Monty Liong
Monty Liong, Ph.D.
Senior Scientist
Polymer Science & Materials Chemistry
Menlo Park

Dr. Liong is a materials chemist with a particular focus in solid-state chemistry, including the synthesis and characterization of metal oxides, ceramics, silicates, and polymeric composites. He has expertise in the mechanisms for particulate and chemical release from medical devices and consumer products, and the implications of these mechanisms for failure analysis and for human exposures affecting the nature of potential health effects. His experience in failure analysis and investigating health issues related to materials and chemicals includes medical devices (e.g., injectable drug formulations, hip implants, polymeric coatings), consumer products (e.g., automobile interiors, consumer electronics, batteries, clothing materials, brake pads, cosmetic powders, foods), and industrial products (e.g., abrasive blasting materials, membranes for water desalination, catalysts).

Dr. Liong has combined experience in solid-state chemistry techniques (electron microscopy, EDS, FTIR, X-ray diffraction, magnetometer, TGA, X-ray photoelectron spectroscopy, ICP-AES, ICP-MS, solid-state NMR), and analytical chemistry (gas chromatography-mass spectrometry, liquid chromatography-mass spectrometry, size-exclusion chromatography, MALDI-ToF). His research interests pertain to issues related to drug delivery technologies, medical implants, medical diagnostic devices, contrast agents, wearable technologies, nanoscale materials, volatiles in food products, adhesives, surface coatings, insulation materials, construction materials, consumer electronics, membrane filters, cosmetics, and automobile components.

Prior to joining Exponent, Dr. Liong was a National Institutes of Health Postdoctoral Fellow in the Department of Radiology at Massachusetts General Hospital – Harvard Medical School, where he developed medical diagnostic devices for analysis of human patient tissue samples in cancer and infectious diseases. Additionally, he was a Research Assistant at University of California, Los Angeles where he designed drug formulation technologies based on porous silicate nanostructures for the delivery of chemotherapeutic molecules, nucleic acids, and antimicrobials. He also received a University of California Toxic Substances Research and Teaching Program Fellowship to analyze potential health effects related to exposures to nanoscale polymeric and metal oxide particles. Dr. Liong has published 44 peer-reviewed manuscripts, holds several patents, and has been an invited speaker at departmental seminars in universities and conferences.

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Chemistry, University of California, Los Angeles (UCLA), 2009
  • B.S., Chemistry, University of California, Los Angeles (UCLA), 2004
  • National Institutes of Health Postdoctoral Fellowship, Massachusetts General Hospital, Harvard Medical School, 2009–2013

    UC Los Angeles Dissertation Award for Chemistry, 2009

    University of California Toxic Substances Research and Teaching Program Fellowship, 2006–2008

    UC Los Angeles Ernest F. Hare Jr. Research Scholarship, 2007

    UC Los Angeles Ramsey Award in Physical Chemistry, 2004

LANGUAGES

  • Indonesian

Publications

Gaffney SH, Abelmann A, Pierce J, Glynn M, Henshaw J, McCarthy L, Lotter J, Liong M, Finley BL. Naturally occurring diacetyl and 2,3-pentanedione concentrations associated with roasting and grinding unflavored coffee beans in a commercial setting. Toxicol Rep 2015; 2: 1171.

Madl AK*, Liong M*, Kovochich M*, Finley BL, Paustenbach DJ, Oberdörster G. Toxicology of wear particles of cobalt-chromium alloy metal-on-metal hip implants part I: Physicochemical properties in patient and simulator studies. Nanomedicine: NBM 2015; 11: 1201. (*Co-First Authors)

Madl AK*, Kovochich M*, Liong M*, Finley BL, Paustenbach DJ, Oberdörster G. Toxicology of wear particles of cobalt-chromium alloy metal-on-metal hip implants part II: Importance of physicochemical properties and dose in animal and in vitro studies as a basis for risk assessment. Nanomedicine: NBM 2015; 11: 1285. (*Co-First Authors)

Im H*, Castro CM*, Shao H, Liong M, Song J, Pathania D, Fexon L, Min C, Avila-Wallace M, Zurkiya O, Rho J, Magaoay B, Tambouret RH, Pivovarov M, Weissleder R, Lee H. Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone. Proc Natl Acad Sci USA 2015; 112: 5613. (*Co-First Authors)

Issadore D, Park YI, Shao H, Min C, Lee K, Liong M, Weissleder R, Lee H. Magnetic sensing technology for molecular analyses. Lab Chip 2014; 14: 2385.

