Mr. Singhal is an experienced health sciences consultant with primary focus in exposure assessments, dermal sensitization risk assessments for wearable devices, and Proposition 65-related product assessments. He uses his technical expertise in exposure sciences and toxicology along with data analysis and modeling to assist clients with regulatory compliance, product development and management, litigation support, risk management and program management. Mr. Singhal has experience working with a variety of chemical agents such as dermal sensitizers, formaldehyde, metals, phthalates, benzene, asbestos, pesticides and polychlorinated biphenyls. Mr. Singhal actively publishes in the peer reviewed literature and has presented his work at scientific conferences.
His expertise includes:
- Evaluating product lines to assess compliance with California's Proposition 65
- Dermal sensitization and biocompatibility assessment for consumer wearables -- Conducted seminal work to assess and analyze dermal sensitizers released from consumer wearables and helped create the first known predictive risk model for allergic contact dermatitis to forecast sensitization risk from dermal sensitizers
- Conducted the largest known study to date to collect data on formaldehyde exposures from laminate flooring in U.S. homes and used various statistical and mathematical models to predict risk from formaldehyde exposures
- Physiologically-based pharmacokinetic (PBPK) modeling to assess absorption, distribution, metabolism and excretion of various chemicals including malathion (Bogen and Singhal 2016)
- Conducted risk assessments to estimate exposure to chemicals regulated under federal and state laws, including California's Proposition 65
- Assessed human exposures to a variety of chemical agents such as formaldehyde, lead, BPA, phthalates, asbestos, various pesticides, and metal and organic dermal sensitizers including nickel, chromium, acrylates, and epoxies.
CREDENTIALS & PROFESSIONAL HONORS
- M.A., Endocrinology, University of California, Berkeley, 2011
- B.A., Molecular and Cell Biology, University of California, Berkeley, 2008
Bogen KT, Singhal A. Malathion dermal permeability in relation to dermal load: Assessment by PBPK modeling of in vivo human data. J Env Sci Health, Part B 2016; 0:1–9.
Marconett CN, Singhal A, Sundar SN, Firestone GL. Indole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells. Molecular and Cellular Endocrinology 2012; 363:74-84.
Marconett CN, Morgenstern TJ, San Ramon AK, Sundar SN, Singhal A, Firestone GL. BZL101, a phytochemical extract from Scutellaria barbata plant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype. Cancer Biology and Therapy 2010; 10: 397-405.
Gauthier AM, Lewis RC, Bogen KT, Singhal A, Sheehan PJ. 2017. Wearable Technology Biocompatibility: A Unique Opportunity in Green Chemistry and Engineering. Presented at the 21st Annual Meeting of Green Chemistry and Engineering Conference, Reston, VA, June 13–15, 2017.
Lewis RC, Winegar E, Posson M, Gauthier AM, Singhal A, Sheehan PJ. 2017. Exposure to an Ethanol-based Cleaning Product. Presented at American Industrial Hygiene Conference and Exposition Annual Meeting, Seattle, WA, June 4–7, 2017.
Singhal A, Bogen KT, Lewis RC, Gauthier AM, Winegar E, Sheehan PJ. 2017. A Novel Approach to Estimating Dermal Contact with Hand-Applied Cleaning Solutions: A Simulation Study Involving Denatured Alcohol. Presented at the 56th Annual Meeting of the Society of Toxicology, Baltimore, MD, March 10–16, 2017.
Winegar E, Bogen KT, Lewis RC, Gauthier AM, Singhal A, Sheehan PJ. 2017. A Use-Simulation Study of a Denatured Alcohol Cleaning Product to Assess Potential Worker Exposure. Presented at the 56th Annual Meeting of Society of Toxicology, Baltimore, MD, March 10–16, 2017.
Singhal A, Posson M, Jones A, Lewis RC, Gauthier A, Schenk J, Kalmes R, Sheehan PJ. Assessing Risk for Consumer Products Under California’s Proposition 65 Regulations. 2016. Presented at the 37th Annual Meeting of Society of Environmental Toxicology And Chemistry, Orlando, FL, November 6–10, 2016.
Sheehan P, Singhal A, Bogen KT, Kalmes R. Evaluating the Proposition 65 Health Significance of Formaldehyde Exposures from Chinese Manufactured Laminate Flooring. Presented at the 55th Annual Meeting of the Society of Toxicology, New Orleans, LA, March 13 - 17, 2016.
Singhal A and Bogen KT. How Malathion Dermal Absorption Varies with Dermal Load, Based on Physiologically Based Pharmacokinetic Modeling of In Vivo Human Data. Presented at the 55th Annual Meeting of the Society of Toxicology, New Orleans, LA, March 13 - 17, 2016.
Sheehan P, Lowney Y, Kalmes R, Bogen KT, Posson M, Glomski M, Singhal A, Volberg V, Beckerman B, Goswami E. Assessing User Exposure to Consumer Products: Methods Specific to Product Use and Exposure Route to Assess Consumer Health Risk. Presented at the 36th Annaul Meeting of SETAC North America, Salt Lake City, UT, November 1 - 5, 2015.
Kalmes R, Lowney Y, Sheehan P, Singhal A. Assessing Incidental Hand-to-Mouth Exposure to Lead from Consumer Products. Presented at the 36th Annaul Meeting of SETAC North America, Salt Lake City, UT, November 1 - 5, 2015.
Sheehan P, Bogen KT, Singhal A, Kalmes R, Volberg V. Wearable technology products and allergic contact dermatitis: Chemical exposure and risk assessment challenges & developments. To be presented at the SEATAC North America 36th Annual Meeting, Salt Lake City, UT, November 1-5, 2015.
Sheehan P, Bogen KT, Singhal A, Kalmes R, Roberts M, Fedoruk MJ. Wearable products and allergic contact dermatitis: a new risk assessment challenge. Presented at the 54th Annual Meeting of the Society of Toxicology, San Diego, CA, March 22-26, 2015.
Singhal A, Sheehan P, Turnham P, Bogen KT, Anderson E. Experimental comparison of dust concentrations from simulations in glove box and room chamber test environments. Presented at the American Industrial Hygiene Association Annual Meeting, San Antonio, TX, May 31-June 5, 2014.
Sheehan P, Posson M, Singhal A, Bogen KT, Hellerstein J. Assessing anthraquinone (AQ) exposure from food packaging: A product stewardship challenge in Europe. Presented at the American Industrial Hygiene Association Annual Meeting, San Antonio, TX, May 31-June 5, 2014.
Singhal A, Bogen KT. Benchmark dose analysis of NTP data on tumors induced in rodents chronically exposed to dietary anthraquinone. Presented at the 53rd Annual Meeting of the Society of Toxicology, Phoenix, AZ, March 23-March 27, 2014.
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