Joshua White
Joshua "Josh" White, Ph.D.
Manager
Biomedical Engineering
Philadelphia

Joshua White, Ph.D. expertise includes identifying risks associated with medical devices in and around MRI scanners. He frequently assists clients to develop custom protocols for performing MRI compatibility testing according to the relevant ASTM and ISO standards based on the risk profile of the device. His experience in MRI compatibility testing includes performing both multiphysics modeling in COMSOL and experimental testing. While at Exponent, Dr. White has assisted clients with responses to inquiries from both US FDA and international notified bodies related to their MRI compatibility assessments.

Dr. White is knowledgeable in particle analysis of orthopedic and cardiovascular medical devices. He is experienced in the generation of particles using benchtop methods including pin on disc testing, simulator testing, and tortuous track models. For particles embedded in tissue or wear fluid, he is also well-versed in isolation techniques that rely on both chemical- and enzyme-based approaches. Dr. White is also skilled with particle characterization techniques including scanning electron microscopy, energy-dispersive X-ray spectroscopy (EDS), dynamic light scattering and light obscuration, and inductively-coupled plasma mass spectroscopy (ICP-MS).

Dr. White is also experienced with the execution of medical device retrieval programs that incorporate his knowledge of biomaterials, tissue assays, and surface characterization techniques to evaluate devices and associated animal, cadaveric, and human tissues. He has helped clients establish international device and tissue retrieval programs in accordance with ASTM, ISO, and IATA standards. As such, he has evaluated device performance and performed failure analysis of devices at the preclinical, clinical, and post-market surveillance phases of the total product lifecycle.

Prior to joining Exponent, Dr. White’s graduate work focused on fabricating multi-cellular and multidimensional tissue engineered constructs to analyze the effects of solid and fluid mechanical stresses on pulmonary epithelial cells. He also utilized novel multiphase liquid formulations to develop new in vitro biotechnology assays with novel capabilities. Dr. White’s Ph.D. work was leveraged into a new biotechnology company where he performed scientific development, market research, customer discovery, as well as conducted preliminary regulatory strategies. Through these experiences, he has extensive experience in biomolecular techniques and assays including cell culture, soft lithography, image analysis, Western blot, immunofluorescence microscopy, enzyme-linked immunosorbent assay (ELISA), immunocytochemistry, and immunohistochemistry.

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Biomedical Engineering, University of Michigan, Ann Arbor, 2013
  • M.S., Biomedical Engineering, University of Michigan, Ann Arbor, 2011
  • B.S., Biomedical Engineering, University of Wisconsin, Madison, 2009
  • National Science Foundation Graduate Research Fellow, 2010–2013

    Rackham Graduate Research Grant and Rackham Graduate Merit Fellowship, 2009–2011

    Hilldale Undergraduate Research Fellowship, 2009

    Meyerhoff Undergraduate Award for Leadership, Service, and Excellence, 2009

    Academic All-Big Ten Soccer Team, 2006

LANGUAGES

  • Spanish

Publications

Ramamurthy P, White JB, Yull Park J, Hume RI, Ebisu F, Mendez F, Takayama S, Barald KF. Concomitant differentiation of a population of mouse embryonic stem cells into neuron-like cells and Schwann cell-like cells in a slow-flow microfluidic device. Developmental Dynamics; doi: 10.1002/dvdy.24466.

Thames SF, White JB, Ong. The myth: in vivo degradation of polypropylene-based meshes. International Urogynecology Journal; DOI: 10.1007/s00192-016-3131-4.
Ong KL, Yun BM, White JB. New biomaterials for orthopedic implants. Orthopedic Research and Reviews 2015; 7:107-130.

Dixon AR, Bathany C, Tsuei M, White J, Barald KF, Takayama S. Recent developments in multiplexing techniques for immunohistochemistry. Expert Review of Molecular Diagnostics 2015; 1-16.

Frampton JP, Tsuei M, White JB, Abraham AT, Takayama S. Aqueous two-phase system-mediated antibody micropatterning enables multiplexed immunostaining of cell monolayers and tissues. Biotechnology Journal 2015; 10(1): 121-125.

Frampton JP, White JB, Simon AB, Tsuei M, Paczesny S, Takayama S. Aqueous two-phase system patterning of detection antibody solutions for cross-reaction-free multiplex ELISA. Scientific Reports 2014; 4.

Frampton JP, White JB, Abraham AT, Takayama S. Cell co-culture patterning using aqueous two-phase systems. Journal of Visualized Experiments 2013; (73).

Douville NJ, Zamankhan P, Tung YC, Li R, Vaughan BL, Tai CF, White J, Christensen PJ, Grotberg JB, Takayama S. Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model. Lab Chip 2011; 11(4): 609-619.

Park JY, White JB, Walker N, Kuo CH, Cha W, Meyerhoff ME, Takayama S. Responses of endothelial cells to extremely slow flows. Biomicrofluidics 2011; 5(2): 022211.

White JB. Takayama S. Receptor differential activation and cooperativity better explain cellular preference for different chemoattractant gradient shapes in an EGFR system. Integrative Biology 2011; 3(10):1003-1010.

Book Chapters


Takayama S, White JB, Zhang C. Lungs-on-a-Chip. In: Inhalation Toxicology. S. H and K. SA. Boca Raton, FL, CRC Press 2015; 57-70.

