Prem Midha, Ph.D.
Prem Midha, Ph.D.
Manager
Biomedical Engineering
Philadelphia

Dr. Midha's core discipline is in mechanical engineering with a focus in biofluid mechanics. He received his M.S. and Ph.D. in Bioengineering from Georgia Institute of Technology. His doctoral research focused on prosthetic heart valve fluid mechanics, and in particular, the risk factors and mechanisms behind transcatheter aortic valve thrombosis. This work utilized 4-dimensional computed tomography (4DCT), an in vitro left heart simulator, and novel imaging techniques in order to understand how design and procedural factors influence flow stasis around heart valve prostheses. Some of these methods have since been adopted by industry in order to evaluate thrombosis risk in response to increasing concerns surrounding valve thrombosis.

Dr. Midha has experience in hydrodynamic evaluation and performance optimization of cardiovascular medical devices, flow loop design, medical image processing and segmentation, state-of-the-art flow quantification techniques (standard, stereo, high-speed, and plenoptic particle image velocimetry), high-speed photogrammetry, and MRI compatibility testing. He has designed and worked with steady and pulsatile blood flow loops in the evaluation of thrombogenicity of blood contacting devices. In addition, he has performed PMA testing for several transcatheter heart valve FDA submissions under ISO 5840-3.

Since at Exponent, Dr. Midha has served as a liaison between clients and US and EU regulatory bodies, participated in the development of cardiovascular device testing standards, developed custom test methods based on existing and relevant standards, performed a wide range of MRI compatibility testing (active and passive devices), and assisted in numerous product liability cases. In addition, he has done substantial work in clinical image processing and analysis for clients, including performing virtual device implantations after microCT scanning contrast perfused cadaveric specimens.

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Bioengineering, Georgia Institute of Technology (Georgia Tech), 2017
  • M.S., Bioengineering, Georgia Institute of Technology (Georgia Tech), 2009
  • B.S., Mechanical Engineering, Missouri University of Science and Technology, 2007

Publications

Raghav V, Clifford C, Midha PA, Okafor I, Thurow B, Yoganathan AP. Investigation of flow-mediated mechanism for thrombosis in transcatheter heart valves using single camera volumetric velocimetry. Journal of the Royal Society Interface. 2019. [Featured on Cover]

Sadri V, Bloodworth C, Madukauwa-David ID, Midha PA, Raghav V, Yoganathan AP. A mechanistic investigation of the EDWARDS INTUITY Elite valveā€™s hemodynamic performance. General Thoracic and Cardiovascular Surgery. 2019.

Madukauwa-David ID, Sadri V, Midha PA, Babaliaros V, Sharma R, Makkar RR, Yoganathan AP. Might Coronary Flow Influence Transcatheter Heart Valve Neo-Sinus Thrombosis? Circulation: Cardiovascular Interventions. 2019.

Madukauwa-David ID, Sadri V, Kamioka N, Midha PA, Raghav V, Oshinski JN, Sharma R, Babaliaros V, Yoganathan AP. Transcatheter Aortic Valve Deployment Influences Neo-Sinus Thrombosis Risk: An In Vitro Flow Study. Catheterization and Cardiovascular Interventions. 2019.

Schmier JK, Patel JD, Leonhard MJ, Midha PA. Cost-Effectiveness Models of Left Ventricular Assist Devices: Issues and Challenges. Applied Health Economics and Health Policy. 2018.

Madukauwa-David DI, Midha PA, McLain K, Mitra R, Crawford K, Jilaihawi H, Sharma R, Makkar RR, Yoganathan AP. Characterization of aortic root geometry in transcatheter aortic valve replacement patients. Catheterization and Cardiovascular Interventions. 2018.

Schmier JK, Patel JD, Leonhard MJ, Midha PA. Cost-Effectiveness Models of Left Ventricular Assist Devices: Issues and Challenges. Applied Health Economics and Health Policy, 2018.

