Stabler
Collin T. Stabler, Ph.D.
Senior Associate
Biomedical Engineering
Philadelphia

Dr. Stabler’s primary expertise is medical device and drug delivery platform development for pulmonary applications. Such applications include 3D-printing for biomedical purposes, tissue engineering and regenerative medicine, bioreactor design, in-vivo disease modeling, and ex-vivo microphysiologic assay development (e.g., organoids, microfluidic devices). Dr. Stabler is proficient in mechanical testing of engineering and biomaterials, histological analyses, cell and molecular biology techniques, and has extensive experience working with animal models for disease and regeneration studies, as well as a multitude of microscopy and dry lab techniques. As a data scientist, he has expertise in handling large datasets, market and strategic analysis, and data visualization tools.

Dr. Stabler is currently a Visiting Scholar at the Center for Pulmonary Biology at the University of Pennsylvania School of Medicine, where he studies pulmonary development, disease, and regeneration. His research has included the development of methods for bioengineered lung manufacturing, bioreactor design for stem cell culture, disease modeling of acute respiratory distress syndrome and pulmonary fibrosis, and tissue engineering of lung, tracheal, and bone tissues. Dr. Stabler’s experience provides him with the necessary skill sets for solving complex technical problems in the pharmaceutical and medical device industries, enabling companies to address patient needs more effectively and efficiently. 

Dr. Stabler has published a number of papers in the field of tissue engineering and regenerative medicine and his research included the founding of a medical device startup company. He maintains a broad presence in the industry through involvement in professional and entrepreneurial societies. His work has resulted in several academic awards from a government agency, private foundations, and publicly held companies.

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Bioengineering, Temple University, 2016
  • B.S., Engineering Science, Hofstra University, 2008
  • Michael Brown Penn-GSK Postdoctoral Research Fellowship

    Hartwell Foundation Postdoctoral Research Fellowship

    Lung Repair and Regeneration Consortium (LRRC) Travel Award

    National Aeronautics and Space Administration (NASA) Graduate Student Research Program (GSRP) fellowship

    Temple University College of Engineering Poster Competition 1st place award

Publications

Tint D, Stabler CT, Hanifi A, Yousefi F, Linkov G, Hy K, Soliman AMS, Pleshko N. Spectroscopic Analysis of Human Tracheal Tissue during Decellularization. Otolaryngol Head Neck Surg. 2018 Oct 16:194599818806271. doi: 10.1177/0194599818806271. [Epub ahead of print] PubMed PMID: 30325714.

Stabler CT, Morrisey EE. Developmental pathways in lung regeneration. Cell Tissue Res. 2017 Mar;367(3):677-685. doi: 10.1007/s00441-016-2537-0. Epub 2016 Dec 13. Review. PubMed PMID: 27957616; PubMed Central PMCID: PMC5321816.

Stabler CT, Caires LC Jr, Mondrinos MJ, Marcinkiewicz C, Lazarovici P, Wolfson MR, Lelkes PI. Enhanced Re-Endothelialization of Decellularized Rat Lungs. Tissue Eng Part C Methods. 2016 May;22(5):439-50. doi: 10.1089/ten.TEC.2016.0012. Epub 2016 Apr 1. PubMed PMID: 26935764; PubMed Central PMCID: PMC4870653.

Stabler CT, Lecht S, Mondrinos MJ, Goulart E, Lazarovici P, Lelkes PI. Revascularization of decellularized lung scaffolds: principles and progress. Am J Physiol Lung Cell Mol Physiol. 2015 Dec 1;309(11):L1273-85. doi: 10.1152/ajplung.00237.2015. Epub 2015 Sep 25. Review. PubMed PMID: 26408553; PubMed Central PMCID: PMC4669341.

Stabler CT, Lecht S, Lazarovici P, Lelkes PI. Mesenchymal stem cells for therapeutic applications in pulmonary medicine. Br Med Bull. 2015 Sep;115(1):45-56. doi: 10.1093/bmb/ldv026. Epub 2015 Jun 10. Review. PubMed PMID: 26063231.

