Tyler Nicholas

Tyler Nicholas, Ph.D.

Scientist
Health Sciences
Alexandria

Dr. Nicholas is a toxicologist and specializes in the evaluation of chemical and particulate exposures and their impacts on human health. He has experience conducting dose-response assessments for silver nanoparticles in the context of gene-environment interactions and has assisted with developing adverse outcome pathways for human health risk assessment of silver nanoparticles. Dr. Nicholas also has over seven years of laboratory research experience in toxicology with an emphasis on toxicity testing of engineered nanomaterials using a high-content in vitro model of the conducting airway.

Prior to joining Exponent in 2019, Dr. Nicholas received his Ph.D. in Environmental Toxicology from the University of Washington. His dissertation research focused on understanding the in vitro effects of interactions between underlying genetics and diseases in modifying the host response to engineered nanomaterial exposures in the respiratory system. His research highlighted the importance of considering dosimetry as well as gene-environment interactions when screening and prioritizing potential respiratory toxicants.

Dr. Nicholas is an active member of the Society of Toxicology (SOT), American Association for the Advancement of Science (AAAS), and Regulatory Affairs Professionals Society (RAPS). He has received several awards during his graduate studies, including the Graduate Opportunities and Minority Achievement Program (GO-MAP) Dissertation Fellowship in 2018 and the Pacific Science Center (PacSci) Environmental Health Sciences Scholarship in 2016.

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Environmental Toxicology, University of Washington, 2019
  • M.S., Environmental Health, University of Washington, 2014
  • B.S., Environmental Science, University of Rochester, 2012
  • GO-MAP Dissertation Fellowship, University of Washington, 2018

    Environmental Health Sciences Scholarship, Pacific Science Center, 2016

    Environmental Politics and Governance Fellowship, University of Washington, 2014

    Ronald E. McNair Post-Baccalaureate Achievement Program, University of Rochester, 2010

Publications

Nicholas TP, Haick AH, Workman TW, Bammler TK, Kavanagh TJ, Faustman EM, Gharib SA, Altemeier WA. The Effects of Genotype × Phenotype Interactions on Transcriptomic Response to Silver Nanoparticle Toxicity in Organotypic Cultures of Murine Tracheal Epithelial Cells. Toxicol Sci. 2019 Sep 28. pii: kfz209. doi: 10.1093/toxsci/kfz209. [Epub ahead of print]

Nicholas TP, Kavanagh TJ, Faustman EM, Altemeier WA. The Effects of Gene × Environment Interactions on Silver Nanoparticle Toxicity in the Respiratory System. Chem Res in Toxicol. 2019 Jun 17;32(6):952-968. doi: 10.1021/acs.chemrestox.8b00234.

Hazlehurst MF, Spalt EW, Nicholas TP, Curl CL, Davey ME, Burke GL, Watson KE, Vedal S, Kaufman JD. Contribution of the In-Vehicle Microenvironment to Individual Ambient Source Nitrogen Dioxide Exposure: The Multi-Ethnic Study of Atherosclerosis and Air Pollution. J Expo Sci Environ Epidemiol. 2018 Jun;28(4):371-380. doi: 10.1038/s41370-018-0025-1.

Presentations

Nicholas TP, Haick AH, Workman TW, Bammler TK, Kavanagh TJ, Faustman EM, Gharib SA, Altemeier WA. The Effects of Genotype × Phenotype Interactions on Transcriptomic Response to Silver Nanoparticle Toxicity in Airway Epithelium Organotypic Culture Models. Presented at the Society of Toxicology National Meeting, Baltimore, MD, March 2019.

Nicholas TP, Haick AK, Workman TW, Griffith WC, Nolin JD, Kavanagh TJ, Faustman EM, Altemeier WA. The Effects of Genotype × Phenotype Interactions on Silver Nanoparticle Toxicity in Airway Epithelium Organotypic Culture Models. Presented at the STAR Organotypic Culture Models for Predictive Toxicology Research Centers Progress Review, Research Triangle Park, NC, May 2018; and the Society of Toxicology National Meeting, San Antonio, TX, March 2018.

Nicholas TP, Haick AK, Workman TW, Griffith WC, Nolin JD, Kavanagh TJ, Faustman EM, Altemeier WA. Optimization of Airway Epithelium Organotypic Culture Models as a Platform for Adverse Outcome Pathway Assessment of Engineered Nanomaterials. Presented at the World Congress on Alternatives and Animal Use in the Life Sciences, Seattle, WA, August 2017; and the Society of Toxicology National Meeting, Baltimore, MD, March 2017.

Nicholas TP, Hazlehurst MF, Spalt EW, Curl CL, Davey ME, Burke GL, Watson KE, Vedal S, Kaufman JD. Contribution of the In-Vehicle Microenvironment to Ambient Source Nitrogen Dioxide Exposures in the Multi-Ethnic Study of Atherosclerosis and Air Pollution. Presented at the Annual Symposium on Environmental, Occupational and Public Health, Blaine, WA, January 2015.

Professional Affiliations

Regulatory Affairs Professionals Society (2019-present)

American Association for the Advancement of Science (2016-present)

Society of Toxicology (2014-present)
   - Computational Toxicology Specialty Section
   - In Vitro and Alternative Methods Specialty Section
   - Regulatory and Safety Evaluation Specialty Section
   - Pacific Northwest Regional Chapter (2014-2019)

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Environmental Toxicology, University of Washington, 2019
  • M.S., Environmental Health, University of Washington, 2014
  • B.S., Environmental Science, University of Rochester, 2012
  • GO-MAP Dissertation Fellowship, University of Washington, 2018

    Environmental Health Sciences Scholarship, Pacific Science Center, 2016

    Environmental Politics and Governance Fellowship, University of Washington, 2014

    Ronald E. McNair Post-Baccalaureate Achievement Program, University of Rochester, 2010