Liong M, Im H, Majmudar MD, Aguirre AD, Sebas M, Lee H, Weissleder R. Magnetic ligation method for quantitative detection of microRNAs. Adv Healthc Mater 2014; 3: 1015.

Rho J, Chung J, Im H, Liong M, Shao H, Castro CM, Weissleder R, Lee H. Magnetic nanosensor for detection and profiling of erythrocyte-derived microvesicles. ACS Nano 2013; 7: 11227.

Min C, Shao H, Issadore D, Liong M, Weissleder R, Lee H. Diagnostic magnetic resonance technology. Point-of-Care Diagnostics on a Chip 2013; 9: 197.

Tassa C, Liong M, Hilderbrand S, Sandler JE, Reiner T, Keliher EJ, Weissleder R, Shaw SY. Microfluidic on-chip capture-cycloaddition reaction to reversibly immobilize small molecules or multi-component structures for biosensor applications. J Vis Exp 2013; 79: e50772.

Liong M, Chung HJ, Chung J, Min C., Im H, Shao H, Weissleder R, Lee H. Micro-NMR Platform: Genetic detection of infectious pathogens. GIT Laboratory Journal 2013.

Liong M*, Hoang A*, Chung J, Gural N, Ford CB, Min C, Shah RR, Fernandez-Suarez M, Fortune SM, Toner M, Lee H, Weissleder R. Magnetic barcode assay for genetic detection of pathogens. Nat Commun 2013; 4: 1752. (*Co-First Authors)

Agasti SS, Kohler RH, Liong M, Peterson VM, Lee H, Weissleder R. Dual imaging and photoactivated nanoprobe for controlled cell tracking. Small 2013; 9: 222.

Agasti SS*, Liong M*, Peterson VM, Lee H, Weissleder R. Photocleavable DNA barcode-antibody conjugates allow sensitive and multiplexed protein analysis in single cell. J Am Chem Soc 2012; 134: 18499. (*Co-First Authors)

Min C, Shao H, Liong M, Yoon TJ, Weissleder R, Lee H. Mechanism of magnetic relaxation switching sensing. ACS Nano 2012; 6: 6821.

Tassa C, Liong M, Hilderbrand S, Sandler JE, Reiner T, Keliher EJ, Weissleder R, Shaw SY. On-chip bioorthogonal chemistry enables immobilization of in situ modified nanoparticles and small molecules for label-free monitoring of protein binding and reaction kinetics. Lab Chip 2012; 12: 3103.

Issadore D, Chung J, Shao H, Liong M, Ghazani A, Castro C, Weissleder R, Lee H. Ultrasensitive clinical enumeration of rare cells using a μ-hall detector. Sci Transl Med 2012; 141: 141ra92.

Shao H, Min C, Issadore I, Liong M, Yoon TJ, Weissleder W, Lee H. Magnetic nanoparticles and microNMR for diagnostic applications. Theranostics 2012; 2: 55.

Agasti SS*, Liong M*, Tassa C, Chung HJ, Shaw SY, Lee H, Weissleder R. Supramolecular host-guest interaction for detection of cellular biomarkers. Angew Chem Int Ed 2011; 51: 450. (*Co-First Authors)

Liong M*, Fernandez-Suarez M*, Issadore D, Min C, Tassa C, Reiner T, Toner M, Fortune SM, Lee H, Weissleder R. Specific pathogen detection using bioorthogonal chemistry and diagnostic magnetic resonance. Bioconjug Chem 2011; 22: 2390. (*Co-First Authors)

Chung HJ, Reiner T, Budin G, Min C, Liong M, Issadore D, Lee H, Weissleder R. Ubiquitous detection of gram-positive bacteria with bioorthogonal magnetofluorescent nanoparticles. ACS Nano 2011; 5: 8834.

