017.

Ketcherside, A., Filbey, F.M. Model-based differentiation of networks of reward and impulsivity in cannabis use disorders. The Cognitive Neuroscience Society Annual meeting, San Francisco, CA, Mar. 25–28, 2017.

Ketcherside, A. “Connection and Unity Between Mind, Body, and Nature.” Crow Collection of Asian Art, Dallas, TX. Apr. 24, 2016.

Ketcherside, A. “Stressed is Desserts spelled backward.” UT Dallas Lunch and Learn Lecture Series, Jan. 20, 2016.

Ketcherside, A. “Stress, Drugs, and Pizza Rolls: Aberrant reward processing and a proposed intervention.” UT Dallas School of Behavior and Brain Sciences, Nov. 12, 2015.

Ketcherside, A., Filbey, F.M. A novel method for the isolation and quantification of human peripheral cannabinoid receptors. Winter Conference on Brain Research, Breckenridge, CO, Jan. 23–28, 2016. 9. Ketcherside, A., Filbey, F.M. The point of a joint: a multivariate classification of marijuana use motives. College on Problems of Drug Dependence annual meeting, Phoenix, AZ, Jun. 13–18, 2015.

Ketcherside, A. “The Neuroscience of Nirvana: Mindfulness Training for Optimal Decision making.” Center for BrainHealth, Feed the Mind lecture series, Dallas, TX. Nov. 13, 2014.

“Multivariate Analysis of Alcohol Use Disorder Symptoms and Personality Disorders in Cannabis Users.” Texas Research Society on Alcoholism annual meeting, University of Texas Health Science Center, San Antonio, TX, February 21, 2014.

Ketcherside, A., Filbey, F.M. Mediating processes between stress and problematic marijuana use. Society for Neuroscience Annual Meeting, San Diego, CA, Nov. 9–13, 2013.

Ketcherside, A. “Drugs and the Teenage Brain.” Highland Park High School, Dallas, TX. Sept. 18, 2013.

Ketcherside, A. “Investigating the Mechanism of Lithium in Bipolar Disorder treatment GSK-3b.” Austin College, Sherman, TX. May 2010.

Prior Experience

Postdoctoral Fellow, The University of Pennsylvania Perelman School of Medicine, 2017-2019

Additional Information

Peer Reviewer

  • Human Brain Mapping
  • Neroimage: Clinical
  • Alcoholism: Clinical and Experimental Research
  • The American Journal of Drug and Alcohol Dependence
  • Psychiatry Research
  • Current Opinion in Behavioral Sciences

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Cognition and Neuroscience, University of Texas, Dallas, 2017
  • M.Sc., Applied Cognition and Neuroscience, University of Texas, Dallas, 2014
  • B.A., Biology, Austin College, 2010