Pratibha Mistry

Pratibha Mistry, Ph.D.

Managing Scientist
Health Sciences
Harrogate (UK)

Dr. Mistry has a breadth of experience in experimental mammalian toxicology and pathology including crop protection research and development. Dr. Mistry has managed a portfolio of herbicide research projects through the bespoke design and interpretation of early investigative studies, aiding candidate selection and identifying unacceptable hazards early. Dr. Mistry led a comprehensive project from research into development incorporating toxicokinetics to guide dose-setting for chronic mammalian toxicity studies. The US EPA accepted this evidence-based scientific rationale to set appropriate dose levels studies based on dose limiting kinetics rather than dose-limiting toxicity.

Dr. Mistry is an supporter for in vitro methods in toxicology and emerging technologies. Dr. Mistry has championed many initiatives supported by the National Centre of the Replacement, refinement and Reduction of Animal use and has chaired the UK In Vitro Toxicology Society. In addition, Dr. Mistry has written grant applications, successfully supervised four Ph.D students and contributed to numerous publications in the field; including a white paper on the utility of stem cells in Toxicology for a working group supported by the European Partnership for Alternative Approaches to Animal Testing.

Dr Mistry has helped develop and has supported numerous external collaborations exploring multidisciplinary approaches to help solve complex scientific challenges, such as mathematics in experimental in vitro models, through to innovative digital approaches for broader agricultural technology development. Dr Mistry has spent several years promoting external communication and collaboration, as well as developing approaches to survey competitor and technology intelligence.

Prior to 11 years at a major crop protection company, Dr. Mistry worked in smaller start-up companies supporting the development of drug delivery systems, as well as a contract facility providing immunology, inflammation and infection expertise. Dr. Mistry also spent 9 years at University of Leicester studying and researching DNA damage and repair mechanisms, cell signaling and anti-cancer drugs, as well as managing a clinical trial.

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Medicine and Biology Science, University of Leicester, 2002
  • M.Sc., Molecular Pathology and Toxicology, University of Leicester, 1996
  • B.Sc., Pathobiology, University of Reading, UK, 1992

Publications

Kyffin JA, Leedale J, Mistry P, and Webb SD (2018). Mathematical modelling of solute transport through hepatocyte spheroids. Computational Toxicology (submitted).

Kyffin JA, Sharma P, Leedale J, Colley H, Murdoch C, Harding AL, Mistry P, and Webb SD (2018). Characterisation of a functional rat hepatocyte spheroid model. Applied In Vitro Toxicology (submitted).

Kyffin JA, Sharma P, Leedale J, Colley H, Murdoch C, Mistry P and Webb SD (2018). Impact of cell types and culture methods on improving functionality of In Vitro Liver Systems – A review of cell systems for xenobiotic safety. Toxicol In Vitro, 48: 262-275.

Dott W, Mistry P, Wright J, Cain K and Herbert KE (2017). Integrated Metabolic models for xenobiotic induced mitochondrial toxicity in skeletal muscle. Redox 18: 198-210.

Sorrell I, Shipley RJ, Regan S, Gardner I, Storm MP, Ellis M, Ward J, Williams D, Mistry P, Salazar JD, Scott A, Vickers C, and Webb S (2017). Mathematical Modelling of a Liver Hollow Fibre Bioreactor. Biotech. BioEng. (submitted).

Ward J, Dunster J, Derks G, Salazar D and Mistry P (2016). Predicting tyrosinaemia: a mathematical model defining species differences of 4-hydroxyphenylpyruvate dioxygenase inhibition by nitisinone. Math Med Biol June 15.

Suter-Dick L, Ingelman-Sundberg M, Mistry P, Fowler P, Roth A, Stedman D, Bremm KD, Hescheler J, Brito C, Alves PM, Blaauboer BJ, Jennings P, Kelm JM, van der Water B, Coecke S, Manou I, Beilmann M (2015). Stem Cell-Derived Systems in Toxicology Assessment. Stem Cells & Development 24(11).

Dalzell AM, Mistry P, Wright J, Williams FM and Brown CDA (2015). Characterisation of the transport of avermectins by MDR1/Mdr1a and MRP efflux transporters in human SH-SY5Y and mouse N2a neuroblastoma cell lines. Tox Letters 235: 189–198.

Dott W, Mistry P, Wright J, Cain K and Herbert KE (2014). Modulation of mitochondrial bioenergetics in a skeletal muscle cell line model of mitochondrial toxicity. Redox 2: 224-33.

Cantrill C, Mistry P, Wright J, Stevens A and Penny J (2012). Evaluating in vitro models for the prediction of CNS exposure to chemical entities. Tox Sci, 1834.

Taylor L, Penny J, Wright J and Mistry P (2012). Comparative expression analysis of membrane transporters and metabolising enzymes in the rat and human placenta during gestation. Tox Sci, 1942.

Dott W, Mistry P, Wright J and Herbert K (2011). Identification of mechanistic biomarkers of cardiac and skeletal muscle Toxicity to aid the development of tissue-specific in vitro models. Tox Sci, 1589.

Taylor L, Mistry P, Wright J and Penny J (2010). The interaction of placental efflux transporters with xenobiotics. Tox Sci, 1598.

Mistry P, Deacon K, Blank JL and Patel R (2004). NFB activation promotes cell survival in mitotically arrested cells. J Biol Chem 279:1482–1490.

Deacon K, Mistry, P, Chernoff J, Blank J and Patel R (2003). p38 MAP kinase mediates cell death and p21-activated kinase (PAK) mediates cell survival during chemotherapeutic drug-induced mitotic arrest. Mol. Biol. Cell. 14: 2071-2087.

Mistry P and Herbert KE (2003). Modulation of hOGG1 DNA repair enzyme in human cultured cells in response to pro-oxidant and antioxidant challenge. Free Radical Biol Med 35:397–405.

Deacon K, Mistry P, Blank JL and Patel R (2003). p38 MAP kinase mediates cell death and p21-activated kinase (PAK) mediates cell survival during chemotherapeutic drugs-induced mitotic arrest. Mol Biol Cell 14: 2071–2087.

Podmore ID, Griffiths HR, Herbert KE, Mistry N, Mistry P and Lunec J (1998). Vitamin C exhibits pro-oxidant properties. Nature 392:559.

Podmore ID, Griffiths HR, Herbert KE, Mistry N, Mistry P and Lunec J (1998). Does vitamin C have a pro-oxidant effect? Nature 395:231–232.

Prior Experience

Toxicologist & External Collaborations Manager, Syngenta, Bracknell, 2007-2018

Business Project Manager, KWS BioTest, Bristol, 2006-2007

Research Scientist, pSiMedica Ltd, Malvern, 2004-2006

Postdoctoral Research Associate, Dept. of Biochemistry, University of Leicester, 2001-2004

Graduate positions, Dept. of Pathology, University of Leicester, 1996-2001

Professional Affiliations

UK In Vitro Toxicology Society (Honorary member)

Oct 2014 – present Senior Lecturer, University of Liverpool (Honorary position)

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Medicine and Biology Science, University of Leicester, 2002
  • M.Sc., Molecular Pathology and Toxicology, University of Leicester, 1996
  • B.Sc., Pathobiology, University of Reading, UK, 1992