Liong M, Tassa C, Shaw SY, Lee H, Weissleder R. Multiplexed magnetic labeling amplification using oligonucleotide hybridization. Adv Mater 2011; 23: H254.

Hoek EMV, Ghosh AK, Huang X, Liong M, Zink JI. Physical-chemical properties, separation performance, and fouling resistance of mixed-matrix UF membranes. Desalination 2011; 283: 89.

Xie C, Kim HJ, Haw JG, Kalbasi A, Gardner BK, Li G, Rao J, Chia D, Liong M, Punzalan RR, Marks LS, Pantuck AJ, Taille A, Wang G, Mukouyama H, Zeng G. Novel multiplex assay combining autoantibodies plus PSA has potential implications for classification of prostate cancer from non-malignant cases. J Transl Med 2011; 9: 43.

Issadore D, Shao H, Chung J, Min C, Liong M, Weissleder R, Lee H. Miniature magnetic resonance system for point-of-care diagnostics. Lab Chip 2011; 11: 2282.

Shao H, Yoon TJ, Liong M, Weissleder R, Lee H. Magnetic nanoparticles for biomedical NMR-based diagnostics. Beilstein J Nanotechnol 2010; 1: 142.

Liong M, Shao H, Haun JB, Lee H, Weissleder R. Carboxymethylated polyvinyl alcohol stabilizes doped ferrofluids for biological applications. Adv Mater 2010; 22: 5168.

Kabehie S, Xue M, Stieg A, Liong M, Wang KL, Zink JI. Heteroleptic copper switches. J Am Chem Soc 2010; 132: 15987.

Lu J, Liong M, Li Z, Zink JI, Tamanoi F. Biocompatibility, biodistribution and drug delivery efficiency of mesoporous silica nanoparticles for cancer therapy in animals. Small 2010; 6: 1794.

Hom C*, Lu J*, Liong M, Li Z, Zink JI, Tamanoi F. Mesoporous silica nanoparticles facilitate delivery of siRNA to shutdown signaling pathways in mammalian cells. Small 2010; 6: 1185. (*Co-First Authors)

Meng H*, Liong M*, Xia T, Li Z, Zink JI, Nel AE. Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and p-glycoprotein siRNA to overcome drug resistance in a cancer cell line. ACS Nano 2010; 4: 4539. (*Co-First Authors)

Kabehie S, Stieg AZ, Xue M, Liong M, Wang KL, Zink JI. Surface immobilized heteroleptic copper compounds as state variables that show negative differential resistance. J Phys Chem Lett 2010; 1: 589.

Coti KK, Belowich M, Liong M, Ambrogio MW, Lau YA, Khatib HA, Zink JI, Khashab NM, Stoddart JF. Mechanised nanoparticles for drug delivery. Nanoscale 2009; 1: 16.

Xia T*, Kovochich M*, Liong M*, Meng H, Kabehie S, George S, Zink JI, Nel AE. Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs. ACS Nano 2009; 3: 3273. (*Co-First Authors)

Liong M, Angelos S, Choi E, Stoddart JF, Zink JI. Mesostructured multifunctional nanoparticles for imaging and drug delivery. J Mater Chem 2009; 19: 6251.

Liong M*, France B*, Bradley KA, Zink JI. Antimicrobial activity of silver nanocrystals encapsulated in mesoporous silica nanoparticles. Adv Mater 2009; 21: 1684. (*Co-First Authors)

Klichko Y, Liong M, Choi E, Angelos S, Nel AE, Stoddart JF, Tamanoi F, Zink JI. Mesostructured silica for optical functionality, nanomachines, and drug delivery. J Am Ceram Soc 2009; 92: S2.

