Toxicology & Human Health Risk Consulting

Classification & Labeling of Chemical Substances & Mixtures

Thought leadership

Successfully Navigating California Prop 65

Evaluate complex exposures and potential risk

Assessing human health risk requires a rigorous understanding of exposure. Chemical exposures may span products, environments, and populations — and small differences in formulation, use, exposure pathways, or exposure levels can significantly alter human health risk. We evaluate toxicity across real-world conditions, from consumer products and medical devices to industrial chemicals, environmental contaminants, and recreational drugs and alcohol.

Our multidisciplinary teams assess exposure pathways, dose-response relationships, and the alignment of reported effects with known biological mechanisms, helping you determine whether observed or potential health effects are meaningful, defensible, and actionable. Our insights support product development, regulatory and legal strategy, and risk management decisions.

Strengthen regulatory and product decisions

Exponent applies deep toxicological expertise to interpret complex data in the context of regulatory expectations and evolving science. Our work spans product safety, environmental exposures, and occupational risk, including labeling, compliance, environmental remediation, and post-market evaluation.

We also critically assess existing studies and health claims, helping you address challenges in regulatory submissions and disputes. By translating complex science into clear, defensible positions, our teams enable you to manage risk and make decisions based on the best available science and risk assessment methods.

Capabilities

Evaluating chemical hazards and dose-response relationships forms the foundation of human health risk assessment. General and specific disease causation analyses involve an understanding of biological plausibility and require the ability to interpret the weight of scientific evidence. Exponent's toxicologists assess the mechanisms of chemical-specific toxicity to identify potentially relevant hazards under different exposure scenarios.
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Chemical exposure may occur across a wide variety of scenarios — from consumer products, food consumption, occupational settings, or contaminated environments. Exponent's toxicologists identify chemical sources and exposure patterns to support the assessment of real-world human health risks.
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When humans are exposed to chemical contaminants or pharmaceutical drugs, understanding of that chemical's fate in the human body is often critical for assessing potential biological effects. Exponent conducts pharmacokinetic modeling, including physiologically based pharmacokinetic (PBPK) modeling, and dose-response modeling, such as benchmark dose response (BMDR) modeling, to assist with both regulatory and legal risk assessments.
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Exponent's multidisciplinary teams of industrial hygienists, toxicologists, and risk assessors provide the scientific data and analysis required to navigate often complex chemical regulatory requirements. We conduct occupational and consumer product exposure studies, assist clients with EPA TSCA data submissions and Test Orders, and prepare human health and ecological risk evaluations under CERCLA or state-led environmental cleanup programs. Our scientists address human health and environmental compliance challenges across industrial, medical, and consumer products.
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Uncertainty around environmental contamination can drive regulatory action, delay site remediation and redevelopment, and increase liability. A clear understanding of how chemicals move through the environment — and what they mean for human health and ecological risk — is critical.
Our toxicologists and risk assessors characterize contaminants, evaluate exposure pathways, and assess risk under real-world conditions and/or regulatory requirements. We design and execute field studies, develop and/or analyze the data needed for human health risk assessments, and establish risk-based cleanup goals for contaminated sites, informing remediation strategies, regulatory engagement, and long-term site management. Our team also supports public stakeholder engagement, facilitating clear and accurate presentation of complex risk information.
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Our Capabilities Are Unparalleled

With expertise in over 90 disciplines and hundreds of capabilities, tools, and methodologies — we get to the root of even the most complex challenges and give you the objective answers you need.

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Related Expertise

Experts

Our global and comprehensive expertise across industries gives us a deep understanding of current challenges, best practices, and the implications of emerging technologies.