Prem Midha, Ph.D.
Prem Midha, Ph.D.
Senior Associate
Biomedical Engineering
Philadelphia

Dr. Midha's core discipline is in mechanical engineering with a focus in biofluid mechanics. He received his Ph.D. in Bioengineering from Georgia Institute of Technology in 2017. His doctoral research focused on prosthetic heart valve fluid mechanics, and in particular, the risk factors and mechanisms behind transcatheter aortic valve thrombosis. This work utilized 4-dimensional computed tomography (4DCT), an in vitro left heart simulator, and novel imaging techniques in order to understand how design and procedural factors influence flow stasis around heart valve prostheses.

Dr. Midha has experience in hydrodynamic evaluation and performance optimization of cardiovascular medical devices, flow loop design, medical image processing and segmentation, state-of-the-art flow quantification techniques (standard, stereo, high-speed, and plenoptic particle image velocimetry), high-speed photogrammetry, and MRI compatibility testing. He has designed and worked with steady and pulsatile blood flow loops in the evaluation of thrombogenicity of blood contacting devices. In addition, he has performed PMA testing for several transcatheter heart valve FDA submissions (ISO 5840-3).

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Bioengineering, Georgia Institute of Technology (Georgia Tech), 2017
  • M.S., Bioengineering, Georgia Institute of Technology (Georgia Tech), 2009
  • B.S., Mechanical Engineering, Missouri University of Science and Technology, 2007
  • National Collegiate Inventors and Innovators Alliance (NCIAA) Advanced E-Team Grant, 2009

    Georgia Institute of Technology President’s Fellowship, 2011

Publications

Sharma R, Midha PA, Babaliaros V, Makar RR, Yoganathan AP. Response by Sharma et al to Letter Regarding Article, “The Fluid Mechanics of Transcatheter Heart Valve Leaflet Thrombosis in the Neosinus.” Circulation, 2018.

Midha PA, Raghav V, Sharma R, Condado JF, Okafor IU, Rami T, Kumar G, Thourani VH, Jilaihawi H, Babaliaros V, Makkar RR, Yoganathan AP. The Fluid Mechanics of Transcatheter Heart Valve Leaflet Thrombosis in the Neo-Sinus. Circulation. 2017.

Midha PA, Condado JF, Raghav V, Okafor I, Guyton R, Yoganathan AP, Babaliaros, V. How should I treat a small, failing surgical bioprosthesis in a high surgical risk patient? EuroIntervention. 2017.

Okafor I, Raghav V, Condado JF, Midha PA, Kumar G, Yoganathan AP. Aortic Regurgitation Generates a Kinematic Obstruction Which Hinders Left Ventricular Filling. Annals of Biomedical Engineering. 2017.

Dasi LP, Hatoum H, Kheradvar A, Zareian R, Alavi SH, Sun W, Martin C, Pham T, Wang Q, Midha PA, Raghav V, Yoganathan AP. On the Mechanics of Transcatheter Aortic Valve Replacement. Annals of Biomedical Engineering. 2016.

Midha PA, Raghav V, Condado JF, Okafor IU, Lerakis S, Thourani VH, Babaliaros V, Yoganathan AP. Valve Type, Size, and Deployment Location Affect Hemodynamics in an In Vitro Valve-in-Valve Model. JACC: Cardiovascular Interventions. 2016.

Midha PA, Raghav V, Okafor I, Yoganathan AP. The Effect of Valve-in-Valve Implantation Height on Sinus Flow. Annals of Biomedical Engineering. 2016.

Okafor I, Raghav V, Midha PA, Kumar G, Yoganathan AP. The Hemodynamic Effects of Acute Aortic Regurgitation into a Stiffened Left Ventricle Resulting From Chronic Aortic Stenosis. AJP Heart and Circulatory Physiology. 2016.

Tree M, White J, Midha PA, Kiblinger S, Yoganathan AP. Validation of Cardiac Output as Reported by a Permanently Implanted Wireless Sensor. ASME Journal of Medical Devices. 2015.

Midha PA, Raghav V, Condado JF, Arjunon S, Uceda DE, Lerakis, S, Thourani VH, Babaliaros V, Yoganathan AP. How Can We Help a Patient with a Small Failing Bioprosthesis? An In Vitro Case Study. JACC: Cardiovascular Interventions. 2015.

Midha A, Bapat SG, Midha PA. Mechanical Advantage of a Compliant Mechanism and Significant Factors Affecting it, Using the Pseudo-Rigid-Body Model Approach. ASME IDETC/CIE. 2015.

Scholz TL, Midha PA, Anderson LJ, and Ku DN. PneumoniaCheck: A Device for Sampling Lower Airway Aerosols. ASME Journal of Medical Devices. 2010.

Tinsley A, Midha PA, Nagel RL, McAdams DA, Stone RB, & Shu LH. Exploring the Use of Functional Models as a Foundation for Biomimetic Conceptual Design. ASME IDTEC/CIE. 2007.