Xia T*, Kovochich M*, Liong M, Mädler L, Gilbert B, Shi H, Yeh JI, Zink JI, Nel AE. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on the hierarchical oxidative stress paradigm. ACS Nano 2008; 2: 2121. (*Co-First Authors)

Liong M*, Lu J*, Kovochich M*, Xia T, Ruehm SG, Nel AE, Tamanoi F, Zink JI. Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery. ACS Nano 2008; 2: 889. (*Co-First Authors)

Johansson E, Choi E, Angelos S, Liong M, Zink JI. Light-activated functional mesostructured silica. J Sol-Gel Sci Technol 2008; 46: 313.

Xia T*, Kovochich M*, Liong M, Zink JI, Nel AE. Distinct endocytic mechanism determine differential cytotoxic & mitochondrial effects of cationic nanoparticles in variety of different cell types. ACS Nano 2008; 2: 85. (*Co-First Authors)

Angelos S, Liong M, Choi E, Zink JI. Mesoporous silicate materials as substrates for molecular machines and drug delivery. Chem Eng J 2008; 137: 4.

Lu J, Liong M, Sherman S, Xia T, Kovochich M, Nel AE, Zink JI, Tamanoi F. Mesoporous silica nanoparticles for cancer therapy: energy-dependent cellular uptake and delivery of paclitaxel to cancer cells. NanoBioTechnol 2007; 3: 89.

Lu J*, Liong M*, Zink JI, Tamanoi F. Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs. Small 2007; 3: 1341. (*Co-First Authors)

Nguyen TD, Leung KCF, Liong M, Liu Y, Stoddart JF, Zink JI. Versatile supramolecular nanovalves reconfigured for light activation. Adv Funct Mater 2007; 17: 2101.

Nguyen TD, Leung KCF, Liong M, Pentecost CD, Stoddart JF, Zink JI. Construction of a pH-driven supramolecular nanovalve. Org Lett 2006; 8: 3363.

Presentations

Liong M, Lee H, Weissleder R. Point-of-care magnetic platforms for molecular analyses of pathogens. American Chemical Society National Meeting, San Francisco, CA, August, 2014.

Liong M. Diagnostic magnetic resonance for molecular and genetic profiling. Georgia Institute of Technology-Emory University, Department of Biomedical Engineering, Atlanta, GA, April, 2013.

Liong M, Lee H, Weissleder R. Magnetic barcode assay for genetic detection of pathogens. Society for Biomaterials Annual Meeting, Boston, MA, April, 2013.

Liong, M. Diagnostic magnetic resonance for molecular and genetic profiling. Brown University, Department of Chemistry, Providence, RI, December, 2012.

Liong M, Lee H, Weissleder R. Diagnostic magnetic resonance for molecular and genetic profiling. American Chemical Society National Meeting, Philadelphia, PA, August, 2012.

Liong M. Inorganic nanomaterials: Functional scaffold for biomedical applications. National University of Singapore, Department of Chemistry, Singapore, July, 2012.

Liong M. Inorganic nanomaterials: Functional scaffold for biomedical applications. Nanyang Technological University, Division of Chemistry and Biological Chemistry, Singapore, July 2012.

Liong M. Inorganic nanomaterials: Functional scaffold for biomedical applications. University of North Carolina-North Carolina State University Joint Department of Biomedical Engineering, Raleigh, NC, March 2012.

Liong M, Lee H, Weissleder R. Multiplexed labeling and signal amplification in diagnostic magnetic resonance. American Chemical Society National Meeting, San Diego, CA, March, 2012.

Liong M, Tassa C, Shaw SY, Lee H, Weissleder R. Multiplexed magnetic labeling amplification for cell-based diagnostics. Materials Research Society Meeting, Boston, MA, November, 2011.

