Nektaria Pasiotis
Nektaria Pasiotis, Ph.D.
Senior Scientist
Chemical Regulation & Food Safety
Harrogate (UK)

Dr. Pasiotis has over 7 years of regulatory toxicology experience, working for both government and industry. She has a comprehensive knowledge of EU toxicology risk assessment with respect to pesticides, biocides, and REACH. Dr. Pasiotis provides advice on toxicology programmes; unusual findings in toxicology studies, cases, and opinions for consideration by regulators; and toxicology sections for dossiers. She also performs human risk assessments and study monitoring, as well as preparing data gaps analyses, following on the experience she gained at her previous position at APC Ltd, where she spent more than 3 years working as a Regulatory Toxicology consultant.

Prior to entering consultancy, Dr Pasiotis spent three years at the Greek regulatory authority (Benaki Phytopathological Institute), where she was involved in the evaluation, authorization, and classification & labelling of active substances and products according to Dir. 91/414/EEC (later Reg EC 1107/2009), Dir. 98/8/EC (later Reg EU 528/2012) and Reg EC 1272/2008, respectively.

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Chemistry, University of Athens, Greece, 2009
  • M.Sci., Lipid Biochemistry, University of Athens, Greece
  • B.Sc., Class 2 Honours Degree, Chemistry, University of Athens, Greece, 2001

Publications

Kasiotis K.M., Kyriakopoulou K., Emmanouil C., Tsantila N., Liesivuori J., Souki H., Manakis S., Machera K. Monitoring of Systemic Exposure to Plant Protection Products and DNA Damage in Orchard Workers. Toxicology Letters, 2012, 210 (2), 182-188.

Tsoupras A.B., Chini M., Mangafas N., Tsogas N., Stamatakis G., Tsantila N., Fragopoulou E., Antonopoulou S., Gargalianos P., Demopoulos C.A., Lazanas M.C. Platelet-Activating Factor and its basic metabolic enzymes in blood of naïve HIV infected patients. Angiology, 2012, 63 (5), 343-352 (in press).

Dontas I.A., Marinou K.A., Iliopoulos D., Tsantila N., Agrogiannis G., Papalois A., Karatzas T. Lipids in Health and Disease, 2011, 10(1), 139Changes of blood biochemistry in the rabbit animal model in atherosclerosis research; a time- or stress-effect.

Tsantila N., Tsoupras A.B., Fragopoulou E., Antonopoulou S., Iatrou C., Demopoulos C.A. In vitro and in vivo effects of statins on Platelet Activating Factor and its metabolism. Angiology, 2011, 62 (3), 209-218.

Marinou K.A., Georgopoulou, K., Agrogiannis, G., Karatzas, T., Iliopoulos, D., Papalois, A., Chatziioannou, A., Magiatis, P., Halabalaki, M., Tsantila, N., Skaltsounis, L.A., Patsouris, E., Dontas, I.A. Differential effect of Pistacia vera extracts on experimental atherosclerosis in the rabbit animal model: An experimental study. Lipids in Health and Disease, 2010, 9, Article number 73.

Tsantila N., Karantonis H.C., Perrea D.N., Theocharis S.E., Iliopoulos D.G., Iatrou C., Antonopoulou S., Demopoulos C.A. Atherosclerosis regression study in rabbits upon olive pomace polar lipid extract administration. Nutrition Metabolism and Cardiovascular Diseases, 2010, 20(10), 740-747.

Stamatakis G., Tsantila N., Karantonis H.C., Samiotaki M., Panayotou G.N., Dimopoulos A.C., Halvadakis C.P., Demopoulos C.A. Detection and Isolation of Antiatherogenic and Antioxidant Substances Present in Olive Mill Wastes by a Novel Filtration System. Journal of Agricultural and Food Chemistry, 2009, 57(22), 10554-10564.

Philippopoulos A.I., Tsantila N., Demopoulos C.A., Raptopoulou C.P., Likodimos V., Falaras P. Synthesis, characterization and crystal structure of the cis-[RhL2Cl2]Cl complex with the bifunctional ligand (L) 2-(2'-pyridyl)quinoxaline. Biological activity towards PAF (Platelet Activating Factor) induced platelet aggregation. Polyhedron 2009, 28(15), 3310-3316.

Karantonis H.C., Tsantila N., Stamatakis G., Antonopoulou S., Demopoulos C.A. Bioactive Polar Lipids in Olive Oil, Pomace and Waste by products. Journal of Food Biochemistry 2008, 32, 443-459.

Tsantila N., Karantonis H.C., Perrea D.N., Theocharis S.E., Iliopoulos D.G., Antonopoulou S., Demopoulos C.A. Antithrombotic and antiatherosclerotic properties of olive oil and olive pomace polar extracts in rabbits. Mediators of Inflammation, Volume 2007, 2007, Article number 36204.