Madukauwa-David DI, Midha PA, McLain K, Mitra R, Crawford K, Jilaihawi H, Sharma R, Makkar RR, Yoganathan AP. Characterization of aortic root geometry in transcatheter aortic valve replacement patients. Catheterization and Cardiovascular Interventions,. 2018.

Sharma R, Midha PA, Babaliaros V, Makar RR, Yoganathan AP. Response by Sharma et al to Letter Regarding Article, “The Fluid Mechanics of Transcatheter Heart Valve Leaflet Thrombosis in the Neosinus.” Circulation, 2018.

Midha PA, Raghav V, Sharma R, Condado JF, Okafor IU, Rami T, Kumar G, Thourani VH, Jilaihawi H, Babaliaros V, Makkar RR, Yoganathan AP. The Fluid Mechanics of Transcatheter Heart Valve Leaflet Thrombosis in the Neo-Sinus. Circulation. 2017.

Midha PA, Condado JF, Raghav V, Okafor I, Guyton R, Yoganathan AP, Babaliaros, V. How should I treat a small, failing surgical bioprosthesis in a high surgical risk patient? EuroIntervention. 2017.

Okafor I, Raghav V, Condado JF, Midha PA, Kumar G, Yoganathan AP. Aortic Regurgitation Generates a Kinematic Obstruction Which Hinders Left Ventricular Filling. Annals of Biomedical Engineering. 2017.

Dasi LP, Hatoum H, Kheradvar A, Zareian R, Alavi SH, Sun W, Martin C, Pham T, Wang Q, Midha PA, Raghav V, Yoganathan AP. On the Mechanics of Transcatheter Aortic Valve Replacement. Annals of Biomedical Engineering. 2016.

Midha PA, Raghav V, Condado JF, Okafor IU, Lerakis S, Thourani VH, Babaliaros V, Yoganathan AP. Valve Type, Size, and Deployment Location Affect Hemodynamics in an In Vitro Valve-in-Valve Model. JACC: Cardiovascular Interventions. 2016.

Midha PA, Raghav V, Okafor I, Yoganathan AP. The Effect of Valve-in-Valve Implantation Height on Sinus Flow. Annals of Biomedical Engineering. 2016.

Okafor I, Raghav V, Midha PA, Kumar G, Yoganathan AP. The Hemodynamic Effects of Acute Aortic Regurgitation into a Stiffened Left Ventricle Resulting From Chronic Aortic Stenosis. AJP Heart and Circulatory Physiology. 2016.

Tree M, White J, Midha PA, Kiblinger S, Yoganathan AP. Validation of Cardiac Output as Reported by a Permanently Implanted Wireless Sensor. ASME Journal of Medical Devices. 2015.

Midha PA, Raghav V, Condado JF, Arjunon S, Uceda DE, Lerakis, S, Thourani VH, Babaliaros V, Yoganathan AP. How Can We Help a Patient with a Small Failing Bioprosthesis? An In Vitro Case Study. JACC: Cardiovascular Interventions. 2015.

Midha A, Bapat SG, Midha PA. Mechanical Advantage of a Compliant Mechanism and Significant Factors Affecting it, Using the Pseudo-Rigid-Body Model Approach. ASME IDETC/CIE. 2015.

Scholz TL, Midha PA, Anderson LJ, and Ku DN. PneumoniaCheck: A Device for Sampling Lower Airway Aerosols. ASME Journal of Medical Devices. 2010.

Tinsley A, Midha PA, Nagel RL, McAdams DA, Stone RB, & Shu LH. Exploring the Use of Functional Models as a Foundation for Biomimetic Conceptual Design. ASME IDTEC/CIE. 2007.

Nagel RL, Midha PA, Tinsley A, McAdams DA, Stone RB, Shu L. Exploring the use of Functional Models in Biomimetic Conceptual Design. ASME Journal of Medical Devices. 2008.