Liong M, Tassa C, Shaw SY, Lee H, Weissleder R. Multiplexed magnetic labeling amplification using oligonucleotide hybridization. Biomedical Engineering Society Annual Meeting, Hartford, CT, October, 2011.

Liong M, Lee H, Weissleder R. Multiplexed magnetic labeling amplification. American Chemical Society National Meeting, Denver, CO, August, 2011.

Published Abstracts 

Liang L, Liong M, Gaffney SH. Evaluation of exposures to naturally generated diacetyl and 2,3-pentanedione from thermally processed and fermented food products. Society of Environmental Toxicology and Chemistry North America Annual Meeting, Salt Lake City, UT, November, 2015.

Urban AM, Gaffney SH, McCarthy L, Hollins DM, Abelmann A, Unice K, Liong M, Finley BL, Henshaw JL. Volatile organic compounds released from spreading ground coffee during a simulated industrial task. Society of Toxicology Annual Meeting, San Diego, CA, March, 2015.

Abelmann A, Unice K, Gaffney SH, Urban AM, Liong M, McCarthy L, Hollins DM, Henshaw JL, Finley BL. Airborne concentrations of naturally occurring diacetyl associated with various coffee products. Poster Presentation at the American Industrial Hygiene Conference & Expo, Salt Lake City, UT, May 30-June 4, 2015.

Liong M, Kovochich M, Finley BL, Paustenbach DJ, Madl A. Nanoparticles from the wear of cobalt-chromium alloy metal-on-metal hip implants: Physicochemical and dose analysis of patient and toxicology studies. Society of Toxicology Annual Meeting, Phoenix, AZ, March, 2014. 

Song J, Im H, Liong M, Fexon L, Pivovarov M, Weissleder R, Lee H. Miniaturized holographic imaging system for real-time cellular detection. American Physical Meeting, Baltimore, MD, March, 2013.

Im H, Song J, Liong M, Fexon L, Pivovarov M, Weissleder R, Lee H. Rapid Detection and profiling of rare cancer cells with a portable holographic imaging system. American Physical Meeting, Baltimore, MD, March, 2013.

Issadore D, Chung J, Shao H, Liong M, Weissleder R, Lee H. Chip-based magnetic cytometer for high-throughput cellular profiling in unprocessed biological samples. American Physical Meeting, Boston, MA, March, 2012.

Min C, Issadore D, Chung J, Shao H, Liong M, Weissleder R, Lee H. Miniature magnetic resonance system for robust and portable diagnostics. American Physical Meeting, Boston, MA, March, 2012.

Mädler L, Pokhrel S, Xia T, Liong M, Gilbert B, Zink JI, Nel AE. Comparison of the mechanism of toxicity of binary metal oxide nanoparticles based on dissolution and oxidative stress properties. American Institute of Chemical Engineers. Nashville, TN, November, 2009. 

Patents

Zink JI, Thomas CR, Liong M, Henscheid SA, Cheon J, Lee JH, Ferris DP. Method of Controlled Delivery Using Sub-Micron-Scale Machines. 2013, US 20130046274 A1.

Zink JI, Nel AE, Xia T, Ji Z, Meng H, Li Z, Liong M, Xue M, Tarn D. Cationic Polymer Coated Mesoporous Silica Nanoparticles and Uses Thereof. 2012, US 20120207795 A1.

Zink JI, Liong M, France BD, Bradley KA. Structured Silver-Mesoporous Silica Nanoparticles Having Antimicrobial Activity. 2010, WO 2010071831 A3.

Liong M, Lu J, Tamanoi F, Zink JI, Nel AE. Mesoporous Silica Nanoparticles for Biomedical Applications. 2009, US 20100255103 A1.

