Amanda Pentecost
Amanda Pentecost, Ph.D.
Associate
Biomedical Engineering
Philadelphia

Dr. Pentecost’s primary expertise focuses on nanomaterials for biomedical applications. She has worked extensively to evaluate the therapeutic potential of several carbon nanomaterials as well as metal carbides. Her current interests include biomaterial-tissue interactions, biocompatibility, and the foreign body response to biomaterials. She has extensive experience with numerous materials and in vitro and in vivo biological characterization techniques, including: dynamic light scattering, scanning (DLS), zeta potential measurements, Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), gene expression analysis (RT-PCR and NanoString), protein secretion (ELISAs), immunohistochemistry, and histology.

Prior to joining Exponent, she concurrently completed both a Ph.D. in Materials Science and Engineering and a M.S. in Biomedical Engineering at Drexel University. Since her undergraduate tenure, her research focused on designing and utilizing diamond nanoparticles as drug delivery vehicles for several therapeutic applications, including preventing biofilm formation on implants, treating brain cancer, and treating chronic inflammatory diseases. As part of her thesis research, she was awarded Whitaker International and David L. Boren fellowships in order travel to and work at the Center for Theragnosis at the Korea Institute of Science and Technology (KIST) for one year. Here, she collaborated with KIST researchers to determine the biodistribution and therapeutic efficacy of modified diamond nanoparticles in a mouse model of rheumatoid arthritis. She was also involved as a technical editor for ISO TC 229 (Nanotechnologies), as is interested in regulatory affairs governing nanomaterials for biomedical applications.

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Materials Science and Engineering, Drexel University, 2018
  • M.S., Biomedical Engineering, Drexel University, 2016
  • M.S., Materials Science and Engineering, Drexel University, 2014
  • B.S., Materials Science and Engineering, Drexel University, 2013, magna cum laude
  • Whitaker International Fellow to South Korea, 2016-2017

    David L. Boren Fellow to South Korea, 2016

    National Science Foundation Graduate Research Fellow, 2013-2016

    Tau Beta Pi National Engineering Honor Society

    Alpha Sigma Mu International Professional Honor Society

Publications

Pentecost, A., Gogotsi, Y., Spiller K. Anti-inflammatory effects of octadecylamine-functionalized nanodiamond on primary human macrophages. Biomaterials Science, 2017. 5(10): p. 2131-2143.

Cheng, X.-B., Zhao, M., Chen, C. Pentecost, A., et al. Nanodiamonds suppress the growth of lithium dendrites. Nature Communications, 2017. 8(336).

Mochalin, V., Pentecost, A., et al. Adsorption of Drugs on Nanodiamond: Toward Development of a Drug Delivery Platform. Molecular Pharmaceutics, 2013. 10(10): p. 3728-3735.

Pentecost, A., et al., Deaggregation of Nanodiamond Powders Using Salt- and Sugar-Assisted Milling. ACS Applied Materials & Interfaces, 2010. 2(11): p. 3289-3294.

Oral Presentations

Pentecost, A., Kim, M.J., Jeon, S.M., Ko, Y.J., Kim, K.M., Gogotsi, Y., Spiller, K. Nanodiamond-based drug delivery system for the modulation of macrophage behavior. 2018 Northeast Bioengineering Conference, 2018, Podium presentation, Philadelphia, PA.

Pentecost, A., Kim, M.J., Jeon, S.M., Ko, Y.J., Kim, K.M., Gogotsi, Y., Spiller, K. Macrophage-targeted drug delivery system for the treatment of rheumatoid arthritis. 2017 Society for Biomaterials Annual Meeting and Exposition, 2017, Podium presentation, Minneapolis, MN.

Pentecost, A., Gogotsi, Y., Spiller, K. Development of a novel nanodiamond-based drug delivery system for the treatment of chronic inflammation. Materials Research Society Spring Meeting, 2016, Podium presentation, Phoenix, AZ.

Pentecost, A., Mochalin, V., Hickok, N., Forsberg, F., Gogotsi, Y. Adsorption and desorption of drug-adsorbed nanodiamond delivery systems. Materials Research Society Spring Meeting, 2012, Podium presentation, San Francisco, CA.

Poster Presentations

Pentecost, A., Gogotsi, Y. Spiller, K. “The effect of dexamethasone-loaded nanodiamond particles on macrophage phenotype.” BioNanotechnology Summer Institute at the University of Illinois – Urbana-Champaign, 2014. Poster presentation, Urbana-Champaign, IL. 

Pentecost, A., Gour, S., Mochalin, V., Knoke, I., Gogotsi Y. “Diamond nanoparticles: Protein mimics and drug delivery vehicles.” Materials Research Society Fall Meeting, 2011, Poster presentation, Boston, MA. 

Pentecost, A., Mochalin, V., Knoke, I., Gogotsi Y. “De-aggregation of nanodiamond powders using salt-assisted milling.” Materials Research Society Fall Meeting, 2009, Poster presentation, Boston, MA. 

Book Chapters

Pentecost, A., et al. Nanoparticulate systems for controlling monocyte/macrophage behavior. In Microscale Technologies for Cell Engineering. Springer, 2015.

Patents

U.S. Patent 15/945,903, Complexes And Methods of Reducing Inflammation, filed April 5, 2018. (KL Spiller, AE Pentecost, Y Gogotsi).

Prior Experience

Visiting Research Fellow, Korea Institute of Science and Technology, Center for Theragnosis, 2016-2017

Graduate Research Assistant, Drexel University, Biomaterials and Regenerative Medicine Lab, 2013-2018

Co-op Research Assistant, Shanghai Advanced Research Institute, Center for Nanomedicine and Translational Medicine, 2012

Undergraduate/Graduate Research Assistant, Drexel University, Drexel Nanomaterials Institute, 2008 – 2018

Professional Affiliations

Society for Biomaterials

Materials Research Society

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Materials Science and Engineering, Drexel University, 2018
  • M.S., Biomedical Engineering, Drexel University, 2016
  • M.S., Materials Science and Engineering, Drexel University, 2014
  • B.S., Materials Science and Engineering, Drexel University, 2013, magna cum laude
  • Whitaker International Fellow to South Korea, 2016-2017

    David L. Boren Fellow to South Korea, 2016

    National Science Foundation Graduate Research Fellow, 2013-2016

    Tau Beta Pi National Engineering Honor Society

    Alpha Sigma Mu International Professional Honor Society