Frohbergh ME, Katsman A, Mondrinos MJ, Stabler CT, Hankenson KD, Oristaglio JT, Lelkes PI. Osseointegrative properties of electrospun hydroxyapatite-containing nanofibrous chitosan scaffolds. Tissue Eng Part A. 2015 Mar;21(5-6):970-81. doi: 10.1089/ten.TEA.2013.0789. Epub 2014 Dec 16. PubMed PMID: 25336062; PubMed Central PMCID: PMC4356216. 

Pimton P, Lecht S, Stabler CT, Johannes G, Schulman ES, Lelkes PI. Hypoxia enhances differentiation of mouse embryonic stem cells into definitive endoderm and distal lung cells. Stem Cells Dev. 2015 Mar 1;24(5):663-76. doi: 10.1089/scd.2014.0343. Epub 2014 Oct 27. PubMed PMID: 25226206; PubMed Central PMCID: PMC4333609. 

Lecht S, Gerstenhaber JA, Stabler CT, Pimton P, Karamil S, Marcinkiewicz C, Schulman ES, Lelkes PI. Heterogeneous mixed-lineage differentiation of mouse embryonic stem cells induced by conditioned media from a549 cells. Stem Cells Dev. 2014 Aug 15;23(16):1923-36. doi: 10.1089/scd.2014.0042. Epub 2014 Jun 3. PubMed PMID: 24720740. 

Júnior LC, Guimarães Eda S, Musso CM, Stabler CT, Garcia RM, Mourão-Júnior CA, Andreazzi AE. Behavior and memory evaluation of Wistar rats exposed to 1·8 GHz radiofrequency electromagnetic radiation. Neurol Res. 2014 Sep;36(9):800-3. doi: 10.1179/1743132813Y.0000000276. Epub 2014 Jan 27. PubMed PMID: 24620965. 

Lecht S, Stabler CT, Rylander AL, Chiaverelli R, Schulman ES, Marcinkiewicz C, Lelkes PI. Enhanced reseeding of decellularized rodent lungs with mouse embryonic stem cells. Biomaterials. 2014 Mar;35(10):3252-62. doi: 10.1016/j.biomaterials.2013.12.093. Epub 2014 Jan 15. PubMed PMID: 24439414; PubMed Central PMCID: PMC5030820. 

Presentations

Stabler, CT. Integrin specific re-endothelialization of decellularized rodent lungs. Tissue Engineering and Regenerative Medicine International Society World Congress. Boston MA, 2016. 

Stabler, CT. Positional and Integrin-Specific Re-endothelializtion of Decellularized Rodent Lungs. Stem Cells and Cell Therapies in Lung Biology and Lung Diseases Conference, Burlington VT, 2015.

Stabler, CT. Enhanced reseeding of decellularized rodent lung airway and vasculature. Biomedical Engineering Society International Conference, San Antonio TX, 2014.

Prior Experience

Postdoctoral Fellow, University of Pennsylvania School of Medicine, 2016-2018

Research Assistant, Temple University, 2013-2016

Research Assistant, Drexel University, 2009-2013

Associate Scientist, SBH Sciences, 2008-2009

Research Intern, North Shore University Hospital, 2007-2008

Academic Appointments

Visiting Scholar, Penn Center for Pulmonary Biology and Penn Institute for Regenerative Medicine, University of Pennsylvania School of Medicine (2018)

Professional Affiliations

Biomedical Engineering Society, Member

Tissue Engineering and Regenerative Medicine International Society, Member

Theta Tau, Member

Additional Information

Peer Reviewer

ACS Biomaterials Science & Engineering

CREDENTIALS & PROFESSIONAL HONORS

  • Ph.D., Bioengineering, Temple University, 2016
  • B.S., Engineering Science, Hofstra University, 2008
  • Michael Brown Penn-GSK Postdoctoral Research Fellowship

    Hartwell Foundation Postdoctoral Research Fellowship

    Lung Repair and Regeneration Consortium (LRRC) Travel Award

    National Aeronautics and Space Administration (NASA) Graduate Student Research Program (GSRP) fellowship

    Temple University College of Engineering Poster Competition 1st place award