Prior Experience

Senior Health Scientist, Cardno ChemRisk – Natural Resources & Health Sciences Division, 2013–2015

Research Associate, Massachusetts General Hospital – Harvard Medical School, 2009–2013

Research Assistant, University of California Los Angeles, 2004–2009

Professional Affiliations

American Chemical Society

Materials Research Society

Project Experience

Medical Devices

Analyzed physical and chemical characteristics of wear debris particulates that are generated from cobalt-chromium alloy metal-on-metal hip implants. The work was published in a two-part peer-reviewed manuscript.

Developed injectable delivery technologies for small molecule drugs, nucleic acids, and antimicrobials. The work was supported by the National Science Foundation and the National Institutes of Health, and resulted in a series of peer-reviewed manuscripts and patents.

Developed non-invasive disease monitoring methods via CT scan and magnetic resonance imaging using inorganic nanomaterials. The work was supported by the National Science Foundation and the National Institutes of Health, and resulted in a peer-reviewed manuscript and a patent.

Developed an integrated device that identifies nucleic acids of Mycobacterium tuberculosis and antibiotic-resistant strains in patient sputum. The work was supported by the National Heart, Lung, and Blood Institute, and was published in a peer-reviewed manuscript.

Created multiplexed assays for profiling cellular biomarkers in tumor biopsies, and implemented analytical methods for measuring binding kinetics of drugs, nucleic acids, and proteins. The work was supported by the National Cancer Institute, and resulted in several peer-reviewed publications.

Developed a multiplexed assay for prostate cancer diagnosis and risk assessment. The work was supported by the National Institutes of Health, and was published in a peer-reviewed journal.

Consumer and Industrial Products


Analyzed the level of isocyanates in clothing materials and evaluated potential health risks associated with dermal exposure to isocyanates.

Conducted exposure and risk assessment of plasticizer present in automobile interiors.

Evaluated the occupational health hazards of materials used in abrasive blasting operations.

Assessed the potential health effects associated with the use of talc-containing products.

Conducted a quantitative evaluation on the release of diacetyl from thermal processing of food products and compared the measurement with proposed occupational exposure limits. 

Evaluated the release of formaldehyde from cosmetic products along with the analytical methods for quantifying methylene glycol and formaldehyde.

Performed an evaluation of mixture of chemicals listed under Proposition 65 that may have been present as contaminant or generated as byproducts in cleaning agents.

Conducted a quantitative evaluation to determine the thermal decomposition of chrysotile asbestos fibers in friction products.

Performed an evaluation on the composition of mineral fibers used in thermal insulation. 

Synthesized nanomaterials used in consumer products including titanium dioxide, silica, zinc oxide, and performed high-throughput screening for cellular toxicity studies. The work was supported by the National Science Foundation and the US EPA, and was published in several peer-reviewed manuscripts. 

Developed antimicrobial composites based on inorganic materials for use in biomedical implants, textiles, and surface coatings. The work resulted in a peer-reviewed publication and a patent. 

Developed polymeric membrane filter with inorganic nanomaterials filler for water desalination. This project was published in a peer-reviewed journal. 

Synthesized nanomaterials used in catalysts, and performed high-throughput screening for cellular toxicity studies. The work was supported by the National Science Foundation and the US EPA, and was published in several peer-reviewed manuscripts. 

Additional Information

Peer Reviewer

ACS Nano

Advanced Functional Materials

Advanced Healthcare Materials

Advanced Materials

Analytical Chemistry

Angewandte Chemie International Edition

Nanomedicine: Nanotechnology, Biology and Medicine

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Chemistry, University of California, Los Angeles (UCLA), 2009
  • B.S., Chemistry, University of California, Los Angeles (UCLA), 2004
  • National Institutes of Health Postdoctoral Fellowship, Massachusetts General Hospital, Harvard Medical School, 2009–2013

    UC Los Angeles Dissertation Award for Chemistry, 2009

    University of California Toxic Substances Research and Teaching Program Fellowship, 2006–2008

    UC Los Angeles Ernest F. Hare Jr. Research Scholarship, 2007

    UC Los Angeles Ramsey Award in Physical Chemistry, 2004

LANGUAGES

  • Indonesian