Nagel RL, Midha PA, Tinsley A, McAdams DA, Stone RB, Shu L. Exploring the use of Functional Models in Biomimetic Conceptual Design. ASME Journal of Medical Devices. 2008.

Presentations

Madukauwa-David DI, Sadri V, Midha PA, Raghav V, Kamioka N, Sharma R, Babaliaros V, Yoganathan AP. Neo-Sinus Washout Quantification in Transcatheter Heart Valves. Heart Valve Society Annual Scientific Meeting, New York, NY, 2018.

Midha PA, Okafor I, Raghav V, Sadri V, Condado JF, Sharma R, Makkar RR, Babaliaros V, Yoganathan AP. Neo-Sinus Washout is Faster in Supra-Annular Transcatheter Heart Valves. American Heart Association Scientific Sessions, Anaheim, CA, 2017.

Raghav V, Clifford C, Midha PA, Okafor I, Thurow B, Yoganathan AP. Volumetric velocimetry downstream of a percutaneous heart valve. 70th Annual Meeting of the APS Division of Fluid Dynamics, Denver, CO, 2017.

Clifford C, Raghav V, Midha PA, Okafor I, Johnson C, Thurow B, Yoganathan AP. Assessment of thrombosis potential of a transcatheter heart valve using a novel single-camera volumetric PIV technique. Summer Biomechanics, Bioengineering, & Biotransport Conference, Tucson, AZ, 2017.

Yoganathan AP, Okafor I, Midha PA, Raghav V, Babaliaros V, Kumar G. Paravalvular leak in transcatheter aortic valve replacement. Summer Biomechanics, Bioengineering, & Biotransport Conference, Tucson, AZ, 2017.

Midha PA, Yoganathan, AP. In vitro valve-in-valve evaluation. Invited webinar to Boston Scientific TAVR team in Los Gatos, CA, Marlboro, MA, Minneapolis, MN, and Galway, Ireland, 2016.

Clifford C, Thurow B, Midha PA, Okafor I, Raghav V, Yoganathan, A. Single camera volumetric velocimetry in aortic sinus with a percutaneous valve. 69th Annual Meeting of the APS Division of Fluid Dynamics, Portland, OR, 2016.

Okafor I, Raghav V, Midha PA, Kumar G, Yoganathan A. Aortic regurgitation on left ventricular diastolic flow. Summer Biomechanics, Bioengineering, & Biotransport Conference, National Harbor, MD, 2016.

Midha PA, Raghav V, Condado JF, Okafor I, Lerakis, S, Thourani VH, Babaliaros V, Yoganathan AP. Optimisation of transcatheter valve-in-valve therapy: an in vitro haemodynamic evaluation. EuroPCR 2016, Paris, France, 2016.

Midha PA, Arjunon S, Uceda DE, Raghav V, Condado JF, Lerakis, S, Thourani VH, Babaliaros V, Yoganathan AP, An In Vitro Investigation of Hemodynamic and Pullout Forces in a Valve-in-Valve Implantation, BMES/FDA Frontiers in Medical Devices Conference, College Park, MD, 2015.

Midha PA, Arjunon S, Uceda DE, Raghav V, Condado JF, Lerakis, S, Thourani VH, Babaliaros V, Yoganathan AP. An In Vitro Case Study: How Can We Help a Patient with a Small Failing Bioprosthesis? Heart Valve Society Inaugural Scientific Meeting, Monte Carlo, Monaco, 2015.

Ku DN, Midha PA. Design of a Vein Valve Replacement. American Venous Forum Annual Meeting, Orlando, FL, 2012.

Patents

US Patent 8,821,409 B2: Lung aerosol collection device, September 2012 (Ku DN, Anderson LJ, Midha PA, Bergman HL, Scholz T).

US Patent Application 20,120,053,676 A1: Implantable Prosthetic Vascular Valves, November 2011 (Ku DN, Midha PA, Bergman HL).

Prior Experience

Graduate Research Assistant, Georgia Institute of Technology, 2014-2017

Engineering Consultant (External), Edwards Lifesciences, 2017

Engineering Consultant (External), Boston Scientific, 2015-2017

Engineering Consultant (External), CardioMEMS (St. Jude Medical), 2014-2015

Research & Engineering Contractor, Kimberly-Clark, 2012-2014

Professional Affiliations

Association for the Advancement of Medical Instrumentation (AAMI; Member of the Cardiac Valves and Vascular Prostheses Committees)

Heart Valve Society

American Heart Association

Pi Tau Sigma

American Society of Mechanical Engineers (ASME)

Additional Information

Peer Reviewer

Journal of the American College of Cardiology (JACC): Cardiovascular Interventions

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Bioengineering, Georgia Institute of Technology (Georgia Tech), 2017
  • M.S., Bioengineering, Georgia Institute of Technology (Georgia Tech), 2009
  • B.S., Mechanical Engineering, Missouri University of Science and Technology, 2007
  • National Collegiate Inventors and Innovators Alliance (NCIAA) Advanced E-Team Grant, 2009

    Georgia Institute of Technology President’s Fellowship, 2011