Jessica Lee
Jessica P. Lee, Ph.D.
Senior Scientist
Polymer Science & Materials Chemistry
Hong Kong

Dr. Lee’s areas of expertise include chemical and biological synthesis of polymers, with an emphasis on protein modifications and characterization. She has employed her chemical, materials and biological knowledge to address challenges in the development of bioconjugate materials for biomedical and industrial applications.

She is well-versed in standard organic synthesis and purification methods, including high-pressure liquid chromatography (HPLC), flash chromatography and size-exclusion chromatography. She also gained experience in a wide variety of characterization techniques, including nuclear magnetic resonance (NMR), mass spectrometry (MALDI-TOF, GC-MS, LC-MS and ICP-MS), spectroscopy (UV-vis and FTIR), scanning electron microscopy (SEM) and dynamic light scattering (DLS).

Dr. Lee has extensive experience in in vitro and in vivo biological characterization techniques, fluorometry, protein expression, modification and purification. She has studied cell response to polymeric biomaterials, which involved immunoassays, protein quantification techniques, cell-line culture, rheometry, as well as optical, fluorescent, and confocal microscopy.

Prior to joining Exponent, Dr. Lee was a research assistant in the Department of Chemistry and the Department of Bioengineering at the University of California, Berkeley. She developed a novel technique to functionalize synthetic polymers with proteins and applied it to study how cells respond to polymeric biomaterials with different mechanical properties. Her doctoral research was supported by the Croucher Foundation of Hong Kong.

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Chemistry, University of California, Berkeley, 2016
  • B.A., Chemistry, Pomona College, 2009
  • Croucher Scholarship for Graduate Studies, 2011-2013

    Genentech Fellowship, Chemical Biology Graduate Program, University of California, Berkeley, 2011-2012

    Outstanding Graduate Student Instructor Award, 2012

    Phi Beta Kappa Honor Society, Pomona College, 2009

LANGUAGES

  • Cantonese Chinese
  • Mandarin Chinese

Publications

Lee JP, Kassianidou E, MacDonald JI, Francis MB, Kumar S. N-terminal specific conjugation of extracellular matrix proteins to 2-pyridinecarboxaldehyde functionalized polyacrylamide hydrogels. Biomaterials 2016; 102:268–276.

Bhagawati M, Rubashkin MG, Lee JP, Ananthanarayanan B, Weaver VM, Kumar S. Site-specific modulation of charge controls the structure and stimulus responsiveness of intrinsically disordered peptide brushes. Langmuir 2016; 32 (23):5990–5996.

Presentations

Lee JP, Kumar S, Francis MB. A new strategy to end-tether extracellular matrix proteins to polymer hydrogel surfaces. Poster presentation, 251st American Chemical Society Spring Meeting, San Diego, CA, 2016.

Lee JP, Chang CJ. Engineering new photophysical properties into fluorescent copper sensors. Oral presentation, UC Berkeley Department of Chemistry Graduate Research Seminar, Berkeley, CA, 2012.

Lee JP, Palaniappan KK, Bertozzi CR. Chemically-directed glycoproteomics of cell-surface glycoproteins. Poster presentation, UC Berkeley Chemical Biology Graduate Program Fall Meeting, Berkeley, CA, 2010.

Professional Affiliations

American Chemical Society—ACS

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Chemistry, University of California, Berkeley, 2016
  • B.A., Chemistry, Pomona College, 2009
  • Croucher Scholarship for Graduate Studies, 2011-2013

    Genentech Fellowship, Chemical Biology Graduate Program, University of California, Berkeley, 2011-2012

    Outstanding Graduate Student Instructor Award, 2012

    Phi Beta Kappa Honor Society, Pomona College, 2009

LANGUAGES

  • Cantonese Chinese
  • Mandarin Chinese