Presentations

Madukauwa-David DI, Kamioka N, Sadri V, Sharma R, Midha PA, Babaliaros V, Yoganathan AP. How Can We Peri-procedurally Evaluate Transcatheter Heart Valve Thrombosis Risk? Heart Valve Society Annual Meeting, Barcelona, Spain, 2019.

Sadri V, Madukauwa-David DI, Bloodworth C, Midha PA, Raghav V, Yoganathan AP. In Vitro Forward Flow Performance of the EDWARDS INTUITY Elite Rapid Deployment Aortic Valve Replacement in Patient-Specific Anatomy. Heart Valve Society Annual Meeting, Barcelona, Spain, 2019.

Midha PA, Madukauwa-David DI, Sharma R, McLain K, Mitra R, Crawford K, Yoon SH, Makkar RR, Yoganathan AP. Systolic and Diastolic Geometry of the Aortic Root Before and After TAVR. BMES/FDA: Frontiers in Medical Devices Conference, Washington DC, 2019.

Madukauwa-David DI, Midha PA, Babaliaros V, Sharma R, Makkar RR, Yoganathan AP, Coronary Flow Influences Transcatheter Aortic Valve Leaflet Thrombosis Risk. ACC, New Orleans, LA, 2019

Siskey RL, Midha PA, Okafor IU, White J, Shaw CB, Ochoa, JA. MRI Heating of Interbody Fusion Devices with Radiographic Markers. Orthopaedic Research Society, Austin, TX, 2019.

Midha PA, Raghav V, Sharma R, Madukauwa-David DI, Sadri V, Condado JF, Okafor IU, Rami T, Kumar G, Thourani VH, Makkar RR, Babaliaros V, Yoganathan AP. Transcatheter aortic valve leaflet thrombosis in the neosinus: fluid mechanics factors. World Congress of Biomechanics, Dublin, Ireland, 2018.

Acharya N, Clifford C, Midha PA, Okafor I, Thurow B, Raghav V, Yoganathan AP. Thrombogenicity of Transcatheter Heart Valves: In-vitro Fluid Dynamic Assessment Using Volumetric Velocimetry. World Congress of Biomechanics, Dublin, Ireland, 2018.

Midha PA, Raghav V, Sharma R, Madukauwa-David DI, Sadri V, Condado JF, Okafor IU, Rami T, Kumar G, Thourani VH, Makkar RR, Babaliaros V, Yoganathan AP. Fluid mechanics factors influence transcatheter aortic valve leaflet thrombosis in the neo-sinus. 8th Biennial Heart Valve Biology & Tissue Engineering Meeting, London, UK, 2018.

Midha PA, McLain K, Condado JF, Mitra R, Crawford K, Raghav V, Okafor I, Babaliaros V, Yoganathan AP. Effects of surgical aortic valve type and size on valve-in-valve performance. TCT, San Diego, CA, 2018.

Madukauwa-David DI, Sadri V, Midha PA, Raghav V, Kamioka N, Sharma R, Babaliaros V, Yoganathan AP. Neo-Sinus Washout Quantification in Transcatheter Heart Valves. Heart Valve Society Annual Scientific Meeting, New York, NY, 2018.

Midha PA, Okafor I, Raghav V, Sadri V, Condado JF, Sharma R, Makkar RR, Babaliaros V, Yoganathan AP. Neo-Sinus Washout is Faster in Supra-Annular Transcatheter Heart Valves. American Heart Association Scientific Sessions, Anaheim, CA, 2017.

Raghav V, Clifford C, Midha PA, Okafor I, Thurow B, Yoganathan AP. Volumetric velocimetry downstream of a percutaneous heart valve. 70th Annual Meeting of the APS Division of Fluid Dynamics, Denver, CO, 2017.

Clifford C, Raghav V, Midha PA, Okafor I, Johnson C, Thurow B, Yoganathan AP. Assessment of thrombosis potential of a transcatheter heart valve using a novel single-camera volumetric PIV technique. Summer Biomechanics, Bioengineering, & Biotransport Conference, Tucson, AZ, 2017.