White JB, Douville NJ, Moraes C, Grotberg JB, Takayama S. Chapter 10 - Microfluidic Approaches Toward Pulmonary Tissue Constructs. Microfluidic Cell Culture Systems. Bettinger C, Borenstein JT, Tao SL (eds), Oxford, William Andrew Publishing 2013; 247-278.

Hu Y, Bian S, Filoche M, Grotberg J, White J, Takayama S, Grotberg J. Flow and Sound Generation in Human Lungs: Models of Wheezes and Crackles. Fluid-Structure-Sound Interactions and Control. Y. Zhou, Y. Liu, L. Huang and D. H. Hodges, Springer Berlin Heidelberg 2014; 301-317.

Conference Presentations

Arnholt CM, White JB, Higgs GB, MacDonald DW, Lowell JA, Perkins MR, Mihalko WM, Kurtz SM. Associations Between Metallosis and Tissue Metal Concentration in Autopsy Retrieved TKA. Paper 207, Transactions of the Orthopaedic Research Society, New Orleans, LA, March 10-13, 2018.

Lowell JA, Perkins MR, Arnholt CM, White JB, MacDonald DW, Kerkhof A, Kurtz SM, Mihalko WM. Establishing a Baseline for the Relationship between Inflammatory Cytokines and Tissue Metal Concentrations in Autopsy Retrieved Total Hip Implants. Poster 1006, Transactions of the Orthopaedic Research Society, New Orleans, LA, March 10-13, 2018.

Perkins MR, Lowell JA, Butler R, Arnholt CM, White JB, Kerkhof A, MacDonald DW, Kurtz SM, Mihalko WM. Does a Correlation Exist between Soft Tissue Laxity and Tissue Metal Concentrations in Total Knee Arthroplasty(TKA)? Poster 991, Transactions of the Orthopaedic Research Society, New Orleans, LA, March 10-13, 2018.

Arnholt CM, Patel J, Lal S, White JB, Perkins MR, Mihalko WM, Tipper J, Kurtz SM. Metallic Wear Debris Isolation and Characterization: A Cadaver TKA Study. Paper 5904, International Society for Technology in Arthoplasty. London, UK, October 10-13, 2018.

Arnholt CM, White JB, Macdonald DW, Lowell JA, Perkins MR, Mihalko WM, Kurtz SM. Metallosis and Tissue Metal Concentrations From Autopsy Retrieved TKA. Paper 5905, International Society for Technology in Arthoplasty. London, UK, October 10-13, 2018.

Shaw CB, Hamed E, Siskey RL, White JW, Ochoa JO. Simulating MRI Heating of Surgical Staples for Wound Closure in Orthopaedic Surgery. Poster No. 0920, Orthopaedic Research Society Annual Meeting. Austin, TX, February 2-5, 2019.

Siskey RL, Midha P, Okafor I, White JW, Shaw C, Ochoa JO. MRI Heating of Interbody Fusion Devices with Radiographic Markers. Poster No. 0873, Orthopaedic Research Society Annual Meeting. Austin, TX, February 2-5, 2019.

Murdock K, Gross DC, Leewood A, Serano P, Horner M, Nyenhuis J, Afshari P, Moreno D, White J, Alnnasouri R, Ferry P, Ponvianne Y, Kozlov M, Gerber C, Bibiano C, Rajan SS, Angelone L. Computational modeling of RF-induced heating due to a titanium-alloy rod: An Interlaboratory Comparison for the ASTM F2182 task group. Submission No. 4948. International Society for Magnetic Resonance in Medicine Annual Meeting. Montreal, QC, Canada. May 11-16, 2019.

White JB. Aqueous-two phase-mediated wound assay of epithelial cells cultured at air-liquid interface. Biomedical Engineering Society, Atlanta, GA, 2012.

White JB. Receptor differential activation and cooperativity can modify cell chemosensing. Microtechnologies in Medicine and Biology, Lucerne, Switzerland, 2011.

White JB. Applying multiple, independent chemical gradients to human stem cells in 3D culture environments. Biomedical Engineering Society, Austin, TX, 2010.

Prior Experience

Co-founder and Chief Scientific Officer, PhasiQ, Inc., 2012–2013

Contract Editor, American Journal Experts, 2012–2013

Lab Manager, Micro/Nano/Molecular Biotechnology Lab, 2010–2013

NSF Graduate Research Fellow, University of Michigan, 2010–2013

Academic Appointments

Tau Beta Pi

Phi Kappi Phi

Knowledge

News & Events

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Biomedical Engineering, University of Michigan, Ann Arbor, 2013
  • M.S., Biomedical Engineering, University of Michigan, Ann Arbor, 2011
  • B.S., Biomedical Engineering, University of Wisconsin, Madison, 2009
  • National Science Foundation Graduate Research Fellow, 2010–2013

    Rackham Graduate Research Grant and Rackham Graduate Merit Fellowship, 2009–2011

    Hilldale Undergraduate Research Fellowship, 2009

    Meyerhoff Undergraduate Award for Leadership, Service, and Excellence, 2009

    Academic All-Big Ten Soccer Team, 2006

LANGUAGES

  • Spanish