April 8, 2017
Dr. Abby Li, Senior Managing Scientist in Exponent's Health Sciences practice, was recently awarded The Journal Award For Best Paper for the article, "Recommended Methods for Brain Processing and Quantitative Analysis in Rodent Developmental Neurotoxicity Studies." The article was published in the journal Toxicologic Pathology. (Citation: Garman RH, Li AA, Kaufmann W, Auer RN, Bolon B. Recommended Methods for Brain Processing and Quantitative Analysis in Rodent Developmental Neurotoxicity Studies. Toxicol Pathol 2016 Jan; 44(1):14-42. doi: 10.1177/0192623315596858. Epub 2015 Aug 21).
Neuropathology methods in rodent developmental neurotoxicity (DNT) studies have evolved with experience and changing regulatory guidance. This article emphasizes principles and methods to promote more standardized DNT neuropathology evaluation, particularly procurement of highly homologous brain sections and collection of the most reproducible morphometric measurements.
Dr. Li has extensive experience addressing toxicology, human health risk assessment, and other regulatory science issues for pesticides, industrial chemicals, medical devices, and pharmaceuticals. She is recognized internationally for her expertise in regulatory neurotoxicology testing. She recently led a panel of neuropathologists, toxicologists, and regulatory scientists from industry, government, and academia from the US, Canada, and Germany to complete a manuscript accepted by Neurotoxicology and Teratology entitled, "Recommendations for harmonization of data collection and analysis of developmental neurotoxicity endpoints in regulatory guideline studies." The manuscript is now available online.