Yoganathan AP, Okafor I, Midha PA, Raghav V, Babaliaros V, Kumar G. Paravalvular leak in transcatheter aortic valve replacement. Summer Biomechanics, Bioengineering, & Biotransport Conference, Tucson, AZ, 2017.

Midha PA, Yoganathan, AP. In vitro valve-in-valve evaluation. Invited webinar to Boston Scientific TAVR team in Los Gatos, CA, Marlboro, MA, Minneapolis, MN, and Galway, Ireland, 2016.

Clifford C, Thurow B, Midha PA, Okafor I, Raghav V, Yoganathan, A. Single camera volumetric velocimetry in aortic sinus with a percutaneous valve. 69th Annual Meeting of the APS Division of Fluid Dynamics, Portland, OR, 2016.

Okafor I, Raghav V, Midha PA, Kumar G, Yoganathan A. Aortic regurgitation on left ventricular diastolic flow. Summer Biomechanics, Bioengineering, & Biotransport Conference, National Harbor, MD, 2016.

Midha PA, Raghav V, Condado JF, Okafor I, Lerakis, S, Thourani VH, Babaliaros V, Yoganathan AP. Optimisation of transcatheter valve-in-valve therapy: an in vitro haemodynamic evaluation. EuroPCR 2016, Paris, France, 2016.

Midha PA, Arjunon S, Uceda DE, Raghav V, Condado JF, Lerakis, S, Thourani VH, Babaliaros V, Yoganathan AP, An In Vitro Investigation of Hemodynamic and Pullout Forces in a Valve-in-Valve Implantation, BMES/FDA Frontiers in Medical Devices Conference, College Park, MD, 2015.

Midha PA, Arjunon S, Uceda DE, Raghav V, Condado JF, Lerakis, S, Thourani VH, Babaliaros V, Yoganathan AP. An In Vitro Case Study: How Can We Help a Patient with a Small Failing Bioprosthesis? Heart Valve Society Inaugural Scientific Meeting, Monte Carlo, Monaco, 2015.

Ku DN, Midha PA. Design of a Vein Valve Replacement. American Venous Forum Annual Meeting, Orlando, FL, 2012.

Patents

US Patent 8,821,409 B2: Lung aerosol collection device, September 2012 (Ku DN, Anderson LJ, Midha PA, Bergman HL, Scholz T).

US Patent Application 20,120,053,676 A1: Implantable Prosthetic Vascular Valves, November 2011 (Ku DN, Midha PA, Bergman HL).

Prior Experience

Graduate Research Assistant, Georgia Institute of Technology, 2014-2017

Engineering Consultant (External), Edwards Lifesciences, 2017

Engineering Consultant (External), Boston Scientific, 2015-2017

Engineering Consultant (External), CardioMEMS (St. Jude Medical), 2014-2015

Research & Engineering Contractor, Kimberly-Clark, 2012-2014

Professional Affiliations

Association for the Advancement of Medical Instrumentation (AAMI; Member of the Cardiac Valves and Vascular Prostheses Committees)

American Society of Testing Materials (ASTM; Member of Committee F04 on Medical and Surgical Materials and Devices)

Heart Valve Society (HVS)

Biomedical Engineering Society (BMES)

American Heart Association (AHA)

Pi Tau Sigma

American Society of Mechanical Engineers (ASME)

Additional Information

Peer Reviewer

Journal of the American College of Cardiology (JACC): Cardiovascular Interventions

PLOS ONE

Cardiovascular Engineering and Technology (CVET)

Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C)

Knowledge

News & Events

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Bioengineering, Georgia Institute of Technology (Georgia Tech), 2017
  • M.S., Bioengineering, Georgia Institute of Technology (Georgia Tech), 2009
  • B.S., Mechanical Engineering, Missouri University of Science and Technology, 2007