Fragopoulou E., Nomikos T., Tsantila N., Mitropoulou A., Zabetakis I., Demopoulos C.A. Biological activity of total lipids from red and white wine/must. J. Agric. Food Chem. 2001, 49, 5186 - 5193.

Presentations


Systemic exposure and DNA effect monitoring of operators following applications of plant protection products. K. Kyriakopoulou, K.M. Kasiotis, Ch. Emmanouil, N. Τsantila, H. Souki, S. Μanakis and Κ. Machera. 7th Aegean Analytical Chemistry Days Conference, 29Sep-3Oct, 2010 Lesvos, Greece.

Beneficial effect of Pistacia vera methanolic extract on experimentat atherosclerosis in a rabbit animal model. Marinou K, Agrogiannis G, lliopoulos D, Karatzas T, Papalois A, Chatziioannou A, Tsantila N, Skaltsounis LA, Lelovas P, Dontas I. 11th Jοint Scientific Meeting of European Society of Laboratory Animal Veterinarians (ESLAV), Septernber 26-28, 2010, Toulouse, France.

Can PAF Inhibitors in Olive Oil and its Respective Pomace Reduce Atherosclerotic Lesions Formation? N. Tsantila, H.C. Karantonis, D.N. Perrea, D.G. Iliopoulos, S.A. Theocharis, C. Iatrou, S. Antonopoulou, C.A. Demopoulos. 6th Euro Fed Lipid Congress "Oils, Fats and Lipids in the 3rd Millennium", 07-10 September, 2008, Athens, Greece. (oral presentation).

Atherosclerosis inhibition and regression can be induced by extracts of olive oil and its respective pomace. Tsantila N, Karantonis HC, Perrea DN, Iliopoulos DG, Theocharis SΕ, Iatrou C, Antonopoulou S, Demopoulos CA. 33rd FEBS Congress & 11th IUBMB Conference, June 28- July 3, 2008, Athens, Greece.

Biological effects of lipids from olive oil and olive pomace, in early atherosclerosis development. Implication of Platelet Activating Factor (PAF). Karantonis H.C., Tsantila N., Antonopoulou S., Perrea D.N., Theocharis S.E., Kavantzas F., Sokolis D.P., Demopoulos C.A. 2nd International Conference on Traditional Mediterranean Diet: Past, Present and Future, MeDiet, 20-22th April 2005, Athens, Greece.

Existence of lipids with antiatherogenic properties in wines and musts: implication of PAF in a possible explanation of ‘French Paradox’. Fragopoulou E., Antonopoulou S., Tsoupras A., Tsantila N., Grypioti A., Gribilas G., Gritzapi H., Konsta E., Skandalou E., Papadopoulou A., Demopoulos C.A., Samiotaki M., Panayotou G. 2nd International Conference on Traditional Mediterranean Diet: Past, Present and Future, MeDiet, 20-22th April 2005, Athens, Greece.

Induction of liver fibrosis in the rat did not affect liver Platelet Activating Factor activity. Gribilas G., Stamoulis J., Karantonis H.C., Tsantila N., Demopoulos C.A., Theocharis S. 10th International Congress of Toxicology, 11-15th July 2004, Tampere, Finland. (Abstract in: Toxicology and Applied Pharmacology, ICT X-2004).

Antiatherogenic properties of red/white wine, musts, grape-skins, and yeasts. Fragopoulou E., Antonopoulou S., Tsoupras A., Tsantila N., Grypioti A., Gribilas G., Gritzapi H., Konsta E., Skandalou E., Papadopoulou A., Samiotaki M., Panayotou G., Demopoulos C.A. 45th International Conference on the Bioscience of Lipids, 25-29th May 2004, Ioannina, Greece. (Abstract in: Chemistry and Physics of Lipids, Vol. 130, Issue 1, June 2004).

In vivo antiatherogenic properties of olive oil and its constituent lipid classes in hyperlipidemic rabbits. Karantonis H.C., Tsantila N., Antonopoulou S., Perrea D.N., Sokolis D.P., Theocharis S.E., Demopoulos C.A. 45th International Conference on the Bioscience of Lipids, 25-29th May 2004, Ioannina, Greece. (Abstract in: Chemistry and Physics of Lipids, Vol. 130, Issue 1, June 2004).

Professional Affiliations

The British Toxicology Society

Royal Society of Chemistry

Association of Greek Chemists

Hellenic Atherosclerosis Society

Hellenic Society of Toxicology

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Chemistry, University of Athens, Greece, 2009
  • M.Sci., Lipid Biochemistry, University of Athens, Greece
  • B.Sc., Class 2 Honours Degree, Chemistry, University of Athens, Greece, 2001